المؤلفون: Nancy Chen, David E. Ehmann, Robert Crooker, Katayoun Derakhchan, Xiaodong Fang, Brian Felice, Elizabeth J. Galbreath, Charles Glaus, Hongbo Gu, Yan Huang, Christine Li, Xing Li, Nan Liu, Kathleen Palmieri, Damir Simic, Joseph Sypek, Susan Thompson, Christopher T. Winkelmann, Vivian W. Choi

المصدر: Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 286-302 (2023)

مصطلحات موضوعية: gene therapy, AAV, MPS II, cross-correction, non-human primates, iduronate-2-sulfatase, Genetics, QH426-470, Cytology, QH573-671

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050123000505; https://doaj.org/toc/2329-0501

URL الوصول: https://doaj.org/article/b33a6cf79e06450e92ea9144dc1312b7

المؤلفون: Nianli Sang, Damir Simic

المصدر: Experimental Hematology. 72:36-46

مصطلحات موضوعية: 0301 basic medicine, Proteasome Endopeptidase Complex, Cancer Research, Megakaryocyte differentiation, CD34, Antigens, CD34, Hydroxamic Acids, Cell Maturation, Article, 03 medical and health sciences, 0302 clinical medicine, Megakaryocyte, Cell Line, Tumor, Genetics, medicine, Humans, Anilides, GATA1 Transcription Factor, Molecular Biology, Transcription factor, business.industry, Cell Differentiation, Cell Biology, Hematology, Hematopoietic Stem Cells, Thrombocytopenia, Histone Deacetylase Inhibitors, Haematopoiesis, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Proteolysis, Cancer research, Histone deacetylase, Stem cell, business, Megakaryocytes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb0dd15d42f96d765248b2dadd876fa
https://doi.org/10.1016/j.exphem.2018.12.007

المؤلفون: Geraldine A. Hamilton, Katia Karalis, Jacob P. Fraser, Monicah A. Otieno, Riccardo Barrile, Fang Teng, Mimi Zhou, Donald E. Ingber, Andries D. van der Meer, Justin Nguyen, David Conegliano, Hyoungshin Park, Damir Simic, Abhishek Jain

المساهمون: Applied Stem Cell Technologies

المصدر: Clinical pharmacology & therapeutics, 104(6), 1240-1248. Wiley-Blackwell

مصطلحات موضوعية: Blood Platelets, 0301 basic medicine, Endothelium, medicine.drug_class, CD40 Ligand, UT-Hybrid-D, Antibodies, Monoclonal, Humanized, Monoclonal antibody, Risk Assessment, Fibrin, Autoimmune Diseases, Endothelial activation, 03 medical and health sciences, 0302 clinical medicine, Thrombin, Drug Development, Lab-On-A-Chip Devices, Microchip Analytical Procedures, medicine, Immunologic Factors, Pharmacology (medical), Prospective Studies, Receptor, Blood Coagulation, Retrospective Studies, Pharmacology, biology, business.industry, Receptors, IgG, Endothelial Cells, Thrombosis, medicine.disease, 22/4 OA procedure, 030104 developmental biology, medicine.anatomical_structure, Drug Design, 030220 oncology & carcinogenesis, Monoclonal, biology.protein, Cancer research, business, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae54f10c9f3efaaf70dbe17018e47b84
https://doi.org/10.1002/cpt.1054

المؤلفون: Erio Barale, Katia Karalis, Riccardo Barrile, Kyung-Jin Jang, Monica Singer, Abhishek Srivastava, Anna Herland, Josiah Sliz, Barry Jones, Hyoungshin Park, Janna Nawroth, Geraldine A. Hamilton, Dominic P. Williams, Wing W. Lam, Gauri Kulkarni, Jonathan E. Rubins, Suzzette Haney, Linda C. Andersson, Manisha Sonee, Konstantia Kodella, Debora B. Petropolis, Monicah A. Otieno, Heng-Keang Lim, Lorna Ewart, Bhanu Singh, Carl L. Manthey, Janey Ronxhi, Donald E. Ingber, David Conegliano, Anthony J. Streeter, Damir Simic

مصطلحات موضوعية: Drug, business.industry, media_common.quotation_subject, Pharmacology, medicine.disease, Phenotype, Cholestasis, Fibrosis, Toxicity, medicine, Hepatic stellate cell, Animal studies, Steatosis, business, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77153c2fec6be0820279936c4ea70992

