نتائج البحث - "DBD, DNA-binding domain"

المصدر: Journal of Biological Chemistry, 296:100551. American Society for Biochemistry and Molecular Biology Inc.
'Journal of Biological Chemistry ', vol: 296, pages: 100551-1-100551-15 (2021)
The Journal of Biological Chemistry

مصطلحات موضوعية: Threonine, 0301 basic medicine, MINK1, misshapen-like kinase 1, Biochemistry, LBD, ligand-binding domain, Glucocorticoid receptor, MINK1, HATU, 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, glucocorticoid receptor, nuclear receptor, ROCK1, Phosphorylation, Kinase, Chemistry, TBST, tris-buffered saline with Polysorbate 20, DCM, dichloromethane, Cell biology, ROCK1, Rho-associated coiled-coil containing protein kinase 1, DMF, dimethylformamide, FP, fluorescence polarization, Protein Binding, Research Article, Transcriptional Activation, MINK1 kinase, TCEP, tris(2-carboxyethyl)phosphine, SPR, surface plasmon resonance, Protein Serine-Threonine Kinases, 03 medical and health sciences, Receptors, Glucocorticoid, PDB, Protein Data Bank, DIPEA, N,N-diisopropylethylamine, Humans, NTD, N-terminal domain, NMP, N-methyl-2-pyrrolidone, Protein kinase A, Molecular Biology, Transcription factor, GR, glucocorticoid receptor, 030102 biochemistry & molecular biology, 14-3-3 protein, ERα, estrogen receptor α, Cell Biology, KPSI, kilopounds per square inch, HEK293 Cells, protein–protein interaction, 030104 developmental biology, 14-3-3 Proteins, Gene Expression Regulation, Nuclear receptor, DBD, DNA-binding domain, Mutation, ERRγ, estrogen-related receptor γ, Co-IP, co-immunoprecipitation

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb0fd7d87324c6afe121d7cb8644cf8
https://doi.org/10.1016/j.jbc.2021.100551

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5

Using biochemistry and biophysics to extinguish androgen receptor signaling in prostate cancer

المؤلفون: Trevor M. Penning, Gregory D. Van Duyne, Irfan A. Asangani, A. Joshua Wand, Vincent J. Hilser, Ian A. Blair, Vera Y. Moiseenkova-Bell, Cynthia C. Sprenger, Stephen R. Plymate

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Male, 0301 basic medicine, Biochemistry, aldo-keto reductase, LBD, ligand-binding domain, T, testosterone, androgen receptor, SHR, steroid hormone receptor, mass spectrometry, allostery, splice variants, Drug discovery, Chemistry, AKR1C3, aldo-keto reductase 1C3, EAM, ensemble allosteric model, SILAC, stable isotope labeling of amino acids in cell culture, Chromatin, Cell biology, Prostatic Neoplasms, Castration-Resistant, Receptors, Androgen, HSP, heat shock protein, IHC, immunohistochemistry, Signal Transduction, Biochemical Phenomena, Steroid hormone receptor, PPI, protein–protein interaction, Allosteric regulation, Reviews, cryo-electron microscopy, FBDD, fragment-based drug discovery, Biophysical Phenomena, SID-IP-LC-MS, stable isotope dilution–immunoprecipitation–liquid chromatography–mass spectrometry, 03 medical and health sciences, proteomics, PSA, prostatic-specific antigen, NR, nuclear receptors, NTD, N-terminal transactivation domain, Coactivator, AF, activation function, Humans, ADT, androgen deprivation therapy, Molecular Biology, 030102 biochemistry & molecular biology, Cell Biology, DNA-binding domain, RISH, rapid in situ hybridization, CTC, circulating tumor cells, DHT, 5α-dihydrotestosterone, Androgen receptor, qrtPCR, quantitative real-time polymerase chain reaction, nuclear magnetic resonance, 030104 developmental biology, ARSI, androgen receptor signaling inhibitor, Nuclear receptor, DBD, DNA-binding domain, RM, reverse micelle, AR, androgen receptor, CDK7, cyclin dependent kinase 7, CAK, CDK-activating kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604026f0eb231823b774b11f3348def9
http://europepmc.org/articles/PMC7949100

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6

Allosteric regulation of the nickel-responsive NikR transcription factor from Helicobacter pylori

المؤلفون: Karina A. Baksh, Robert Scott Prosser, Deborah B. Zamble, Dmitry Pichugin

