المؤلفون: Reshmi, R^{1, 1}, Damodaran, Geetha², Vijayalekshmi, M T³, Roy, Dinesh D⁴

المصدر: International Journal of Physiology 5(1):145-149. 2017

المؤلفون: Lan Ni, Pei Wang, Fang Wang, Jian-Guo Chen, Peng-Fei Wu

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 599-608 (2021)

مصطلحات موضوعية: EPSPs, excitatory postsynaptic potentials, Review, medicine.disease_cause, Cognitive disorder, NMDARs, N-methyl-d-aspartate receptors, 0302 clinical medicine, LTP, long-term potentiation, Medicine, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, Hydrogen sulfide, TFAM, mitochondrial transcription factor A, DG, dentate gyrus, Cognition, Long-term potentiation, DS, Down syndrome, AMPARs, α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate receptors, HFS, high-frequency stimulation, 030220 oncology & carcinogenesis, H2O2, hydrogen peroxide, NMDA receptor, LFS, low-frequency stimulation, SNOC, S-nitrosocysteine, AD, Alzheimer's disease, DTNB, 5,5-dithio-bis-2-nitrobenzoic acid, LTD, long-term depression, MF, mossy fiber, Synaptic plasticity, Learning and memory, 03 medical and health sciences, ROS, reactive oxygen species, VD, vascular dementia, Memory impairment, Vascular dementia, CaMKII, Ca2+/calmodulin-dependent protein kinase II, 030304 developmental biology, GSK-3β, glycogen synthase kinase-3β, NO, nitric oxide, N-Methyl-d-aspartate receptor, Glu, glutamate, business.industry, lcsh:RM1-950, NADPH, nicotinamide adenine dinucleotide phosphate, medicine.disease, lcsh:Therapeutics. Pharmacology, SC, Schaffer collateral, Oxidative stress, DTT, dithiothreitol, NAC, N-acetyl cysteine, AAMI, age-associated memory impairment, PTM, posttranslational modification, business, Reactive oxygen species, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21b63fdf19c7ae5028af59b5579ddfe
http://europepmc.org/articles/PMC7982492

المؤلفون: Seyed Mohammad Nabavi, Samira Shirooie, Rosa Anna Vacca, Ipek Süntar, Tarun Belwal, Ana Sanches Silva, Antoni Sureda, Maryam Majidinia, Suowen Xu, Giuseppe D'Antona, Ahmad Reza Dehpour, Seyed Fazel Nabavi, Devesh Tewari, Eduardo Sobarzo-Sánchez, Bahman Yousefi, Maria Daglia

المساهمون: Suntar, I., Sureda, A., Belwal, T., Sanches Silva, A., Vacca, R. A., Tewari, D., Sobarzo-Sanchez, E., Nabavi, S. F., Shirooie, S., Dehpour, A. R., Xu, S., Yousefi, B., Majidinia, M., Daglia, M., D'Antona, G., Nabavi, S. M.

