يعرض 1 - 20 نتائج من 22,282 نتيجة بحث عن '"Cyclin-Dependent Kinases"', وقت الاستعلام: 0.57s تنقيح النتائج
  1. 1
    Academic Journal
    Large Unstained Cells (LUC): A Novel Predictor of CDK4/6 Inhibitor Outcomes in HR+ HER2-Negative Metastatic Breast Cancer.

    المؤلفون: Ceylan, Furkan1 (AUTHOR) drfurkanceylan@gmail.com, Mehdiyev, Mirmehdi1 (AUTHOR), Dede, Didem Şener1,2 (AUTHOR), Efil, Safa Can1 (AUTHOR), Tenekeci, Ateş Kutay3 (AUTHOR), Bilgin, Burak1,2 (AUTHOR), Yücel, Şebnem1,2 (AUTHOR), Tatlı Doğan, Hayriye4 (AUTHOR), Şendur, Mehmet Ali Nahit1,2 (AUTHOR), Akıncı, Muhammed Bülent1,2 (AUTHOR), Uncu, Doğan1 (AUTHOR), Yalçın, Bülent1,2 (AUTHOR)

    المصدر: Journal of Clinical Medicine. Jan2025, Vol. 14 Issue 1, p173. 15p.

    مصطلحات موضوعية: *METASTATIC breast cancer, *CYCLIN-dependent kinases, *CYCLIN-dependent kinase inhibitors, *LEUCOCYTES, *OVERALL survival

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  2. 2
    Academic Journal
    Compromised CDK12 activity causes dependency on the high activity of O-GlcNAc transferase.

    المؤلفون: Pallasaho, Satu1 (AUTHOR), Gondane, Aishwarya1 (AUTHOR), Kutz, Julia2 (AUTHOR), Liang, Jing1 (AUTHOR), Yalala, Shivani1 (AUTHOR), Duveau, Damien Y3 (AUTHOR), Pospiech, Helmut2,4 (AUTHOR), Thomas, Craig J3,5 (AUTHOR), Loda, Massimo6,7,8 (AUTHOR), Itkonen, Harri M1,6 (AUTHOR)

    المصدر: Glycobiology. Dec2024, Vol. 34 Issue 12, p1-10. 10p.

    مصطلحات موضوعية: *CYCLIN-dependent kinases, *PROSTATE cancer patients, *PROTEIN kinases, *DRUG target, *PROSTATE cancer


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  3. 3
    Academic Journal
    Analysis of Breast Cancer Brain Metastases Reveals an Enrichment of Cyclin-Dependent Kinase 12 Structural Rearrangements in Human Epidermal Growth Factor Receptor 2–Positive Disease.

    المؤلفون: Bhogal, Talvinder1,2 (AUTHOR), Giannoudis, Athina1 (AUTHOR), Sokol, Ethan3 (AUTHOR), Ali, Simak4 (AUTHOR), Palmieri, Carlo1,2 (AUTHOR) c.palmieri@liverpool.ac.uk

    المصدر: JCO Precision Oncology. 12/1/2024, Vol. 8, p1-6. 6p.

    مصطلحات موضوعية: *EPIDERMAL growth factor receptors, *CYCLIN-dependent kinases, *BRCA genes, *BRAIN cancer, *GENE rearrangement


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  4. 4
    Academic Journal
    Population Pharmacokinetic and Pharmacodynamic Study of Palbociclib in Children and Young Adults with Recurrent, Progressive, or Refractory Brain Tumors.

    المؤلفون: Panetta, John C.1 (AUTHOR) carl.panetta@stjude.org, Selvo, Nicholas S.1 (AUTHOR) nick.selvo@stjude.org, Mater, David Van2 (AUTHOR) david.vanmater@duke.edu, Stewart, Clinton F.1 (AUTHOR) clinton.stewart@stjude.org

    المصدر: Pharmaceutics. Dec2024, Vol. 16 Issue 12, p1528. 18p.

    مصطلحات موضوعية: *CYCLIN-dependent kinases, *BRAIN tumors, *YOUNG adults, *PLATELET count, *PHARMACOKINETICS

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  5. 5
    Academic Journal
    Design, Synthesis and Molecular Modeling of Pyrazolo[1,5- a ]pyrimidine Derivatives as Dual Inhibitors of CDK2 and TRKA Kinases with Antiproliferative Activity.

