المؤلفون: Yan Gu, Daniel C-H Lin, Paul H. Lee, Ryan White, Xiaosu Wu, Daniel B. Horne, Yonghong Bai, Xinchao Yu, Hao Chen, Sudipa Ghimire-Rijal, Xin Huang

المصدر: eLife
eLife, Vol 9 (2020)

مصطلحات موضوعية: Agonist, Models, Molecular, medicine.drug_class, QH301-705.5, Protein Conformation, Science, Structural Biology and Molecular Biophysics, Drug action, Ligands, General Biochemistry, Genetics and Molecular Biology, TRPC6, drug discovery, Diglycerides, Transient receptor potential channel, Protein Domains, medicine, TRPC6 Cation Channel, structural biology, Humans, Biology (General), TRPC, Cryo-EM, Binding Sites, General Immunology and Microbiology, Drug discovery, Chemistry, Glomerulosclerosis, Focal Segmental, General Neuroscience, Cryoelectron Microscopy, General Medicine, Calcium Channel Blockers, Small molecule, Structural biology, Mutation, Biophysics, Medicine, Research Article, Human

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5cea2718121b864c5ca48f8ee2ded6a
http://europepmc.org/articles/PMC7082128

المؤلفون: Jaan A. Pesti, Ahmed F. Abdel-Magid, Rajappa Vaidyanathan, Yi-Yin Ku, Michael D. Wendt, Robert Dugger, Bryan Li, Paul Richardson, Rémy Angelaud, Steve Staben, Timothy Heffron, Andreas Schuster, Frédéric St-Jean, Stefan G. Koenig, Thomas H. Pillow, Andreas Stumpf, Daniel Sutherlin, Christoph M. Dehnhardt, Neil F. Langille, Daniel B. Horne, David C. Blakemore, Thomas Brandt, Craig Knight, Sarah E. Skerratt, Christian Harcken, Joshuaine Grant, Hossein Razavi, Maurice A. Marsini, Frederic G. Buono, Jon C. Lorenz, Jonathan T. Reeves, James J. Crawford, Haiming Zhang, David W. Piotrowski, Emma L. McInturff, Andrew J. Peat, Shiping Xie

Resource Type: eBook.

الموضوعات: Drug development, Pharmaceutical industry, Pharmaceutical technology

Categories: MEDICAL / Pharmacy, SCIENCE / Chemistry / Organic

المؤلفون: Daniel B. Horne, Neil F. Langille

المصدر: ACS Symposium Series ISBN: 9780841234321
ACS Symposium Series

مصطلحات موضوعية: Migraine, Chemistry, Antagonist, medicine, TRPM8, Pharmacology, medicine.disease

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::52e519a4055511097d8575e0d4be97a6
https://doi.org/10.1021/bk-2019-1332.ch006

المؤلفون: Jeffrey Clarine, Qingyian Liu, Beth D. Youngblood, Chester Chenguang Yuan, Michelle Horner, James Brown, Jian J. Chen, Michael D. Bartberger, Vu Van Ma, Matthew R. Kaller, Carl D. Davis, Maosheng Zhang, Thomas T. Nguyen, Narender R. Gavva, Scott Harried, Sonya G. Lehto, Jennifer R. Allen, Holger Monenschein, Daniel B. Horne, Vijay Keshav Gore, Wenge Zhong, Kaustav Biswas

المصدر: Journal of medicinal chemistry. 61(18)

مصطلحات موضوعية: 0301 basic medicine, Male, Models, Molecular, Migraine Disorders, TRPM Cation Channels, Pyrimidinones, Pharmacology, Niacin, Pathogenesis, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Seizures, Drug Discovery, TRPM8, medicine, Animals, Humans, Molecular Structure, Drug discovery, Chemistry, Antagonist, medicine.disease, Rats, Clinical trial, Calcium Channel Agonists, 030104 developmental biology, Nicotinic agonist, medicine.anatomical_structure, Migraine, 030220 oncology & carcinogenesis, Peripheral nervous system, Microsomes, Liver, Molecular Medicine, Anticonvulsants

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c32a8bd8200356c5984cf6c6b54e8a8
https://pubmed.ncbi.nlm.nih.gov/30148953

المؤلفون: Narender R. Gavva, Gregory Dussor, Christina M. Bischoff, Weiya Wang, Carolina C. Burgos-Vega, David Dong Uk Ahn, Judy Wang, Daniel B. Horne