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 5, Pp 734-745 (2020)
Acta pharmaceutica sinica B
info:cnr-pdr/source/autori:Suntar I.; Sureda A.; Belwal T.; Sanches Silva A.; Vacca R.A.; Tewari D.; Sobarzo-Sanchez E.; Nabavi S.F.; Shirooie S.; Dehpour A.R.; Xu S.; Yousefi B.; Majidinia M.; Daglia M.; D'Antona G.; Nabavi S.M./titolo:Natural products, PGC-1alpha, and Duchenne muscular dystrophy/doi:10.1016%2Fj.apsb.2020.01.001/rivista:Acta pharmaceutica sinica B (Print)/anno:2020/pagina_da:734/pagina_a:745/intervallo_pagine:734–745/volume:10
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: MSCs, mesenchymal stem cells, Duchenne muscular dystrophy, Peroxisome proliferatoractivated receptor gamma coactivator 1 alpha, MD, muscular dystrophy, Peroxisome proliferator-activated receptor, HDAC, histone deacetylase, Review, GPX, glutathione peroxidase, TNF-α, tumor necrosis factor-α, CREB, cyclic AMP response element-binding protein, AAV, adeno-associated virus, AMPK, 5′ adenosine monophosphate-activated protein kinase, 0302 clinical medicine, BMD, Becker muscular dystrophy, ASO, antisense oligonucleotides, General Pharmacology, Toxicology and Pharmaceutics, Muscular dystrophy, NOS, NO synthase, PGC-1, peroxisome proliferator-activated receptor γ coactivator 1, chemistry.chemical_classification, EGCG, epigallocatechin-3-gallate, 0303 health sciences, LDH, lactate dehydrogenase, SIRT1, silent mating type information regulation 2 homolog 1, Chemistry, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, iPSCs, induced pluripotent stem cells, DMD, Duchenne muscular dystrophy, MCP-1, monocyte chemoattractant protein-1, DRP1, dynamin-related protein 1, NMJ, neuromuscular junctions, VEGF, vascular endothelial growth factor, DS, Down syndrome, ECM, extracellular matrix, Cell biology, Mitochondrial oxidative phosphorylation, PPARγ activation, MyoD, myogenic differentiation, 030220 oncology & carcinogenesis, FOXO1, forkhead box class-O1, UCP, uncoupling protein, Signal transduction, ATF2, activating transcription factor 2, ATP, adenosine triphosphate, FDA, U. S. Food and Drug Administration, PDGF, platelet derived growth factor, HIF-1α, hypoxia-inducible factors, GSK3b, glycogen synthase kinase 3b, Peroxisome proliferator-activated receptor ? coactivator 1?, Natural product, PPAR gamma activation, MEF2, myocyte enhancer factor 2, 03 medical and health sciences, ROS, reactive oxygen species, ERRα, estrogen-related receptor alpha, SOD, superoxide dismutase, Coactivator, medicine, DGC, dystrophin–glycoprotein complex, Transcription factor, DAGC, dystrophin-associated glycoprotein complex, 030304 developmental biology, NO, nitric oxide, SPP1, secreted phosphoprotein 1, lcsh:RM1-950, Autophagy, GABP, GA-binding protein, NADPH, nicotinamide adenine dinucleotide phosphate, medicine.disease, CnA, calcineurin a, FGF, fibroblast growth factor, IL, interleukin, PPARγ, peroxisome proliferator-activated receptor γ, HCT, hydrochlorothiazide, lcsh:Therapeutics. Pharmacology, COPD, chronic obstructive pulmonary disease, Mitochondrial biogenesis, AMP, adenosine monophosphate, cGMP, cyclic guanosine monophosphate, p38 MAPK, p38 mitogen-activated protein kinase, Peroxisome proliferator-activated receptor γ coactivator 1α, Reactive oxygen species

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e63841db77843060607354e31e90f64
https://hdl.handle.net/20.500.13003/17243

المؤلفون: Belinda Enriquez Estrada, Cory A. Dunnick, Angela L. Rachubinski, Joaquín M. Espinosa, David A. Norris, Jennifer C. Boldrick

المصدر: JAAD Case Reports

مصطلحات موضوعية: vitiligo, medicine.medical_specialty, Down syndrome, AA, alopecia areata, Case Report, Dermatology, Vitiligo, medicine.disease_cause, stat, Autoimmunity, Interferon, STAT, signal transducer activator of transcription, medicine, Janus kinase inhibition, IFN, interferon, alopecia areata, atopic dermatitis, business.industry, autoimmunity, tofacitnib, Atopic dermatitis, interferon, Xeljanz, Alopecia areata, medicine.disease, DS, Down syndrome, trisomy 21, T21, trisomy 21, eczema, business, Janus kinase, JAK, Janus kinase, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d551e8896bd91cc21df17b47497ad50
http://europepmc.org/articles/PMC6453941

المؤلفون: Maria M. Usowicz, James J L Hodge, Simon Lowe

المصدر: Neurobiology of Disease
Lowe, S A, Hodge, J J L & Usowicz, M M 2018, ' A third copy of the Down syndrome cell adhesion molecule (Dscam) causes synaptic and locomotor dysfunction in Drosophila ', Neurobiology of Disease, vol. 110, pp. 93-101 . https://doi.org/10.1016/j.nbd.2017.11.013
Neurobiology of Disease, Vol 110, Iss, Pp 93-101 (2018)

