المؤلفون: Alessandra S.P. Cereghetti, Patrick Turko, Phil Cheng, Stephan Benke, Ala’a Al Hrout, Andreas Dzung, Reinhard Dummer, Michael O. Hottiger, Richard Chahwan, Lorenza P. Ferretti, Mitchell P. Levesque

المصدر: JID Innovations, Vol 5, Iss 2, Pp 100319- (2025)

مصطلحات موضوعية: DNA methyltransferase, DNMTi, Epigenetics, ICAM-1, Melanoma, Dermatology, RL1-803

Relation: http://www.sciencedirect.com/science/article/pii/S2667026724000675; https://doaj.org/toc/2667-0267; https://doaj.org/article/7b33cfbacca54bb998e1d072e00a6e3e

الاتاحة: https://doi.org/10.1016/j.xjidi.2024.100319
https://doaj.org/article/7b33cfbacca54bb998e1d072e00a6e3e

المؤلفون: Angelo B. A. Laranjeira, Dat Nguyen, Lorraine C. Pelosof, James H. Doroshow, Sherry X. Yang

المصدر: Diseases, Vol 12, Iss 7, p 163 (2024)

مصطلحات موضوعية: azacitidine, 5-aza-4′-thio-2′-deoxycytidine, decitabine, DNA methyltransferase inhibitors (DNMTi), TET2, p16ink4A, Medicine

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2079-9721/12/7/163; https://doaj.org/toc/2079-9721

URL الوصول: https://doaj.org/article/e14f5360823048fb8a95a0df85fa0113

المؤلفون: Alina-Teodora Nicu, Ileana Paula Ionel, Ileana Stoica, Liliana Burlibasa, Viorel Jinga

المصدر: Biomedicines, Vol 12, Iss 5, p 1041 (2024)

مصطلحات موضوعية: testicular germ cell tumors, DNA methylation, liquid biopsy, biomarkers, epidrugs, DNMTi, Biology (General), QH301-705.5

Relation: https://www.mdpi.com/2227-9059/12/5/1041; https://doaj.org/toc/2227-9059; https://doaj.org/article/976862fe91654da5a9cd77651be8432c

الاتاحة: https://doi.org/10.3390/biomedicines12051041
https://doaj.org/article/976862fe91654da5a9cd77651be8432c

المؤلفون: Alain Chebly, Joana Ropio, Jean‐Marie Peloponese, Sandrine Poglio, Martina Prochazkova‐Carlotti, Floriane Cherrier, Jacky Ferrer, Yamina Idrissi, Evelyne Segal‐Bendirdjian, Eliane Chouery, Chantal Farra, Anne Pham‐Ledard, Marie Beylot‐Barry, Jean‐Philippe Merlio, Roland Tomb, Edith Chevret

المصدر: Molecular Oncology, Vol 16, Iss 9, Pp 1931-1946 (2022)

مصطلحات موضوعية: cutaneous T‐cell lymphomas, DNA methylation, DNMTi, HDACi, telomerase, TERT, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

URL الوصول: https://doaj.org/article/819e3dd1237742258055914e28ab5f6e

المؤلفون: Lemieux, Nicole

المصدر: University of Toronto's Journal of Scientific Innovation; Volume 2: Issue 1 (Fall 2023); 57-70

مصطلحات موضوعية: major depressive disorder, epigenetics, acetylation, methylation, HDAC, HDACi, DNMTi, BDNF, GDNF, valproic acid, vorinostat, sirt1, escitalopram, imipramine, zebularine

وصف الملف: application/pdf

Relation: https://jps.library.utoronto.ca/index.php/jsi/article/view/41266/31599; https://jps.library.utoronto.ca/index.php/jsi/article/view/41266

الاتاحة: https://jps.library.utoronto.ca/index.php/jsi/article/view/41266

المؤلفون: Joanna Szczepanek, Monika Skorupa, Joanna Jarkiewicz-Tretyn, Cezary Cybulski, Andrzej Tretyn

المصدر: International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7235

مصطلحات موضوعية: biomarkers, chemoresistance, epigenetic targets, histone deacetylase inhibitors (HDACi), DNA methyltransferase inhibitors (DNMTi), antagomiRs, mimic RNA

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Biology; https://dx.doi.org/10.3390/ijms24087235

الاتاحة: https://doi.org/10.3390/ijms24087235

المؤلفون: Amorim, Samara Ellen Da Silva, Melo, Milena Santos De, Silva, Marta Maria Da

