المؤلفون: Shaw, Duncan, Smith, Nichola, Cotesta, Simona, Williams, Gareth, Sohal, Bindi, Rynn, Caroline, Troxler, Thomas J., D'Souza, Anne-Marie, Lattmann, Rene, Beerli, Rene, Pulz, Robert, Guth-Gundel, Sabine, Rowlands, David

Relation: Shaw, Duncan, Smith, Nichola, Cotesta, Simona, Williams, Gareth, Sohal, Bindi, Rynn, Caroline, Troxler, Thomas J., D'Souza, Anne-Marie, Lattmann, Rene, Beerli, Rene, Pulz, Robert, Guth-Gundel, Sabine and Rowlands, David (2023) Design and synthesis of inhibitors of the E3 ligase SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) as a treatment for lung remodeling in Pulmonary Arterial Hypertension (PAH). Journal of medicinal chemistry. ISSN 1520-4804; 0022-2623

الاتاحة: https://oak.novartis.com/48049/
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00229

المؤلفون: Petrassi, Mike, Barber, Rob, Be, Celine, Beach, Sarah, Cox, Brian, D’Souza, Anne-Marie, Duggan, Nick, Hussey, Martin, Fox, Roy, Hunt, Peter, Jarai, Gabor, Kosaka, Takatoshi, Oakley, Paul, Patel, Viral, Press, Neil, Rowlands, David, Scheufler, Clemens, Schmidt, Oliver, Srinivas, Honnappa, Turner, Mary, Turner, Rob, Westwick, John, Wolfreys, Alison, Pathan, Nuzhat, Watson, Simon, Thomas, Matthew

مصطلحات موضوعية: QD0241 Organic chemistry, QD0901 Crystallography, RM Therapeutics. Pharmacology

وصف الملف: application/pdf

Relation: http://sro.sussex.ac.uk/id/eprint/84307/1/TPH-1%20Paper%202017.pdf; Petrassi, Mike, Barber, Rob, Be, Celine, Beach, Sarah, Cox, Brian, D’Souza, Anne-Marie, Duggan, Nick, Hussey, Martin, Fox, Roy, Hunt, Peter, Jarai, Gabor, Kosaka, Takatoshi, Oakley, Paul, Patel, Viral, Press, Neil, Rowlands, David, Scheufler, Clemens, Schmidt, Oliver, Srinivas, Honnappa, Turner, Mary, Turner, Rob, Westwick, John, Wolfreys, Alison, Pathan, Nuzhat, Watson, Simon and Thomas, Matthew (2017) Identification of a novel allosteric inhibitory site on tryptophan hydroxylase 1 enabling unprecedented selectivity over all related hydroxylases. Frontiers in Pharmacology, 8 (240). pp. 1-12. ISSN 1663-9812

الاتاحة: http://sro.sussex.ac.uk/id/eprint/84307/
http://sro.sussex.ac.uk/id/eprint/84307/1/TPH-1%20Paper%202017.pdf
https://doi.org/10.3389/fphar.2017.00240

المؤلفون: Martin, Benjamin, Lai, Xinzhong, Baettig, Urs, Neumann, Eva, Kuhnle, Thomas, Porter, David, Robinson, Richard, Hatto, Julia, D’Souza, Anne-Marie, Steward, Oliver, Watson, Simon, Press, Neil J.

المصدر: Organic Process Research & Development ; volume 19, issue 8, page 1038-1043 ; ISSN 1083-6160 1520-586X

الاتاحة: http://dx.doi.org/10.1021/acs.oprd.5b00072
https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.5b00072

المؤلفون: Rooney, Lisa, D'Souza, Anne-Marie, Devereux, Nicholas, Boissel, Valerie, West, Ryan, Stringer, Rowan, Head, Victoria, Nash, Mark, Tully, David, Petrassi, Hank, Masick, Brian, Lao, Jianmin, Vidal-Biggart, Agnes, Petrus, Matthew, Schumacher, Andrew, Verkuijl, Martin, Stoakley, Natalie, Panesar, Moh, Patapoutian, Ardem

Relation: Rooney, Lisa, D'Souza, Anne-Marie, Devereux, Nicholas, Boissel, Valerie, West, Ryan, Stringer, Rowan, Head, Victoria, Nash, Mark, Tully, David, Petrassi, Hank, Masick, Brian, Lao, Jianmin, Vidal-Biggart, Agnes, Petrus, Matthew, Schumacher, Andrew, Verkuijl, Martin, Stoakley, Natalie, Panesar, Moh and Patapoutian, Ardem (2014) Discovery, optimization, and biological evaluation of 5-(2- (trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists. Journal of Medicinal Chemistry, 57 (12). pp. 5129-5140. ISSN 1520-4804

الاتاحة: https://oak.novartis.com/21717/
https://doi.org/10.1021/jm401986p