مصطلحات موضوعية: 0301 basic medicine, NMJ, neuromuscular junction, DSCAM, Down syndrome, Neuromuscular Junction, DSCAM, Down syndrome cell adhesion molecule, Biology, Neurotransmission, Synaptic Transmission, Article, Neuromuscular junction, lcsh:RC321-571, 03 medical and health sciences, Glutamatergic, mEJP, miniature excitatory junction potential, 0302 clinical medicine, medicine, HSA21, human chromosome 21, EJP, excitatory junction potential, Animals, Drosophila Proteins, Synaptic transmission, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Neuronal Plasticity, Excitatory Postsynaptic Potentials, DS, Down syndrome, 3. Good health, Cell biology, Motor coordination, Disease Models, Animal, Drosophila melanogaster, 030104 developmental biology, medicine.anatomical_structure, Neurology, Synaptic plasticity, Excitatory postsynaptic potential, Drosophila, Chromosome 21, Cell Adhesion Molecules, Locomotion, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5dc5bbc6bc0a0f6e6d88b36a27bea6
https://doi.org/10.1016/j.nbd.2017.11.013

المؤلفون: Edyta Heropolitanska Pliszka, Małgorzata Pac, Mateusz Maciejczyk, Bożena Mikołuć, Barbara Pietrucha, Halina Car, Radosław Motkowski

المصدر: Redox Biology, Vol 11, Iss, Pp 375-383 (2017)
Redox Biology

مصطلحات موضوعية: Prx 3, mitochondrial peroxiredoxin 3, DNA Repair, LCLs, lymphoblastoid cell lines, Fe, iron, Review Article, Biochemistry, Antioxidants, Nijmegen breakage syndrome (NBS), Glx, glyoxal, Bloom syndrome, mtETC, mitochondrial electron transport chain, lcsh:QH301-705.5, Cu, copper, 8-OHdG, 8-hydroxy-2-deoxyguanosine, ox-LDL, oxidised low-density lipoprotein, food and beverages, DS, Down Syndrome, UA, uric acid, Lipoproteins, LDL, CS, Cockayne Syndrome, Poly(ADP-ribose) Polymerases, lcsh:Medicine (General), Bloom Syndrome, GSH-Px, glutathione peroxidase, G6PD, glucose-6 phosphate dehydrogenase, DNA damage, TOP1mt, mitochondrial topoisomerase I, FA, Fanconi anaemia, mTOR, mammalian target of rapamycin, XP, Xeroderma pigmentosum, DDR, DNA damage response, 03 medical and health sciences, Oxidative damage, Humans, HO, heme oxygenase, BS, Bloom syndrome, NOX4, NADPH oxidase 4, Nijmegen Breakage Syndrome, Ataxia-telangiectasia (A-T), DNA-PKcs, DNA-dependent protein kinase catalytic subunit, MDA, malondialdehyde, XO, xanthine oxidase, GSSG, oxidised glutathione, medicine.disease, LWMA, low molecular weight antioxidants, 030104 developmental biology, DSBs, double strand breaks, Ataxia-telangiectasia, AA, ascorbic acid, GSSG-R, glutathione reductase, CAT, catalase, HR, homologous recombination, PARP, Poly (ADP-ribose) polymerases, Reactive Oxygen Species, Nijmegen breakage syndrome, 0301 basic medicine, MGlx, methylglyoxal, GSH, reduced glutathione, PDTC, ammonium pyrrolidinedithiocarbamate, Clinical Biochemistry, Mitochondrion, medicine.disease_cause, ALA, α-lipolic acid, HGS, Hutchinson-Gilford syndrome, LOX, lipoxygenase, t-butyl-OOH, tert-Butyl-hydroperoxide, CBS, chromosomal breakage syndromes, NAC, N-acetyl-L-cysteine, lcsh:R5-920, NADPH oxidase, GPx, glutathione peroxidase, biology, mROS, mitochondrial reactive oxygen species, Zn, zinc, Mitochondria, AOA3, ataxia with oculomotor apraxia type 3, PKC-δ, protein kinase C, X/XO, xanthine/xanthine oxidase, NADPH Oxidase 4, Signal Transduction, Premature aging, Bloom syndrome (BS), AOS, antioxidant defense systems, NAD+, oxidised nicotinamide adenine dinucleotide, Se, selenium, Ataxia Telangiectasia, ROS, reactive oxygen species, SOD, superoxide dismutase, GST, glutathione-S-transferase, medicine, Q10, ubiquinone, IR, ionising radiation, Organic Chemistry, A-T, Ataxia-telangiectasia, mtDNA, mitochondrial DNA, POLG, polymerase gamma, Oxidative Stress, NBS, Nijmegen breakage syndrome, Gene Expression Regulation, lcsh:Biology (General), ATM, Ataxia Telangiectasia Mutated gene, NOX2, NADPH oxidase 2, biology.protein, Cancer research, WS, Werner syndrome (WS), SMG-1, suppressor with morphological effect on genitalia family member, ATR, ATM and Rad3-related, Oxidative stress, DNA Damage

