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المؤلفون: Yanfei Cai, Jingyu Zhu, Yun Chen, Jian Jin, Xinling Zhao, Kan Li, Lei Xu, Huazhong Li, Gang Huang
المصدر: Journal of Advanced Research
Journal of Advanced Research, Vol 36, Iss, Pp 1-13 (2022)مصطلحات موضوعية: SMILES, simplified molecular input line entry specification, 0301 basic medicine, Medicine (General), Science (General), CADD, computer-aided drug design, AUC, area under receiver operations characteristic curve, VS, virtual screening, Ionic, ionic interactions, computer.software_genre, PI3Kγ, Machine Learning, Q1-390, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Protein structure, Basic and Biological Science, PI3K, Phosphoinositide 3-kinase, RTK, receptor tyrosine kinases, IMDM, Iscove’s Modified Dulbecco’s Medium, PDB, protein data bank, Cytotoxicity, PARP, poly ADP-ribose polymerase, XP, extra precision, Phosphoinositide-3 Kinase Inhibitors, Selective inhibitor, chemistry.chemical_classification, Multidisciplinary, Chemistry, JN-KI3, GPCR, G protein-coupled receptors, MD, molecular dynamics, Molecular Docking Simulation, PAINS, pan-assay interference compounds, NBC, naive Bayesian classifier, RMSD, root-mean-squared-deviation, RMSF, root-mean-squared-fluctuation, MM/GBSA, molecular mechanics/generalized born surface area, 030220 oncology & carcinogenesis, CDRA, confirmatory dose–response assays, SP, standard precision, DMEM, Dulbecco’s Modified Eagle Medium, Virtual screening, Gene isoform, H-bond, hydrogen bond, DS3.5, discovery studio 3.5, Molecular Dynamics Simulation, Machine learning, AKT, protein kinase B, 03 medical and health sciences, R5-920, FBS, fetal bovine serum, ROC, receiver operations characteristic, REOS, rapid elimination of swill, Badapple, bioactivity data associative promiscuity pattern learning engine, PAGE, polyacrylamide gel electrophoresis, PI3K/AKT/mTOR pathway, ComputingMethodologies_COMPUTERGRAPHICS, Water Bridge, hydrogen bonds through water molecular bridge, business.industry, Mechanism (biology), PSA, primary screening assays, 030104 developmental biology, Enzyme, Cell culture, Hematologic malignancies, Artificial intelligence, SD, standard deviation, business, ADMET, absorption, distribution, metabolism, excretion, and toxicity, computer
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المؤلفون: Floris J.M. Roos, Qiuwei Pan, Petra E. de Ruiter, Jan N. M. IJzermans, Arif I. Ardisasmita, Henk P. Roest, Shaojun Shi, Monique M A Verstegen, Luc J. W. van der Laan, Marije Niemeijer, Wanlu Cao
المساهمون: Surgery, Gastroenterology & Hepatology
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 541-564 (2022)
Cellular and Molecular Gastroenterology and Hepatology
CMGH, 13(2), 541-564. Elsevier Inc.مصطلحات موضوعية: NSA, necrosulfonamide, medicine.medical_treatment, MLKL, mixed lineage kinase domain-like, DAMP, damage-associated molecular pattern, Apoptosis, RC799-869, Liver transplantation, TNF-α, tumor necrosis factor-α, Liver disease, Nec-1s, 7-Cl-O-necrostatin-1, RIPK, receptor-interacting protein, T, tumor necrosis factor, Caspase, Original Research, LDLT, living donor liver transplantation, biology, Liver Disease, Gastroenterology, Diseases of the digestive system. Gastroenterology, Organoids, Liver, Necroptosis, hICO, intrahepatic cholangiocyte organoid derived from human donor liver, POA, palmitoleic acid, NASH, nonalcoholic steatohepatitis, Programmed cell death, ALD, alcoholic liver disease, mICO, murine intrahepatic cholangiocyte organoid, NF-κB, nuclear factor-κB, Cholangiocyte, Primary sclerosing cholangitis, CTR, control, PI, propidium iodide, Smac, second mitochondria-derived activator of caspases, SDG 3 - Good Health and Well-being, medicine, Humans, TEM, transmission electron microscopy, Hepatology, business.industry, Nec-1, necrostatin-1, Z, Z-VAD-FMK, ICO, intrahepatic cholangiocyte organoid, pMLKL, phosphorylated mixed lineage kinase domain-like, Epithelial Cells, S, Smac mimetic, medicine.disease, Biliary Injury, PSC, primary sclerosing cholangitis, Cancer research, biology.protein, p-IKKα/β, phosphorylated inhibitory-κB kinase α/β, DMEM, Dulbecco’s modified Eagle medium, PBC, primary biliary cholangitis, business, ERCP, endoscopic retrograde cholangiopancreatography
