نتائج البحث - "DRUG development"

المؤلفون: Brahma, Rahul¹ (AUTHOR), Moon, Sunghyun¹ (AUTHOR), Shin, Jae-Min² (AUTHOR) jmshin@azothbio.com, Cho, Kwang-Hwi¹ (AUTHOR) chokh@ssu.ac.kr

المصدر: Journal of Cheminformatics. 1/29/2025, Vol. 17 Issue 1, p1-19. 19p.

مصطلحات موضوعية: *DRUG discovery, *HIGH throughput screening (Drug development), *G protein coupled receptors, *VIRTUAL high-throughput screening (Drug development), *PEARSON correlation (Statistics)

Full Text Finder

5

Academic Journal

Optimization of SARS-CoV-2 M pro Inhibitors by a Structure-Based Multilevel Virtual Screening Method.

المؤلفون: Jing, Lanlan¹ (AUTHOR), Zhao, Fabao¹ (AUTHOR), Zheng, Lin¹ (AUTHOR), Meng, Bairu¹ (AUTHOR), Gao, Shenghua¹ (AUTHOR), Laporte, Manon² (AUTHOR), Jochmans, Dirk² (AUTHOR), De Jonghe, Steven³ (AUTHOR), Neyts, Johan² (AUTHOR), Zhan, Peng¹ (AUTHOR), Kang, Dongwei^1,4 (AUTHOR) kangdongwei@sdu.edu.cn, Liu, Xinyong^1,4 (AUTHOR) kangdongwei@sdu.edu.cn

المصدر: International Journal of Molecular Sciences. Jan2025, Vol. 26 Issue 2, p670. 19p.

مصطلحات موضوعية: *VIRTUAL high-throughput screening (Drug development), *MOLECULAR dynamics, *DRUG development, *SARS-CoV-2, *COVID-19

Full Text Finder

6

Academic Journal

One size does not fit all: revising traditional paradigms for assessing accuracy of QSAR models used for virtual screening.

المؤلفون: Wellnitz, James¹ (AUTHOR) jwellnitz@unc.edu, Jain, Sankalp² (AUTHOR) sankalp.jain@nih.gov, Hochuli, Joshua E.¹ (AUTHOR) jhochuli@live.unc.edu, Maxfield, Travis¹ (AUTHOR) tmaxfield@unc.edu, Muratov, Eugene N.¹ (AUTHOR) murik@email.unc.edu, Tropsha, Alexander¹ (AUTHOR) tropsha@email.unc.edu, Zakharov, Alexey V.² (AUTHOR) alexey.zakharov@nih.gov

المصدر: Journal of Cheminformatics. 1/16/2025, Vol. 17 Issue 1, p1-8. 8p.

مصطلحات موضوعية: *VIRTUAL high-throughput screening (Drug development), *HIGH throughput screening (Drug development), *DRUG discovery, *STRUCTURE-activity relationships, *QSAR models

Full Text Finder

7

Academic Journal

Structural Insights and Drug Repurposing of FDA-Approved Molecules against Human Agmatinase in Cancer Therapy.

المؤلفون: Khan, Zeeshan¹ (AUTHOR), Ikram, Saima¹ (AUTHOR), Ahmad, Jamshaid¹ (AUTHOR) jamshaidbiotech@yahoo.com, Rehman, Irshad Ur¹ (AUTHOR), Ahsan, Hina² (AUTHOR), Ullah, Amin³ (AUTHOR) Aminbiotech7@gmail.com, Alshaya, Dalal Sulaiman⁴ (AUTHOR), Fayad, Eman⁵ (AUTHOR), Hassan, Hesham M.⁶ (AUTHOR), Eldeen, Muhammad Alaa⁷ (AUTHOR)

المصدر: Journal of Computational Biophysics & Chemistry. Jan2025, p1-14. 14p.

مصطلحات موضوعية: *VIRTUAL high-throughput screening (Drug development), *MANGANESE enzymes, *HIGH throughput screening (Drug development), *DRUG repositioning, *CHEMICAL libraries, *ORNITHINE decarboxylase

الشركة/الكيان: UNITED States. Food & Drug Administration

8

Academic Journal

Physiological liver microtissue 384-well microplate system for preclinical hepatotoxicity assessment of therapeutic small molecule drugs.

المؤلفون: Fäs, Lola¹ (AUTHOR), Chen, Minjun² (AUTHOR), Tong, Weida² (AUTHOR), Wenz, Friederike¹ (AUTHOR), Hewitt, Nicola J³ (AUTHOR), Tu, Monika¹ (AUTHOR), Sanchez, Katarzyna¹ (AUTHOR), Zapiórkowska-Blumer, Natalia¹ (AUTHOR), Varga, Hajnalka¹ (AUTHOR), Kaczmarska, Karolina¹ (AUTHOR), Colombo, Maria Vittoria¹ (AUTHOR), Filippi, Bruno G H¹ (AUTHOR)

المصدر: Toxicological Sciences. Jan2025, Vol. 203 Issue 1, p79-87. 9p.

