المؤلفون: Hui Li, Qiyan Hu, Yongbo Zhu

المصدر: Biochemical and Biophysical Research Communications. 516:784-789

مصطلحات موضوعية: 0301 basic medicine, Indoles, RHOA, medicine.medical_treatment, Biophysics, Mice, Nude, Mice, SCID, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, otorhinolaryngologic diseases, medicine, Animals, Humans, Protein Methyltransferases, Molecular Biology, Cisplatin, Messenger RNA, Chemotherapy, Nasopharyngeal Carcinoma, biology, Effector, Chemistry, Cysmethynil, Cancer, Nasopharyngeal Neoplasms, Cell Biology, medicine.disease, Xenograft Model Antitumor Assays, Enzyme Activation, stomatognathic diseases, 030104 developmental biology, Nasopharyngeal carcinoma, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, ras Proteins, Cancer research, biology.protein, RNA Interference, Fluorouracil, rhoA GTP-Binding Protein, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7b179471d0819d096264ef8ef831a9
https://doi.org/10.1016/j.bbrc.2019.06.074

المؤلفون: Hasina Banu, Hui Li, Rong Liu, Qin Pan, Liang Ma

المصدر: Biomedicine & Pharmacotherapy. 99:169-175

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Uterine Cervical Neoplasms, Antineoplastic Agents, Mice, SCID, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Downregulation and upregulation, Cell Line, Tumor, medicine, Animals, Humans, Doxorubicin, Protein Methyltransferases, Enzyme Inhibitors, Pharmacology, Cervical cancer, Chemotherapy, business.industry, Cysmethynil, General Medicine, medicine.disease, Xenograft Model Antitumor Assays, 030104 developmental biology, Paclitaxel, chemistry, Apoptosis, 030220 oncology & carcinogenesis, ras Proteins, Cancer research, Protein prenylation, Female, business, Signal Transduction, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d347f809c8533237b905c9fa8de6ed0
https://doi.org/10.1016/j.biopha.2018.01.048

المؤلفون: Seung-Gu Yeo, Jae Youl Cho, Woo Seok Yang, Kyung-Hee Kim, Sungjae Yang, Byong Chul Yoo

المصدر: Amino Acids

مصطلحات موضوعية: 0301 basic medicine, Methyltransferase, Indoles, Clinical Biochemistry, Antineoplastic Agents, Review Article, Biology, Pharmacology, Biochemistry, Methylation, Patents as Topic, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, ICMT inhibitor, Neoplasms, medicine, Structure–activity relationship, Animals, Humans, Protein Methyltransferases, Enzyme Inhibitors, Cancer, Indole test, chemistry.chemical_classification, Organic Chemistry, Cysmethynil, medicine.disease, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Enzyme, chemistry, Ras Signaling Pathway, 030220 oncology & carcinogenesis, Drug Design, ras Proteins, Intercellular Signaling Peptides and Proteins, Signal transduction, Protein Processing, Post-Translational, Ras, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a4d1427a319681c295a6aea97873bb
http://europepmc.org/articles/PMC5561173

المؤلفون: Kristina A.M. Arendt, Giannoula Ntaliarda, Vasileios Armenis, Danai Kati, Christin Henning, Georgia A. Giotopoulou, Mario A.A. Pepe, Laura V. Klotz, Anne-Sophie Lamort, Rudolf A. Hatz, Sebastian Kobold, Georgios T. Stathopoulos

مصطلحات موضوعية: CCR2, endocrine system diseases, medicine.disease_cause, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Medicine, neoplasms, 030304 developmental biology, 0303 health sciences, Oncogene, business.industry, Cysmethynil, digestive system diseases, 3. Good health, Blockade, respiratory tract diseases, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, KRAS, Bone marrow, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870c9f1b3a2fb0851c201499c11f4095

المؤلفون: Sophia Magkouta, Charalampos Moschos, Katherina Psarra, Maria-Eleni Vazakidou, Apostolos Pappas, Ioannis Kalomenidis

المصدر: Oncotarget

مصطلحات موضوعية: 0301 basic medicine, Male, Pathology, medicine.medical_specialty, Indoles, Lung Neoplasms, Angiogenesis, Vascular permeability, Adenocarcinoma of Lung, Apoptosis, Capillary Permeability, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, In vivo, Cell Movement, medicine, Tumor Cells, Cultured, Malignant pleural effusion, Animals, malignant pleural effusion, Protein Methyltransferases, Icmt, Cell Proliferation, Tube formation, adenocarcinoma, GTPases, Neovascularization, Pathologic, business.industry, Macrophages, Cysmethynil, medicine.disease, 3. Good health, Pleural Effusion, Malignant, Mice, Inbred C57BL, 030104 developmental biology, Oncology, chemistry, Tumor progression, 030220 oncology & carcinogenesis, mesothelioma, Cancer research, Adenocarcinoma, business, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1f7a75652a67ea94fbb26900622901
http://europepmc.org/articles/PMC4991451

