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1Academic Journal
المؤلفون: Resnati M., Pennacchio S., Viviani L., Perini T., Materozzi M., Orfanelli U., Bordini J., Molteni R., Nuvolone M., Da Vià M., Lazzaroni F., Bolli N., Cenci S., Milan E.
المساهمون: Resnati, M., Pennacchio, S., Viviani, L., Perini, T., Materozzi, M., Orfanelli, U., Bordini, J., Molteni, R., Nuvolone, M., Da Vià, M., Lazzaroni, F., Bolli, N., Cenci, S., Milan, E.
Relation: info:eu-repo/semantics/altIdentifier/pmid/38385303; info:eu-repo/semantics/altIdentifier/wos/WOS:001250402000042; volume:109; issue:6; firstpage:1966; lastpage:1972; numberofpages:7; journal:HAEMATOLOGICA; https://hdl.handle.net/20.500.11768/165744
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2Academic Journal
المؤلفون: Lionetti M., Da Via M. C., Albano F., Neri A., Bolli N., Musto P.
المساهمون: Lionetti, M., Da Via, M. C., Albano, F., Neri, A., Bolli, N., Musto, P.
مصطلحات موضوعية: Asymptomatic stage, Genomic alteration, Multiple myeloma, Tumor evolution
Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:000671246800001; volume:13; issue:13; firstpage:1; lastpage:13; numberofpages:13; journal:CANCERS; https://hdl.handle.net/11586/370525
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3Academic JournalActin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemia
المؤلفون: Garitano-Trojaola A., Sancho A., Gotz R., Eiring P., Walz S., Jetani H., Gil-Pulido J., Da Vià M. C., Teufel E., Rhodes N., Haertle L., Arellano-Viera E., Tibes R., Rosenwald A., Rasche L., Hudecek M., Sauer M., Groll J., Einsele H., Kraus S., Kortum M. K.
المساهمون: A. Garitano-Trojaola, A. Sancho, R. Gotz, P. Eiring, S. Walz, H. Jetani, J. Gil-Pulido, M.C. Da Vià, E. Teufel, N. Rhode, L. Haertle, E. Arellano-Viera, R. Tibe, A. Rosenwald, L. Rasche, M. Hudecek, M. Sauer, J. Groll, H. Einsele, S. Krau, M.K. Kortum
مصطلحات موضوعية: Actin Cytoskeleton, Antineoplastic Agent, Apoptosi, Bridged Bicyclo Compounds, Heterocyclic, Cell Line, Tumor, Drug Resistance, Neoplasm, Human, Leukemia, Myeloid, Acute, Proto-Oncogene Proteins c-bcl-2, Pyrone, Quinoline, Staurosporine, Sulfonamide, fms-Like Tyrosine Kinase 3, rac1 GTP-Binding Protein, Mutation, Settore MED/15 - Malattie del Sangue
Relation: info:eu-repo/semantics/altIdentifier/pmid/34172833; info:eu-repo/semantics/altIdentifier/wos/WOS:000668739900005; volume:4; issue:1; firstpage:1; lastpage:14; numberofpages:14; journal:COMMUNICATIONS BIOLOGY; http://hdl.handle.net/2434/892432; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85111784275
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4Academic Journal
المؤلفون: Haertle, L., Barrio, S., Munawar, U., Han, S., Zhou, X., Vogt, C., Fernandez, R. A., Bittrich, M., Ruiz-Heredia, Y., Da Via, M. C., Zovko, J., Garitano-Trojaola, A., Bolli, N., Ruckdeschel, A., Stuhmer, T., Chatterjee, M., Kull, M., Kronke, J., Agirre, X., Martin-Subero, J. I., Raab, P., Einsele, H., Rasche, L., Martinez-Lopez, J., Haaf, T., Kortum, K. M.