المصدر: Cephalalgia. 36:185-193

مصطلحات موضوعية: Male, 0301 basic medicine, Migraine Disorders, TRPM Cation Channels, Pyrimidinones, Neurological disorder, Article, Rats, Sprague-Dawley, 03 medical and health sciences, Transient receptor potential channel, 0302 clinical medicine, medicine, Animals, business.industry, Rodent model, General Medicine, medicine.disease, Rats, Disease Models, Animal, Sumatriptan, 030104 developmental biology, Allodynia, Migraine, Hyperalgesia, Anesthesia, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc36959bb88dfdaef32efd8defeeaf8
https://doi.org/10.1177/0333102415584313

المؤلفون: Essa Hu, Samer Chmait, Thomas T. Nguyen, Amy Porter, Kristin L. Andrews, Silke Miller, Carl Davis, Jennifer R. Allen, Robert M. Rzasa, James J. S. Treanor, Alexander J. Pickrell, Adrie D. Jones, Roxanne Kunz, Daniel B. Horne, Xiaoning Zhao, Matthew R. Kaller, Holger Monenschein, Ning Chen, Heather Eastwood, Jeffrey Clarine, Michael J. Frohn, Andreas Reichelt

المصدر: Bioorganic & Medicinal Chemistry. 22:6570-6585

مصطلحات موضوعية: Models, Molecular, Phosphodiesterase Inhibitors, Stereochemistry, Clinical Biochemistry, Azetidine, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Structure–activity relationship, Solubility, Molecular Biology, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Phosphoric Diester Hydrolases, Chemistry, Organic Chemistry, Bioavailability, Enzyme, Quinolines, Alkoxy group, Molecular Medicine, Lead compound, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a111fa0c0183c52c1f5301e3654201e
https://doi.org/10.1016/j.bmc.2014.10.013

المؤلفون: Vinod F. Patel, Thomas T. Nguyen, Lewis D. Pennington, Daniel B. Horne, Michael D. Bartberger, Holger Monenschein, Stephen Hitchcock, Wenge Zhong

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3607-3611

مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Cathepsin D, Biochemistry, Structure-Activity Relationship, stomatognathic system, Aspartate protease, Alzheimer Disease, Catalytic Domain, Drug Discovery, Ethylamines, Humans, Moiety, Computer Simulation, Protease Inhibitors, Molecular Biology, Binding Sites, Chemistry, Organic Chemistry, Toxicity, Microsomes, Liver, Microsome, β secretase, Molecular Medicine, Amine gas treating, Amyloid Precursor Protein Secretases, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee9cf462951bcfa5784ecb95fc1ba18
https://doi.org/10.1016/j.bmcl.2012.04.060

المؤلفون: Yuan Cheng, Matthew R. Kaller, Steven W. Louie, Martin Citron, Lewis D. Pennington, Daniel S. La, Matthew Weiss, Stephen J. Wood, Wenge Zhong, Michael Croghan, Toni Williamson, Scott Harried, James Brown, Kui Chen, Tisha San Miguel, Ronke Imbeah-Ampiah, Holger Monenschein, Qiufen Xue, Hongbing Huang, Patricia Lopez, Claire Rattan, Thomas Dineen, Daniel B. Horne, E. Allen Sickmier, Dean Hickman, Safura Babu-Khan, Charles Kreiman, Vivian S. W. Li, Paul H. Wen, Michael D. Bartberger, Russell Graceffa, Robert C. Wahl, Thomas T. Nguyen, Bryant Yang, Ted Judd, Joel Esmay, Vinod F. Patel, Stephen Hitchcock

المصدر: Journal of Medicinal Chemistry. 55:9009-9024

مصطلحات موضوعية: Male, Models, Molecular, Protein Conformation, Administration, Oral, Biological Availability, Stereoisomerism, Pharmacology, Crystallography, X-Ray, Rats, Sprague-Dawley, Structure-Activity Relationship, Dogs, Pharmacokinetics, Oral administration, Drug Discovery, Ethylamines, Animals, Aspartic Acid Endopeptidases, Humans, Structure–activity relationship, ATP Binding Cassette Transporter, Subfamily B, Member 1, chemistry.chemical_classification, Amyloid beta-Peptides, Brain, Dioxolanes, Macaca mulatta, Peptide Fragments, Rats, Bioavailability, Protein Transport, Enzyme, chemistry, Biochemistry, Drug Design, Microsomes, Liver, Microsome, Molecular Medicine, Efflux, Amyloid Precursor Protein Secretases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282a471f56ccce495f911c58f29307ea
https://doi.org/10.1021/jm300119p