مصطلحات موضوعية: *MICROPHYSIOLOGICAL systems, *HIGH throughput screening (Drug development), *DRUG development, *INVESTIGATIONAL drugs, *SMALL molecules

9

Academic Journal

Development of a FUT8 Inhibitor with Cellular Inhibitory Properties.

المؤلفون: Manabe, Yoshiyuki^1,2 (AUTHOR) manabey12@chem.sci.osaka-u.ac.jp, Takebe, Tomoyuki¹ (AUTHOR), Kasahara, Satomi¹ (AUTHOR), Hizume, Koki¹ (AUTHOR), Kabayama, Kazuya^1,2,3 (AUTHOR), Kamada, Yoshihiro⁴ (AUTHOR), Asakura, Akiko⁵ (AUTHOR), Shinzaki, Shinichiro^5,6 (AUTHOR), Takamatsu, Shinji⁷ (AUTHOR), Miyoshi, Eiji⁷ (AUTHOR), García‐García, Ana⁸ (AUTHOR), Vakhrushev, Sergey Y.⁹ (AUTHOR), Hurtado‐Guerrero, Ramón^8,9,10 (AUTHOR), Fukase, Koichi^1,2,11 (AUTHOR) koichi@chem.sci.osaka-u.ac.jp

المصدر: Angewandte Chemie. 12/20/2024, Vol. 136 Issue 52, p1-8. 8p.

مصطلحات موضوعية: *HIGH throughput screening (Drug development), *FUCOSE, *FUCOSYLATION, *DRUG development, *STRUCTURAL optimization

10

Academic Journal

Protein language models are performant in structure-free virtual screening.

المؤلفون: Lam, Hilbert Yuen In^1,2 (AUTHOR), Guan, Jia Sheng¹ (AUTHOR), Ong, Xing Er² (AUTHOR), Pincket, Robbe³ (AUTHOR), Mu, Yuguang^1,2 (AUTHOR) ygmu@ntu.edu.sg

المصدر: Briefings in Bioinformatics. Nov2024, Vol. 25 Issue 6, p1-13. 13p.

مصطلحات موضوعية: VIRTUAL high-throughput screening (Drug development), COMPUTER-assisted drug design, LANGUAGE models, MOLECULAR graphs, PROTEIN models, DRUG design

Full Text Finder

11

Academic Journal

Tolerance Intervals Under a Class of Unbalanced Linear Mixed Models.

المؤلفون: Oliva-Aviles, Cristian¹ (AUTHOR) cris.oliva88@gmail.com, Hauser, Paloma¹ (AUTHOR)

المصدر: Technometrics. Sep2024, p1-10. 10p. 5 Illustrations.

مصطلحات موضوعية: *PROBABILITY theory, DRUG development

12

Academic Journal

Are Drug Prices Abroad Too Low?

المؤلفون: FRECH III, H. E.¹, PAULY, MARK V.², COMANOR, WILLIAM S.^3,4

المصدر: Regulation. Fall2024, Vol. 47 Issue 3, p26-29. 4p.

مصطلحات موضوعية: *DRUG prices, *PUBLIC goods, *ECONOMICS, *GROSS domestic product, DRUG development, PHARMACEUTICAL research

Full Text Finder

13

Academic Journal

On the use of RWD in support of regulatory submission in drug development.

المؤلفون: Chow, Shein-Chung¹ (AUTHOR), Wang, Peijin¹ (AUTHOR) pj.wang@duke.edu

المصدر: Journal of Biopharmaceutical Statistics. Oct2024, Vol. 34 Issue 6, p777-804. 28p.

مصطلحات موضوعية: FALSE positive error, DRUG development, DRUG approval, STATISTICAL power analysis, RARE diseases

14

Academic Journal

Regional consistency assessment in multiregional clinical trials.

المؤلفون: Li, Gang¹ (AUTHOR) Gang_Li@eisai.com, Quan, Hui² (AUTHOR), Wang, Yining³ (AUTHOR)

المصدر: Journal of Biopharmaceutical Statistics. Oct2024, Vol. 34 Issue 6, p973-985. 13p.

مصطلحات موضوعية: DRUG development, LIKELIHOOD ratio tests, CLINICAL trials, NULL hypothesis, SAMPLE size (Statistics)

15

Academic Journal

Covariate adjusted meta-analytic predictive (CA-MAP) prior for historical borrowing using patient-level data.

المؤلفون: Hupf, Bradley¹ (AUTHOR) Bradley.hupf@takeda.com, Yang, Yunlong² (AUTHOR), Gryder, Ryan¹ (AUTHOR), Bunn, Veronica¹ (AUTHOR), Lin, Jianchang¹ (AUTHOR)

المصدر: Journal of Biopharmaceutical Statistics. Oct2024, Vol. 34 Issue 6, p944-952. 9p.