وصف الملف: application/pdf
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المؤلفون: Jinze Li, Maria M. Disotuar, Nai-Pin Lin, Jake A. Smith, Danny Hung-Chieh Chou, Steve L. Alam
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2719-2725 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: Alb, albumin, Insulin degludec, pAkt, phosphorylated protein kinase B, Boc, tert-butyloxycarbonyl, medicine.medical_treatment, Lysine, DMSO, dimethyl sulfoxide, EDT, 1,2-ethanedithiol, 0302 clinical medicine, Diabetes mellitus, HATU, 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, NBD-X, 6-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoic acid, t-Bu, tert-butyl, General Pharmacology, Toxicology and Pharmaceutics, HTRF, homogeneous time resolved fluorescence, Mtt, 4-methyltrityl, Insulin detemir, Long-acting insulin, 0303 health sciences, Chemistry, Albumin-binding peptide SA21, i.p., intraperitoneal, Therapeutic Insulin, DCM, dichloromethane, Biochemistry, HPLC, high performance liquid chromatography, 030220 oncology & carcinogenesis, Sortase A, DMF, dimethylformamide, Fmoc, 9-fluorenylmethoxycarbonyl, medicine.drug, DOI, desoctapeptide (B23−30) insulin, Short Communication, RM1-950, DMEM, Dulbecco's Modified Eagle Medium, STZ, streptozotocin, TIS, triisoproylsilane, 03 medical and health sciences, FBS, fetal bovine serum, Insulin synthesis, medicine, ITT, insulin tolerance test, 030304 developmental biology, Insulin, THF, triflouroacetic acid, HBTU, O-(benxontriazol-1-yl)-1,1,3,3-tetramethyluronium, Sortase A (SrtA) ligation, medicine.disease, IR-B, human insulin receptor isoform B, LC‒MS, liquid chromatography mass spectrometry, DIEA, N,N-diisopropylethylamine, Therapeutics. Pharmacology, Ligation, SrtA, sortase A
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المؤلفون: Tongtong Miao, Haiyan Chen, Jiang Ni, Liang Han, Naveed Ullah Khan, Xiufeng Ju
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1341-1354 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: medicine.medical_treatment, PLGA, poly(lactic-co-glycolic acid), PLGA-PLL, poly(lactic-co-glycolic acid)-poly(ε-carbobenzoxy-l-lysine), t1/2, half time, Aβ, amyloid beta, DMSO, dimethyl sulfoxide, LRP1, low density lipoprotein receptor-related protein 1, PVA, polyvinyl alcohol, Targeted therapy, Blood‒brain barrier, 0302 clinical medicine, MAL-PEG-SCM, maleimide polyethylene glycol succinimidyl carboxymethyl ester, Fusion peptide, Medicine, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, MMP, A, angiopep-2, AUC0‒t, area under the curve from zero to time t, Brain clearance, LRP1, i, insensitive GDQGIAGF, MRT0‒t, mean residence time from zero to time t, MCM, MDA-MB-231Br-HER2 conditioned medium, medicine.anatomical_structure, Transcytosis, Abluminal LRP1, 030220 oncology & carcinogenesis, Drug delivery, Original Article, medicine.drug, SDS, sodium dodecyl sulfate, 231Br, MDA-MB-231Br-HER2, RM1-950, Lapatinib, Blood–brain barrier, 03 medical and health sciences, FBS, fetal bovine serum, K, KAAYSL, BBB, blood‒brain barrier, Doxorubicin, NPs, nanoparticles, 030304 developmental biology, business.industry, s, sensitive VPMS-MRGG, Amyloid beta, CI, combination index, Fa, the fraction of tumor cells affected, MMP1, matrix metalloproteinase-1, BCBMs, breast cancer brain metastases, medicine.disease, DOX, doxorubicin, BMECs, brain microvascular endothelial cells, tPA, tissue plasminogen activator, PLL, poly(ε-carbobenzoxy-l-lysine), Breast cancer brain metastases, DMEM, Dulbecco's modified eagle medium, LAP, lapatinib, Cancer research, Nanoparticles, Therapeutics. Pharmacology, business, CL, clearance, Brain metastasis
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المؤلفون: Yu Yamasaki, Daisuke Sasaki, Katsuhisa Matsuura, Tatsuya Shimizu
المصدر: Regenerative Therapy