المساهمون: L. Haertle, S. Barrio, U. Munawar, S. Han, X. Zhou, C. Vogt, R.A. Fernandez, M. Bittrich, Y. Ruiz-Heredia, M.C. Da Via, J. Zovko, A. Garitano-Trojaola, N. Bolli, A. Ruckdeschel, T. Stuhmer, M. Chatterjee, M. Kull, J. Kronke, X. Agirre, J.I. Martin-Subero, P. Raab, H. Einsele, L. Rasche, J. Martinez-Lopez, T. Haaf, K.M. Kortum
مصطلحات موضوعية: Adaptor Proteins, Signal Transducing, Antineoplastic Agents, Immunological, DNA Methylation, Drug Resistance, Neoplasm, Enhancer Elements, Genetic, Human, Immunomodulating Agent, Intron, Multiple Myeloma, Ubiquitin-Protein Ligases, Settore MED/06 - Oncologia Medica
Relation: info:eu-repo/semantics/altIdentifier/pmid/34115836; info:eu-repo/semantics/altIdentifier/wos/WOS:000727820300012; volume:138; issue:18; firstpage:1721; lastpage:1726; numberofpages:6; journal:BLOOD; https://hdl.handle.net/2434/932162; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85115336007
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5Academic Journal
المؤلفون: Steinhardt, M. J., Wiercinska, E., Pham, M., Grigoleit, G. U., Mazzoni, A., Da-Via, M., Zhou, X., Meckel, K., Nickel, K., Duell, J., Krummenast, F. C., Kraus, S., Hopkinson, C., Weissbrich, B., Müllges, W., Stoll, G., Kortüm, K. M., Einsele, H., Bonig, H., Rasche, L.
مصطلحات موضوعية: ddc:610
وصف الملف: application/pdf
Relation: https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/22930; urn:nbn:de:bvb:20-opus-229307; https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-229307; https://doi.org/10.1186/s12967-020-02337-5; https://opus.bibliothek.uni-wuerzburg.de/files/22930/s12967-020-02337-5.pdf
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6Academic Journal
المؤلفون: Da Via M. C., Solimando A. G., Garitano-Trojaola A., Barrio S., Munawar U., Strifler S., Haertle L., Rhodes N., Teufel E., Vogt C., Lapa C., Beilhack A., Rasche L., Einsele H., Kortum K. M.
المساهمون: M.C. Da Via, A.G. Solimando, A. Garitano-Trojaola, S. Barrio, U. Munawar, S. Strifler, L. Haertle, N. Rhode, E. Teufel, C. Vogt, C. Lapa, A. Beilhack, L. Rasche, H. Einsele, K.M. Kortum
مصطلحات موضوعية: BRAF mutation, Capicua transcriptional repressor, Drug resistance, Extramedullary disease, Multiple myeloma, Settore MED/15 - Malattie del Sangue
Relation: info:eu-repo/semantics/altIdentifier/pmid/32043788; info:eu-repo/semantics/altIdentifier/wos/WOS:000490968500001; volume:25; issue:2; firstpage:112; lastpage:118; numberofpages:7; journal:THE ONCOLOGIST; https://hdl.handle.net/2434/950761; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85077394071
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7Academic Journal
المؤلفون: Rao L., Giannico D., Leone P., Solimando A. G., Maiorano E., Caporusso C., Duda L., Tamma R., Mallamaci R., Susca N., Buonavoglia A., Da Via M. C., Ribatti D., De Re V., Vacca A., Racanelli V.
المساهمون: L. Rao, D. Giannico, P. Leone, A.G. Solimando, E. Maiorano, C. Caporusso, L. Duda, R. Tamma, R. Mallamaci, N. Susca, A. Buonavoglia, M.C. Da Via, D. Ribatti, V. De Re, A. Vacca, V. Racanelli
مصطلحات موضوعية: Bone marrow angiogenesi, EGFR, Endothelial cell, HB-EGF, Multiple myeloma, Settore MED/15 - Malattie del Sangue
Relation: info:eu-repo/semantics/altIdentifier/pmid/31936715; info:eu-repo/semantics/altIdentifier/wos/WOS:000516826700173; volume:12; issue:1; numberofpages:18; journal:CANCERS; http://hdl.handle.net/2434/811700; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85078226471
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8Academic Journal
المؤلفون: Barrio S., Munawar U., Zhu Y. X., Giesen N., Shi C. -X., Da Vià M. C., Sanchez R., Bruins L., Demler T., Muller N., Haertle L., Garitano A., Steinbrunn T., Danhof S., Cuenca I., Barrio-Garcia C., Braggio E., Rosenwald A., Martinez-Lopez J., Rasche L., Raab M. S., Stewart A. K., Einsele H., Stuhmer T., Kortum K. M.