    المؤلفون: Attia, Mohamed H.1 (AUTHOR) mohammed_attia@o6u.edu.eg, Lasheen, Deena S.2 (AUTHOR) deenalasheen@pharma.asu.edu.eg, Samir, Nermin2 (AUTHOR) nerminsamir@pharma.asu.edu.eg, Taher, Azza T.3,4 (AUTHOR) azza.shalaby@pharma.cu.edu.eg, Abdel-Aziz, Hatem A.5,6 (AUTHOR) ha.abdel-aziz@nrc.sci.eg, Abou El Ella, Dalal A.2 (AUTHOR) mohammed_attia@o6u.edu.eg

    المصدر: Pharmaceuticals (14248247). Dec2024, Vol. 17 Issue 12, p1667. 30p.

    مصطلحات موضوعية: *DRUG resistance in cancer cells, *CYCLIN-dependent kinases, *PYRIMIDINE derivatives, *MOLECULAR docking, *KINASES, *PYRIMIDINES

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  6. 6
    Academic Journal
    Thrombosis in breast cancer patients on cyclin-dependent kinase inhibitors: Survival impact and predictive factors - A study by the cancer and thrombosis group of the spanish society of medical oncology (SEOM).

    المؤلفون: Sánchez Cánovas, Manuel1 (AUTHOR) manuelsanchezcanovas@gmail.com, López Robles, Javier1 (AUTHOR), Adoamnei, Evdochia2 (AUTHOR), Cacho Lavin, Diego3 (AUTHOR), Diaz Pedroche, Carmen4 (AUTHOR), Coma Salvans, Eva5 (AUTHOR), Quintanar Verduguez, Teresa6 (AUTHOR), García Verdejo, Francisco José7 (AUTHOR), Cejuela Solís, Mónica8 (AUTHOR), García Adrián, Silvia9 (AUTHOR), Obispo Portero, Berta10 (AUTHOR), Garrido Fernández, Alberto11 (AUTHOR), Salvador Coloma, Carmen12 (AUTHOR), Martínez del Prado, María Purificación13 (AUTHOR), Mendiola, Jaime14 (AUTHOR), Muñoz Martín, Andres J.15 (AUTHOR)

    المصدر: European Journal of Internal Medicine. Dec2024, Vol. 130, p98-105. 8p.

    مصطلحات موضوعية: *CYCLIN-dependent kinase inhibitors, *CYCLIN-dependent kinases, *MEDICAL personnel, *THROMBOEMBOLISM, *INDEPENDENT variables


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  7. 7
    Academic Journal
    Palbociclib as an Antitumor Drug: A License to Kill.

    المؤلفون: Łupicka-Słowik, Agnieszka1 (AUTHOR) agnieszka.lupicka-slowik@pwr.edu.pl, Cossu, Federica2 (AUTHOR) federica.cossu@cnr.it, Sieńczyk, Marcin1 (AUTHOR)

    المصدر: Molecules. Nov2024, Vol. 29 Issue 22, p5334. 26p.

    مصطلحات موضوعية: *CYCLIN-dependent kinases, *HEMATOLOGIC malignancies, *CELL division, *BREAST cancer, *CELL cycle

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  8. 8
    Academic Journal
    Long-term breast cancer response to CDK4/6 inhibition defined by TP53-mediated geroconversion.

    المؤلفون: Kudo, Rei1,2 (AUTHOR), Safonov, Anton1,3,4 (AUTHOR), Jones, Catherine1 (AUTHOR), Moiso, Enrico5,6 (AUTHOR), Dry, Jonathan R.7 (AUTHOR), Shao, Hong1 (AUTHOR), Nag, Sharanya1 (AUTHOR), da Silva, Edaise M.8 (AUTHOR), Yildirim, Selma Yeni8 (AUTHOR), Li, Qing1 (AUTHOR), O'Connell, Elizabeth1 (AUTHOR), Patel, Payal1 (AUTHOR), Will, Marie1,3,9 (AUTHOR), Fushimi, Atsushi2 (AUTHOR), Benitez, Marimar10 (AUTHOR), Bradic, Martina10 (AUTHOR), Fan, Li11 (AUTHOR), Nakshatri, Harikrishna12 (AUTHOR), Sudhan, Dhivya R.13 (AUTHOR), Denz, Christopher R.13 (AUTHOR)

    المصدر: Cancer Cell. Nov2024, Vol. 42 Issue 11, p1919-19193. 17275p.