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67542494f0fd02567e8cbe6a4d847ca2

المؤلفون: Lena Schepergerdes, Astrid Buchberger, Reinhard W. Köster, Conrad Kunick, Maren Flaßhoff

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Cerebellum, DYRK1A, Down syndrome, Purkinje cell, TL, torus longitudinalis, DMSO, dimethyl sulfoxide, Biochemistry, CLKs, Cdc2-like kinases, Purkinje Cells, neurological disease, Phosphorylation, Zebrafish, Neurons, education.field_of_study, biology, imaging, Brain, Protein-Tyrosine Kinases, Phenotype, DS, Down syndrome, Cell biology, medicine.anatomical_structure, ca8, carbonic anhydrase 8, AD, Alzheimer's disease, GCL, granule cell layer, Research Article, dpt, days post treatment, PBS, phospahte buffered saline, Cell type, cerebellum, ML, molecular layer, Population, Central nervous system, Protein Serine-Threonine Kinases, PCs, Purkinje cells, 03 medical and health sciences, cpce, ca8 promoter–derived PC-specific enhancer element, medicine, Dyrk1A, Animals, Humans, education, Dyrk1A, dual-specificity tyrosine phosphorylation–regulated kinase 1A, Molecular Biology, dpf, days post fertilization, 030102 biochemistry & molecular biology, da, anterior distance, Cell Biology, Zebrafish Proteins, biology.organism_classification, Disease Models, Animal, 030104 developmental biology, ap, anterior–posterior, PFA, paraformaldehyde, Protein Kinases, SSC, saline sodium citrate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0952dd9f67f6207359a9f832035fd59
https://doi.org/10.1016/j.jbc.2021.100853

المؤلفون: Phill Lee, Rebecca J. Lepping, Anna M. Gorczyca, Joseph R. Sherman, Richard A. Washburn, Daniel Forsha, Laura E. Martin, Matthew S. Mayo, Lauren T. Ptomey, Joseph E. Donnelly, Jessica C. Danon, Amanda N. Szabo-Reed

المصدر: Contemporary Clinical Trials Communications, Vol 19, Iss, Pp 100607-(2020)
Contemporary Clinical Trials Communications

مصطلحات موضوعية: Gerontology, Technology, Down syndrome, education, Article, law.invention, 03 medical and health sciences, Cognition, 0302 clinical medicine, Randomized controlled trial, Quality of life, law, Medicine, 030212 general & internal medicine, Young adult, AD, Alzheimer's Disease, Cardiovascular fitness, RH, remote high, Pharmacology, lcsh:R5-920, Physical activity, business.industry, Attendance, General Medicine, DS, Down Syndrome, RL, remote low, Alzheimer's disease, medicine.disease, UC, Usual Care, Health education, lcsh:Medicine (General), business, human activities, MVPA, moderate to vigorous physical activity, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc8fc0c8b690ad6cc5a1cb2f74ee5f4
https://doi.org/10.1016/j.conctc.2020.100607

المؤلفون: Laura Rusconi, C. Fuchs, L. Trovò, Isabella Barbiero, Charlotte Kilstrup-Nielsen, Elisabetta Ciani, Marco Tramarin, R. De Rosa

المساهمون: Trovo L., Fuchs C., De Rosa R., Barbiero I., Tramarin M., Ciani E., Rusconi L., Kilstrup-Nielsen C.

