المؤلفون: Kelly-Ann S. Schlegel, Peter S. Kutchukian, Lee Warren, Sophie Parmentier-Batteur, Jason Cassaday, Victor N. Uebele, Brian C. Magliaro, Brian Squadroni, Danielle M. Hurzy, Eric N. Johnson, J. Chris Culberson, Gregory O'Donnell, Adam Amoss, Fiona Thomson, Michael F.A. Finley, Paul Zuck, Andrew J. Cooke, Danette Pascarella, Jeffrey D. Hermes

مصطلحات موضوعية: 0301 basic medicine, Amino Acid Transport System y+, Synaptic cleft, Central nervous system, Hippocampus, CHO Cells, Biology, Biochemistry, Machine Learning, 03 medical and health sciences, Glutamatergic, Cricetulus, 0302 clinical medicine, Cricetinae, medicine, Animals, Humans, Receptor, Bayes Theorem, Transporter, General Medicine, High-Throughput Screening Assays, 030104 developmental biology, medicine.anatomical_structure, nervous system, Glycine, Molecular Medicine, NMDA receptor, Neuroscience, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ee89032dec0bd4c1bf64d0fea584c0
https://eprints.gla.ac.uk/146530/1/146530.pdf

المؤلفون: Cyrille Sur, Danette Pascarella, Constantine Kreatsoulas, Marlene A. Jacobson, Julie A. O'Brien

المصدر: Molecular Pharmacology. 78:648-657

مصطلحات موضوعية: Pharmacology, Binding Sites, Stereochemistry, Molecular Sequence Data, Receptor, Muscarinic M1, Allosteric regulation, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M1, Acetylcholine, Protein Structure, Secondary, chemistry.chemical_compound, Transmembrane domain, Allosteric Regulation, Piperidines, chemistry, Biochemistry, Docking (molecular), Muscarinic acetylcholine receptor, Humans, Molecular Medicine, Benzimidazoles, Amino Acid Sequence, Binding site, Xanomeline, Allosteric Site

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2255a5df92fab94cb358d2b1020876f2
https://doi.org/10.1124/mol.110.065771

المؤلفون: Marlene A. Jacobson, P. Jeffrey Conn, Douglas J. Pettibone, Cyrille Sur, Jacinta B. Williams, Danette Pascarella, Marion Wittmann, Philip E. Brandish, Edward M. Scolnick, Pierre Mallorga

المصدر: Proceedings of the National Academy of Sciences. 100:13674-13679

مصطلحات موضوعية: Agonist, DNA, Complementary, Time Factors, medicine.drug_class, Biology, Pharmacology, Hippocampus, Receptors, N-Methyl-D-Aspartate, Muscarinic agonist, Cell Line, Inhibitory Concentration 50, chemistry.chemical_compound, Cricetinae, Muscarinic acetylcholine receptor M5, Muscarinic acetylcholine receptor M4, medicine, Animals, Humans, Clozapine, Neurons, Multidisciplinary, Dose-Response Relationship, Drug, Receptor, Muscarinic M1, Brain, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M1, Biological Sciences, Rats, Electrophysiology, chemistry, Guanosine 5'-O-(3-Thiotriphosphate), Mutagenesis, Site-Directed, Xanomeline, Allosteric Site, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76584414cdb348c17970f608ec700f2d
https://doi.org/10.1073/pnas.1835612100

المؤلفون: Pierre Mallorga, Douglas J. Pettibone, E V Lis, Marlene A. Jacobson, Michael Leviten, J. Fred Hess, Melissa A. Snyder, Patricia J. Hey, Danette Pascarella, Jacinta B. Williams, Zhizhen Zeng

المصدر: Journal of Pharmacology and Experimental Therapeutics. 300:305-313

مصطلحات موضوعية: Central Nervous System, medicine.medical_specialty, Ileum, In situ hybridization, Biology, Body Temperature, Cell Line, Mice, Radioligand Assay, chemistry.chemical_compound, In vivo, Internal medicine, Peripheral Nervous System, medicine, Animals, Receptors, Neurotensin, RNA, Messenger, Neurotensin receptor, Receptor, Postural Balance, In Situ Hybridization, Neurotensin, Pain Measurement, Mice, Knockout, Pharmacology, Analgesics, Reverse Transcriptase Polymerase Chain Reaction, Blotting, Northern, In vitro, Mice, Inbred C57BL, Phenotype, medicine.anatomical_structure, Endocrinology, chemistry, Knockout mouse, Molecular Medicine, Gastrointestinal Motility, Psychomotor Performance

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd39e9e57602354df52746c24316563
https://doi.org/10.1124/jpet.300.1.305