المؤلفون: Amy E. Chadwick, Oisin Douglas, Dominic P. Williams, B. Kevin Park, Damir Simic, Carol E. Jolly, Laleh Kamalian, Mario Monshouwer, Jan Snoeys

المصدر: Current protocols in toxicology

مصطلحات موضوعية: 0301 basic medicine, Period (gene), Mitochondria, Liver, Mitochondrion, Toxicology, medicine.disease_cause, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Humans, Drug toxicity, Chemistry, Toxin, Galactose, medicine.disease, Culture Media, Mitochondrial toxicity, Glucose, 030104 developmental biology, Biochemistry, Cell culture, Hepg2 cells, Hepatocytes, Biological Assay, Chemical and Drug Induced Liver Injury, 030215 immunology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f063e1eeaf43c7963149955df9892dd4
https://doi.org/10.1002/cptx.76

المؤلفون: Bhanu Singh, Suzzette Haney, Carl L. Manthey, Riccardo Barrile, Anna Herland, Dominic P. Williams, Manisha Sonee, Katia Karalis, Monica Singer, David Conegliano, Heng-Keang Lim, Geraldine A. Hamilton, Donald E. Ingber, Monicah A. Otieno, Anthony J. Streeter, Lorna Ewart, Erio Barale, Linda C. Andersson, Barry Jones, Wing W. Lam, Damir Simic, Konstantia Kodella, Debora B. Petropolis, Josiah Sliz, Janey Ronxhi, Janna Nawroth, Abhishek Srivastava, Kyung-Jin Jang, Gauri Kulkarni, Hyoungshin Park, Jonathan E. Rubins

المصدر: Science translational medicine. 11(517)

مصطلحات موضوعية: 0301 basic medicine, Drug, Drug-Related Side Effects and Adverse Reactions, Kupffer Cells, media_common.quotation_subject, Pharmacology, 03 medical and health sciences, 0302 clinical medicine, Dogs, Cholestasis, Species Specificity, Fibrosis, Risk Factors, Lab-On-A-Chip Devices, Medicine, Animals, Humans, media_common, business.industry, Liver Diseases, Reproducibility of Results, General Medicine, medicine.disease, Rats, Clinical trial, 030104 developmental biology, Phenotype, Liver, 030220 oncology & carcinogenesis, Toxicity, Hepatic stellate cell, Animal studies, Steatosis, Chemical and Drug Induced Liver Injury, business, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e12fac7c745aecb2cdd286e4f142c77
https://pubmed.ncbi.nlm.nih.gov/31776474

المؤلفون: Hollie Skaggs, Heng-Keang Lim, Damir Simic, Alessandro Pocai, Wing W. Lam, Mark R. Player, Rhys Salter, Bhanu Singh, Monicah A. Otieno, Jan Snoeys, Avi Ghosh

المصدر: Toxicological Sciences. 163:374-384

مصطلحات موضوعية: 0301 basic medicine, Pathology, medicine.medical_specialty, Bilirubin, Metabolite, Gene Expression, Organic Anion Transporters, Mitochondria, Liver, Mitochondrion, Pharmacology, Toxicology, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Oxygen Consumption, Species Specificity, In vivo, medicine, Animals, Humans, Sulfones, Benzofurans, Liver injury, Dose-Response Relationship, Drug, Chemistry, Multidrug resistance-associated protein 2, Hep G2 Cells, medicine.disease, In vitro, Rats, Macaca fascicularis, Mitochondrial toxicity, 030104 developmental biology, Hepatocytes, Chemical and Drug Induced Liver Injury, Multidrug Resistance-Associated Proteins, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c8dabc0d28e07f9ae32807bc3b23e3
https://doi.org/10.1093/toxsci/kfx040

المؤلفون: Marc H. Davies, Megan Fuller, Jamie J. Arnold, Craig E. Cameron, Terry Van Vleet, Michael J. Graziano, Thomas P. Sanderson, Damir Simic, Chris Storck, Catherine Euler, Oliver P. Flint, Bethany R. Baumgart, Suresh D. Sharma, Faye Wang, Roderick T. Bunch, Jae Kwagh