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, inorganic chemicals, DNA, Bacterial, structure–function, DTNB, 5,5'-dithiobis-(2-nitrobenzoic acid), Protein Conformation, nuclear magnetic resonance (NMR), 5F-Trp-HpNikR, 5-fluorotryptophan-labeled H. pylori NikR, Allosteric regulation, DNA-binding protein, MBD, metal-binding domain, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, nickel, Allosteric Regulation, Bacterial Proteins, Bacterial transcription, Transcription (biology), otorhinolaryngologic diseases, IPTG, isopropyl-β-D-thiogalactopyranoside, Molecular Biology, Transcription factor, Gene, Nuclear Magnetic Resonance, Biomolecular, CD, circular dichroism, transcription factor, 030102 biochemistry & molecular biology, Helicobacter pylori, Chemistry, PhNikR, P. horikoshii NikR, metalloprotein, HpNikR, H. pylori NikR, Cell Biology, DNA-binding domain, bacterial transcription, Cell biology, Repressor Proteins, 030104 developmental biology, DBD, DNA-binding domain, metal homeostasis, Thermodynamics, EcNikR, E.coli NikR, DNA, Protein Binding, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6564cd1b9f4682991067e1c1cd6026b
https://pubmed.ncbi.nlm.nih.gov/33199369

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7

Heterodimer formation with retinoic acid receptor RXRα modulates coactivator recruitment by peroxisome proliferator-activated receptor PPARγ

المؤلفون: Whitney Kilu, Dieter Steinhilber, Daniel Merk, Jan Heering, Ewgenij Proschak

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, PPARγ, Peroxisome proliferator-activated receptor, PPAR, peroxisome proliferator-activated receptor, Ligands, Biochemistry, Benzoates, drug target, Nuclear Receptor Coactivator 1, LBD, ligand-binding domain, heterodimer, TETRAC, non-classical thyroid hormone 3,3',5,5'-tetraiodothyroacetic acid, homogeneous time-resolved FRET (HTRF), Tb-SA, terbium cryptate conjugated to streptavidin, chemistry.chemical_classification, allostery, Protein Stability, cofactor recruitment, NR, nuclear receptor, Ligand (biochemistry), CREB-Binding Protein, Cell biology, Research Article, Transcriptional Activation, homodimer, RXR, retinoid X receptor, Allosteric regulation, Retinoid X receptor, Rosiglitazone, 03 medical and health sciences, Retinoids, CBP-1, CREB-binding protein coactivator motif 1, FXR, farnesoid X receptor, Protein Domains, Coactivator, RXRα, Humans, HTRF, homogeneous time-resolved FRET, Molecular Biology, Retinoid X Receptor alpha, 030102 biochemistry & molecular biology, SRC1-2, steroid receptor coactivator 1 motif 2, Reproducibility of Results, sGFP, super folder green fluorescent protein, Cell Biology, PPAR gamma, Retinoic acid receptor, 030104 developmental biology, HEK293 Cells, chemistry, Nuclear receptor, DBD, DNA-binding domain, Mutation, Farnesoid X receptor, Protein Multimerization, AF-2, activation function 2

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a651259b1d286bcaadc32e55691b956
https://pubmed.ncbi.nlm.nih.gov/34081964

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8

Deciphering the structural and functional impact of missense mutations in Egr1-DNA interacting interface: an integrative computational approach

المؤلفون: Hemavathy Nagarajan (7201508), Umashankar Vetrivel (3388199)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Plant Biology, Computational Biology, Chemical Sciences not elsewhere classified, Egr1-early growth response 1, DBD – DNA binding domain, MD – molecular dynamics simulation, residue interaction network

Relation: https://figshare.com/articles/dataset/Deciphering_the_structural_and_functional_impact_of_missense_mutations_in_Egr1-DNA_interacting_interface_an_integrative_computational_approach/15180297

الاتاحة: https://doi.org/10.6084/m9.figshare.15180297.v1

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9

Characterization of the specific DNA-binding properties of Tnp26, the transposase of insertion sequence IS26

المؤلفون: Ruth M. Hall, Sandro F. Ataide, Christopher J. Harmer, Janine K. Flores, Carol H. Pong