مصطلحات موضوعية: *PHARMACEUTICAL industry, TREATMENT effectiveness, DRUG development, CLINICAL trials, HETEROGENEITY

16

Academic Journal

High-throughput computational screening of MOF adsorbents for efficient propane capture from air and natural gas mixtures.

المؤلفون: Ercakir, Goktug¹ (AUTHOR), Aksu, Gokhan Onder¹ (AUTHOR), Keskin, Seda¹ (AUTHOR) skeskin@ku.edu.tr

المصدر: Journal of Chemical Physics. 2/28/2024, Vol. 160 Issue 8, p1-14. 14p.

مصطلحات موضوعية: *GAS mixtures, *HIGH throughput screening (Drug development), *SORBENTS, *PROPANE, *METAL-organic frameworks, *NATURAL gas, *MIXTURES

17

Academic Journal

Transforming materials discovery for artificial photosynthesis: High-throughput screening of earth-abundant semiconductors.

المؤلفون: Stafford, Sean M.¹ (AUTHOR), Aduenko, Alexander² (AUTHOR), Djokic, Marcus¹ (AUTHOR), Lin, Yu-Hsiu¹ (AUTHOR), Mendoza-Cortes, Jose L.^1,3 (AUTHOR) jmendoza@msu.edu

المصدر: Journal of Applied Physics. 12/21/2023, Vol. 134 Issue 23, p1-12. 12p.

مصطلحات موضوعية: *ARTIFICIAL photosynthesis, *HIGH throughput screening (Drug development), *OXYGEN evolution reactions, *SEMICONDUCTORS, *HYDROGEN evolution reactions, *PHOTOCATHODES

18

Academic Journal

High-throughput point-of-care serum iron testing utilizing machine learning-assisted deep eutectic solvent fluorescence detection platform.

المؤلفون: Li, Hui^1,2,3 (AUTHOR), Yue, Hengmao^1,4 (AUTHOR), Li, Haixiang^1,2,3 (AUTHOR), Zhu, Maolin^1,2,3 (AUTHOR), He, Xicheng^1,2,3 (AUTHOR), Liu, Meng^1,2,3 (AUTHOR), Li, Xiaoxia^1,2,3 (AUTHOR) lixx@tjutcm.edu.cn, Qiu, Feng^1,2,3 (AUTHOR) fengqiu20070118@163.com

المصدر: Journal of Colloid & Interface Science. Feb2025:Part B, Vol. 680, p389-404. 16p.

مصطلحات موضوعية: *HIGH throughput screening (Drug development), *IRON in the body, *IRON ions, *QUANTUM dots, *DENSITY functional theory

19

Academic Journal

Autophagy-targeted Pt(IV) agents: a new horizon in antitumor drug development.

المؤلفون: Li, Suying¹ (AUTHOR), Chen, Yan^1,2 (AUTHOR), Feng, Shuaiqi¹ (AUTHOR), Liu, Zhifang¹ (AUTHOR), Gan, Linling³ (AUTHOR), Wang, Qingpeng¹ (AUTHOR) lywqp@126.com

المصدر: Dalton Transactions: An International Journal of Inorganic Chemistry. 2/7/2025, Vol. 54 Issue 5, p1770-1778. 9p.

مصطلحات موضوعية: *ANTINEOPLASTIC agents, *DRUG development, *DRUG resistance, *DRUG efficacy, *TUMOR microenvironment, *PRODRUGS

20

Academic Journal

Evaluating Natural Compounds as Inhibitors of Lipopolysaccharide Biosynthesis in Acinetobacter baumannii: A Comprehensive Method Employing Molecular Docking and Dynamics Simulations.

المؤلفون: Haryini, Sree¹ (AUTHOR) sreeharyini.s2024@vitstudent.ac.in, Rais, Affan² (AUTHOR) an.rais2023@vitstudent.ac.in, Gopikrishnan, Mohanraj¹ (AUTHOR) mohanrajgopirkishnan@gmail.com, Elavarasu, Santhosh Mudipalli¹ (AUTHOR) santhosh.me2024@vitstudent.ac.in, Thirumal Kumar, D.³ (AUTHOR) thirumal@maher.ac.in, Sasikumar, K.⁴ (AUTHOR) sasikumar.k@vit.ac.in, George Priya Doss, C.¹ (AUTHOR) georgepriyadoss@vit.ac.in

المصدر: Journal of Computational Biophysics & Chemistry. Jan2025, p1-24. 24p.

مصطلحات موضوعية: *VIRTUAL high-throughput screening (Drug development), *MOLECULAR dynamics, *GRAM-negative bacteria, *PROTEIN stability, *COMPLEX compounds, *ACINETOBACTER baumannii

تنقيح النتائج