المؤلفون: Haas, Roni, Frame, Gavin, Khan, Shahbaz, Neilsen, Beth K, Hong, Boon Hao, Yeo, Celestia PX, Yamaguchi, Takafumi N, Ong, Enya HW, Zhao, Wenyan, Carlin, Benjamin, Yeo, Eugenia LL, Tan, Kah Min, Bugh, Yuan Zhe, Zhu, Chenghao, Hugh-White, Rupert, Livingstone, Julie, Poon, Dennis JJ, Chu, Pek Lim, Patel, Yash, Tao, Shu, Ignatchenko, Vladimir, Kurganovs, Natalie J, Higgins, Geoff S, Downes, Michelle R, Loblaw, Andrew, Vesprini, Danny, Kishan, Amar U, Chua, Melvin LK, Kislinger, Thomas, Boutros, Paul C, Liu, Stanley K

المصدر: Cancer Research Communications. 4(9)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Human Genome, Cancer Genomics, Urologic Diseases, Prostate Cancer, Biotechnology, Precision Medicine, Cancer, Aging, Genetics, Radiation Oncology, Male, Humans, Prostatic Neoplasms, Radiation Tolerance, Proteogenomics, Cell Line, Tumor, DNA Polymerase theta, Genomic Instability, DNA Mismatch Repair, Gene Expression Regulation, Neoplastic, DNA-Directed DNA Polymerase, Radiation Dose Hypofractionation

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/7x67g8p6
https://escholarship.org/content/qt7x67g8p6/qt7x67g8p6.pdf

المؤلفون: László G. Boros, Anthony M. Kyriakopoulos, Carlo Brogna, Marina Piscopo, Peter A. McCullough, Stephanie Seneff

المصدر: Pharmacology Research & Perspectives, Vol 12, Iss 3, Pp n/a-n/a (2024)

مصطلحات موضوعية: acid hydrolysis, deutenomics, deuterium, DNA polymerase theta, hypoxia, modified mRNA, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2052-1707

URL الوصول: https://doaj.org/article/d8adc73757d441748dd3eeb83c070bcf

المؤلفون: Llorens-Agost, Marta, Ensminger, Michael, Le, Hang Phuong, Gawai, Anugrah, Liu, Jie, Cruz-García, Andrés, Bhetawal, Sarita, Wood, Richard D, Heyer, Wolf-Dietrich, Löbrich, Markus

المصدر: Nature Cell Biology. 23(10)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Women's Health, Genetics, Breast Cancer, Cancer, Generic health relevance, BRCA2 Protein, Cell Cycle, DNA Breaks, Double-Stranded, DNA End-Joining Repair, DNA-Directed DNA Polymerase, HeLa Cells, Homologous Recombination, Humans, Mitosis, Rad52 DNA Repair and Recombination Protein, DNA Polymerase theta, Hela Cells, Medical and Health Sciences, Developmental Biology, Biochemistry and cell biology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/6mq6p52g
https://escholarship.org/content/qt6mq6p52g/qt6mq6p52g.pdf

المؤلفون: Ayako Nishizawa‐Yokoi, Stanton B. Gelvin

المصدر: Plant Direct, Vol 7, Iss 9, Pp n/a-n/a (2023)

مصطلحات موضوعية: Agrobacterium‐mediated plant transformation, DNA polymerase theta, plant regeneration, rice, Botany, QK1-989

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2475-4455

URL الوصول: https://doaj.org/article/5c8d839dab8a46eeb1e122cf05a7f432

المؤلفون: Mackenzie, Kenneth, V

المصدر: UVM Honors College Senior Theses

مصطلحات موضوعية: Protein purification, DNA Polymerase Theta, Helicase-Like Domain, X-Ray Crystallography, Honors College, College of Arts and Science Honors

وصف الملف: application/pdf

Relation: https://scholarworks.uvm.edu/hcoltheses/568; https://scholarworks.uvm.edu/context/hcoltheses/article/1638/viewcontent/auto_convert.pdf

الاتاحة: https://scholarworks.uvm.edu/hcoltheses/568
https://scholarworks.uvm.edu/context/hcoltheses/article/1638/viewcontent/auto_convert.pdf