المساهمون: Melo, Alyne

مصطلحات موضوعية: BVS- Biblioteca virtual em saúde, Covid - Corona vírus disease, DNA - Ácido desoxirribonucleico, DNMTI- DNA- metiltransferase-1, OMS- organização mundial da saúde, DOPA- Descarboxilase, IMC- índice de massa corporal, PUBMED- Nacional library of medicine, PUFs- Ácido graxo poli-insaturado, SCIELO- Scientific electronic library online, 5HT- 5-Hidroxitriptamina

جغرافية الموضوع: Recife - PE

وصف الملف: 24 f.; application/pdf

Relation: https://repositorio.animaeducacao.com.br/handle/ANIMA/31718

الاتاحة: https://repositorio.animaeducacao.com.br/handle/ANIMA/31718

المؤلفون: Catharina Muylaert, Lien Ann Van Hemelrijck, Anke Maes, Kim De Veirman, Eline Menu, Karin Vanderkerken, Elke De Bruyne

المصدر: Frontiers in Oncology, Vol 12 (2022)

مصطلحات موضوعية: multiple myeloma, epigenetics, DNA methylation modifiers, MM cell plasticity, DNMTi, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.979569/full; https://doaj.org/toc/2234-943X

URL الوصول: https://doaj.org/article/aa9ed1f467844905aa29fbd891cea6e2

المؤلفون: Mikhlid H. Almutairi, Turki M. Alrubie, Bader O. Almutairi, Abdullah M. Alamri, Abdulwahed F. Alrefaei, Maha M. Arafah, Mohammad Alanazi, Abdelhabib Semlali

المصدر: Pharmaceuticals; Volume 15; Issue 11; Pages: 1319

مصطلحات موضوعية: cancer-testis (CT) gene, DNA methyl-transferase inhibitor (DNMTi), histone deacetylase inhibitor (HDACi), immunotherapy, colon cancer

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/ph15111319

الاتاحة: https://doi.org/10.3390/ph15111319

المؤلفون: Marcelo Ehrlich, Eran Bacharach

المصدر: Cancers; Volume 13; Issue 5; Pages: 939

مصطلحات موضوعية: oncolytic viruses, immunoediting, oncogenic signaling, RAS, DNA methyltransferase inhibitor (DNMTi), viral mimicry, epigenetic silencing

وصف الملف: application/pdf

Relation: Cancer Immunology and Immunotherapy; https://dx.doi.org/10.3390/cancers13050939

الاتاحة: https://doi.org/10.3390/cancers13050939

المؤلفون: Borutinskaite Veronika, Bauraite-Akatova Justina, Navakauskiene Ruta

المصدر: Open Life Sciences, Vol 11, Iss 1, Pp 322-330 (2016)

مصطلحات موضوعية: dnmti, procaine, chromatin, remodeling, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2391-5412

URL الوصول: https://doaj.org/article/8e8871789d784af19c225cc5d1d163ae

المؤلفون: Fabio Coppedè

المصدر: Expert Opinion on Therapeutic Targets. 25:283-298

مصطلحات موضوعية: 0301 basic medicine, Alzheimer’s disease, animal models, DNA methylation, epigenetic drugs, epigenetic therapy, epigenetics, histone tail modifications, inhibitors of DNA methyltransferases (DNMTi), S-adenosylmethionine, Clinical Biochemistry, Mice, Transgenic, Disease, Bioinformatics, Epigenesis, Genetic, Mice, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Drug Discovery, medicine, Animals, Humans, Dementia, Molecular Targeted Therapy, Epigenetics, skin and connective tissue diseases, Aged, Pharmacology, business.industry, DNA Methylation, Middle Aged, medicine.disease, 030104 developmental biology, Drug Design, 030220 oncology & carcinogenesis, Molecular Medicine, sense organs, business, Protein Processing, Post-Translational, Epigenetic therapy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98589e21eeff12c31e69a954070b4897
https://doi.org/10.1080/14728222.2021.1916469

المؤلفون: Xiaohui Pan, Bo Yang, Hongjie Guo, Shuyuan Cheng, Xi Chen, Ling Ding, Qiaojun He, Wenxin Zhang