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: TIRL, left terminal inverted repeat, MST, microscale thermophoresis, Transposases, Helix-turn-helix, Biochemistry, Cm, chloramphenicol, Tnpase, transposase, Tc, tetracycline, Insertion sequence, Transposase, chemistry.chemical_classification, terminal inverted repeat, Escherichia coli Proteins, protein domain, transposable element, Amino acid, Sm, streptomycin, protein–DNA interaction, Research Article, insertion sequence, DNA, Bacterial, IS26, Stereochemistry, HTH, helix–turn–helix, MBP, maltose-binding protein, Protein domain, Mutation, Missense, DNA-binding protein, Protein Domains, PDB, Protein Data Bank, Escherichia coli, Protein–DNA interaction, Ap, ampicillin, Binding site, Molecular Biology, TIRR, right terminal inverted repeat, Terminal Repeat Sequences, ApR, ampicillin resistant, TCEP, Tris(2-carboxyethyl)phosphine, Cell Biology, DNA-binding domain, Amino Acid Substitution, chemistry, DBD, DNA-binding domain, IS, insertion sequence, DNA Transposable Elements, DDE, aspartate–aspartate–glutamate, transposase Tnp26, helix–turn–helix DNA-binding domain, bacterial genetics, TIR, terminal inverted repeat

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696d1c4bff8e2263d9d9b1a4de459cce
https://doi.org/10.1016/j.jbc.2021.101165

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10

Characterization of the transactivation and nuclear localization functions of Pichia pastoris zinc finger transcription factor Mxr1p

المؤلفون: Umakant Sahu, Pundi N. Rangarajan, Kamisetty Krishna Rao, Aditi Gupta

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: NCBI, National Center for Biotechnology Information, MXRE, Mxr1p response element, ACS, acetyl-CoA synthetase, Biochemistry, Transactivation, Pichia pastoris, Transcription (biology), Gene Expression Regulation, Fungal, transcriptional regulation, GEO, Gene Expression Omnibus, nuclear localization, Mxr1p, alcohol oxidase, chemistry.chemical_classification, Zinc finger transcription factor, biology, Chemistry, ALD6-1Myc, Myc-tagged ALD6-1, Zinc Fingers, Amino acid, yeast metabolism, Research Article, Transcriptional Activation, 9aaTAD, nine-amino acid TAD, Active Transport, Cell Nucleus, transactivation domain, Fungal Proteins, cDNA, complementary DNA, aldehyde dehydrogenase, GO, Gene Ontology, PGK, phosphoglycerate kinase, Ethanol metabolism, Molecular Biology, YNBE, YNB and 1% ethanol, YNBM, YNB and 1% methanol, Cell Nucleus, MUT, methanol utilization, Promoter, TAD, transactivation domain, Cell Biology, DNA-binding domain, biology.organism_classification, ALD, aldehyde dehydrogenase, DBD, DNA-binding domain, NLS, nuclear localization signal, Saccharomycetales, YPD, yeast extract, peptone, and dextrose, qPCR, quantitative PCR, YNB, yeast nitrogen base, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26a21aaf288c7873ed4261530a4b4fc
https://doi.org/10.1016/j.jbc.2021.101247

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11

Helix 12 stabilization contributes to basal transcriptional activity of PXR

المؤلفون: Ryota Shizu, Sarii Tashiro, Takamitsu Sasaki, Ayaka Sugawara, Takuomi Hosaka, Takumi Sato, Yuichiro Kanno, Kouichi Yoshinari, Hikaru Nishiguchi

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: DMEM, Dulbecco's modified Eagle medium, Transcription, Genetic, Protein Conformation, AF2, activation function 2, RXR, retinoid X receptor, Peroxisome proliferator-activated receptor, PPAR, peroxisome proliferator-activated receptor, transactivation domain, DMSO, dimethyl sulfoxide, Retinoid X receptor, Crystallography, X-Ray, Ligands, digestive system, Biochemistry, pregnane X receptor, Transactivation, LBD, ligand-binding domain, Two-Hybrid System Techniques, Chlorocebus aethiops, Coactivator, Animals, Humans, nuclear receptor, PGC1α, peroxisome proliferator-activated receptor gamma coactivator-1α, Molecular Biology, chemistry.chemical_classification, Pregnane X receptor, PXR, pregnane X receptor, SRC, steroid receptor coactivator, Cell Biology, DNA-binding domain, Ligand (biochemistry), WT, wild-type, coactivator, digestive system diseases, Cell biology, chemistry, Nuclear receptor, DBD, DNA-binding domain, COS Cells, Mutation, VDR, vitamin D receptor, CAR, constitutive active/androstane receptor, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524b61ffd67bb30c70482d6926a1c177
https://doi.org/10.1016/j.jbc.2021.100978

