المؤلفون: Nguyen, D. Grace¹ (AUTHOR), Morris, Sarah A.¹ (AUTHOR), Hamilton, Alicia² (AUTHOR), Kwange, Simeon O.¹ (AUTHOR), Steuerwald, Nury^2,3 (AUTHOR), Symanowski, James⁴ (AUTHOR), Moore, Donald C.⁵ (AUTHOR), Hanson, Sarah⁵ (AUTHOR), Mroz, Kaitlyn¹ (AUTHOR), Lopes, Karine E.¹ (AUTHOR), Larck, Chris⁵ (AUTHOR), Musselwhite, Laura^3,6 (AUTHOR), Kadakia, Kunal C.^3,6 (AUTHOR), Koya, Brinda⁶ (AUTHOR), Chai, Seungjean^3,6 (AUTHOR), Osei-Boateng, Kwabena^3,6 (AUTHOR), Kalapurakal, Sini⁶ (AUTHOR), Swift, Kristen⁶ (NURSE), Hwang, Jimmy^3,6 (AUTHOR), Patel, Jai N.^1,3 (AUTHOR) jai.patel@atriumhealth.org

المصدر: JCO Precision Oncology. 12/1/2024, Vol. 8, p1-13. 13p.

مصطلحات موضوعية: *DIHYDROPYRIMIDINE dehydrogenase, *FISHER exact test, *GENETIC variation, *LOGISTIC regression analysis, *TOXICITY testing

المؤلفون: Miteva-Marcheva, Nelly¹ (AUTHOR) miteva_md@abv.bg, Ivanov, Hristo¹ (AUTHOR), Bangieva-Ivanova, Elena¹ (AUTHOR), Boyanov, Nikola^2,3 (AUTHOR), Stoyanova, Vili¹ (AUTHOR)

المصدر: Biotechnology & Biotechnological Equipment. Dec2024, Vol. 38 Issue 1, p1-13. 13p.

مصطلحات موضوعية: *DIHYDROPYRIMIDINE dehydrogenase, *CONSCIOUSNESS raising, *INDIVIDUALIZED medicine, *TOXICITY testing, *GENETIC variation

المؤلفون: de Baco, Lucas Silva^1,2 (AUTHOR), da Silva, Laura Cé³ (AUTHOR), Antunes, Luis Carlos Moreira⁴ (AUTHOR), Antunes, Marina Venzon³ (AUTHOR), Linden, Rafael³ (AUTHOR), Moreira, Mauber Eduardo Schultz⁴ (AUTHOR), Radins, Ricardo Bolsson⁴ (AUTHOR), Maranhão, Sarayane Araújo Brandão⁴ (AUTHOR), da Silva Barbosa, Sylvio Elvis⁴ (AUTHOR), Volpato, Lucimara⁴ (AUTHOR), Stefanon, Lauren Razzera⁴ (AUTHOR), Brucker, Natália^1,2 (AUTHOR) natalia.brucker@ufsm.br

المصدر: Fundamental & Clinical Pharmacology. Dec2024, Vol. 38 Issue 6, p1190-1202. 13p.

مصطلحات موضوعية: *DIHYDROPYRIMIDINE dehydrogenase, *GASTROINTESTINAL cancer, *TOXICITY testing, *BRAZILIANS, *CANCER patients

المؤلفون: Launay, Manon^1,2 (AUTHOR), Raymond, Laure^3,4 (AUTHOR), Guitton, Jérôme^2,5,6 (AUTHOR), Loriot, Marie-Anne^4,7,8 (AUTHOR), Chatelut, Etienne^2,9 (AUTHOR), Haufroid, Vincent^4,10 (AUTHOR), Thomas, Fabienne^2,4,9 (AUTHOR) thomas.fabienne@iuct-oncopole.fr, Etienne-Grimaldi, Marie-Christine^2,4,11 (AUTHOR)

المصدر: Clinical Chemistry & Laboratory Medicine. Nov2024, Vol. 62 Issue 12, p2415-2424. 10p.