Regenerative Therapy, Vol 18, Iss, Pp 66-75 (2021)مصطلحات موضوعية: 0301 basic medicine, Medicine (General), medicine.medical_specialty, ATP, adenosine triphosphate, Biomedical Engineering, Cardiomyopathy, Heart failure, DMEM, Dulbecco's Modified Eagle Medium, Contractile force, Re-oxygenation, PLN, phospholamban, Sarcomere, Biomaterials, 03 medical and health sciences, R5-920, 0302 clinical medicine, FBS, fetal bovine serum, Internal medicine, HFrEF, heart failure with reduced EF, HFpEF, heart failure with preserved EF, hiPSC-CMs, human induced pluripotent stem cell-derived cardiomyocytes, medicine, cTnT, cardiac troponin T, EF, ejection fraction, Induced pluripotent stem cell, Hypoxia, Ejection fraction, QH573-671, Chemistry, Human induced pluripotent stem cells, Hypoxia (medical), HFmrEF, heart failure with midrange EF, medicine.disease, Functional recovery, NPPA, natriuretic peptide precursor A, 030104 developmental biology, Cardiac cell sheet, SERCA, sarco/endoplasmic reticulum Ca2+ ATPase, Cardiology, Original Article, medicine.symptom, Cytology, 030217 neurology & neurosurgery, Function (biology), Developmental Biology
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المؤلفون: Young Yun Jung, Jae-Young Um, Kwang Seok Ahn, In Jin Ha, Gautam Sethi
المصدر: Journal of Advanced Research
Journal of Advanced Research, Vol 35, Iss, Pp 245-257 (2022)مصطلحات موضوعية: 0301 basic medicine, Medicine (General), IHC, Immunohistochemistry, Science (General), FCN, Fangchinoline, STAT3, signal transducer and activator of transcription 3, Pharmaceutical Science, P/S, Penicillin-streptomycin, Apoptosis, Fangchinoline, NT, Non treat, medicine.disease_cause, Stat3 Signaling Pathway, STAT3, Q1-390, Mice, 0302 clinical medicine, Multiple myeloma, Multidisciplinary, SHP-1, Src homology 2 domain-containing protein tyrosine phosphatase-1, biology, Chemistry, Protein Tyrosine Phosphatase, Non-Receptor Type 6, ROS, c/w, Cell per well, VEGF, vascular endothelial growth factor, Cell biology, 030220 oncology & carcinogenesis, JAK, Janus kinase, PARP, Poly (ADP-ribose) polymerase, DMEM, Dulbecco’s Modified Eagle Medium, HRP, Horseradish peroxidase, STAT3 Transcription Factor, Programmed cell death, MMP, Matrix metalloproteinase, Benzylisoquinolines, 03 medical and health sciences, R5-920, RTCA, Real-time cell analysis, medicine, GSH, Animals, Electrophoretic mobility shift assay, ComputingMethodologies_COMPUTERGRAPHICS, GAPDH, Glyceraldehyde 3-phosphate dehydrogenase, Cell growth, RT-PCR, Reverse transcription polymerase chain reaction, ICC, Immunocytochemistry, Oxidative Stress, 030104 developmental biology, ip, Intraperitoneal injection, Tumor progression, DAPI, 4′,6-Diamidino-2-Phenylindole, Dihydrochloride, biology.protein, STAT protein, FBS, Fetal bovine serum, Carcinogenesis
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المؤلفون: Narihito Nagoshi, Taro Matsumoto, Rina Fujii-Tezuka, Ichiro Morioka, Hideyuki Okano, Shori Takahashi, Hideo Mugishima, Mika Ishige-Wada
المصدر: Regenerative Therapy
Regenerative Therapy, Vol 16, Iss, Pp 1-11 (2021)مصطلحات موضوعية: 0301 basic medicine, Medicine (General), DMEM, Dulbecco's modified Eagle medium, MSCs, mesenchymal stem cells, WJ, Wharton's jelly, FGF-2, fibroblast growth factor-2, ASMA, α-smooth muscle actin, vWF, von Willebrand factor, PDGF, platelet-derived growth factor, 0302 clinical medicine, Immunophenotyping, βME, β-mercaptoethanol, DAPI, 4′,6-diamino-2-phenylindole, p75 neurotrophin receptor, UA, umbilical artery, CFU-F, colony-forming unit fibroblast, FSK, forskolin, EdU, 5-ethynyl-2′-deoxyuridine, UC, umbilical cord, Neural crest, EGFP, enhanced green fluorescent protein, Cell biology, medicine.anatomical_structure, NCSCs, neural crest-derived stem cells, CD146, Original Article, Pericyte, Neural crest stem cells, Stem cell, α-MEM, alpha-modified minimum essential medium, BDNF, bone-derived neurotrophic factor, PBS, phosphate-buffered saline, Biomedical Engineering, Neurosphere, Biology, p75NTR, p75 neurotrophin receptor, Biomaterials, MAP2, microtubule-associated protein 2, 03 medical and health sciences, R5-920, FBS, fetal bovine serum, medicine, CD90, NG2, neuron-glial antigen 2, Umbilical cord, EGF, epidermal growth factor, QH573-671, Mesenchymal stem cell, GFAP, glial fibrillary acidic protein, NF200, neurofilament 200, TBS, Tris-buffered saline, 030104 developmental biology, UV, umbilical vein, Mesenchymal stem cells, sense organs, Cytology, RA, all-trans-retinoic acid, 030217 neurology & neurosurgery, Developmental Biology