المصدر: Neurobiology of Disease
Neurobiology of Disease, Vol 138, Iss, Pp 104791-(2020)

مصطلحات موضوعية: Male, 0301 basic medicine, DIV, days in vitro, DYRK1A, PND, postnatal day, CDD, CDKL5 deficiency disorder, CDKL5, Hippocampus, Catechin, WB, western blot, Mice, Synaptic defects, 0302 clinical medicine, Neurodevelopmental disorder, Phosphorylation, GFP, green fluorescent protein, Epigallatocathechin-3-gallate, Mice, Knockout, Neurons, Kinase, Brain, Protein-Tyrosine Kinases, DS, Down syndrome, Cell biology, CDKL5, cyclin-dependen kinase-like 5, Neurology, Spasms, Infantile, DYRK1A, dual-specificity tyrosine-phosphorylation-regulated kinase, AMPA-R, α-amino-3-hydroxy-5-methylisozasole-4-propionic acid receptor, Protein Serine-Threonine Kinases, Biology, EGCG, eipgallatocathechin-3-gallate, Article, lcsh:RC321-571, 03 medical and health sciences, Downregulation and upregulation, In vivo, medicine, Animals, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, KO, knockout, Tea, Polyphenols, PSD95, post-synaptic density protein 95, medicine.disease, WT, wild-type, In vitro, 030104 developmental biology, Epileptic Syndromes, 030217 neurology & neurosurgery

وصف الملف: STAMPA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff98f468a3002138ba81cf1aef3aed87
https://doi.org/10.1016/j.nbd.2020.104791

المؤلفون: Menahem Segal, Elisha Moses, Shani Stern

المصدر: EBioMedicine, Vol 2, Iss 9, Pp 1048-1062 (2015)
EBioMedicine

مصطلحات موضوعية: WT, wild type, Male, Patch-Clamp Techniques, Potassium, Down syndrome, ROI, region of interest, Cell Culture Techniques, Action Potentials, Gene Expression, lcsh:Medicine, HCN, hyperpolarization-activated cyclic nucleotide-gated, Hippocampus, chemistry.chemical_compound, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels, 2D, two-dimensional, Cells, Cultured, Neurons, Mice, Inbred C3H, lcsh:R5-920, Reverse Transcriptase Polymerase Chain Reaction, Inward-rectifier potassium ion channel, Depolarization, General Medicine, DS, Down syndrome, Potassium channel, SEM, standard error of mean, medicine.anatomical_structure, Tetrodotoxin, Female, lcsh:Medicine (General), Potassium currents, Research Paper, Sodium Channel Blockers, Mice, 129 Strain, GIRK, G protein-coupled inwardly-rectifying potassium channels, chemistry.chemical_element, Biology, Inward rectifiers, Ts65Dn, General Biochemistry, Genetics and Molecular Biology, Potassium channels, EPSC, excitatory post synaptic current, medicine, Animals, Reduced excitability, G protein-coupled inwardly-rectifying potassium channel, Patch clamp, TTX, tetrodotoxin, Potassium Channels, Inwardly Rectifying, DC, direct current, 1D, one-dimensional, lcsh:R, Mice, Inbred C57BL, RT-PCR, real time polymerase chain reaction, chemistry, GABA, gamma-aminobutyric acid, Biophysics, Calcium, Neuron, Tc1

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8018db3f076e938647c4fa6657ffa062
http://www.sciencedirect.com/science/article/pii/S2352396415300906

المؤلفون: Natalie Neale, Shahid Zaman, Tony Holland, Concepcion Padilla, Luciana Mascarenhas Fonseca

المساهمون: Holland, Anthony [0000-0003-4107-130X], Zaman, Shahid [0000-0003-1639-6014], Apollo - University of Cambridge Repository

المصدر: NeuroImage : Clinical
NeuroImage: Clinical, Vol 17, Iss, Pp 263-271 (2018)

مصطلحات موضوعية: 0301 basic medicine, Magnetic Resonance Imaging (MRI), Review Article, Aβ, amyloid beta, Electroencephalography, lcsh:RC346-429, 0302 clinical medicine, Cognitive decline, education.field_of_study, medicine.diagnostic_test, Brain, Magnetic Resonance Imaging, DS, Down syndrome, Diffusion Tensor Imaging, Neurology, Positron emission tomography, lcsh:R858-859.7, AD, Alzheimer's disease, EEG, electroencephalography, medicine.drug, Cognitive Neuroscience, Population, Neuroimaging, lcsh:Computer applications to medicine. Medical informatics, PET, positron emission tomography, 03 medical and health sciences, APP, amyloid precursor protein, Alzheimer Disease, medicine, Dementia, Humans, Radiology, Nuclear Medicine and imaging, Electroencephalography (EEG), education, lcsh:Neurology. Diseases of the nervous system, Fluorodeoxyglucose, business.industry, NFT, neurofibrillary tangles, sMRI, structural magnetic resonance imaging, biomarkers, medicine.disease, FDG, fluordexoyglucose, 030104 developmental biology, Positron-Emission Tomography, Positron Emission Tomography (PET), Neurology (clinical), DTI, diffusion tensor imaging, Down Syndrome, business, Neuroscience, Diffusion Tensor Imaging (DTI), 030217 neurology & neurosurgery, Diffusion MRI, dementia