المساهمون: S. Barrio, U. Munawar, Y.X. Zhu, N. Giesen, C.-. Shi, M.C. Da Vià, R. Sanchez, L. Bruin, T. Demler, N. Muller, L. Haertle, A. Garitano, T. Steinbrunn, S. Danhof, I. Cuenca, C. Barrio-Garcia, E. Braggio, A. Rosenwald, J. Martinez-Lopez, L. Rasche, M.S. Raab, A.K. Stewart, H. Einsele, T. Stuhmer, K.M. Kortum
مصطلحات موضوعية: Settore MED/15 - Malattie del Sangue
Relation: info:eu-repo/semantics/altIdentifier/pmid/31558666; info:eu-repo/semantics/altIdentifier/wos/WOS:000530645400009; volume:105; issue:5; firstpage:E237; lastpage:E241; numberofpages:5; journal:HAEMATOLOGICA; http://hdl.handle.net/2434/814460; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85086035029
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9Academic Journal
المؤلفون: Munawar U., Rasche L., Muller N., Vogt C., Da Vià M. C., Haertle L., Arampatzi P., Dietrich S., Roth M., Garitano-Trojaola A., Steinhardt M. J., Strifler S., Gallardo M., Martinez-Lopez J., Bargou R. C., Heckel T., Einsele H., Stuhmer T., Kortum K. M., Barrio S.
المساهمون: U. Munawar, L. Rasche, N. Muller, C. Vogt, M.C. Da Vià, L. Haertle, P. Arampatzi, S. Dietrich, M. Roth, A. Garitano-Trojaola, M.J. Steinhardt, S. Strifler, M. Gallardo, J. Martinez-Lopez, R.C. Bargou, T. Heckel, H. Einsele, T. Stuhmer, K.M. Kortum, S. Barrio
مصطلحات موضوعية: Allele, Cell Proliferation, Clonal Evolution, Disease Progression, Gene Deletion, Gene Dosage, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Human, Metabolic Networks and Pathway, Multiple Myeloma, Mutation, Recurrence, Survival Analysi, Tumor Cells, Cultured, Tumor Suppressor Protein p53, Settore MED/15 - Malattie del Sangue
Relation: info:eu-repo/semantics/altIdentifier/pmid/31340981; info:eu-repo/semantics/altIdentifier/wos/WOS:000484574000010; volume:134; issue:10; firstpage:836; lastpage:840; numberofpages:5; journal:BLOOD; http://hdl.handle.net/2434/814464; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85071786784
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10Academic Journal
المؤلفون: Lapa, Constantin, Kircher, M., Da Via, M., Kortüm, K. M., Rasche, L., Einsele, H., Buck, A. K., Hänscheid, H., Samnick, S.
مصطلحات موضوعية: ddc:610
وصف الملف: application/pdf
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11Academic Journal
المؤلفون: Barrio, S., Munawar, U., Haertle, L., Da Viá, M., Cuenca, I., Rasche, L., Steinbrunn, T., Martin, L., Vogt, C., Gallardo, M., Einsele, H., Martinez‐Lopez, J., Stühmer, T., Kortüm, K.M.