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المؤلفون: Zhouhong Ge, Ron Smits, Lucia Campos Carrascosa, Dave Sprengers, Jaap Kwekkeboom, Jan N. M. IJzermans, Guoying Zhou, Maikel P. Peppelenbosch, Ruby Lieshout, Ling Wang, Wanlu Cao, Lisanne Noordam, Pengfei Li, Qin Yang, Junhong Su, Jiaye Liu, Luc J. W. van der Laan, Meng Li, Buyun Ma, Monique M A Verstegen, Qiuwei Pan, Ruyi Zhang
المساهمون: Gastroenterology & Hepatology, Surgery
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, 11(2), 407-431. Elsevier Inc.مصطلحات موضوعية: FAP, fibroblast-associated protein, 0301 basic medicine, IGF, insulin-like growth factor, Liver Tumor Organoids, Wnt, wingless-related integration site, Cell–Cell Contact, Mice, PCR, polymerase chain reaction, Liver Neoplasms, Experimental, 0302 clinical medicine, Cancer-Associated Fibroblasts, Tumor Cells, Cultured, Tumor Microenvironment, Diethylnitrosamine, Paracrine Effect, OEM, organoids expansion medium, Original Research, AFP, α-fetoprotein, Liver Neoplasms, Gastroenterology, ECM, extracellular matrix, Organoids, EpCAM, epithelial cell adhesion molecule, NSG, NOD scid γ mouse, FACS, fluorescence-activated cell sorter, 030211 gastroenterology & hepatology, Liver cancer, medicine.drug, Sorafenib, CCA, cholangiocarcinoma, Carcinoma, Hepatocellular, Stromal cell, Liver tumor, Primary Cell Culture, PBS, phosphate-buffered saline, Antineoplastic Agents, Biology, α-SMA, α-smooth muscle actin, Co-Culture, PDGFRA, platelet-derived growth factor receptor α, 03 medical and health sciences, Paracrine signalling, SDG 3 - Good Health and Well-being, 3D, 3-dimensional, Paracrine Communication, OBM, organoids basic medium, medicine, Animals, Humans, CAF, cancer-associated fibroblast, EGF, epidermal growth factor, Hepatology, Cancer, DEN, N-nitrosodiethylamine, medicine.disease, CSC, cancer stem cell, Xenograft Model Antitumor Assays, Coculture Techniques, FGF, fibroblast growth factor, IL, interleukin, 030104 developmental biology, Drug Resistance, Neoplasm, Culture Media, Conditioned, Cancer cell, Cancer research, TCGA, The Cancer Genome Atlas, DMEM, Dulbecco’s modified Eagle medium, 5-FU, 5-fluorouracil, HGF, hepatocyte growth factor, FCS, fetal calf serum, Stromal Cells, HCC, hepatocellular carcinoma
وصف الملف: application/pdf
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المؤلفون: Rui Wang, Dandan Zhong, Yiqing Qiu, Jingni Wu, Yongliang Zhu, Zhenya Song, Jingwen Liu, Hongping Wang
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1433-1455 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: Models, Molecular, ANKRD22, ankyrin repeat domain-containing protein 22, RC799-869, BrdU+, bromodeoxyuridine-incorporating, Receptors, G-Protein-Coupled, Mice, FACS, fluorescence-activated cell sorting, Macrophage, IFN-γ, interferon-γ, Receptor, Wnt Signaling Pathway, TNF-α, tumor necrosis factor α, Original Research, Mice, Knockout, medicine.diagnostic_test, Chemistry, Wnt, Wingless/Int1, Gastroenterology, LGR5, ELISA, enzyme-linked immunosorbent assay, Diseases of the digestive system. Gastroenterology, FCM, flow cytometry, Immunohistochemistry, mRNA, messenger RNA, Ssea, stage-specific embryonic antigen, Mitochondria, Sox, SRY-box transcription factor, NFAT, nuclear factor of activated T cells, Rhod-2, Dihydrorhod-2, c-Myc, Myc proto-oncogene protein, AXIN2, axis inhibition protein 2, LPS, lipopolysaccharide, Tumor necrosis factor alpha, FITC, fluorescein isothiocyanate, RIPA, radioimmunoprecipitation assay, medicine.symptom, IL1α, interleukin-1α, IHC, immunohistochemistry, Targeted Gene Repair, Gastric Mucosal Injury, PBS, phosphate-buffered saline, Stomach Diseases, Inhibitory Compound, Inflammation, THP-1, Human myeloid leukemia mononuclear cell, Immunophenotyping, Flow cytometry, Structure-Activity Relationship, FBS, fetal bovine serum, Drug Development, In vivo, Cell Line, Tumor, medicine, Animals, Progenitor cell, Cell Proliferation, Cd, cluster of differentiation, Hepatology, Macrophages, Lgr5+, leucine-rich repeat-containing G-protein–coupled receptor 5–positive, Membrane Proteins, PE, Phycoerythrin, Macrophage Activation, WT, wild-type, qRT-PCR, quantitative reverse-transcription polymerase chain reaction, ANKRD22, TBS, Tris-buffered saline, Disease Models, Animal, Gene Expression Regulation, Mist, Muscle, intestine and stomach expression, Gastric Mucosa, CaMKII, calmodulin-dependent protein kinase II, Cancer research, EPC, epithelial progenitor cell, DMEM, Dulbecco’s modified Eagle medium, Epithelial Progenitor Cells, Biomarkers