المؤلفون: Sunggyu Kim, Ji Hye Kim, Woo Seok Yang, Jae Youl Cho, Keejung Yoon, Han Gyung Kim, Yunmi Lee

المصدر: Biochemical Pharmacology. 182:114219

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Cell signaling, Indoles, Lipopolysaccharide, p38 mitogen-activated protein kinases, Anti-Inflammatory Agents, Pharmacology, Biochemistry, Hepatitis, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Animals, Humans, Protein Methyltransferases, Mice, Inbred BALB C, Mice, Inbred ICR, Dose-Response Relationship, Drug, Macrophages, Cysmethynil, Colitis, Mice, Inbred C57BL, HEK293 Cells, RAW 264.7 Cells, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Phosphorylation, Tumor necrosis factor alpha, Signal transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a5e7ecd443c97a452e90f29fc6fa2e
https://doi.org/10.1016/j.bcp.2020.114219

المؤلفون: Ying Zhao, Jie Dai, Jun Chen, Lin Lai, Bingbing Fu, Qiong Liu

المصدر: Biochemical and biophysical research communications. 501(2)

مصطلحات موضوعية: 0301 basic medicine, Indoles, endocrine system diseases, medicine.medical_treatment, Biophysics, Antineoplastic Agents, Apoptosis, Mice, SCID, Carcinoma, Ovarian Epithelial, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Downregulation and upregulation, Prenylation, Mice, Inbred NOD, Cell Line, Tumor, Medicine, Animals, Humans, Neoplasms, Glandular and Epithelial, Protein Methyltransferases, Molecular Biology, Ovarian Neoplasms, Chemotherapy, business.industry, Effector, Cysmethynil, Cell Biology, medicine.disease, 030104 developmental biology, chemistry, Cell culture, 030220 oncology & carcinogenesis, Cancer research, ras Proteins, Female, business, Ovarian cancer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356f3ab648097c7c57b24db3abca1bc9
https://pubmed.ncbi.nlm.nih.gov/29746868

المؤلفون: Mei Wang, Jing T. Teh, Tin Fan Chai, Patrick J. Casey, Wan Zhu, Kanjoormana Aryan Manu

المصدر: Cancer Research. 78:2339-2339

مصطلحات موضوعية: Cancer Research, Programmed cell death, business.industry, ATG5, Cysmethynil, Autophagy, Cancer, Cell cycle, medicine.disease, chemistry.chemical_compound, Oncology, chemistry, Apoptosis, Pancreatic cancer, Cancer research, medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::01c353fdae5fb3d44eef394ef977b8e3
https://doi.org/10.1158/1538-7445.am2018-2339

المؤلفون: Mei-Lin Go, Patrick J. Casey, Wanloo Tan, Jin Zhou, Mei Wang, How Sung Lee, Jolene Leow

المصدر: Journal of Biological Chemistry. 283:18678-18684

مصطلحات موضوعية: Male, Programmed cell death, Indoles, Cell cycle checkpoint, Protein Prenylation, Apoptosis, Biology, medicine.disease_cause, Biochemistry, chemistry.chemical_compound, Cell Line, Tumor, Autophagy, medicine, Humans, Protein Methyltransferases, Enzyme Inhibitors, Molecular Biology, PI3K/AKT/mTOR pathway, Cell growth, TOR Serine-Threonine Kinases, Cysmethynil, G1 Phase, Prostatic Neoplasms, Cell Biology, Neoplasm Proteins, Protein Structure, Tertiary, Cell biology, chemistry, Cancer cell, ras Proteins, Protein prenylation, Drug Screening Assays, Antitumor, Carcinogenesis, Protein Kinases, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda5b252ad7a51639d069984a6b6938b
https://doi.org/10.1074/jbc.m801855200