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12

An overview on medicinal perspective of thiazolidine-2,4-dione: A remarkable scaffold in the treatment of type 2 diabetes

المؤلفون: Punniyakoti Veeraveedu Thanikachalam, Pooja Chawla, Rahul K. Maurya, Srinivasan Ramamurthy, Garima Bansal

المصدر: Journal of Advanced Research, Vol 23, Iss, Pp 163-205 (2020)
Journal of Advanced Research

مصطلحات موضوعية: NFκB, nuclear factor kappa-B, 0301 basic medicine, HFD, high-fat diet, Scaffold, mCPBA, meta-chloroperoxybenzoic acid, endocrine system diseases, IL-β, interlukin-beta, OGTT, oral glucose tolerance test, medicine.medical_treatment, Type 2 diabetes, Boc, Butyloxycarbonyl, DMSO, dimethyl sulfoxide, Pharmacology, GPT, glutamic pyruvic transaminase, TFAA, trifluoroacetic anhydride, DNA, deoxyribonucleic acid, LBD, ligand-binding domain, 0302 clinical medicine, AST, aspartate transaminase, DM, diabetes mellitus, LDL, low-density lipoprotein, NBS, N-bromosuccinimide, Thiazolidine-2,4-diones, PDB, protein data bank, TZD, thiazolidine-2,4-dione, AF, activation factor, lcsh:R5-920, Multidisciplinary, E, Entgegen, GLUT4, glucose transporter type 4, Drug discovery, Diabetes, WAT, white adipose tissue, TG, triglycerides, DCM, dichloromethane, PTP1B, protein-tyrosine phosphatase 1B, 030220 oncology & carcinogenesis, DMF, dimethylformamide, Rosiglitazone, lcsh:Medicine (General), THF, tetrahydrofuran, medicine.drug, KOH, potassium hydroxide, PPAR-γ, HEp-2, Human epithelial type 2, ALT, alanine transaminase, RXR, retinoid X receptor, HDL, high-density lipoprotein, PPAR, peroxisome-proliferator activated receptor, STZ, streptozotocin, SAR, structure-activity relationship, Article, ADDP, 1,1′-(Azodicarbonyl)dipiperidine, TFA, trifluoroacetic acid, HEK, human embryonic kidney, 03 medical and health sciences, Diabetes mellitus, FFA, free fatty acid, INS-1, insulin-secreting cells, medicine, lcsh:Science (General), HCl, Hydrochloric Acid, ComputingMethodologies_COMPUTERGRAPHICS, Thiazolidine 2 4 dione, GAL4, Galactose transporter type, MDA, malondialdehyde, PPRE, peroxisome proliferator response element, NO, nitric oxide, Pioglitazone, ALP, alkaline phosphatase, Z, Zusammen, business.industry, Pd, Palladium, Insulin, TNF-α, tumor necrosis factor-alpha, T2DM, type 2 diabetes mellitus, K2CO3, Potassium carbonate, medicine.disease, NaH, Sodium Hydride, QSAR, quantitative structure-activity relationship, 030104 developmental biology, FDA, food and drug administration, DBD, DNA-binding domain, NA, nicotinamide, ECG, electrocardiogram, IDF, international diabetes federation, i.m, Intramuscular, business, lcsh:Q1-390

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5fc0ed6fb3fffcffa5bcfde8b3fa5b
https://pubmed.ncbi.nlm.nih.gov/32154036

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13

Regulation of stress signaling pathways by protein lipoxidation

المؤلفون: Anna-Liisa Levonen, Carlos Cruz Cortés, Tommi Patinen, Jouni Härkönen, Ashik Jawahar Deen, Simone Adinolfi