مصطلحات موضوعية: *DIHYDROPYRIMIDINE dehydrogenase, *URACIL, *PHENOTYPES, *GENOTYPES, *RETROSPECTIVE studies

المؤلفون: Thompson, Jack T.¹ (AUTHOR), Wood, David M.^1,2 (AUTHOR), Dargan, Paul I.^1,2 (AUTHOR) paul.dargan@gstt.nhs.uk

المصدر: British Journal of Clinical Pharmacology. Oct2024, p1. 13p. 1 Illustration.

مصطلحات موضوعية: *CLINICAL trials, *DIHYDROPYRIMIDINE dehydrogenase, *BOLUS drug administration, *NUCLEOTIDES, *TRIACETATE, *URIDINE, *GLUCOSE-6-phosphate dehydrogenase

المؤلفون: Servier

المصدر: TRIFLUOX-DP: Safety of Trifluridine/Tipiracil as Replacement of Fluoropyrimidines (5-fluorouracil and Capecitabine) Based Chemotherapy as First Line Metastatic Colorectal or Gastroesophageal Cancer Regimens in Patients With Dihydropyrimidine Dehydrogenase Deficiency: a Phase II Trial

المؤلفون: Blomstrand, Hakon, Bodarve, Malin, Groth, Fredrik, Naredi, Peter, Sund, Malin, Vilhav, Caroline, Green, Henrik, Björnsson, Bergthor, Öhlund, Daniel, 1979, Lindblad, Stina, Franklin, Oskar, 1985, Elander, Nils O.

المصدر: Oncology Letters. 29(2)

مصطلحات موضوعية: adjuvant chemotherapy, dihydropyrimidine dehydrogenase, gemcitabine, pancreatic cancer, pancreatic ductal carcinoma, prognosis, prognostic factors

وصف الملف: electronic

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-233391
https://doi.org/10.3892/ol.2024.14845
https://umu.diva-portal.org/smash/get/diva2:1925787/FULLTEXT01.pdf

المؤلفون: Kato, Hiroyuki¹ (AUTHOR) h.kato@med.nagoya‐cu.ac.jp, Sato, Motonori¹ (AUTHOR), Naiki‐Ito, Aya¹ (AUTHOR), Inaguma, Shingo¹ (AUTHOR), Sano, Makoto² (AUTHOR), Komura, Masayuki¹ (AUTHOR), Nagayasu, Yuko¹ (AUTHOR), Xiaochen, Kuang¹ (AUTHOR), Kato, Akihisa³ (AUTHOR), Matsuo, Yoichi⁴ (AUTHOR), Ijichi, Hideaki⁵ (AUTHOR), Takahashi, Satoru¹ (AUTHOR)

المصدر: Cancer Medicine. Aug2024, Vol. 13 Issue 16, p1-11. 11p.

مصطلحات موضوعية: *DIHYDROPYRIMIDINE dehydrogenase, *COMBINATION drug therapy, *PANCREATIC duct, *FLAVONOIDS, *PANCREATIC cancer

المؤلفون: Medwid, Samantha^1,2,3 (AUTHOR), Kim, Richard B.^1,2,3 (AUTHOR) richard.kim@lhsc.on.ca

المصدر: British Journal of Clinical Pharmacology. Aug2024, Vol. 90 Issue 8, p1763-1781. 19p.

مصطلحات موضوعية: *DIHYDROPYRIMIDINE dehydrogenase, *GENETIC variation, *DRUG metabolism, *TURNAROUND time, *PHARMACOGENOMICS

المؤلفون: Ikonnikova, Anna¹ (AUTHOR) anyuik@gmail.com, Fedorinov, Denis^2,3 (AUTHOR) fedorinov.denis@gmail.com, Gryadunov, Dmitry¹ (AUTHOR) emel.marina85@gmail.com, Heydarov, Rustam⁴ (AUTHOR) rustam.heydarov@gmail.com, Lyadova, Marina^2,5 (AUTHOR) dr.lyadova@gmail.com, Moskalenko, Alexey² (AUTHOR) mansurgkokod@gmail.com, Mikhailovich, Vladimir⁴ (AUTHOR) v.mikhailovich@gmail.com, Emelyanova, Marina^1,4 (AUTHOR), Lyadov, Vladimir^2,3,5 (AUTHOR) vlyadov@gmail.com

المصدر: International Journal of Molecular Sciences. Aug2024, Vol. 25 Issue 15, p8503. 13p.