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المؤلفون: Andreas Natsch, Heike Laue, Lu Hostettler, Tina Haupt
المصدر: Toxicology Reports, Vol 8, Iss, Pp 1002-1007 (2021)
Toxicology Reportsمصطلحات موضوعية: MCF7 proliferation assay, ER, estrogen receptor, OECD, Organisation of Economic Co-operation and Development, Health, Toxicology and Mutagenesis, CoRAP, Community Rolling Action Plan, NOAEL, no observed adverse effect level, Benzyl salicylate, Estrogen receptor, SCCS, European Scientific Committee for Consumer Safety: SRB, sulforhodamine B, YES, Yeast Estrogen screen, Reporter assay, BS, Benzyl salicylate, BPA, Bisphenol A, 010501 environmental sciences, Pharmacology, DMEM, Dulbecco's Modified Eagle Medium, Toxicology, 01 natural sciences, Partial agonist, HEPES, N-2-hydroxyethylpiperazine-N-ethanesulfonic acid, 03 medical and health sciences, chemistry.chemical_compound, HRPT, Human Relevant Potency Threshold, 0302 clinical medicine, In vivo, RA1190-1270, ERE, estrogen response element, Potency, TG, test guideline, CAT, chloramphenicol acetyl transferase gene, 0105 earth and related environmental sciences, 4−OHT, 4-hydroxy-tamoxifen, Reporter gene, MoA, Mode of action, ATCC, American Type Culture Collection, Cell growth, DMSO, Dimethyl sulfoxide, Regular Article, In vitro, Substance evaluation, chemistry, Toxicology. Poisons, FBS, foetal bovine serum, REACH, Registration, Evaluation, Authorisation and Restriction of Chemicals, E2, 17β-estradiol, 030217 neurology & neurosurgery
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المصدر: Toxicology Reports, Vol 8, Iss, Pp 1143-1155 (2021)
Toxicology Reportsمصطلحات موضوعية: Health, Toxicology and Mutagenesis, Lipid nanocarriers, Nanoparticle, DMSO, dimethyl sulfoxide, 010501 environmental sciences, Toxicology, 01 natural sciences, chemistry.chemical_compound, CA, cellulose acetate, 0302 clinical medicine, Nanoemulsion, RA1190-1270, TG, triglyceride, DPBS, Dulbecco’s phosphate buffered saline, Occlusion, P/S, penicillin/streptomycin, CUR, curcumin, RT, room temperature, Solid lipid nanoparticle, Wound healing agent, EtOH, ethanol, Curcumin, NLC, nanostructured lipid carriers, SLN, solid lipid nanoparticles, Wound healing, Nanotechnology, Nanostructured lipid carrier, DMEM, Dulbecco’s modified eagle medium, UV-VIS, ultraviolet – visible spectrophotometry, 03 medical and health sciences, NE, nanoemulsion, PBS, phosphate buffered saline, FBS, fetal bovine serum, SEM, scanning electron microscopy, ComputingMethodologies_COMPUTERGRAPHICS, 0105 earth and related environmental sciences, ELS, Electrophoretic Light Scattering, RH, relative humidity, WFI, water for injection, Toxicology and Redox Biology under the frame of their historical evolution, DLS, Dynamic Light Scattering, Topical application, chemistry, Toxicology. Poisons, BSA, bovine serum albumin, History of use, Nanocarriers, SD, standard deviation, PdI, polydispersity index, MeOH, methanol, 030217 neurology & neurosurgery
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المؤلفون: Djedjiga Abdelhamid, Massoud Mirshahi, Shahsoltan Mirshahi, Iman Al dybiat, Meriem Belalou, Marc Pocard, Matti Ullah, Jeannette Soria, Shahid Shah
المصدر: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 809-819 (2020)
Neoplasia (New York, N.Y.)مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Plasmin, medicine.medical_treatment, Cell Culture Techniques, Fluorescent Antibody Technique, HMCs, human mesothelial cells, Mice, 0302 clinical medicine, DMEM, dulbecco's Modified Eagle Medium, Aprotinin, PCI, peritoneal Cancer Index, uPA, urokinase plasminogen activator, PA, plasminogen activator, biology, Chemistry, ELISA, enzyme-linked immunosorbent assay, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 030220 oncology & carcinogenesis, CTRL, control, qPCR, quantitative polymerase chain reaction, Female, Peritoneum, PAR, protease-activated receptors, medicine.drug, Original article, NETs, neutrophil extracellular traps, SEM, scanning electron microscope, CT26, mouse colon cancer cell line, PBS, phosphate-buffered saline, lcsh:RC254-282, Fibrin, Cicatrix, 03 medical and health sciences, Thrombin, Cell Line, Tumor, Fibrinolysis, Cell Adhesion, medicine, Animals, Humans, ATCC, American Type Culture Collection, Fibrin degradation product, Cancer, medicine.disease, PAI-1, plasminogen activator inhibitor, Molecular biology, tPA, tissue plasminogen activator, Disease Models, Animal, 030104 developmental biology, Cancer cell, biology.protein, PFA, paraformaldehyde, Neoplasm Transplantation