    مصطلحات موضوعية: *PATIENT experience, *CYCLIN-dependent kinases, *BREAST cancer, *RESPONSE inhibition, *CANCER invasiveness, *P53 antioncogene

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  9. 9
    Academic Journal
    Molecular docking, DFT and antiproliferative properties of 4‐(3,4‐dimethoxyphenyl)−3‐(4‐methoxyphenyl)−1‐phenyl‐1H‐pyrazolo[3,4‐b]pyridine as potent anticancer agent with CDK2 and PIM1 inhibition potency

    المؤلفون: Binjubair, Faizah A.1 (AUTHOR), Almansour, Basma S.1 (AUTHOR), Ziedan, Noha I.2 (AUTHOR), Abdel‐Aziz, Alaa A.‐M.1 (AUTHOR), Al‐Rashood, Sara T.1 (AUTHOR), Elgohary, Mohamed K.3 (AUTHOR), Elkotamy, Mahmoud S.3 (AUTHOR) mahmoud-elkotamy@eru.edu.eg, Abdel‐Aziz, Hatem A.4,5 (AUTHOR)

    المصدر: Drug Development Research. Nov2024, Vol. 85 Issue 7, p1-19. 19p.

    مصطلحات موضوعية: *MOLECULES, *CYCLIN-dependent kinases, *MOLECULAR docking, *BOND angles, *KINASES


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  10. 10
    Academic Journal
    Double-Faced Immunological Effects of CDK4/6 Inhibitors on Cancer Treatment: Challenges and Perspectives.

    المؤلفون: Liu, Yongqin1,2 (AUTHOR), Deng, Yiying1,2 (AUTHOR), Yang, Chang1,2 (AUTHOR), Naranmandura, Hua1,2,3 (AUTHOR) narenman@zju.edu.cn

    المصدر: Bioengineering (Basel). Nov2024, Vol. 11 Issue 11, p1084. 19p.

    مصطلحات موضوعية: *CYCLIN-dependent kinase inhibitors, *CYCLIN-dependent kinases, *CELL division, *METASTATIC breast cancer, *DRUG resistance, *EPIDERMAL growth factor receptors

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  11. 11
    Academic Journal
    Structural basis of the human transcriptional Mediator regulated by its dissociable kinase module.

    المؤلفون: Chao, Ti-Chun1 (AUTHOR), Chen, Shin-Fu1 (AUTHOR), Kim, Hee Jong2 (AUTHOR), Tang, Hui-Chi1 (AUTHOR), Tseng, Hsiang-Ching1 (AUTHOR), Xu, An3 (AUTHOR), Palao III, Leon2 (AUTHOR), Khadka, Subash4 (AUTHOR), Li, Tao1 (AUTHOR), Huang, Mo-Fan3,5 (AUTHOR), Lee, Dung-Fang3,5,6,7 (AUTHOR), Murakami, Kenji1,2 (AUTHOR) kenjim@pennmedicine.upenn.edu, Boyer, Thomas G.1,4 (AUTHOR) boyer@uthscsa.edu, Tsai, Kuang-Lei1,5 (AUTHOR) kuang-lei.tsai@uth.tmc.edu

    المصدر: Molecular Cell. Oct2024, Vol. 84 Issue 20, p3932-39394. 35463p.

    مصطلحات موضوعية: *RNA polymerase II, *CYCLIN-dependent kinases, *GENETIC transcription, *BINDING sites, *FUNCTIONAL analysis

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  12. 12
    Academic Journal
    CDK12 is a promising therapeutic target for the transcription cycle and DNA damage response in metastatic osteosarcoma.

    المؤلفون: Li, Zihao1 (AUTHOR), Li, Xiaoyang2 (AUTHOR), Seebacher, Nicole A3,4 (AUTHOR), Liu, Xu2 (AUTHOR), Wu, Wence2 (AUTHOR), Yu, Shengji2 (AUTHOR), Hornicek, Francis J5 (AUTHOR), Huang, Changzhi1 (AUTHOR) huangcz@cicams.ac.cn, Duan, Zhenfeng5 (AUTHOR) zxd221@med.miami.edu

    المصدر: Carcinogenesis. Oct2024, Vol. 45 Issue 10, p786-798. 13p.

    مصطلحات موضوعية: *DNA repair, *CYCLIN-dependent kinases, *SMALL interfering RNA, *GENE expression, *NON-coding RNA


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  13. 13
    Academic Journal
    Advances in Cancer Therapy: A Comprehensive Review of CDK and EGFR Inhibitors.

    المؤلفون: Hawash, Mohammed1 (AUTHOR) mohawash@najah.edu

    المصدر: Cells (2073-4409). Oct2024, Vol. 13 Issue 19, p1656. 37p.

    مصطلحات موضوعية: *PROTEIN kinases, *CYCLIN-dependent kinases, *EPIDERMAL growth factor receptors, *PROTEIN kinase inhibitors, *CELL cycle

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  14. 14
    Academic Journal
    Role of protein kinase PLK1 in the epigenetic maintenance of centromeres.