المؤلفون: Patrick J. Casey, Jolene Leow, Rudi A. Baron, Mei-Lin Go

المصدر: Bioorganic & Medicinal Chemistry Letters. 17:1025-1032

مصطلحات موضوعية: Models, Molecular, Quantitative structure–activity relationship, Indoles, Chemical Phenomena, Databases, Factual, Molecular model, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Substituent, Quantitative Structure-Activity Relationship, Pharmaceutical Science, Carboxamide, Biochemistry, Article, chemistry.chemical_compound, Acetamides, Drug Discovery, medicine, Humans, Protein Methyltransferases, Enzyme Inhibitors, Molecular Biology, Indole test, Principal Component Analysis, Chemistry, Physical, Organic Chemistry, Cysmethynil, Protein-S-isoprenylcysteine O-methyltransferase, chemistry, Lipophilicity, Linear Models, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69283a72707b557c3ad4f24a36dee260
https://doi.org/10.1016/j.bmcl.2006.11.030

المؤلفون: Wei Xiang, Kartini Asari, Bee Ling Ng, Mei Wang, Charles Chuah, Ralph M. Bunte, Wen Tian Sun, Patrick J. Casey

المصدر: Experimental hematology. 44(3)

مصطلحات موضوعية: 0301 basic medicine, Male, Cancer Research, Indoles, MAP Kinase Signaling System, Fusion Proteins, bcr-abl, Apoptosis, Biology, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, hemic and lymphatic diseases, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Genetics, medicine, Animals, Humans, Protein Methyltransferases, Molecular Biology, Cysmethynil, Myeloid leukemia, Imatinib, Cell Biology, Hematology, 030104 developmental biology, Imatinib mesylate, Protein kinase domain, chemistry, 030220 oncology & carcinogenesis, Cancer research, Imatinib Mesylate, Neoplastic Stem Cells, Protein prenylation, Female, Tyrosine kinase, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8b102e3a518c3545385c3c6cd8e0d7
https://pubmed.ncbi.nlm.nih.gov/26706195

المؤلفون: Johannes Rudolph, Rudi A. Baron, Patrick J. Casey, Yuri K. Peterson, James C. Otto

المصدر: Biochemistry. 46:554-560

مصطلحات موضوعية: Indole test, Indoles, Methyltransferase, Stereochemistry, Cysmethynil, Protein Prenylation, Protein-S-isoprenylcysteine O-methyltransferase, In Vitro Techniques, Biochemistry, Recombinant Proteins, Dissociation constant, Kinetics, chemistry.chemical_compound, Non-competitive inhibition, chemistry, Endopeptidases, Humans, Protein prenylation, Protein Methyltransferases, Enzyme Inhibitors, Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c625ae5814298f5e8def91869065ba7
https://doi.org/10.1021/bi060344n

المؤلفون: Ann M. Winter-Vann, Patrick J. Casey

المصدر: Nature Reviews Cancer. 5:405-412

مصطلحات موضوعية: Protease, Methyltransferase, Cell growth, Applied Mathematics, General Mathematics, medicine.medical_treatment, Cysmethynil, Protein-S-isoprenylcysteine O-methyltransferase, Biology, medicine.disease_cause, chemistry.chemical_compound, Prenylation, Biochemistry, chemistry, medicine, Protein prenylation, Carcinogenesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e420480cbbf0c747c309fc73852fb0f1
https://doi.org/10.1038/nrc1612

المؤلفون: John D. York, Patrick J. Casey, Ann M. Winter-Vann, June dela Cruz, David M. Gooden, Rudi Baron, Waihay J. Wong, Eric J. Toone, Martin O. Bergo, Stephen G. Young

المصدر: Proceedings of the National Academy of Sciences. 102:4336-4341

مصطلحات موضوعية: Recombinant Fusion Proteins, Antineoplastic Agents, GTPase, Biology, Cell Line, Mice, chemistry.chemical_compound, Dogs, Prenylation, Epidermal growth factor, Cell Line, Tumor, Acetamides, Animals, Humans, Protein Methyltransferases, Enzyme Inhibitors, Multidisciplinary, Cell growth, C-terminus, Cysmethynil, Protein-S-isoprenylcysteine O-methyltransferase, Biological Sciences, Cell biology, Cell Transformation, Neoplastic, Phenotype, chemistry, Biochemistry, Colonic Neoplasms, Cancer cell, ras Proteins, Cell Division

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f41bcb4eb2d107f5c5a970974fe3032
https://doi.org/10.1073/pnas.0408107102

المؤلفون: Melissa Wirawan, Tianming Yang, Dianyan Guo, Hiu Yeung Lau, Mei-Lin Go, Pondy Murugappan Ramanujulu, Patrick J. Casey, Mei Wang

المصدر: Cancer biologytherapy. 15(9)