المؤلفون: Paul H. Wen, Robert C. Wahl, Michael Croghan, Ronke Imbeah-Ampiah, Paul Acton, Stephen J. Wood, Charles Kreiman, Vivian S. W. Li, Qiufen Xue, Lewis D. Pennington, Safura Babu-Khan, Daniel B. Horne, Thomas Dineen, Wenge Zhong, Scott Harried, Douglas A. Whittington, Dean Hickman, James Brown, Martin Citron, Matthew Weiss, Daniel S. La, Holger Monenschein, Bryant Yang, E. Allen Sickmier, Tisha San Miguel, Robert T. Dunn, Russell Graceffa, Patricia Lopez, Toni Williamson, Hongbing Huang, Yuan Cheng, Kui Chen, Matthew R. Kaller, Michael D. Bartberger, Steven W. Louie, Hugo M. Vargas, Stephen Hitchcock, Thomas T. Nguyen, Vinod F. Patel, Ted Judd, Joel Esmay

المصدر: Journal of Medicinal Chemistry. 55:9025-9044

مصطلحات موضوعية: Male, Models, Molecular, Protein Conformation, Swine, Administration, Oral, Peptide, In Vitro Techniques, Pharmacology, Crystallography, X-Ray, Inhibitory postsynaptic potential, Cell Line, Rats, Sprague-Dawley, Structure-Activity Relationship, Dogs, Pharmacokinetics, mental disorders, Drug Discovery, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Humans, Spiro Compounds, Dosing, chemistry.chemical_classification, Amyloid beta-Peptides, Cardiovascular safety, biology, Brain, Stereoisomerism, Blood Proteins, Peptide Fragments, Rats, Bioavailability, Thiazoles, Enzyme, Biochemistry, chemistry, Drug Design, Microsomes, Liver, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8863b7dd3a68852600abaa1a5773f2a
https://doi.org/10.1021/jm300118s

المؤلفون: Matthew R. Kaller, Stephen Hitchcock, Michael D. Bartberger, Wenge Zhong, Holger Monenschein, Daniel B. Horne

المصدر: Tetrahedron Letters. 50:5452-5455

مصطلحات موضوعية: Aryl, Organic Chemistry, Xenon difluoride, Biochemistry, Combinatorial chemistry, Chloride, chemistry.chemical_compound, chemistry, Drug Discovery, Pyridine, medicine, Computational analysis, Methylene, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::02128f6f6dbc9202b4d198da8bcf58eb
https://doi.org/10.1016/j.tetlet.2009.07.060

المؤلفون: Daniel B. Horne, Barry M. Trost, Yimin Hu

المصدر: Journal of the American Chemical Society. 129:11781-11790

مصطلحات موضوعية: Biological Products, Chemistry, Stereochemistry, Anti-Inflammatory Agents, Absolute configuration, Total synthesis, Regioselectivity, Stereoisomerism, General Chemistry, Ring (chemistry), Biochemistry, Ruthenium, Catalysis, Cycloaddition, Porifera, Claisen rearrangement, Bridged Bicyclo Compounds, Colloid and Surface Chemistry, Models, Chemical, Cyclization, Animals

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857c226bced3fb1fea495be59dbbb0de
https://doi.org/10.1021/ja073272b

المؤلفون: Daniel B. Horne, Michael J. Woltering, Barry M. Trost

المصدر: Chemistry - A European Journal. 12:6607-6620

مصطلحات موضوعية: Pyrrolidines, Alkylation, Chemistry, Stereochemistry, Organic Chemistry, Synthon, Glycopeptides, Enantioselective synthesis, Iminosugar, Total synthesis, chemistry.chemical_element, Stereoisomerism, General Chemistry, Catalysis, Tsuji–Trost reaction, Alkaloids, Epoxy Compounds, Mannitol, Amine gas treating, Nuclear Magnetic Resonance, Biomolecular, Palladium, Imino Pyranoses

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4c577ad163e738c8bd5bd35f060cf3
https://doi.org/10.1002/chem.200600202

المؤلفون: Vu Van Ma, Maosheng Zhang, Nuria A. Tamayo, Vijay Keshav Gore, Weiya Wang, Phi Tang, Holger Monenschein, Daniel B. Horne, Mark H. Norman, Michael D. Bartberger, Yunxin Bo, Jeffrey Clarine, Thomas T. Nguyen, Carl Davis, Beth D. Youngblood, Matthew R. Kaller, Sonya G. Lehto, Narender R. Gavva, Nobuko Nishimura