    المؤلفون: Conti, Duccio1 duccio.conti@mpi-dortmund.mpg.de, Verza, Arianna Esposito1,2, Pesenti, Marion E.1, Cmentowski, Verena1,2, Vetter, Ingrid R.1, Dongqing Pan1, Musacchio, Andrea1,2 andrea.musacchio@mpi-dortmund.mpg.de

    المصدر: Science. 9/6/2024, Vol. 385 Issue 6713, p1091-1097. 7p. 4 Diagrams.

    مصطلحات موضوعية: *PROTEIN kinases, *CYCLIN-dependent kinases, *CELL cycle, *CELL physiology, *EPIGENETICS


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  15. 15
    Academic Journal
    Molecular insights into kaempferol derivatives as potential inhibitors for CDK2 in colon cancer: pharmacophore modeling, docking, and dynamic analysis.

    المؤلفون: Xing, Fei1, Wang, Zhicheng1, Bahadar, Noor2, Wang, Can1, Wang, Xu-Dong1 wangxud@jlu.edu.cn, Hisham, Mohamed3, Darwish, Khaled Mohamed4

    المصدر: Frontiers in Chemistry. 2024, p1-20. 20p.

    مصطلحات موضوعية: *CYCLIN-dependent kinases, *COLON cancer, *PHARMACOPHORE, *CELL cycle regulation, *MOLECULAR dynamics

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  16. 16
    Academic Journal
    Cyclin-Dependent Kinase 8 Represents a Positive Regulator of Cytomegalovirus Replication and a Novel Host Target for Antiviral Strategies.

    المؤلفون: Obergfäll, Debora1 (AUTHOR) debora.obergfaell@fau.de, Wild, Markus1 (AUTHOR) markus-wild@mail.de, Sommerer, Mona1 (AUTHOR) mona.sommerer@googlemail.com, Barillas Dahm, Malena1 (AUTHOR) malena.barillas@fau.de, Kicuntod, Jintawee1 (AUTHOR) jintawee.kicuntod@extern.uk-erlangen.de, Tillmanns, Julia1 (AUTHOR) jul.tillmanns@fau.de, Kögler, Melanie1 (AUTHOR) melanie.koegler@uk-erlangen.de, Lösing, Josephine1 (AUTHOR) josi.loesing@fau.de, Dhotre, Kishore1 (AUTHOR) kishore.dhotre@uk-erlangen.de, Müller, Regina1 (AUTHOR) mueller.regina@uk-erlangen.de, Wangen, Christina1 (AUTHOR) christina.wangen@uk-erlangen.de, Wagner, Sabrina1 (AUTHOR) sabrina.wagner@uk-erlangen.de, Phan, Quang V.2,3 (AUTHOR) qvphan@bwh.harvard.edu, Wiebusch, Lüder2 (AUTHOR) lueder.wiebusch@charite.de, Briestenská, Katarína4,5 (AUTHOR) katarina.briestenska@savba.sk, Mistríková, Jela4,5 (AUTHOR) jela.mistrikova@savba.sk, Kerr-Jones, Lauren6 (AUTHOR) kerrle@cardiff.ac.uk, Stanton, Richard J.6 (AUTHOR) stantonrj@cardiff.ac.uk, Voigt, Sebastian7 (AUTHOR) sebastian.voigt@uk-essen.de, Hahn, Friedrich1 (AUTHOR) friedrich.hahn@uk-erlangen.de

    المصدر: Pharmaceutics. Sep2024, Vol. 16 Issue 9, p1238. 21p.

    مصطلحات موضوعية: *CYCLIN-dependent kinases, *PROTEIN kinases, *CYCLIN-dependent kinase inhibitors, *DRUG synergism, *SMALL molecules

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  17. 17
    Academic Journal
    Enriching Anticancer Drug Pipeline with Potential Inhibitors of Cyclin-Dependent Kinase-8 Identified from Natural Products.

    المؤلفون: Zehra1 (AUTHOR), Hussain, Afzal2 (AUTHOR), AlAjmi, Mohamed F.2 (AUTHOR), Ishrat, Romana1 (AUTHOR) rishrat@jmi.ac.in, Hassan, Md Imtaiyaz1 (AUTHOR) mihassan@jmi.ac.in

    المصدر: OMICS: A Journal of Integrative Biology. Sep2024, Vol. 28 Issue 9, p478-488. 11p.

    مصطلحات موضوعية: *DRUG discovery, *CYCLIN-dependent kinases, *ACUTE myeloid leukemia, *AUTISM spectrum disorders, *PROTEIN conformation, *BREAST


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  18. 18
    Academic Journal
    CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13.