مصطلحات موضوعية: *DIHYDROPYRIMIDINE dehydrogenase, *GENETIC variation, *GENETIC polymorphisms, *GASTROINTESTINAL tumors, *NEUTROPENIA, *PHARMACOGENOMICS

المؤلفون: Ambrodji, Alisa^1,2 (AUTHOR) alisa.ambrodji@extern.insel.ch, Sadlon, Angélique¹ (AUTHOR) angelique.sadlon@insel.ch, Amstutz, Ursula¹ (AUTHOR) ursula.amstutz@insel.ch, Hoch, Dennis³ (AUTHOR) dennis.hoch@insel.ch, Berger, Martin D.³ (AUTHOR) martin.berger@insel.ch, Bastian, Sara⁴ (AUTHOR) sara.bastian@ksgr.ch, Offer, Steven M.⁵ (AUTHOR) steven-offer@uiowa.edu, Largiadèr, Carlo R.¹ (AUTHOR) carlo.largiader@insel.ch

المصدر: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 14, p7599. 15p.

مصطلحات موضوعية: *DIHYDROPYRIMIDINE dehydrogenase, *GENOTYPES, *FLUOROPYRIMIDINES, *CHIMERISM, *ALLELES, *CANCER patients

مصطلحات جغرافية: EUROPE

المصدر: Prospective Study of the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders
Shchelochkov OA, Manoli I, Juneau P, Sloan JL, Ferry S, Myles J, Schoenfeld M, Pass A, McCoy S, Van Ryzin C, Wenger O, Levin M, Zein W, Huryn L, Snow J, Chlebowski C, Thurm A, Kopp JB, Chen KY, Venditti CP. Severity modeling of propionic acidemia using clinical and laboratory biomarkers. Genet Med. 2021 Aug;23(8):1534-1542. doi: 10.1038/s41436-021-01173-2. Epub 2021 May 18.
Sloan JL, Johnston JJ, Manoli I, Chandler RJ, Krause C, Carrillo-Carrasco N, Chandrasekaran SD, Sysol JR, O'Brien K, Hauser NS, Sapp JC, Dorward HM, Huizing M; NIH Intramural Sequencing Center Group; Barshop BA, Berry SA, James PM, Champaigne NL, de Lonlay P, Valayannopoulos V, Geschwind MD, Gavrilov DK, Nyhan WL, Biesecker LG, Venditti CP. Exome sequencing identifies ACSF3 as a cause of combined malonic and methylmalonic aciduria. Nat Genet. 2011 Aug 14;43(9):883-6. doi: 10.1038/ng.908.
Balasubramaniam S, Duley JA, Christodoulou J. Inborn errors of purine metabolism: clinical update and therapies. J Inherit Metab Dis. 2014 Sep;37(5):669-86. doi: 10.1007/s10545-014-9731-6. Epub 2014 Jun 28.
Shchelochkov OA, Manoli I, Sloan JL, Ferry S, Pass A, Van Ryzin C, Myles J, Schoenfeld M, McGuire P, Rosing DR, Levin MD, Kopp JB, Venditti CP. Chronic kidney disease in propionic acidemia. Genet Med. 2019 Dec;21(12):2830-2835. doi: 10.1038/s41436-019-0593-z. Epub 2019 Jun 28.
Balasubramaniam S, Duley JA, Christodoulou J. Inborn errors of pyrimidine metabolism: clinical update and therapy. J Inherit Metab Dis. 2014 Sep;37(5):687-98. doi: 10.1007/s10545-014-9742-3. Epub 2014 Jul 17.
Chu Y, Sun S, Huang Y, Gao Q, Xie X, Wang P, Li J, Liang L, He X, Jiang Y, Wang M, Yang J, Chen X, Zhou C, Zhao Y, Ding F, Zhang Y, Wu X, Bai X, Wu J, Wei X, Chen X, Yue Z, Fang X, Huang Q, Wang Z, Huang R. Metagenomic analysis revealed the potential role of gut microbiome in gout. NPJ Biofilms Microbiomes. 2021 Aug 9;7(1):66. doi: 10.1038/s41522-021-00235-2.
Han ST, Kim AC, Garcia K, Schimmenti LA, Macnamara E, Network UD, Gahl WA, Malicdan MC, Tifft CJ. PUS7 deficiency in human patients causes profound neurodevelopmental phenotype by dysregulating protein translation. Mol Genet Metab. 2022 Mar;135(3):221-229. doi: 10.1016/j.ymgme.2022.01.103. Epub 2022 Feb 1.