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342227257ef5298e38f37e4cfdd552af
https://www.repository.cam.ac.uk/handle/1810/271374

المؤلفون: Curie, Aurore, Friocourt, Gaëlle, Des Portes, Vincent, Roy, Alice, Nazir, Tatjana, Brun, Amandine, Cheylus, Anne, Marcorelles, Pascale, Retzepi, Kalliroi, Maleki, Nasim, Bussy, Gérald, Paulignan, Yves, Reboul, Anne, Ibarrola, Danielle, Kong, Jian, Hadjikhani, Nouchine, Laquerrière, Annie, Gollub, Randy

المساهمون: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital [Boston]-Harvard Medical School [Boston] (HMS), centre de référence 'Déficiences intellectuelles de causes rares' (CRDI), Hospices Civils de Lyon (HCL)-Ministère de la santé-Hôpital Femme-Mère Enfant (HFME), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Psychiatric Neuroimaging Program, Department of Psychiatry, Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston], Gillberg Neuropsychiatry Centre [Göteborg, Sueden], Institute of Neuroscience and Physiology [Göteborg]-University of Gothenburg (GU), Institut des Sciences cognitives Marc Jeannerod - Laboratoire sur le langage, le cerveau et la cognition (L2C2), École normale supérieure - Lyon (ENS Lyon)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) (GGB), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Laboratoire d'Anatomie Pathologique, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Hôpital Morvan Brest, Laboratoire de Neurosciences de Brest (LNB), Université de Brest (UBO), Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), EFS-Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Hôpital Morvan Brest-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)

المصدر: Neuroimage-Clinical
Neuroimage-Clinical, Elsevier, 2018, 19, pp.454-465. ⟨10.1016/j.nicl.2018.04.001⟩
NeuroImage: Clinical, Vol 19, Iss, Pp 454-465 (2018)
NeuroImage : Clinical
Neuroimage-Clinical, 2018, 19, pp.454-465. ⟨10.1016/j.nicl.2018.04.001⟩

مصطلحات موضوعية: Doublecortin Protein, CP, cortical plate, ROI, region of interest, Intellectual disability, SVZ, subventricular zone, ICV, intracranial volume, lcsh:Computer applications to medicine. Medical informatics, Limb, MGE, medial ganglionic eminence, Basal Ganglia, lcsh:RC346-429, VZ, ventricular zone, WG, weeks of gestation, Interneurons, Pregnancy, Humans, Human brain development, CGE, caudal ganglionic eminence, LGE, lateral ganglionic eminence, SGL, subpial granular layer, gamma-Aminobutyric Acid, lcsh:Neurology. Diseases of the nervous system, Homeodomain Proteins, Neurons, IZ, intermediate zone, Hand Strength, Morphometric MRI, Genes, Homeobox, Apraxia, Ideomotor, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Regular Article, Kinematic, DS, down syndrome, IQ, intelligence quotient, [SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis, Mutation, Limb Kinetic Apraxia, lcsh:R858-859.7, Female, ARX, MZ, marginal zone, ID, Intellectual Disability, LKA, Limb Kinetic Apraxia, MRI, magnetic resonance imaging, GE, ganglionic eminences, XLAG, X-linked lissencephaly with abnormal genitalia, ARX, Aristaless-Related homeoboX gene (according to the genetic convention, ARX was written in italics when it refers to the gene, in plain-text characters when it refers to the protein, in capital letters when it refers to the human gene, and in lowercase when it refers to the mouse gene), Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6e2db2ea8fae19ea784f74603ec0adb6
https://hal.archives-ouvertes.fr/hal-01803002/document

المؤلفون: Sacha Salameh, Marjorie Renon, Nathalie Janel, M.L. Arbonés, Jean-Maurice Delabar, Jean-Louis Paul, Jamileh Movassat, Alizée Latour, Christophe Noll