    المؤلفون: Tien, Jean, Luo, Jie, Chang, Yu, Zhang, Yuping, Cheng, Yunhui, Wang, Xiaoju, Yang, Jianzhang, Mannan, Rahul, Mahapatra, Somnath, Shah, Palak, Wang, Xiao-Ming, Todd, Abigail, Eyunni, Sanjana, Cheng, Caleb, Rebernick, Ryan, Xiao, Lanbo, Bao, Yi, Neiswender, James, Brough, Rachel, Pettitt, Stephen, Cao, Xuhong, Miner, Stephanie, Zhou, Licheng, Wu, Yi-Mi, Labanca, Estefania, Wang, Yuzhuo, Parolia, Abhijit, Cieslik, Marcin, Robinson, Dan, Wang, Zhen, Feng, Felix, Chou, Jonathan, Lord, Christopher, Ding, Ke, Chinnaiyan, Arul

    المصدر: Cell Reports Medicine. 5(10)

    مصطلحات موضوعية: CDK12, CDK13, Cdk12 knockout, R-loops, paralog-based synthetic lethality, prostate cancer, transcription-replication conflicts, Male, Animals, Humans, Cyclin-Dependent Kinases, Mice, Synthetic Lethal Mutations, Prostatic Neoplasms, Tumor Suppressor Protein p53, Disease Progression, PTEN Phosphohydrolase, Genomic Instability, Transcription, Genetic, Organoids, Prostatic Neoplasms, Castration-Resistant, Cell Proliferation, DNA Replication, Mice, Knockout, Cell Line, Tumor, Mice, Inbred C57BL, CDC2 Protein Kinase

    وصف الملف: application/pdf

    URL الوصول: https://escholarship.org/uc/item/6467c3sr
    https://escholarship.org/content/qt6467c3sr/qt6467c3sr.pdf

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  19. 19
    Academic Journal
    Real-world data on the prevalence of BRCA1/2 and HRR gene mutations in patients with primary and metastatic castration resistant prostate cancer.

    المؤلفون: Hommerding, Moritz1 (AUTHOR), Hommerding, Oliver1 (AUTHOR), Bernhardt, Marit1 (AUTHOR), Kreft, Tobias1 (AUTHOR), Sanders, Christine1 (AUTHOR), Tischler, Verena1 (AUTHOR), Basitta, Patrick1 (AUTHOR), Pelusi, Natalie1 (AUTHOR), Wulf, Anna-Lena1 (AUTHOR), Ohlmann, Carsten-Henning2 (AUTHOR), Ellinger, Jörg3 (AUTHOR), Ritter, Manuel3 (AUTHOR), Kristiansen, Glen1 (AUTHOR) glen.kristiansen@ukbonn.de

    المصدر: World Journal of Urology. 8/22/2024, Vol. 42 Issue 1, p1-7. 7p.

    مصطلحات موضوعية: *BRCA genes, *CYCLIN-dependent kinases, *GENETIC mutation, *CHECKPOINT kinase 2, *PROSTATE cancer, *CASTRATION-resistant prostate cancer, *METASTASIS


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  20. 20
    Academic Journal
    Role of CDK4 as prognostic biomarker in Soft Tissue Sarcoma and synergistic effect of its inhibition in dedifferentiated liposarcoma sequential treatment.

    المؤلفون: Vanni, Silvia1 (AUTHOR), Miserocchi, Giacomo1 (AUTHOR) giacomo.miserocchi@irst.emr.it, Gallo, Graziana2 (AUTHOR), Fausti, Valentina3 (AUTHOR), Gabellone, Sofia1 (AUTHOR), Liverani, Chiara1 (AUTHOR), Spadazzi, Chiara1 (AUTHOR), Cocchi, Claudia1 (AUTHOR), Calabrese, Chiara1 (AUTHOR), De Luca, Giovanni2 (AUTHOR), Bassi, Massimo4 (AUTHOR), Gessaroli, Manlio4 (AUTHOR), Tomasetti, Nicola4 (AUTHOR), Campobassi, Angelo4 (AUTHOR), Pieri, Federica5 (AUTHOR), Ercolani, Giorgio6 (AUTHOR), Cavaliere, Davide6 (AUTHOR), Gurrieri, Lorena3 (AUTHOR), Riva, Nada3 (AUTHOR), Recine, Federica7 (AUTHOR)

    المصدر: Experimental Hematology & Oncology. 8/5/2024, Vol. 13 Issue 1, p1-4. 4p.

    مصطلحات موضوعية: *SARCOMA, *CYCLIN-dependent kinases, *PROGNOSIS, *LIPOSARCOMA, *PROOF of concept, *BIOMARKERS

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