المصدر: Toxicological Sciences

مصطلحات موضوعية: Male, 0301 basic medicine, Mitochondrial DNA, POLRMT, DNA polymerase, 030106 microbiology, Guanosine Monophosphate, Guanosine, Guanosine triphosphate, Mitochondrion, Kidney, Kidney Function Tests, Toxicology, DNA, Mitochondrial, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, Adenosine Triphosphate, Inosine Monophosphate, Gene expression, Guanosine monophosphate, Animals, Humans, Letter to the Editor, Dose-Response Relationship, Drug, biology, Heart, Molecular biology, Macaca fascicularis, 030104 developmental biology, chemistry, Heart Function Tests, biology.protein, Female, Guanosine Triphosphate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83bd630158a6ca1a75515f89888cc40
https://doi.org/10.1093/toxsci/kfw135

المؤلفون: Carol E. Jolly, Rosalind E. Jenkins, B. Kevin Park, Alison J. Beckett, Jan Snoeys, Amy E. Chadwick, Sophie L. Penman, Oisin Douglas, Laleh Kamalian, Mario Monshouwer, Dominic P. Williams, Damir Simic

المصدر: Toxicology and Applied Pharmacology

مصطلحات موضوعية: 0301 basic medicine, Mitochondrion, Pharmacology, Toxicology, 0302 clinical medicine, CE, coupling efficiency, Cytotoxic T cell, PHH, primary human hepatocytes, ALR, ATP-linked respiration, mtDNA, Chemistry, SRC, spare respiratory capacity, PL, proton leak, Mitochondria, DILI, drug-induced liver injury, Mitochondrial toxicity, Liver, hENT1, human equilibrative nucleoside transporter 1, MR, maximal respiration, 030220 oncology & carcinogenesis, Toxicity, HepaRG, medicine.drug, DNA Replication, Mitochondrial DNA, Fialuridine, Antiviral Agents, DNA, Mitochondrial, Thymidylate kinase, Article, 03 medical and health sciences, FIAM, pharmacologically inactive epimer of fialuridine, TK1, TK2, thymidine kinase-1 and -2, Cell Line, Tumor, medicine, Humans, TEM, transmission electron microscopy, Cmax, maximal plasma concentration, Dose-Response Relationship, Drug, Hepatotoxicity, Arabinofuranosyluracil, BR, basal respiration, medicine.disease, In vitro, mtDNA, mitochondrial DNA, 030104 developmental biology, FIAU, fialuridine, Hepatocytes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc33f6f2025f2dc67b6c695ac4dfd787
https://doi.org/10.1016/j.taap.2020.115163

المؤلفون: Jan Snoeys, Laleh Kamalian, B. Kevin Park, Dominic P. Williams, Amy E. Chadwick, Carol E. Jolly, Damir Simic, Mario Monshouwer, Oisin Douglas

المصدر: TOXICOLOGY IN VITRO

مصطلحات موضوعية: 0301 basic medicine, L-Lactate Dehydrogenase, Bioenergetics, Chemistry, General Medicine, Rotenone, Mitochondrion, Toxicology, medicine.disease, Mitochondria, 03 medical and health sciences, Mitochondrial toxicity, chemistry.chemical_compound, Respirometry, Adenosine Triphosphate, 030104 developmental biology, Biochemistry, Cell culture, Cell Line, Tumor, medicine, Humans, Crabtree effect, Glycolysis, Chemical and Drug Induced Liver Injury, Energy Metabolism

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c30df695ad74462d47bc4f79e7ec50
http://livrepository.liverpool.ac.uk/3025983/1/Resubmission_HepaRG_Final.docx

المؤلفون: Marc H. Davies, Roderick T. Bunch, Robert W. Lange, Bethany R. Baumgart, Michael Donegan, Damir Simic, Theodora W. Salcedo, Kimberley A. Lentz, Terry Van Vleet, Thomas P. Sanderson

المصدر: Journal of Applied Toxicology. 35:791-798

مصطلحات موضوعية: Chemistry, Vitamin E, medicine.medical_treatment, Pharmacology, Toxicology, Malondialdehyde, medicine.disease_cause, Lipid peroxidation, chemistry.chemical_compound, Oral administration, In vivo, medicine, Oxidative stress, Ex vivo, Whole blood

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::635f7d6cb8d0ab56a34aafd029e327fc
https://doi.org/10.1002/jat.3072

المؤلفون: Terry Van Vleet, Michael Isaacs, W. Michael Peden, Catherine Euler, Susan Gillham, Damir Simic

المصدر: Journal of Histotechnology. 38:2-8

مصطلحات موضوعية: Messenger RNA, Histology, Formalin fixed paraffin embedded, RNA, Biology, Molecular biology, law.invention, Medical Laboratory Technology, medicine.anatomical_structure, law, Gene expression, medicine, Anatomy, Frozen tissue, Pancreas, Polymerase chain reaction, RNA amplification