مصطلحات موضوعية: Cancer Research, Programmed cell death, Indoles, Cell Survival, Protein Prenylation, Antineoplastic Agents, Apoptosis, Mice, SCID, Biology, Oncogene Protein p21(ras), Methylation, chemistry.chemical_compound, Gefitinib, In vivo, Cell Line, Tumor, medicine, Autophagy, Animals, Humans, Protein Methyltransferases, Cell Proliferation, Pharmacology, Cysmethynil, Liver Neoplasms, Drug Synergism, Cell Cycle Checkpoints, Lamin Type A, Embryonic stem cell, Cell biology, ErbB Receptors, Pyrimidines, Oncology, chemistry, Cancer cell, Quinazolines, Molecular Medicine, Protein prenylation, Heterografts, Female, medicine.drug, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1c9e87e3859d819e517a258450bf2c
https://pubmed.ncbi.nlm.nih.gov/24971579

المؤلفون: Wang, M.

المساهمون: DUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE

المصدر: Scopus

مصطلحات موضوعية: Autophagy, Cell death, Cell migration, Cysmethynil, Isoprenylcysteine Carboxylmethyl Transferase (Icmt) inhibitor, Prenylation

Relation: Wang, M. (2011). Cysmethynil, a Specific Small-Molecule Inhibitor of Isoprenylcysteine Carboxylmethyl Transferase (Icmt). Enzymes 30 : 259-278. ScholarBank@NUS Repository. https://doi.org/10.1016/B978-0-12-415922-8.00011-2; http://scholarbank.nus.edu.sg/handle/10635/110004; NOT_IN_WOS

الاتاحة: http://scholarbank.nus.edu.sg/handle/10635/110004

المؤلفون: Mei Wang, Fui-Chung Wong, Tianming Yang, Patrick J. Casey, Siew Qi Yap, Mei-Lin Go, Pondy Murugappan Ramanujulu

المصدر: European journal of medicinal chemistry. 63

مصطلحات موضوعية: Drug, Methyltransferase, Indoles, Tertiary amine, Stereochemistry, Cell Survival, media_common.quotation_subject, Antineoplastic Agents, medicine.disease_cause, chemistry.chemical_compound, Amide, Cell Line, Tumor, Drug Discovery, medicine, Humans, Protein Methyltransferases, Amines, Enzyme Inhibitors, media_common, Pharmacology, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Cell growth, Organic Chemistry, Cysmethynil, General Medicine, Hep G2 Cells, Amides, Enzyme, Pyrimidines, chemistry, Biochemistry, Carcinogenesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148463f7a578d59e1e492d78c7aa0baf
https://pubmed.ncbi.nlm.nih.gov/23514631

المؤلفون: Wang, M., ZHOU JIN, Casey, P., Khoo, Y.M., Lee, H.S.

المساهمون: PHARMACOLOGY

المصدر: Scopus

مصطلحات موضوعية: Cysmethynil, Drug quantification, HPLC, Isoprenylcysteine carboxylmethyltransferase (Icmt), Preclinical study

Relation: Wang, M., ZHOU JIN, Casey, P., Khoo, Y.M., Lee, H.S. (2009). A high-performance liquid chromatography method for the quantification of cysmethynil, an inhibitor of isoprenylcysteine carboxylmethyl transferase, in mouse plasma. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 877 (5-6) : 553-557. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jchromb.2008.12.067; http://scholarbank.nus.edu.sg/handle/10635/27292; 000263623900015

الاتاحة: http://scholarbank.nus.edu.sg/handle/10635/27292

المؤلفون: Mei Wang

مصطلحات موضوعية: Programmed cell death, chemistry.chemical_compound, Biochemistry, chemistry, Prenylation, Cysmethynil, Autophagy, Transferase, Cell migration, Small molecule, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d4a0c732de4e8db57d3c749dff179371
https://doi.org/10.1016/b978-0-12-415922-8.00011-2

المؤلفون: Suresh Kumar Gorla, Jo Lene Leow, Andreas Schüller, Mei-Lin Go, Mei Wang, Patrick J. Casey

المصدر: Journal of medicinal chemistry. 53(19)

مصطلحات موضوعية: Methyltransferase, Indoles, Stereochemistry, Cell Survival, Stereoisomerism, Antineoplastic Agents, chemistry.chemical_compound, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Side chain, Structure–activity relationship, Humans, Protein Methyltransferases, Amines, Cell Proliferation, chemistry.chemical_classification, Indole test, Cysmethynil, Enzyme, chemistry, Biochemistry, Molecular Medicine, Drug Screening Assays, Antitumor, Acetamide

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7abdb8fbecc71fd613e7811cd45b4b1
https://pubmed.ncbi.nlm.nih.gov/20809634