المساهمون: Jérôme Lejeune Foundation, L'Association Gaspard Félix (France)

المصدر: Molecular Genetics and Metabolism Reports, Vol 1, Iss C, Pp 487-492 (2014)
Molecular Genetics and Metabolism Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: medicine.medical_specialty, Hyperhomocysteinemia, GK, Goto-Kakizaki, Homocysteine, DYRK1A, DYRK, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase, Short Communication, Transsulfuration, PLP, pyridoxal phosphate, Biology, NQO1, NAD(P)H:quinone oxidoreductase, hcy, homocysteine, chemistry.chemical_compound, Endocrinology, Internal medicine, Genetics, medicine, SAHH, SAH hydrolase, PTZ, pentylenetetrazole, Molecular Biology, lcsh:QH301-705.5, Cystathionine beta synthase, lcsh:R5-920, Methionine, GABA, gamma-amino-butyric-acid, SAH, S-adenosylhomocysteine, medicine.disease, DS, Down syndrome, CBS, cystathionine beta synthase, chemistry, Biochemistry, Liver, lcsh:Biology (General), biology.protein, Dyrk1a, Murine model, EGCG, epigallocatechin-gallate, Signal transduction, lcsh:Medicine (General), Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f108e23c05bbadaab2c2a13ce888f782
http://www.sciencedirect.com/science/article/pii/S2214426914000743

المؤلفون: Claire L.P. Garden, Maria M. Usowicz

المصدر: Brain Research

مصطلحات موضوعية: Male, Research Report, Cerebellum, Patch-Clamp Techniques, Down syndrome, QH301 Biology, Action Potentials, Mice, 0302 clinical medicine, PC, Purkinje cell, Neurons, Mice, Inbred C3H, P, postnatal day, 0303 health sciences, General Neuroscience, Rin, input resistance, DS, Down syndrome, Up-Regulation, Motor Skills Disorders, Cin, input capacitance, medicine.anatomical_structure, Cerebellar cortex, Female, Neuroscience(all), Clinical Neurology, Biology, Inhibitory postsynaptic potential, Mice, Neurologic Mutants, 03 medical and health sciences, Organ Culture Techniques, Downregulation and upregulation, Granule cell, medicine, Animals, Patch clamp, GC, granule cell, Molecular Biology, 030304 developmental biology, Motor control, medicine.disease, Hypoplasia, EPSC, excitatory postsynaptic current, Mice, Inbred C57BL, Disease Models, Animal, nervous system, AP, action potential, Neurology (clinical), Neuroscience, 030217 neurology & neurosurgery, Developmental Biology

وصف الملف: PDF

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac735aafb7db754710a675fdc2610e5
https://doi.org/10.1016/j.brainres.2012.05.027

المؤلفون: Matthew D. Howell, Paul E. Gottschall

المصدر: ASN Neuro, Vol 4 (2012)
ASN NEURO

مصطلحات موضوعية: Male, Down syndrome, chondroitin sulfate proteoglycan, CSPG, chondroitin sulfate proteoglycan, PSD-95, postsynaptic density 95, Hippocampal formation, Hippocampus, Mice, chemistry.chemical_compound, Versicans, 0302 clinical medicine, LTP, long-term potentiation, OCT, optimal cutting temperature, LMC, littermate control, stratum oriens, versican, 0303 health sciences, Reverse Transcriptase Polymerase Chain Reaction, General Neuroscience, Perineuronal net, HRP, horseradish peroxidase, Immunohistochemistry, DSCR, Down syndrome critical region, DS, Down syndrome, qRT–PCR, quantitative reverse transcription–PCR, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Versican, Research Article, S1, Ct, threshold cycle value, extracellular matrix, Blotting, Western, ECM, extraceullar matrix, Enzyme-Linked Immunosorbent Assay, Neurotransmission, Biology, CNS, central nervous system, Inhibitory postsynaptic potential, Ts65Dn, lcsh:RC321-571, 03 medical and health sciences, WFA, Wisteria floribunda agglutinin, Animals, Lectican, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, 030304 developmental biology, RAWM, radial-arm water maze, SNAP-25, 25 kDa synaptosome-associated protein, GFAP, glial fibrillary acidic protein, ADAMTS, a distintegrin and metalloproteinase with thrombospondin motifs, PNN, perineuronal net, BCA, bicinchoninic acid, Disease Models, Animal, chemistry, Chondroitin sulfate proteoglycan, Synapses, biology.protein, Neurology (clinical), Cognition Disorders, GABA, γ-aminobutyric acid, Postsynaptic density, Neuroscience, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7d92b1729fc367b67f3d6bd5036631
https://doaj.org/article/4d3faf4a9dbd490e985fda3b42edfb36