المصدر: Redox Biology, Vol 23, Iss, Pp-(2019)
Redox Biology

مصطلحات موضوعية: RES, Reactive electrophilic species, ARE, Antioxidant response element, Biochemistry, Lipid peroxidation, 0302 clinical medicine, Heat Shock Transcription Factors, HSR, Heat shock response, lcsh:QH301-705.5, Protein lipoxidation, SILAC, Stable isotope labeling with amino acids in cell culture, chemistry.chemical_classification, CUL3, (Cullin-3)-ubiquitin E3 ligase complex, Kelch-Like ECH-Associated Protein 1, PGA2, Prostaglandin A2, NTR, N-terminal region, CTD, C-terminal domain, RD, Regulatory domain, Cell biology, NO2-CLA, nitro-conjugated linoleic acid, KEAP1, Kelch-like ECH-associated protein 1, OA-NO2, Nitro-oleic acid, lcsh:Medicine (General), NF-E2-Related Factor 2, 4-HNE, 4-hydroxy-2-nonenal, NRF2, LNO2, 9-, 10-, 12-, or 13-nitro-octadeca-9, 12-dienoic acid, 03 medical and health sciences, Humans, NTD, N-terminal domain, PARP13, Poly(ADP-ribose) Polymerase 13, Heat shock, LDE, Lipid-derived electrophiles, MS, Mass spectrometry, GCLC, Glutamate cysteine ligase catalytic, POLK, DNA polymerase kappa, Heat shock proteins, SH, sulfhydryl group, T-REX, Targetable reactive electrophiles and oxidants, DMSO, Dimethyl sulfoxide, 15d-PGJ2, 15-deoxy-Δ-12,14-prostaglandin J2, SQSTM1, Autophagosome cargo protein Sequestosome 1, KEAP1, 030104 developmental biology, HSP90, 90-kDa heat shock proteins from HSP90 family, chemistry, Redox regulation, Lipid Peroxidation, Biomarkers, 030217 neurology & neurosurgery, PEIPC, 1-palmitoyl-2-(5, 6)-epoxy isoprostane E2)-sn-glycero-3-phosphocholine, ROS, Reactive oxygen species, LC-MS, Liquid chromatography-mass spectrometry, 0301 basic medicine, Cysteine modification, Clinical Biochemistry, H2O2, Hydrogen peroxide, IA, Iodoacetamide alkyne, PARP1, Poly(ADP-ribose) polymerase 1, chemistry.chemical_compound, HSPD1/E1, Heat shock protein family D/E (Hsp60/Hsp10) member 1, LOX12/15, 12/15-Lipoxygenase, HSF1, HSPA8, Heat shock protein family A (Hsp70) member 8, Ub, ubiquitin, lcsh:R5-920, IER5, Immediate early response 5, HSP, Heat shock protein, NQO1, NAD(P)H:quione oxidoreductase 1, HSP40, 40-kDa heat shock proteins from HSP40 family, LZ4, Leucine zipper 4 domain, sMAF, small musculoaponeurotic fibrosarcoma oncogene homolog protein family, TEV, Tobacco etch virus, HSE, Heat shock element, GST, Gluthathione S-transferase, Second messenger system, Signal transduction, Oxidation-Reduction, Signal Transduction, CTAD, C-terminal transactivation domain, MD, Middle domain, ZAK, Animal-specific MAP kinase found in stress responses, Stress, Physiological, Implications of lipoxidation in cellular defense and stress pathway, Heat shock protein, GCLM, Glutamate-Cysteine Ligase Modifier Subunit, Animals, aLA, Alkyne-labeled linoleic acid, oxPAPC, Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine, Cysteine, ABPP, Affinity based protein profiling, IVR, Intervening region, Stress response, PRDX1, Peroxiredoxin 1, Organic Chemistry, Neh, Nrf2-ECH homology, HSF1, Heat shock factor 1, NRF2, NF-E2-related factor 2, Oxidative Stress, BTB, Broad complex, Tram-track, and Bric-a-Brac, Enzyme, lcsh:Biology (General), DBD, DNA binding domain, TXNR1D1, Thioredoxin reductase 1, LZ1–3, Leucine zipper 1–3 domains, HSP70, 70-kDa heat shock proteins from HSP70 family, G-REX, Genome-wide variant of T-REX, MRP, Multidrug-resistance-associated protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafcf94c34748fdbf80fa6cb081441fc
http://www.sciencedirect.com/science/article/pii/S221323171831067X

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14

Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization

المؤلفون: Pingping Shen, WenYu, Dan Weng, Xiujing Feng, Jian-Xin Li, Dianhua Chen, Haijian Fu, Nanfei Yang, Jingfa Zhao, Yahong Huang, Jiajia Chen, Ren-Xiang Tan, Haohan Qin, Young D. Owen, Feifei Zhou