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e34dd25d4225356205187ce76222c7f5
https://doi.org/10.1179/2046023614y.0000000051

المؤلفون: W. Lam, Monica Singer, Heng-Keang Lim, Gauri Kulkarni, Monicah A. Otieno, Konstantia Kodella, Janey Ronxhi, Debora B. Petropolis, J. Chen, P. Guzzie-Peck, Damir Simic, Jonathan E. Rubins, K. Karalis, Kyung-Jin Jang, Geraldine A. Hamilton

المصدر: Toxicology Letters. 295:S129-S130

مصطلحات موضوعية: Agonist, Innate immune system, business.industry, medicine.drug_class, 0206 medical engineering, 02 engineering and technology, General Medicine, 021001 nanoscience & nanotechnology, Toxicology, medicine.disease_cause, 020601 biomedical engineering, Cell biology, Free fatty acid receptor 1, Toxicity, Medicine, 0210 nano-technology, business, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8915932a9b9c36ec1c9d05a2b896334f
https://doi.org/10.1016/j.toxlet.2018.06.691

المؤلفون: Aiqing He, Terry Van Vleet, Thomas P. Sanderson, R. Todd Bunch, Damir Simic, Emily Haines, Catherine Euler, W. Mike Peden

المصدر: Toxicology. 311:169-177

مصطلحات موضوعية: Untranslated region, Aminopyridines, Biology, Real-Time Polymerase Chain Reaction, Toxicology, Rats, Sprague-Dawley, Formaldehyde, microRNA, Gene expression, Cytochrome P-450 CYP1A1, Animals, Gene silencing, RNA, Messenger, Gene, Oligonucleotide Array Sequence Analysis, Messenger RNA, Paraffin Embedding, Microarray analysis techniques, Gene Expression Profiling, Molecular biology, Rats, MicroRNAs, Liver, Enzyme Induction, Pyrazines, ABCC3, biology.protein, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d045bfb4979af101913f448373e86d06
https://doi.org/10.1016/j.tox.2013.06.006

المؤلفون: Michael J. Graziano, Mausumee Guha, Julia Li, Nicola Wallis, Damir Simic, James Hennan, Bethany R. Baumgart, Jochen Woicke, Thomas P. Sanderson, Roderick T. Bunch

المصدر: Cancer chemotherapy and pharmacology. 79(4)

مصطلحات موضوعية: Male, Cancer Research, Pulmonary Circulation, medicine.drug_class, Hypertension, Pulmonary, Dasatinib, Gene Expression, Antineoplastic Agents, 030204 cardiovascular system & hematology, Pharmacology, Pulmonary Artery, Toxicology, Nitric Oxide, Tyrosine-kinase inhibitor, Muscle, Smooth, Vascular, Nitric oxide, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, hemic and lymphatic diseases, medicine.artery, medicine, Animals, Pharmacology (medical), RNA, Messenger, Lung, Protein Kinase Inhibitors, Endothelin-1, business.industry, Hemodynamics, Imatinib, medicine.disease, Rats, Oncology, chemistry, 030220 oncology & carcinogenesis, Pulmonary artery, Imatinib Mesylate, medicine.symptom, business, Vasoconstriction, Chronic myelogenous leukemia, medicine.drug, Muscle Contraction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c08283b00eb8606e79958f117abd3a
https://pubmed.ncbi.nlm.nih.gov/28283735

المؤلفون: M. Zhou, Patrick Ray Ng, A.D. van der Meer, Fang Teng, Damir Simic, Jacob P. Fraser, Hyoungshin Park, Geraldine A. Hamilton, Justin Nguyen, David Conegliano, Katia Karalis, Monicah A. Otieno, Donald E. Ingber, Y. Wang, Sonalee Barthakur, Riccardo Barrile

المصدر: Toxicology Letters. 295:S15

مصطلحات موضوعية: Pathology, medicine.medical_specialty, Lung, medicine.anatomical_structure, business.industry, Toxicity, Medicine, General Medicine, Toxicology, Chip, business, medicine.disease, Thrombosis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::289d6325906ca6c50a03ea77311ae4de
https://doi.org/10.1016/j.toxlet.2018.06.1086

المؤلفون: Fang Teng, Nancy Bogdan, Damir Simic, Monicah A. Otieno

المصدر: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 23(6)