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 5, Pp 723-733 (2020)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: TIM-3, T cell immunoglobulin and mucin domain 3, H3K27me3, tri-methylation of lysine 27 on histone H3, MDSCs, myeloid-derived suppressor cells, medicine.medical_treatment, Review, TAA, tumor-associated antigen, DC, dendritic cell, 0302 clinical medicine, EZH2, enhancer of zeste homolog 2, LAG-3, lymphocyte activation gene-3, CTLA-4, cytotoxic T lymphocyte antigen 4, Medicine, BETi, bromodomain and extra-terminal motif inhibitors, General Pharmacology, Toxicology and Pharmaceutics, FOXP3, forkhead box P3, HDACi, histone deacetylase inhibitor, Cancer, 0303 health sciences, ACE1, angiotensin converting enzyme, CLL, chronic lymphocytic leukemia, biology, IDO, indoleamine 2,3-dioxygenase, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Tregs, regulatory T cells, PD-L1/PD-1 blockade, CCL22 (MDC), macrophage-derived chemokine, Immunotherapy, TET2, ten-eleven translocation 2, CTLs, cytotoxic T lymphocytes, FDA, U. S. Food and Drug Administration, PD-L1, programmed cell death ligand 1, T cell, CTA, cancer testis antigen, Immune cycle, TIL, tumor infiltrating lymphocytes, Epigenetic regulation, OS, overall survival, 03 medical and health sciences, Immune system, Antigen, PD-L1, TH-1, T helper type 1, DNMT1, DNA methyltransferase 1, MHC, major histocompatibility complex, CX3CL1, C-X3-C motif chemokine ligand 1, IFN-γ, interferon-gamma, 030304 developmental biology, business.industry, lcsh:RM1-950, biochemical phenomena, metabolism, and nutrition, medicine.disease, CXCL, CXC chemokine ligand, Blockade, lcsh:Therapeutics. Pharmacology, APC, antigen-presenting cell, UHRF1, ubiquitin-like PHD and RING finger domain-containing 1, 5-AzaC, 5-azacitidine, ACP1, human red cell acid phosphatase, biology.protein, Cancer research, bacteria, DNMTi, DNA methyltransferase inhibitors, PD-1, programmed cell death 1, business, PRC2, polycomb repressive complex 2

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ca7b0479f6fea7a89a3e1eb06905c5
https://doi.org/10.1016/j.apsb.2019.09.006

المؤلفون: Sambathkumar, Rangarajan, Kalo, Eric, Van Rossom, Rob, Faas, Marijke M., de Vos, Paul, Verfaillie, Catherine M.

المصدر: Sambathkumar , R , Kalo , E , Van Rossom , R , Faas , M M , de Vos , P & Verfaillie , C M 2016 , ' Epigenetic Induction of Definitive and Pancreatic Endoderm Cell Fate in Human Fibroblasts ' , Stem cells international , vol. 2016 , 7654321 . https://doi.org/10.1155/2016/7654321

مصطلحات موضوعية: Reprogramming can occur by the introduction of key transcription factors (TFs) as well as by epigenetic changes. We demonstrated, that histone deacetylase inhibitor (HDACi) Trichostatin A (TSA) combined with a chromatin remodeling medium (CRM), induced expression of a number of definitive endoderm and early and late pancreatic marker genes. When CRM was omitted, endoderm/pancreatic marker genes were not induced. Furthermore, treatment with DNA methyltransferase inhibitor (DNMTi), 5-azacytidine (5AZA) CRM did not affect gene expression changes, and when 5AZA was combined with TSA, no further increase, in gene expression of endoderm, pancreatic endoderm, and endocrine markers was seen over levels induced with TSA alone, Interestingly, TSA-CRM did not affect expression of pluripotency and hepatocyte genes but induced some mesoderm transcripts, Upon removal of TSA-CRM, the endoderm/pancreatic gene expression profile returned to baseline. Our findings underscore the, role epigenetic modification in transdifferentiation of one somatic cell into another. However, full reprogramming of fibroblasts to beta-cells will require combination of this approach with TF overexpression and/or culture of the partially reprogrammed cells under beta-cell specific conditions, INSULIN-SECRETING CELLS, PLURIPOTENT STEM-CELLS, BETA-CELLS, IN-VITRO, SMALL MOLECULES, DIFFERENTIATION, TRICHOSTATIN, CONVERSION, CHROMATIN, VIVO

وصف الملف: application/pdf

Relation: https://research.rug.nl/en/publications/bf1df5bc-02cc-4e6f-9ce3-58335ac1f159

الاتاحة: https://hdl.handle.net/11370/bf1df5bc-02cc-4e6f-9ce3-58335ac1f159
https://research.rug.nl/en/publications/bf1df5bc-02cc-4e6f-9ce3-58335ac1f159
https://doi.org/10.1155/2016/7654321
https://pure.rug.nl/ws/files/35733716/7654321.pdf

المؤلفون: Pinho dos Santos Graça, Maria Inês, Pereira-Silva, Eva, Henrique, Rui, Packham, Graham, Crabb, Simon J., Jerónimo, Carmen