المصدر: HemaSphere ; volume 3, issue S1, page 620 ; ISSN 2572-9241 2572-9241
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12Academic Journal
المؤلفون: Caira, M., Candoni, A., Verga, L., Busca, A., Delia, M., Nosari, A., Caramatti, C., Castagnola, C., Cattaneo, C., Fanci, R., Chierichini, A., Melillo, L., Mitra, M. E., Picardi, M., Potenza, L., Salutari, P., Vianelli, N., Facchini, L., Cesarini, M., De Paolis, M. R., Di Blasi, R., Farina, F., Venditti, A., Ferrari, A., Garzia, M., Gasbarrino, C., Invernizzi, R., Lessi, F., Manna, A., Martino, B., Nadali, G., Offidani, M., Paris, L., Pavone, V., Rossi, G., Spadea, A., Specchia, G., Trecarichi, E. M., Vacca, A., Cesaro, S., Perriello, V., Aversa, F., Tumbarello, M., Pagano, L., Ragionieri, R., Orsola Malpighi, O. S., Antoniazzi, F., Storti, S., Luppi, M., Pagliuca, S., Rossetti, E., Da Vià, M., Di Caprio, L., Majolino, I., Cascavilla, N., Turri, G., FANIN, Renato, Sorveglianza Epidemiologica Infezioni Fungine in Emopatie Maligne
المساهمون: Caira, M., Candoni, A., Verga, L., Busca, A., Delia, M., Nosari, A., Caramatti, C., Castagnola, C., Cattaneo, C., Fanci, R., Chierichini, A., Melillo, L., Mitra, M. E., Picardi, M., Potenza, L., Salutari, P., Vianelli, N., Facchini, L., Cesarini, M., De Paolis, M. R., Di Blasi, R., Farina, F., Venditti, A., Ferrari, A., Garzia, M., Gasbarrino, C., Invernizzi, R., Lessi, F., Manna, A., Martino, B., Nadali, G., Offidani, M., Paris, L., Pavone, V., Rossi, G., Spadea, A., Specchia, G., Trecarichi, E. M., Vacca, A., Cesaro, S., Perriello, V., Aversa, F., Tumbarello, M., Pagano, L., Ragionieri, R., Orsola Malpighi, O. S., Antoniazzi, F., Storti, S., Luppi, M., Pagliuca, S., Rossetti, E., Da Vià, M., Di Caprio, L., Majolino, I., Cascavilla, N., Turri, G., Fanin, Renato, Sorveglianza Epidemiologica Infezioni Fungine in Emopatie, Maligne
Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:000351278900028; volume:100; issue:2; firstpage:284; lastpage:292; numberofpages:9; journal:HAEMATOLOGICA; http://hdl.handle.net/11390/1110263; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84926501164; https://www.scopus.com/inward/record.uri?eid=2-s2.0-84926501164&partnerID=40&md5=d0e071272bafd7e5ceb8354589d5f4e6
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13Academic Journal
المؤلفون: Borlenghi E., Pagani C., Zappasodi P., Bernardi M., Basilico C., Cairoli R., Fracchiolla N., Todisco E., Turrini M., Cattaneo C., Da Via M., Ciceri F., Passamonti F., Mancini V., Sciume M., Cerqui E., Rossi G.
المساهمون: Borlenghi, E., Pagani, C., Zappasodi, P., Bernardi, M., Basilico, C., Cairoli, R., Fracchiolla, N., Todisco, E., Turrini, M., Cattaneo, C., Da Via, M., Ciceri, F., Passamonti, F., Mancini, V., Sciume, M., Cerqui, E., Rossi, G.
مصطلحات موضوعية: Acute myeloid leukemia, Fitness, Karyotype, Older, Treatment
Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:000647749600007; volume:12; issue:4; firstpage:550; lastpage:556; numberofpages:7; journal:JOURNAL OF GERIATRIC ONCOLOGY; https://hdl.handle.net/20.500.11768/138364
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14Academic Journal
المؤلفون: Da Vià M. C., Dietrich O., Truger M., Arampatzi P., Duell J., Heidemeier A., Zhou X., Danhof S., Kraus S., Chatterjee M., Meggendorfer M., Twardziok S., Goebeler M. -E., Topp M. S., Hudecek M., Prommersberger S., Hege K., Kaiser S., Fuhr V., Weinhold N., Rosenwald A., Erhard F., Haferlach C., Einsele H., Kortum K. M., Saliba A. -E., Rasche L.