مصطلحات موضوعية: 0301 basic medicine, CD40 Ligand, Inflammation, 03 medical and health sciences, Mediator, Medicine, Humans, Platelet activation, Blood Specimen Collection, CD40, biology, Blocking (radio), business.industry, Thrombosis, Hematology, General Medicine, Platelet Activation, Antibodies, Neutralizing, Healthy Volunteers, Blockade, 030104 developmental biology, Solubility, Hemostasis, Immunology, Cancer research, biology.protein, medicine.symptom, Antibody, business, Integrin alpha5beta1

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f684bdd7d25004f7482dc0aad47e533a
https://pubmed.ncbi.nlm.nih.gov/26719354

المؤلفون: Anja Rode, Xiaoyan Chu, Esaie Pierre, Thomas Wanek, Jeevan Kunta, Mario Mezler, Clara Andonian, Jocelyn Yabut, Jodie Pang, Carolin Hoft, Stéphanie Chasseigneaux, Shannon Dallas, Oliver Langer, Xiaolin Zhang, Damir Simic, David Gomez-Zepeda, Karen DiLoreto, Liangfu Chen, Loic Laplanche, Tony Pereira, Marie-Claude Menet, Laurent Salphati, Nico Scheer, Xavier Declèves

المصدر: Molecular pharmacology. 89(5)

مصطلحات موضوعية: 0301 basic medicine, Male, Abcg2, Biological Availability, ATP-binding cassette transporter, Mice, Transgenic, Biology, Pharmacology, Blood–brain barrier, 030226 pharmacology & pharmacy, Intestinal absorption, Xenobiotics, 03 medical and health sciences, 0302 clinical medicine, Membrane Transport Modulators, medicine, ATP Binding Cassette Transporter, Subfamily G, Member 2, Animals, Humans, Drug Interactions, Tissue Distribution, Gene Knock-In Techniques, RNA, Messenger, Promoter Regions, Genetic, Biotransformation, Mice, Knockout, Transporter, Recombinant Proteins, Cell biology, Neoplasm Proteins, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, Intestinal Absorption, Blood-Brain Barrier, Humanized mouse, Knockout mouse, biology.protein, Molecular Medicine, ATP-Binding Cassette Transporters, Female, Drug metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0f3f7f274bf64d012abb659bb9c9f6
https://pubmed.ncbi.nlm.nih.gov/26893303

المؤلفون: Maria Eugenia Verdugo-Gazdik, Damir Simic, Alan C. Opsahl, Mark W. Tengowski

المصدر: ASSAY and Drug Development Technologies. 4:695-707

مصطلحات موضوعية: macromolecular substances, Biology, Retina, Rats, Sprague-Dawley, chemistry.chemical_compound, In vivo, Lens, Crystalline, Drug Discovery, medicine, Animals, Humans, Cytoskeleton, Cells, Cultured, Actin, Dose-Response Relationship, Drug, Retinal, Haplorhini, Actin cytoskeleton, Actins, Rats, rac GTP-Binding Proteins, Cell biology, Tamoxifen, medicine.anatomical_structure, chemistry, Drug development, Lens (anatomy), Toxicity, Molecular Medicine, Androstenes, sense organs, Hydroxymethylglutaryl-CoA Reductase Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08f127f83521eec0ee47a05e0a0c841
https://doi.org/10.1089/adt.2006.4.695

المؤلفون: Frank J. Simutis, Terry Van Vleet, Thomas P. Sanderson, R. Todd Bunch, Damir Simic, Christina Thurby, Catherine Euler, W. Mike Peden, Gary Pilcher

المصدر: Gene Expr

مصطلحات موضوعية: medicine.medical_specialty, Cellular differentiation, Notch signaling pathway, Gene Expression, Biology, Kidney, Article, Rats, Sprague-Dawley, Internal medicine, Gene expression, Genetics, medicine, Basic Helix-Loop-Helix Transcription Factors, Presenilin-1, Animals, Kidney surgery, Receptor, Notch1, Molecular Biology, Laser capture microdissection, Regulation of gene expression, Homeodomain Proteins, Kidney metabolism, Cell biology, Rats, Endocrinology, medicine.anatomical_structure, Transcription Factor HES-1, Female, Puromycin, Amyloid Precursor Protein Secretases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5424092a291427b81a93ba7eeefd0109
https://pubmed.ncbi.nlm.nih.gov/24397211