المؤلفون: Denise J. Bickel, Lone Veng, Marlene A. Jacobson, William J. Ray, K. H. Jones, Cyrille Sur, Danette Pascarella, Marion Wittmann, Rose Flick, Michelle Pearson, Constantine Kreatsoulas, Paul J. Shughrue, Scott M. Doran, Craig W. Lindsley, Gene G. Kinney, Matthew A. Seager, Guy R. Seabrook, Alexander McCampbell, Maryann Burno, William D. Shipe, Valerie Kuzmick Graufelds, Andrew Danziger, Lei Ma, Christopher P. Regan, Scott D. Kuduk, Guangping Xu, Susan L. Garson, Renee C. Gaspar

مصطلحات موضوعية: Models, Molecular, medicine.medical_specialty, Inositol Phosphates, Allosteric regulation, CHO Cells, Biology, In Vitro Techniques, Quinolones, chemistry.chemical_compound, Mice, Radioligand Assay, Cricetulus, Dogs, Allosteric Regulation, Internal medicine, Cricetinae, Muscarinic acetylcholine receptor, Conditioning, Psychological, medicine, Animals, Humans, Amino Acid Sequence, Calcium Signaling, Cholinergic neuron, Calcium signaling, Mice, Knockout, Multidisciplinary, Arc (protein), Receptor, Muscarinic M1, Brain, Long-term potentiation, Muscarinic acetylcholine receptor M1, Fear, Biological Sciences, Macaca mulatta, Recombinant Proteins, Protein Structure, Tertiary, Rats, Endocrinology, chemistry, Cerebrovascular Circulation, Xanomeline, Sleep, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883d52a829eb7f4a1dfa08990154309a
https://europepmc.org/articles/PMC2732705/

المؤلفون: Nathan O. Surles, Nancy A. Sachs, Jason M. Uslaner, Tim Sparey, Monika Kandebo, Mary Beth Young, Richard M. Hinchliffe, Caitlyn H. McNaughton, Brian A. Jones, Shankar Venkatraman, Marlene A. Jacobson, Peter H. Hutson, Lihang Yao, Sean M. Smith, Sarah L. Huszar, Danette Pascarella, Nicholas J. Brandon, Chadwick M. Mullins

المصدر: The Journal of pharmacology and experimental therapeutics. 328(3)

مصطلحات موضوعية: D-Amino-Acid Oxidase, Male, Models, Molecular, Stereochemistry, Carboxylic acid, D-amino acid oxidase, Thiophenes, Pharmacology, Serine, Animals, Humans, Pyrroles, Rats, Wistar, Receptor, Habituation, Psychophysiologic, Aged, chemistry.chemical_classification, Oxidase test, Recognition, Psychology, In vitro, Rats, chemistry, Glycine, Schizophrenia, Molecular Medicine, NMDA receptor, Dizocilpine Maleate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a89a1799024e687916b557780979727
https://pubmed.ncbi.nlm.nih.gov/19088300

المؤلفون: Marlene A. Jacobson, Shankar Venkatraman, Pete H. Hutson, Nicholas J. Brandon, G. Sridhar Prasad, Pravien Abeywickrema, V V Sardana, Sanjeev Munshi, Melanie Zea Sakatis, Danette Pascarella, Noel Byrne, Alister Campbell, Sarah Almond, Tim Sparey, Nancy A. Sachs, Brian A. Jones, Mary Beth Young, Andrew Pike

المصدر: Bioorganicmedicinal chemistry letters. 18(11)

مصطلحات موضوعية: D-Amino-Acid Oxidase, Carboxylic acid, Clinical Biochemistry, D-amino acid oxidase, Carboxylic Acids, Molecular Conformation, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, In vivo, Drug Discovery, Serine, Animals, Combinatorial Chemistry Techniques, Pyrroles, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Molecular Structure, Organic Chemistry, Metabolism, Rats, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Schizophrenia, Molecular Medicine, NMDA receptor, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa0dda0f6a2a60ea7c3ab6412dc1cf3
https://pubmed.ncbi.nlm.nih.gov/18455394

المؤلفون: Denise J. Bickel, Gene G. Kinney, Matthew A. Seager, Adam J. Simon, Marlene A. Jacobson, Keith Jones, Lone Veng, William J. Ray, Craig W. Lindsley, Valerie Kuzmick Graufields, Scott D. Kuduk, William D. Shipe, Guy R. Seabrook, Guoxin Wu, Marion Wittmann, Lei Ma, Maryann Burno, Diane Posavec, Krista Getty, Jacquelynn J. Cook, Danette Pascarella, Cyrille Sur, Ming-Chih Crouthamel, Sethu Sankaranarayananan, Michael W. Marlatt

المصدر: Alzheimer's & Dementia. 4:T761-T761

مصطلحات موضوعية: Epidemiology, business.industry, Health Policy, Allosteric regulation, M1 muscarinic receptor, Long-term potentiation, Disease, Pharmacology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, Neurology (clinical), Geriatrics and Gerontology, Selectivity, business, Therapeutic strategy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::184217928d5cd00570838bb61bbe51d5
https://doi.org/10.1016/j.jalz.2008.05.2375