المؤلفون: Mélanie K. Prodhomme, Sarah Péricart, Roxane M. Pommier, Anne-Pierre Morel, Anne-Cécile Brunac, Camille Franchet, Caroline Moyret-Lalle, Pierre Brousset, Alain Puisieux, Jean-Sébastien Hoffmann, Agnès Tissier

المصدر: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

مصطلحات موضوعية: epithelial to mesenchymal transition, DNA Repair, TMEJ, DNA polymerase theta, replicative stress, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.727429/full; https://doaj.org/toc/2296-634X

URL الوصول: https://doaj.org/article/62d2634ad0974109888f7e46b74d8f22

المؤلفون: Higgins, Geoffrey S.

المساهمون: McKenna, Gillies

مصطلحات موضوعية: 615.84, Radiation, Tumours, siRNA screen, tumour radiosensitivity, DNA polymerase theta

URL الوصول: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540293

المؤلفون: Juan Carvajal-Garcia (10344987), K. Nicole Crown (10344990), Dale A. Ramsden (638613), Jeff Sekelsky (10901)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Evolutionary Biology, Developmental Biology, Cancer, Astronomical and Space Sciences not elsewhere classified, Cas 9-induced chromosome, resected DNA tails, BRCA, TMEJ, mitotic, Pol θ, SLX 4, GEN 1, Holliday junction resolution, Holiday junction resolvases, protein, Holliday junction resolvases, repair chromosome breaks, DNA polymerase theta, Holliday junction resolvases SLX 4, recombination, Polymerase theta-mediated end

Relation: https://figshare.com/articles/journal_contribution/Primers_used_in_this_study_/14263566

الاتاحة: https://doi.org/10.1371/journal.pgen.1009267.s007

المؤلفون: Anika Trenner, Alessandro A. Sartori

المصدر: Frontiers in Oncology, Vol 9 (2019)

مصطلحات موضوعية: DSB repair, homologous recombination (HR), BRCA, alternative end joining (a-EJ), PARP inhibition (PARPi), DNA polymerase theta, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2019.01388/full; https://doaj.org/toc/2234-943X

URL الوصول: https://doaj.org/article/e1d9de9440b64b93a39d1679ac6bfe34

المؤلفون: Wen-Wei Zhang, Greg Matlashewski

المصدر: mSphere, Vol 4, Iss 4 (2019)

مصطلحات موضوعية: CRISPR-Cas9, DNA polymerase theta, Leishmania, SaCas9, double-strand DNA break repair, gene deletion, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2379-5042

URL الوصول: https://doaj.org/article/6a04c6b29f2849d5825dd05b8dcbe129

المؤلفون: T. Goullet de Rugy, M. Bashkurov, A. Datti, R. Betous, L. Guitton-Sert, C. Cazaux, D. Durocher, J. S. Hoffmann

المصدر: Biology Open, Vol 5, Iss 10, Pp 1485-1492 (2016)

مصطلحات موضوعية: Polθ, DNA polymerase theta, Synthetic lethality, High­-throughput screen, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://bio.biologists.org/content/5/10/1485; https://doaj.org/toc/2046-6390

URL الوصول: https://doaj.org/article/e26e25e2de504aebbc9372769460ddd0

المؤلفون: Randrianjatovo-Gbalou, Irina, Delarue, Marc

المساهمون: Dynamique structurale des Macromolécules / Structural Dynamics of Macromolecules, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), This work was funded by Action Incitative Concertée of Institut Pasteur granted to M.D. The authors declare that they have no conflict of interest. A provisional patent application no. 62/560693, titled DNA POLYMERASE THETA MUTANTS, THE METHODS OF PRODUCING THESE MUTANTS, AND THEIRS USES, has been filed and deposited to the UPSTO on 20th of September 2017., We would like to thank Sandrine Rosario, Institut Pasteur, for her help with the modified nucleotides incorporation experiments (Fig. 5, Fig. 6), and Dr. Michel Ryckelynck from IBMC of CNRS and Strasbourg University for his advices in the SELEX library preparation.

المصدر: ISSN: 1046-2023.