المصدر: EBioMedicine
EBioMedicine, Vol 9, Iss C, Pp 61-76 (2016)

مصطلحات موضوعية: 0301 basic medicine, Male, PPARγ, EMSA, electrophoretic mobility shift assay, lcsh:Medicine, Adipose tissue, Peroxisome proliferator-activated receptor, AST, aspartate aminotransferase, Pharmacology, NF-κB, IHC, Immunological Histological Chemistry, chemistry.chemical_compound, SPF, specific-pathogen-free, Mice, HFD, high fat diet, Obesity-related inflammation, Thiazolidinedione, Apigenin, NF-κB, nuclear factor kappa B, PPARγ, peroxisome proliferator activated receptor γ, chemistry.chemical_classification, Metabolic Syndrome, lcsh:R5-920, ND, normal diet, ITC, isothermal titration calorimetry, NF-kappa B, Api, apigenin, WAT, white adipose tissue, General Medicine, TG, triglycerides, Arg1, arginase, SEM, standard error of mean, Phenotype, Biochemistry, Adipose Tissue, Macrophage polarization, Cytokines, medicine.symptom, TZD, thiazolidinedione, lcsh:Medicine (General), Rosiglitazone, ATM, adipocyte tissue macrophages, medicine.drug, Research Paper, Protein Binding, Signal Transduction, Normal diet, medicine.drug_class, Inflammation, LBD, ligand binding domain, General Biochemistry, Genetics and Molecular Biology, Cell Line, Immunophenotyping, PI, propidium iodide, 03 medical and health sciences, ROS, reactive oxygen species, AnV, Annexin V-FITC, ALT, alanine aminotransferase, medicine, Animals, Protein Interaction Domains and Motifs, Obesity, NO, nitric oxide, Rosi, rosiglitazone, Macrophages, lcsh:R, CT, computer tomography, Macrophage Activation, TC, total cholesterol, PPAR gamma, Disease Models, Animal, 030104 developmental biology, chemistry, DBD, DNA binding domain, ITTs, insulin tolerance tests, H&E, hematoxylin and eosin, Macrophages, Peritoneal, Fizz1, found in inflammatory zone (FIZZ)1, CD206, mannose receptor C type 1, Thiazolidinediones, SPPARMs, selective PPAR modulators, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1907f29710ed6b593e6ac9a2f8177b
http://europepmc.org/articles/PMC4972579

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15

Functional mechanisms of MYRF DNA-binding domain mutations implicated in birth defects

المؤلفون: Mohamed Sharif, Chuandong Fan, Yungki Park, Hongjoo An, Dongkyeong Kim

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, ICA, Intramolecular Chaperone Auto-processing, Biology, medicine.disease_cause, Biochemistry, Congenital Abnormalities, Myrf, myelin regulatory factor, Mice, 03 medical and health sciences, Protein Domains, OPC, OL progenitor cell, medicine, Animals, Humans, disease mechanism, Molecular Biology, Transcription factor, Cells, Cultured, transcription factor, Exome sequencing, MYRF, Mutation, 030102 biochemistry & molecular biology, Myelin regulatory factor, Oligodendrocyte differentiation, Membrane Proteins, Cell Biology, DNA-binding domain, OL, oligodendrocyte, Cell biology, Oligodendroglia, membrane-bound transcription factor, birth defects, 030104 developmental biology, DBD, DNA-binding domain, Haploinsufficiency, Function (biology), Transcription Factors, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea06f64adaed385044ff0e09bd3ea70b
https://doi.org/10.1016/j.jbc.2021.100612

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16

Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb

المؤلفون: Jin Xu, Zhibin Huang, Li Li, Yiyue Zhang, Yali Chi, Wenqing Zhang, Hao Jin, Kemin Chen