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المؤلفون: Fumiyasu Ono, Bual Ronald Perocho, Yasuhiro Ikegami, Hiroyuki Ijima, Kozue Yoshida, Nana Shirakigawa, Takehiro Chouno
المصدر: Regenerative Therapy, Vol 15, Iss, Pp 173-179 (2020)
Regenerative Therapyمصطلحات موضوعية: Osmotic stress, 0301 basic medicine, Cryoprotectant, Osmotic shock, Biomedical Engineering, CCK-8, Cell Counting Kit-8, DMSO, dimethyl sulfoxide, Liver function, Cryopreservation, Biomaterials, Cell membrane, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, FBS, fetal bovine serum, Hepatocytes cryopreservation, medicine, Viability assay, lcsh:QH573-671, Very low concentration of trehalose, lcsh:R5-920, lcsh:Cytology, Chemistry, DMEM, dulbecco's modified Eagle medium, Trehalose, Ice crystal, 030104 developmental biology, medicine.anatomical_structure, Hepatocyte, Biophysics, Original Article, CMIC, cell-membrane-impermeable cryoprotective agent, lcsh:Medicine (General), 030217 neurology & neurosurgery, Developmental Biology
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المؤلفون: Jyotirmoy Chatterjee, Swarnendu Bag, Amrita Chaudhary, Provas Banerjee
المصدر: Journal of Traditional and Complementary Medicine, Vol 10, Iss 6, Pp 529-543 (2020)
Journal of Traditional and Complementary Medicineمصطلحات موضوعية: Angiogenesis, VEGF, Vascular endothelial growth factor, DAB, 3,3′-Diaminobenzidine, Connective tissue, lcsh:Medicine, VG, van Gieson’s, Pharmacology, Wound closure, Manuka Honey, IHC, Immuno-histochemistry, ECM, Extracellular matrix, Western blot, EMT, Epithelial–mesenchymal transition, Medicine, HIF 1 α, Hypoxia-inducible factor 1 α, Diabetic wound, Fibroblast, medicine.diagnostic_test, business.industry, PI, Povidine Iodine, JH, Jamun honey, lcsh:R, food and beverages, H&E, Hematoxylin and Eosin, Jamun honey, STZ, Streptozotocin, Streptozotocin, medicine.anatomical_structure, Complementary and alternative medicine, DBM, Diabetic mice, EGF, Epidermal growth factor, Reepithelialization, Original Article, business, Wound healing, Myofibroblast, MH, Manuka honey, medicine.drug, DMEM, Dulbecco’s Modified Eagle Medium
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المؤلفون: Henry W. Lim, Qing-Sheng Mi, Carla D. Pretto-Kernahan, Jonathan Z. Sexton, Shanthi Narla, Iltefat H. Hamzavi, Carmen Mirabelli, David M. Ozog, Robert J. Tibbetts
المصدر: International Journal of Infectious Diseases, Vol 100, Iss, Pp 224-229 (2020)
International Journal of Infectious Diseasesمصطلحات موضوعية: 0301 basic medicine, business.product_category, FFRs, filtering facepiece respirators, Reuse, UVC, ultraviolet C, 0302 clinical medicine, Ultraviolet C radiation, BSL3, Biosafety Level 3, Healthcare personnel, Medicine, 030212 general & internal medicine, Respirator, Decontamination, COVID-19, coronavirus disease 2019, TCID50, 50% tissue culture infectious dose, HCP, healthcare personnel, Infectious dose, Masks, General Medicine, Human decontamination, Infectious Diseases, CPE, cytopathic effect, HFHS, Henry Ford Health System, UVGI, ultraviolet germicidal irradiation, PPE, personal protective equipment, Microbiology (medical), 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Ultraviolet Rays, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 030106 microbiology, DMEM, Dulbecco's Modified Eagle Medium, Article, WHO, World Health Organization, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, PBS, phosphate-buffered-saline, SARS-Co-V2, Equipment Reuse, Humans, lcsh:RC109-216, Pandemics, Ventilators, Mechanical, Material type, SARS-CoV-2, business.industry, N95, COVID-19, Dose-Response Relationship, Radiation, Disinfection, SARS-CoV-2, Severe Acute Respiratory Syndrome coronavirus 2, HEPES, hydroxyethyl piperazineethanesulfonic acid, Ultraviolet C, business, FBS, Fetal Bovine Serum, Biomedical engineering