مصطلحات موضوعية: 2′-O-methyl library, C2′-modified oligonucleotides, DNA polymerase theta, Functional RNA synthesis, RNA, Randomized library, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology

Relation: info:eu-repo/semantics/altIdentifier/pmid/30926532; pasteur-02170317; https://hal-pasteur.archives-ouvertes.fr/pasteur-02170317; https://hal-pasteur.archives-ouvertes.fr/pasteur-02170317/document; https://hal-pasteur.archives-ouvertes.fr/pasteur-02170317/file/S1046202318302792.pdf; PII: S1046-2023(18)30279-2; PUBMED: 30926532

الاتاحة: https://hal-pasteur.archives-ouvertes.fr/pasteur-02170317
https://hal-pasteur.archives-ouvertes.fr/pasteur-02170317/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-02170317/file/S1046202318302792.pdf
https://doi.org/10.1016/j.ymeth.2019.03.025

المؤلفون: Giuseppe Baldacci, Jean-Sebastien Hoffmann, Jean-Charles Cadoret

المصدر: Genomics Data, Vol 3, Iss C, Pp 90-93 (2015)

مصطلحات موضوعية: DNA polymerase theta, DNA replication timing, Microarray, Genetics, QH426-470

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213596014001275; https://doaj.org/toc/2213-5960

URL الوصول: https://doaj.org/article/165eab501aee4f33bac7e0ea2290f256

المؤلفون: Juan Carvajal-Garcia, Gaorav P. Gupta, Dale A. Ramsden

المصدر: Nature Reviews Molecular Cell Biology. 23:125-140

مصطلحات موضوعية: Genome instability, Mechanism (biology), fungi, DNA Polymerase Theta, Cancer, Cell Biology, Biology, medicine.disease, Cell biology, enzymes and coenzymes (carbohydrates), chemistry.chemical_compound, Mediator, chemistry, biology.protein, medicine, Homologous recombination, Molecular Biology, DNA, Polymerase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1d60771be5b9cb7f61d767995bb31a67
https://doi.org/10.1038/s41580-021-00405-2

المؤلفون: Amos Tanay, Zvi Livneh, Vikas Gupta, Mark D. Minden, Jessie J. F. Medeiros, Nathali Kaushansky, Liran I. Shlush, Tzah Feldman, Amanda Mitchell, Michael Milyavsky, Yoni Moskovitz, Tamir Biezuner, Noa Chapal-Ilani, Akhiad Bercovich

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Aphidicolin, CRISPR-Cas9 genome editing, Myeloid, DNA End-Joining Repair, Science, DNA Polymerase Theta, Poly (ADP-Ribose) Polymerase-1, General Physics and Astronomy, DNA-Directed DNA Polymerase, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, PARP1, medicine, Cancer genomics, Leukaemia, Humans, DNA Breaks, Double-Stranded, Enzyme Inhibitors, Polymerase, Myeloid Progenitor Cells, Sequence Deletion, Genetics, Multidisciplinary, biology, Serine-Arginine Splicing Factors, DNA damage and repair, General Chemistry, medicine.disease, Repressor Proteins, Leukemia, 030104 developmental biology, Microhomology-mediated end joining, medicine.anatomical_structure, chemistry, Leukemia, Myeloid, 030220 oncology & carcinogenesis, biology.protein, Stem cell, Clonal Hematopoiesis, Calreticulin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584d2822f7612580ca0d4036323b9ce2
https://doaj.org/article/5cd49203803b4c6e921be0f40f64c457

المؤلفون: Razq Hakem, Arash Algouneh, Parasvi S. Patel

المصدر: Oncogene. 40:3001-3014

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, DNA Polymerase Theta, Synthetic lethality, Biology, Endodeoxyribonuclease, medicine.disease, Phenotype, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Fanconi anemia, 030220 oncology & carcinogenesis, Genetics, Cancer research, biology.protein, medicine, Lethality, Molecular Biology, Gene, Polymerase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a56d8c8012153c7e1a94bb8c543feccf
https://doi.org/10.1038/s41388-021-01744-2