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Neutrophils, hpf, hours postfertilization, Lyz, lysozyme C, Biochemistry, Transactivation, hemic and lymphatic diseases, VE DIC, video-enhanced differential interference contrast, Myeloid Cells, MYB, Zebrafish, Myelopoiesis, RHD, RUNT homology domain, biology, ID, inhibitory domain, SB, Sudan black B, neutrophil, Cell biology, ChIP, chromatin immunoprecipitation, Myeloperoxidase, Core Binding Factor Alpha 2 Subunit, embryonic structures, Research Article, WISH, whole mount in situ hybridization, SEM, standard error of the mean, Proto-Oncogene Proteins c-myb, 03 medical and health sciences, c-myb, Animals, Srgn, serglycin, Npsn, nephrosin, NRD, negative-regulatory domain, Molecular Biology, Transcription factor, Innate immune system, 030102 biochemistry & molecular biology, Cell growth, Co-IP, coimmunoprecipitation, Mpx, myeloperoxidase, TAD, transactivation domain, Cell Biology, Zebrafish Proteins, AD, activation domain, biology.organism_classification, dpf, days postfertilization, Hematopoiesis, runx1, 030104 developmental biology, DBD, DNA-binding domain, biology.protein, Chromatin immunoprecipitation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b282343557a5338075945024e6c52ad
https://doi.org/10.1016/j.jbc.2021.100272

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17

A Cas9–transcription factor fusion protein enhances homology-directed repair efficiency

المؤلفون: Huaqiang Yang, Zhenfang Wu, Guoling Li, Xianwei Zhang, Haoqiang Wang

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, KI, knock-in, TF, transcription factor, DNA End-Joining Repair, small molecule, Computational biology, Biology, knock-in, Biochemistry, THAP11, Homology directed repair, 03 medical and health sciences, Genome editing, THAP11, THAP domain-containing 11, CRISPR-Associated Protein 9, genome editing, Humans, CRISPR, valnemulin, Insertion, Enhancer, CRISPR/Cas9, Molecular Biology, transcription factor, HDR, homology-directed repair, Gene Editing, ATF3, activating transcription factor 3, 030102 biochemistry & molecular biology, Cas9, DBCO, dibenzylcyclooctyne, mTHAP11, mouse THAP11, Recombinational DNA Repair, Cell Biology, DNA-binding domain, EGFP, enhanced green fluorescent protein, Fusion protein, ChIP, chromatin immunoprecipitation, SSA, single-strand annealing, Repressor Proteins, homology-directed repair, ssODN, single-stranded oligodeoxynucleotide, HEK293 Cells, 030104 developmental biology, DBD, DNA-binding domain, CRISPR-Cas Systems, Research Article, T7E1, T7 Endonuclease I

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a8fe044fd2ac76e19bfb1d1476e8c1
https://doi.org/10.1016/j.jbc.2021.100525

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18

Predicting Puberty in Partial Androgen Insensitivity Syndrome: Use of Clinical and Functional Androgen Receptor Indices

المؤلفون: I A Hughes, Philippa Prentice, Trevor Bunch, Ngee Lek, Nigel P. Mongan, Jonathan B Whitchurch, Veronika M. Metzler, Karolina Zielińska, Harriet L Miles, David M. Heery, Rieko Tadokoro-Cuccaro, Bismoy Mazumder

المساهمون: Whitchurch, Jonathan B [0000-0002-1465-9311], Mongan, Nigel P [0000-0001-5438-1126], Heery, David M [0000-0002-5035-2392], Apollo - University of Cambridge Repository

المصدر: EBioMedicine

مصطلحات موضوعية: 0301 basic medicine, Oncology, Male, Pediatrics, Research paper, Sex assignment, medicine.medical_treatment, Gene Expression, Gynaecomastia, in silico modelling, 0302 clinical medicine, LBD, ligand-binding domain, DSD, disorder of sex development, PAIS, partial androgen insensitivity syndrome, EMS, external masculinisation score, Young adult, 050207 economics, 050208 finance, 05 social sciences, Androgen insensitivity, General Medicine, Androgen-Insensitivity Syndrome, Pubic hair, 3. Good health, Androgen receptor, medicine.anatomical_structure, Receptors, Androgen, Research centre, Dihydrotestosterone, Androgen insensitivity syndrome, Reporter assays, Mastectomy, medicine.drug, Adult, medicine.medical_specialty, Adolescent, Genotype, DHT, dihydrotestosterone, medicine.drug_class, General Biochemistry, Genetics and Molecular Biology, Cell Line, 03 medical and health sciences, Young Adult, NID, nuclear receptor interaction domain, 030225 pediatrics, Internal medicine, 0502 economics and business, medicine, Animals, Humans, Allele, Partial androgen insensitivity syndrome, Alleles, Puberty outcome, External masculinisation score, Research ethics, business.industry, Puberty, medicine.disease, Androgen, WT, wild-type, 030104 developmental biology, SDS, standard deviation score, DBD, DNA-binding domain, Mutation, AR, androgen receptor, business, Biomarkers