المصدر: Journal of medicinal chemistry. 57(7)

مصطلحات موضوعية: Male, TRPM Cation Channels, Pyrimidinones, Pharmacology, Motor Activity, Rats, Sprague-Dawley, chemistry.chemical_compound, Transient receptor potential channel, Dogs, In vivo, Tetrahydroisoquinolines, Drug Discovery, TRPM8, Potency, Animals, Humans, Tissue Distribution, Behavior, Animal, Tetrahydroisoquinoline, Circular Dichroism, Icilin, Cold pressor test, Stereoisomerism, Rats, Cold Temperature, chemistry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Microsomes, Liver, Molecular Medicine, Menthol

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31259e241c7b92b3f659ee0304d6bff2
https://pubmed.ncbi.nlm.nih.gov/24597733

المؤلفون: Yi Luo, Matthew Weiss, Stephen J. Wood, Tom Dineen, Kui Chen, Jodi Bradley, Hongbing Huang, Ted Judd, Patricia Lopez, Li Zhu, Yuan Cheng, Patricia Amarante, Dean Hickman, Bryant Yang, Paul Acton, Safura Babu-Khan, Steven W. Louie, Mathew Kaller, Joel Esmay, Jan Zhang, Russell Graceffa, Wenge Zhong, Daniel B. Horne, Toni Williamson, Paul H. Wen, Robert C. Wahl

المصدر: Alzheimer's & Dementia. 8

مصطلحات موضوعية: biology, Epidemiology, Chemistry, Health Policy, Pharmacology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Pharmacokinetics, Pharmacodynamics, Sprague dawley rats, biology.protein, Neurology (clinical), Geriatrics and Gerontology, Beta (finance), Amyloid precursor protein secretase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cf683c6c08be5e8d466638aed2bc4075
https://doi.org/10.1016/j.jalz.2012.05.522

المؤلفون: Daniel B. Horne, Matthew R. Kaller, Michael D. Bartberger, Holger Monenschein, Stephen Hitchcock, Wenge Zhong

المصدر: ChemInform. 40

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Aryl, Xenon difluoride, Pyridine, medicine, General Medicine, Computational analysis, Methylene, Chloride, Medicinal chemistry, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f4427fc9fa4014398ccae5baf1e27024
https://doi.org/10.1002/chin.200952080

المؤلفون: Yimin Hu, Daniel B. Horne, Barry M. Trost

المصدر: ChemInform. 39

مصطلحات موضوعية: Terpene, Chemistry, Organic chemistry, Total synthesis, General Medicine, Cycloaddition, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::04ce4b633b17382208fe69c30e7bdf0d
https://doi.org/10.1002/chin.200806161

المؤلفون: Michael J. Woltering, Daniel B. Horne, Barry M. Trost

المصدر: ChemInform. 35

مصطلحات موضوعية: Chemistry, Broussonetine G, Enantioselective synthesis, Organic chemistry, chemistry.chemical_element, Total synthesis, General Medicine, Catalysis, Palladium

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a7f280482c782cd04ff7631af7e293b1
https://doi.org/10.1002/chin.200417203

المؤلفون: Daniel B. Horne, Michael J. Woltering, Barry M. Trost

المصدر: Angewandte Chemie (International ed. in English). 42(48)

مصطلحات موضوعية: Pyrrolidines, Chemistry, Broussonetine G, Enantioselective synthesis, chemistry.chemical_element, Total synthesis, Stereoisomerism, General Chemistry, General Medicine, Catalysis, Alkaloids, Organic chemistry, Epoxy Compounds, Enzyme Inhibitors, Palladium

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc7ef72b061c0e920a8de4ce170438c
https://pubmed.ncbi.nlm.nih.gov/14679550

المؤلفون: Barry M. Trost, Daniel B. Horne, Y. Hu

المصدر: Synfacts. 2008:0227-0227

مصطلحات موضوعية: Claisen rearrangement, Chemistry, Organic chemistry, chemistry.chemical_element, Photochemistry, Ruthenium

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4ab67b4953ee04c6df35a4a29f6ccf62
https://doi.org/10.1055/s-2008-1042661

المؤلفون: Barry M. Trost, Hong C. Shen, Daniel B. Horne, F. Dean Toste, Bernhard G. Steinmetz, Christopher Koradin

المصدر: Chemistry - A European Journal; Apr2005, Vol. 11 Issue 8, p2577-2590, 14p