المؤلفون: Louise Prakash, Jung Hoon Yoon, Satya Prakash, Robert E. Johnson

المصدر: J Biol Chem

مصطلحات موضوعية: DNA Replication, 0301 basic medicine, Adenosine, DNA Repair, DNA damage, DNA polymerase, DNA Polymerase Theta, DNA-Directed DNA Polymerase, DNA and Chromosomes, Biochemistry, 03 medical and health sciences, Catalytic Domain, Animals, Humans, Amino Acid Sequence, Molecular Biology, Conserved Sequence, Polymerase, 030102 biochemistry & molecular biology, biology, Chemistry, Mutagenesis, DNA replication, Active site, Cell Biology, Cell biology, 030104 developmental biology, biology.protein, Error-free translesion synthesis, DNA Damage

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3132c411f951fa63ab2df99fc9538ce
https://doi.org/10.1074/jbc.ra120.012816

المؤلفون: Wanjuan Feng, Pablo Carvajal-Garcia, Jeff Sekelsky, Steven A. Roberts, Jang Eun Cho, Richard D. Wood, Juan Carvajal-Garcia, Dale A. Ramsden, Gaorav P. Gupta

المصدر: Proceedings of the National Academy of Sciences of the United States of America

مصطلحات موضوعية: Genome instability, DNA End-Joining Repair, BRCA, chromosome break repair, DNA Polymerase Theta, mutational signatures, Breast Neoplasms, Pol theta, DNA-Directed DNA Polymerase, Computational biology, Biology, Biochemistry, Genome, Genomic Instability, Germline, Resection, Mice, chemistry.chemical_compound, Animals, Humans, DNA Breaks, Double-Stranded, Nucleotide, Germ-Line Mutation, Polymerase, BRCA2 Protein, Mice, Knockout, chemistry.chemical_classification, Multidisciplinary, BRCA1 Protein, Genome, Human, Chromosome Breakage, Biological Sciences, Fibroblasts, microhomology-mediated end joining, Mice, Inbred C57BL, Microhomology-mediated end joining, chemistry, biology.protein, Female, DNA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab85eb44ccc6a968c3bcb634c620724b
https://doi.org/10.1073/pnas.1921791117

المؤلفون: Ahrabi, S, Sarkar, S, Pfister, SX, Pirovano, G, Higgins, GS, Porter, AC, Humphrey, TC

المساهمون: Biotechnology and Biological Sciences Research Council (BBSRC)

المصدر: 5757 ; 5743

مصطلحات موضوعية: Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, DOUBLE-STRAND BREAKS, DNA-POLYMERASE-THETA, LIGASE-III, REPAIR PATHWAY, DIRECTED REPAIR, BRCA1, DAMAGE, CTIP, RESECTION, FIDELITY, BRCA1 Protein, BRCA2 Protein, Base Sequence, Biological Assay, Carrier Proteins, Cell Line, Tumor, DNA, DNA Breaks, Double-Stranded, DNA End-Joining Repair, DNA-Binding Proteins, DNA-Directed DNA Polymerase, Endodeoxyribonucleases, Epithelial Cells, Fibroblasts, Humans

Relation: Nucleic Acids Research; http://hdl.handle.net/10044/1/34553; BB/H003371/1

الاتاحة: http://hdl.handle.net/10044/1/34553
https://doi.org/10.1093/nar/gkw326

المؤلفون: Dennis A. Simpson, Gaorav P. Gupta, Chelsea M. Smith, Wanjuan Feng

المصدر: Seminars in radiation oncology. 32(1)

مصطلحات موضوعية: Cancer Research, DNA End-Joining Repair, DNA Repair, business.industry, Mechanism (biology), medicine.medical_treatment, fungi, DNA Polymerase Theta, Cancer, medicine.disease, Radiation Tolerance, Radiation therapy, enzymes and coenzymes (carbohydrates), Oncology, Neoplasms, Cancer cell, Homologous chromosome, Cancer research, Medicine, Humans, Radiology, Nuclear Medicine and imaging, DNA Breaks, Double-Stranded, Radiosensitivity, Protein kinase A, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a68953b2d8c5b2dc86005b7545dc5e8
https://pubmed.ncbi.nlm.nih.gov/34861993