المساهمون: M.C. Da Vià, O. Dietrich, M. Truger, P. Arampatzi, J. Duell, A. Heidemeier, X. Zhou, S. Danhof, S. Krau, M. Chatterjee, M. Meggendorfer, S. Twardziok, M.-. Goebeler, M.S. Topp, M. Hudecek, S. Prommersberger, K. Hege, S. Kaiser, V. Fuhr, N. Weinhold, A. Rosenwald, F. Erhard, C. Haferlach, H. Einsele, K.M. Kortum, A.-. Saliba, L. Rasche
مصطلحات موضوعية: Aged, Antigens, Neoplasm, B-Cell Maturation Antigen, DNA Copy Number Variation, Homozygote, Human, Magnetic Resonance Imaging, Male, Multiple Myeloma, Receptors, Chimeric Antigen, T-Lymphocyte, Gene Deletion, Settore MED/15 - Malattie del Sangue
Relation: info:eu-repo/semantics/altIdentifier/pmid/33619368; info:eu-repo/semantics/altIdentifier/wos/WOS:000620458400001; volume:27; issue:4; firstpage:616; lastpage:619; numberofpages:4; journal:NATURE MEDICINE; http://hdl.handle.net/2434/892430; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85101196960
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15Academic Journal
المؤلفون: Malcovati L., Papaemmanuil E., Ambaglio I., Elena C., Galli A., Della Porta M. G., Travaglino E., Pietra D., Pascutto C., Ubezio M., Bono E., Da Via M. C., Brisci A., Bruno F., Cremonesi L., Ferrari M., Boveri E., Invernizzi R., Campbell P. J., Cazzola M.
المساهمون: L. Malcovati, E. Papaemmanuil, I. Ambaglio, C. Elena, A. Galli, M.G. Della Porta, E. Travaglino, D. Pietra, C. Pascutto, M. Ubezio, E. Bono, M.C. Da Via, A. Brisci, F. Bruno, L. Cremonesi, M. Ferrari, E. Boveri, R. Invernizzi, P.J. Campbell, M. Cazzola
مصطلحات موضوعية: Settore MED/15 - Malattie del Sangue
Relation: info:eu-repo/semantics/altIdentifier/pmid/24970933; info:eu-repo/semantics/altIdentifier/wos/WOS:000342762100023; volume:124; issue:9; firstpage:1513; lastpage:1521; numberofpages:9; journal:BLOOD; https://hdl.handle.net/2434/950764; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84907346397
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16Academic Journal
المؤلفون: Ambaglio I., Malcovati L., Papaemmanuil E., Laarakkers C. M., Della Porta M. G., Galli A., Da Vià M. C., Bono E., Ubezio M., Travaglino E., Albertini R., Campbell P. J., Swinkels D. W., Cazzola M.
المساهمون: I. Ambaglio, L. Malcovati, E. Papaemmanuil, C.M. Laarakker, M.G. Della Porta, A. Galli, M.C. Da Vià, E. Bono, M. Ubezio, E. Travaglino, R. Albertini, P.J. Campbell, D.W. Swinkel, M. Cazzola
مصطلحات موضوعية: Settore MED/15 - Malattie del Sangue
Relation: info:eu-repo/semantics/altIdentifier/pmid/23300182; info:eu-repo/semantics/altIdentifier/wos/WOS:000317530600018; volume:98; issue:3; firstpage:420; lastpage:423; numberofpages:4; journal:HAEMATOLOGICA; http://hdl.handle.net/2434/814462; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84874533514
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17Academic Journal
المؤلفون: Pietra D., Casetti I., Da Vià M. C., Elena C., Milanesi C., Rumi E.
المساهمون: D. Pietra, I. Casetti, M.C. Da Vià, C. Elena, C. Milanesi, E. Rumi
مصطلحات موضوعية: Settore MED/15 - Malattie del Sangue
Relation: info:eu-repo/semantics/altIdentifier/pmid/22565617; info:eu-repo/semantics/altIdentifier/wos/WOS:000305209700028; volume:87; issue:7; firstpage:746; lastpage:747; numberofpages:2; journal:AMERICAN JOURNAL OF HEMATOLOGY; http://hdl.handle.net/2434/814456; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84862536815
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18Academic Journal
المؤلفون: Lapa C., Kircher M., Da Via M. C., Schreder M., Rasche L., Kortum K. M., Einsele H., Buck A. K., Hanscheid H., Samnick S.