المؤلفون: Ting Zhang¹, Ambrodji, Alisa^2,3, Huixing Huang¹, Bouchonville, Kelly J.¹, Etheridge, Amy S.⁴, Schmidt, Remington E.¹, Bembenek, Brianna M.¹, Temesgen, Zoey B.¹, Zhiquan Wang⁵, Innocenti, Federico⁴, Stroka, Deborah⁶, Diasio, Robert B.¹, Largiadèr, Carlo R.², Offer, Steven M.^1,7,8 soffer@uiowa.edu

المصدر: eLife. 4/30/2024, p1-21. 21p.

مصطلحات موضوعية: *DIHYDROPYRIMIDINE dehydrogenase, *ANTINEOPLASTIC agents, *DRUG metabolism, *DRUG laws, *GENE expression, *GENOME editing, *CIS-regulatory elements (Genetics)

المؤلفون: van Kuilenburg, André B.P.¹ (AUTHOR) a.b.vankuilenburg@amsterdamumc.nl, Pleunis-van Empel, Marjolein C.H.² (AUTHOR), Brouwer, Rick B.³ (AUTHOR), Sijben, Angelique E.J.⁴ (AUTHOR), Knapen, Daan G.⁵ (AUTHOR), Oude Munnink, Thijs H.⁶ (AUTHOR), van Zanden, Jelmer J.⁷ (AUTHOR), Janssens-Puister, Jenny⁸ (AUTHOR), Dobritzsch, Doreen⁹ (AUTHOR), Meinsma, Rutger¹ (AUTHOR), Meijer-Jansen, Judith¹ (AUTHOR), van Dooren, Silvy J.M.¹ (AUTHOR), Vijzelaar, Raymon¹⁰ (AUTHOR), Pop, Ana¹ (AUTHOR), Salomons, Gajja S.¹ (AUTHOR), Maring, Jan Gerard¹¹ (AUTHOR), Niezen-Koning, Klary E.⁸ (AUTHOR)

المصدر: JCO Precision Oncology. 4/11/2024, Vol. 8, p1-7. 7p.

مصطلحات موضوعية: *DIHYDROPYRIMIDINE dehydrogenase, *GLUCOSE-6-phosphate dehydrogenase deficiency

المؤلفون: Malekkou, Anna¹ (AUTHOR), Tomazou, Marios² (AUTHOR), Mavrikiou, Gavriella¹ (AUTHOR), Dionysiou, Maria¹ (AUTHOR), Georgiou, Theodoros¹ (AUTHOR), Papaevripidou, Ioannis³ (AUTHOR), Alexandrou, Angelos³ (AUTHOR), Sismani, Carolina³ (AUTHOR), Drousiotou, Anthi¹ (AUTHOR), Grafakou, Olga⁴ (AUTHOR), Petrou, Petros P.¹ (AUTHOR) petrosp@cing.ac.cy

المصدر: BMC Medical Genomics. 3/25/2024, Vol. 17 Issue 1, p1-10. 10p.