مصطلحات موضوعية: Prostate cancer, DNMTi, Histone modulators

Relation: https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-016-0264-8; Graça, I., Pereira-Silva, E., Henrique, R., Packham, G., Crabb, S. J., & Jerónimo, C. (2016). Epigenetic modulators as therapeutic targets in prostate cancer. Clinical Epigenetics, 8(1), 98. https://doi.org/10.1186/s13148-016-0264-8; http://hdl.handle.net/10400.22/9336

الاتاحة: http://hdl.handle.net/10400.22/9336
https://doi.org/10.1186/s13148-016-0264-8

المؤلفون: Matthias Manuel Pfeiffer, Helen eBurrow, Sabine eSchleicher, Rupert eHandgretinger, Peter eLang

المصدر: Frontiers in Oncology, Vol 3 (2013)

مصطلحات موضوعية: Immunotherapy, NK cells, HDACi, DNMTi, pediatric lymphoblastic leukemia, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00099/full; https://doaj.org/toc/2234-943X

URL الوصول: https://doaj.org/article/d3f8db9aed5e48f2adc6467faf4cf375

المؤلفون: Eran Bacharach, Marcelo Ehrlich

المصدر: Cancers, Vol 13, Iss 939, p 939 (2021)
Cancers

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, medicine.medical_treatment, Review, Biology, lcsh:RC254-282, immunoediting, 03 medical and health sciences, 0302 clinical medicine, Immune system, Immunity, DNA Methyltransferase inhibitor (DNMTi), medicine, Gene silencing, oncogenic signaling, viral mimicry, Immunotherapy, epigenetic silencing, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Oncolytic virus, 030104 developmental biology, Oncology, Immunoediting, Viral replication, oncolytic viruses, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, RAS

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188811e07f12faad58a3415e809ee432
https://www.mdpi.com/2072-6694/13/5/939

المؤلفون: Kogan, Aksinija Aleksandrovna

المساهمون: Rassool, Feyruz V., orcid:0000-0002-6487-6437

مصطلحات موضوعية: Acute Myeloid Leukemia, DNA repair, DNMTi, PARPi, STING, DNA methyltransferase inhibitors, Stimulator of interferon genes, Leukemia, Myeloid, Acute, Poly(ADP-ribose) Polymerase Inhibitors

Relation: http://hdl.handle.net/10713/17962

الاتاحة: http://hdl.handle.net/10713/17962

المؤلفون: Smith, Timothy M, Jr.

المصدر: Theses and Dissertations

مصطلحات موضوعية: DNMTi, 4T1, E0771, Cyclophosphamide, CpG, Tregs, Cancer Biology, Immunity, Immunotherapy

وصف الملف: application/pdf

Relation: https://scholarscompass.vcu.edu/etd/6496; https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=7619&context=etd

الاتاحة: https://scholarscompass.vcu.edu/etd/6496
https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=7619&context=etd

المؤلفون: Sheetal A. Mitra, Yong-Hwee Eddie Loh, Zesheng Wan, Xiaogang Hou, Katherine K. Slemmons, Emad Darvishi, Lee J. Helman, Jean Hugues Parmentier

المصدر: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 7, Pp 274-282 (2020)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Jumonji Domain-Containing Histone Demethylases, Original article, DNA Methyltransferase Inhibitor, Down-Regulation, Antineoplastic Agents, DNMTi, DNA methyltransferase inhibitor, lcsh:RC254-282, Pathogenesis, Histones, 03 medical and health sciences, 0302 clinical medicine, Epigenetic marks, Downregulation and upregulation, Cell Line, Tumor, medicine, Humans, Alveolar rhabdomyosarcoma (aRMS), Receptor, Fibroblast Growth Factor, Type 4, Fibroblast growth factor receptor 4 (FGFR4), Rhabdomyosarcoma, Alveolar, Demethylation, Cell Proliferation, FGFR4, fibroblast growth factor receptor 4, biology, Chemistry, Lysine, Histone lysine demethylase 5B (KDM5B), Nuclear Proteins, eRMS, embryonal rhabdomyosarcoma, Fibroblast growth factor receptor 4, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Molecular biology, aRMS, alveolar rhabdomyosarcoma, Chromatin, Repressor Proteins, ChIP-seq, Chromatin immunoprecipitation-sequencing, 030104 developmental biology, Enhancer Elements, Genetic, 030220 oncology & carcinogenesis, Alveolar rhabdomyosarcoma, biology.protein, Azacitidine, Chromatin Immunoprecipitation Sequencing, TSS, transcription start site, Guadecitabine (SGI-110), JARID1B

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bbb00a4835ceb41f1ff2fb3518bbe12
https://pubmed.ncbi.nlm.nih.gov/32464274