المؤلفون: Grigonienė, Ingrida

المساهمون: Vilkelienė, Doc.dr. Aldona

مصطلحات موضوعية: DS (Down syndrome), musical activity, socialization, psy, musiq

Relation: http://leu.oai.elaba.lt/documents/1908107.pdf

الاتاحة: http://leu.oai.elaba.lt/documents/1908107.pdf

المؤلفون: Nathalie Rouach, Flora Vasile, Elena Dossi

المساهمون: Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)

المصدر: Brain Research Bulletin
Brain Research Bulletin, Elsevier, 2018, 136, pp.139-156. ⟨10.1016/j.brainresbull.2017.02.001⟩

مصطلحات موضوعية: 0301 basic medicine, Neuroscience(all), [SDV]Life Sciences [q-bio], HS, hippocampal sclerosis, IP3R2, inositol triphosphate receptor 2, MDD, major depressive disorder, Biology, AD, Alzheimer’s disease, CNS, central nervous system, Article, GS, glutamine synthetase, Pathogenesis, 03 medical and health sciences, Epilepsy, chemistry.chemical_compound, 0302 clinical medicine, Pathology, medicine, Humans, Cx, connexin, Gliosis, Neurotransmitter, ComputingMilieux_MISCELLANEOUS, Brain Diseases, MTLE, mesial temporal lobe epilepsy, GJ, gap junction, General Neuroscience, Neurogenesis, GFAP, glial fibrillary acidic protein, Brain, Human brain, medicine.disease, DS, Down syndrome, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, chemistry, Astrocytes, mGluR5, metabotropic glutamate receptor 5, Aβ, amyloid Beta, AQP, aquaporin, medicine.symptom, Neuroscience, 030217 neurology & neurosurgery, Homeostasis, Astrocyte

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ea5e6fa89f485e401cf1b19d06c84c

المؤلفون: David Oxley, Maria L. Arbonés, Pamela A. Lochhead, Anne L. Ashford, Maria Jose Barallobre, Juan Arranz, Sonia Najas, Jean M. Delabar, Simon J. Cook

المساهمون: Generalitat de Catalunya, Biotechnology and Biological Sciences Research Council (UK), Jérôme Lejeune Foundation, Ministerio de Economía y Competitividad (España), Association for International Cancer Research

المصدر: EBioMedicine, Vol 2, Iss 2, Pp 120-134 (2015)
EBioMedicine
Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: Telencephalon, Trisomy 21, DYRK1A, Gene Dosage, DYRK kinases, Intellectual disability, lcsh:Medicine, Trisomy, Mice, IP, intermediate progenitor, Neural Stem Cells, Cyclin D1, Original Research Article, health care economics and organizations, RG, radial glia, Cerebral Cortex, lcsh:R5-920, Neurogenesis, Neurodevelopmental disorders, General Medicine, Protein-Tyrosine Kinases, Neural stem cell, DS, Down syndrome, Cerebral cortex development, medicine.anatomical_structure, Cerebral cortex, lcsh:Medicine (General), education, Subventricular zone, SVZ, subventricular zone, Mice, Transgenic, Biology, Protein Serine-Threonine Kinases, General Biochemistry, Genetics and Molecular Biology, VZ, ventricular zone, medicine, Animals, Humans, lcsh:R, G1 Phase, Embryonic stem cell, Mice, Inbred C57BL, Disease Models, Animal, Immunology, Neuron, NSC, neural stem cell, Down Syndrome, Cell cycle regulation, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8157959e7f566763d11e282160e94a

المؤلفون: Grigonienė, Ingrida

المساهمون: Vilkelienė, Doc.dr. Aldona

مصطلحات موضوعية: Dauno sindromas, muzikinė veikla, socializacija, DS (Down syndrome), musical activity, socialization, Edukologija / Education (S007)

وصف الملف: 137 p.; application/pdf

Relation: https://hdl.handle.net/20.500.12259/116634

الاتاحة: https://hdl.handle.net/20.500.12259/116634