المساهمون: C. Lapa, M. Kircher, M.C. Da Via, M. Schreder, L. Rasche, K.M. Kortum, H. Einsele, A.K. Buck, H. Hanscheid, S. Samnick
مصطلحات موضوعية: C-choline, C-methionine, multiple myeloma, PET/CT, Adult, Aged, 80 and over, Female, Human, Male, Middle Aged, Positron Emission Tomography Computed Tomography, Retrospective Studie, Carbon Radioisotope, Choline, Methionine, Settore MED/15 - Malattie del Sangue
Time: 11
Relation: info:eu-repo/semantics/altIdentifier/pmid/31274607; info:eu-repo/semantics/altIdentifier/wos/WOS:000475950300015; volume:44; issue:8; firstpage:620; lastpage:624; numberofpages:5; journal:CLINICAL NUCLEAR MEDICINE; https://hdl.handle.net/2434/892438; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85069267633
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19Academic Journal
المؤلفون: Barrio S., Stuhmer T., Da Vià M. C., Barrio-Garcia C., Lehners N., Besse A., Cuenca I., Garitano-Trojaola A., Fink S., Leich E., Chatterjee M., Driessen C., Martinez-Lopez J., Rosenwald A., Beckmann R., Bargou R. C., Braggio E., Stewart A. K., Raab M. S., Einsele H., Kortum K. M.
المساهمون: S. Barrio, T. Stuhmer, M.C. Da Vià, C. Barrio-Garcia, N. Lehner, A. Besse, I. Cuenca, A. Garitano-Trojaola, S. Fink, E. Leich, M. Chatterjee, C. Driessen, J. Martinez-Lopez, A. Rosenwald, R. Beckmann, R.C. Bargou, E. Braggio, A.K. Stewart, M.S. Raab, H. Einsele, K.M. Kortum
مصطلحات موضوعية: Antineoplastic Combined Chemotherapy Protocol, Biomarkers, Tumor, Boron Compound, Bortezomib, Cohort Studie, Drug Resistance, Neoplasm, Female, Follow-Up Studie, Gene Expression Regulation, Neoplastic, Glycine, Human, Male, Middle Aged, Multiple Myeloma, Neoplasm Recurrence, Local, Oligopeptide, Prognosi, Proteasome Endopeptidase Complex, Survival Rate, Mutation, Settore MED/15 - Malattie del Sangue
Relation: info:eu-repo/semantics/altIdentifier/pmid/30026573; info:eu-repo/semantics/altIdentifier/wos/WOS:000457857300017; volume:33; issue:2; firstpage:447; lastpage:456; numberofpages:10; journal:LEUKEMIA; http://hdl.handle.net/2434/814458; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85050318410
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20Conference
المؤلفون: Cattaneo C, Zappasodi P, Ferrari S, Pavesi F, Annaloro C, Skert C, Todisco E, Ferrario A, Sacca V, Verga L, Passi A, Borlenghi E, Da Via M, Mancini V, Mometto G, Basilico C, Cairoli R, Nosari A, Rossi G.
المساهمون: Cattaneo, C, Zappasodi, P, Ferrari, S, Pavesi, F, Annaloro, C, Skert, C, Todisco, E, Ferrario, A, Sacca, V, Verga, L, Passi, A, Borlenghi, E, Da Via, M, Mancini, V, Mometto, G, Basilico, C, Cairoli, R, Nosari, A, Rossi, G
مصطلحات موضوعية: hematology
Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:000361204901295; 20th Congress of European-Hematology-Association - JUN 11-14, 2015; volume:100; issue:S1; firstpage:136; lastpage:137; numberofpages:2; journal:HAEMATOLOGICA; https://hdl.handle.net/10281/410397
الاتاحة: https://hdl.handle.net/10281/410397