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المؤلفون: Shuya Luo, Lichuan Bai, Guan Wang, Sitong Liu, Hui Wang, Qinghuan Xiao, Ke Ma, Tianyu Wang, Kuan Gao, Hongyue Liang, Mei Liu
المصدر: Journal of Advanced Research
Journal of Advanced Research, Vol 29, Iss, Pp 23-32 (2021)مصطلحات موضوعية: 0301 basic medicine, Patch-Clamp Techniques, Angiogenesis, Endothelial cells, CCK-8, Cell Counting Kit-8, 0302 clinical medicine, Cell Movement, 5-aza, 5-Aza-2′-deoxycytidine, Endothelial dysfunction, Aorta, ANOVA, analysis of variance, Tube formation, lcsh:R5-920, Multidisciplinary, Neovascularization, Pathologic, Chemistry, Cell migration, Transfection, Cell biology, Endothelial stem cell, Cholesterol, Blood-Brain Barrier, 030220 oncology & carcinogenesis, Hypertension, Medicine, lcsh:Medicine (General), HEPES, N-2-hydroxyethil-piperazine-N'-2-ethanesulfonic acid, DMEM, Dulbecco’s Modified Eagle Medium, DNA (Cytosine-5-)-Methyltransferase 1, HAECs, human aortic endothelial cells, PVDF, polyvinylidene fluoride, RIPA, radio immunoprecipitation assay, 03 medical and health sciences, EGTA, ethylene glycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid, ROS, reactive oxygen species, Downregulation and upregulation, FBS, fetal bovine serum, Chloride Channels, medicine, DNMT1, DNA methyltransferase 1, NMDG, N-methyl-D-glucamine, Humans, lcsh:Science (General), shRNAs, short hairpin RNAs, Anoctamin-1, Cell Proliferation, MβCD, methyl-β cyclodextrin, TMEM16A, SE, standard error, HEK 293 cells, medicine.disease, HEK293 Cells, 030104 developmental biology, Calcium, CaCCs, Ca2+-activated Cl− currents, lcsh:Q1-390
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المؤلفون: Giacomo P. Comi, Amalia Gastaldelli, Roberto Piciotti, Anna Ludovica Fracanzani, S. Sabatini, Marica Meroni, Paola Dongiovanni, Massimiliano Ruscica, Giorgio Soardo, Anna Alisi, Luca Miele, Fabrizia Carli, Francesco Fortunato, Chiara Macchi, Veronica Erconi, Miriam Longo, Dario Ronchi, Erika Paolini, Luca Valenti
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 759-788 (2022)مصطلحات موضوعية: BMI, body mass index, PGC1α, Peroxisome proliferator-activated receptor-γ (PPARγ) coactivator-1α, RC799-869, Mitochondrion, DMSO, dimethyl sulfoxide, Mitochondrial Dynamics, ApoB, apolipoprotein B-100, Liver disease, PC, phosphatidylcholine, MT-COX1, mitochondrially encoded cytochrome c oxidase subunit 1, PCR, polymerase chain reaction, Non-alcoholic Fatty Liver Disease, HCC, ANOVA, analysis of variance, Original Research, GFP, green fluorescent protein, Liver injury, LDH, lactate dehydrogenase, Fatty liver, Liver Neoplasms, Gastroenterology, Single Nucleotide, Diseases of the digestive system. Gastroenterology, mRNA, messenger RNA, Hepatocellular carcinoma, Phospholipases A2, Calcium-Independent, ER Stress, SNP, single-nucleotide polymorphism, NASH, nonalcoholic steatohepatitis, Carcinoma, Hepatocellular, ATP, adenosine triphosphate, Genotype, LD, lipid droplet, TAG, triacylglycerol, Settore MED/12 - GASTROENTEROLOGIA, NAFLD, TM6SF2, Calcium-Independent, Cer, ceramide, ORO, Oil Red O, T2D, type 2 diabetes, mTOR, mammalian target of rapamycin, SDHA, succinate dehydrogenase complex flavoprotein subunit A, Biology, Polymorphism, Single Nucleotide, PI, phosphatidylinositol, ER, endoplasmic reticulum, FBS, fetal bovine serum, ORF, open reading frame, NADH, nicotinamide adenine dinucleotide, medicine, Gene silencing, Humans, Genetic Predisposition to Disease, Polymorphism, sgRNA, small guide RNA, TEM, transmission electron microscopy, PCA, principal component analysis, Hepatology, Carcinoma, Membrane Proteins, VLDL, very-low-density lipoprotein, Hepatocellular, Lipase, medicine.disease, digestive system diseases, OR, odds ratio, Phospholipases A2, Anaerobic glycolysis, lyso, lysophosphatidylinositol, Akt, protein kinase B, CRISPR-Cas9, Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9, Unfolded protein response, Cancer research, BSA, bovine serum albumin, DMEM, Dulbecco’s modified Eagle medium, NAFLD, nonalcoholic fatty liver disease, HCC, hepatocellular carcinoma, DAG, diacylglycerol, Acyltransferases
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18Academic Journal