مصطلحات موضوعية: *DIHYDROPYRIMIDINE dehydrogenase, *GLUCOSE-6-phosphate dehydrogenase deficiency, *SINGLE nucleotide polymorphisms, *GENETIC variation, *GENETIC testing, *DEVELOPMENTAL delay

المؤلفون: De Metz, Côme¹ (AUTHOR), Hennart, Benjamin² (AUTHOR), Aymes, Estelle³ (AUTHOR), Cren, Pierre‐Yves^1,3 (AUTHOR), Martignène, Niels³ (AUTHOR), Penel, Nicolas^1,4 (AUTHOR), Barthoulot, Maël³ (AUTHOR), Carnot, Aurélien¹ (AUTHOR) a‐carnot@o‐lambret.fr

المصدر: Cancer Medicine. Mar2024, Vol. 13 Issue 6, p1-12. 12p.

مصطلحات موضوعية: *DIHYDROPYRIMIDINE dehydrogenase, *WHOLE genome sequencing, *LOGISTIC regression analysis, *MEDICAL screening, *NUCLEOTIDE sequencing

المؤلفون: Guevara, Mariela, de la Cruz, Carla González, Rodrigues-Soares, Fernanda, Rodríguez, Ernesto, Manóchio, Caíque, Peñas-Lledó, Eva, Dorado, Pedro, LLerena, Adrián

المصدر: Pharmaceutics; Jan2025, Vol. 17 Issue 1, p8, 13p

مصطلحات موضوعية: BLACK Latin Americans, GENOMICS, GENETIC variation, GENETIC polymorphisms, INDIVIDUALIZED medicine, DIHYDROPYRIMIDINE dehydrogenase

المؤلفون: Cassandra White, Hannah Wardill, Christine Paul, Timothy Price, Christos Karapetis, Mark Nalder, Matthew E. Burge, Ann Thomas, Chris Oldmeadow, Daniel Barker, Laura C. Edney, Janet Coller, Joanne Bowen, Cheri Ostroff, Bruce Cheek, Mel Carlson, Trumaine Rankmore, Adnan Nagrial, Stephen Clarke, Lorraine Chantrill, Stephen Ackland, Rodney J. Scott

المصدر: BMC Cancer, Vol 24, Iss 1, Pp 1-10 (2024)

مصطلحات موضوعية: DPYD, Fluoropyrimidine, Pharmacogenomics, Dihydropyrimidine dehydrogenase, UGT1A1, Irinotecan, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1471-2407

URL الوصول: https://doaj.org/article/4dd039073fb249cbbecad007e14e1be9

المؤلفون: Loison, Gaspard¹ (AUTHOR), Bouges Le Royer, Hélène² (AUTHOR), Marsili, Sabrina^1,3 (AUTHOR), Brice, Aurélie^1,3 (AUTHOR), Vintejoux, Julien^1,3 (AUTHOR), Yakoubi, Malika^1,3 (AUTHOR), Sirgue, Hélène^1,3 (AUTHOR), Chatelut, Etienne^1,3 (AUTHOR), Etienne-Grimaldi, Marie-Christine² (AUTHOR), Thomas, Fabienne^1,3,4,5 (AUTHOR) thomas.fabienne@iuct-oncopole.fr

المصدر: Clinical Chemistry & Laboratory Medicine. May2024, Vol. 62 Issue 6, pe129-e131. 3p.

مصطلحات موضوعية: *DIHYDROPYRIMIDINE dehydrogenase, *HEMOLYSIS & hemolysins, *LIQUID-liquid extraction

المؤلفون: de Haar-Holleman, Amy, Cortoos, Pieter-Jan, Vlaeminck, Jelle, Van Landuyt, Paulien, Steurbaut, Stephane, Vaeyens, Freya, Haufroid, Vincent

المصدر: Frontiers in Pharmacology; 2024, p1-6, 6p

مصطلحات موضوعية: DIHYDROPYRIMIDINE dehydrogenase, GENETIC polymorphisms, FLUOROPYRIMIDINES, URACIL, COLON (Anatomy), HETEROZYGOSITY