المؤلفون: Seredenina, Tamara, Nayernia, Zeynab, Sorce, Silvia, Maghzal, Ghassan J., Filippova, Aleksandra, Ling, Shuo Chien, Basset, Olivier, Plastre, Olivier, Daali, Youssef, Rushing, Elisabeth J., Cleveland, Don W., Aguzzi, Adriano, Stocker, Roland, Krause, Karl Heinz, Jaquet, Vincent, GIORDANA, Maria Teresa
المساهمون: Seredenina, Tamara, Nayernia, Zeynab, Sorce, Silvia, Maghzal, Ghassan J., Filippova, Aleksandra, Ling, Shuo-Chien, Basset, Olivier, Plastre, Olivier, Daali, Youssef, Rushing, Elisabeth J., Giordana, Maria T., Cleveland, Don W., Aguzzi, Adriano, Stocker, Roland, Krause, Karl-Heinz, Jaquet, Vincent
مصطلحات موضوعية: 2-Cl-E+ 2-chloroethidium, 2-OH-E+ 2-hydroxyethidium, BBB blood brain barrier, CNS central nervous system, DMEM Dulbecco's modified Eagle Medium, DMSO Dimethylsulfoxide, DNA deoxyribonucleic acid, DPI diphenyleneiodonium, DUOX dual oxidase, E+ ethidium, EC50 half maximal efficient concentration, FBS fetal bovine serum, FUS/TLS Fused in Sarcoma/Translocated in Sarcoma, GM-CSF granulocyte-macrophage colony-stimulating factor, H2O2 hydrogen peroxide, HBSS Hank's buffered salt solution, HE hydroethidine, HOCl hypochlorous acid, LC/MS/MS Liquid chromatography-tandem mass spectrometry, List of abbreviations ALS amyotrophic lateral sclerosi, MPO myeloperoxidase, NADPH nicotinamide adenine dinucleotide phosphate, NC non-carrier, NOX NADPH oxidase, NOXO1 NADPH oxidase organiser type 1, O2- superoxide radical anion, PBS phosphate buffered saline, PMA phorbol myristate acetate, qPCR quantitative polymerase chain reaction, ROS reactive oxygen specie
Relation: info:eu-repo/semantics/altIdentifier/pmid/27212019; info:eu-repo/semantics/altIdentifier/wos/WOS:000381924100009; volume:97; firstpage:95; lastpage:108; numberofpages:14; journal:FREE RADICAL BIOLOGY & MEDICINE; http://hdl.handle.net/2318/1593371; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84971325737; www.elsevier.com/locate/freeradbiomed
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المؤلفون: Bodin, Raphael, Paillé, Vincent, Oullier, Thibauld, Durand, Tony, Aubert, Philippe, Le Berre-Scoul, Catherine, Hulin, Philippe, Neunlist, Michel, Cissé, Moustapha
المساهمون: Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Plateforme MicroPicell [Nantes], Université de Nantes (UN)
المصدر: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (5), pp.1-14. ⟨10.1016/j.jbc.2021.101300⟩
The Journal of Biological Chemistryمصطلحات موضوعية: DMEM, Dulbecco's modified Eagle medium, MAP Kinase Signaling System, Receptor, EphB2, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV]Life Sciences [q-bio], synapsin I, enteric neurons, CNS, central nervous system, Rats, Sprague-Dawley, EGC, enteric glial cell, enteric nervous system, FBS, fetal bovine serum, synaptic-associated proteins, Animals, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Neurons, ENS, enteric nervous system, Neuronal Plasticity, ephrinB2, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, [SCCO.NEUR]Cognitive science/Neuroscience, SAP, synaptic-associated protein, PSD95, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, EphB2, Rats, OD, optical density, enteric glial cells, nervous system, connectivity, Synapses, Fc, fragment crystalizable, mPSC, miniature postsynaptic current, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Research Article
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المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: structure–function, protein chimera, Endosome, Bacterial Toxins, Endosomes, DMEM, Dulbecco’s modified eagle medium, Biochemistry, protein deamidation, HLH, helix-loop-helix, Protein Domains, DT, diphtheria toxin, LPR, laminin precursor receptor, fusion protein, NLS, bacterial toxin, drug delivery system, Humans, Small GTPase, ABMA, 1-adamantyl (5-bromo-2-methoxybenzyl) amine, Molecular Biology, Late endosome, Diphtheria toxin, protein translocation, Chemistry, molecular evolution, CNF, cytotoxic necrotizing factor, Escherichia coli Proteins, protein engineering, RLU, relative light unit, Cell Biology, Protein engineering, Fusion protein, Cell biology, Protein Transport, HEK293 Cells, small GTPase, Drug delivery, EGA, 4-bromo-benzaldehyde N-(2,6-dimethylphenyl) semi-carbazone, nls, nonlinear least-squares, BTIDD, bacterial toxin-inspired drug delivery, Lysosomes, Research Article