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1Academic Journal
المؤلفون: Xia, Zengjie, Prescott, Emily E, Urbanek, Agnieszka, Wareing, Hollie E, King, Marianne C, Olerinyova, Anna, Dakin, Helen, Leah, Tom, Barnes, Katy A, Matuszyk, Martyna M, Dimou, Eleni, Hidari, Eric, Zhang, Yu P, Lam, Jeff Y L, Danial, John S H, Strickland, Michael R, Jiang, Hong, Thornton, Peter, Crowther, Damian C, Ohtonen, Sohvi, Gómez-Budia, Mireia, Bell, Simon M, Ferraiuolo, Laura, Mortiboys, Heather, Higginbottom, Adrian, Wharton, Stephen B, Holtzman, David M, Malm, Tarja, Ranasinghe, Rohan T, Klenerman, David, De, Suman
المصدر: Xia , Z , Prescott , E E , Urbanek , A , Wareing , H E , King , M C , Olerinyova , A , Dakin , H , Leah , T , Barnes , K A , Matuszyk , M M , Dimou , E , Hidari , E , Zhang , Y P , Lam , J Y L , Danial , J S H , Strickland , M R , Jiang , H , Thornton , P , Crowther , D C , Ohtonen , S , Gómez-Budia , M , Bell , S ....
مصطلحات موضوعية: Neuroglia, Animals, Mice, Transgenic, Humans, Alzheimer Disease, Apolipoproteins E, Protein isoforms, Female, Male, Apolipoprotein E4, Amyloid beta-peptides, Protein aggregates, Protein aggregation, Pathological
وصف الملف: application/pdf
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2Dissertation/ Thesis
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3Book
المؤلفون: Crowther, Damian C., Page, Richard, Rival, Thomas, Chandraratna, Dhianjali S., Lomas, David A.
المصدر: Drosophila: A Toolbox for the Study of Neurodegenerative Disease ; page 57-77 ; ISBN 9781003060796
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4
المؤلفون: Kumita, Janet R, Helmfors, Linda, Williams, Jocy, Luheshi, Leila M, Menzer, Linda, Dumoulin, Mireille, Lomas, David A, Crowther, Damian C, Dobson, Christopher M, Brorsson, Ann-Christin
المصدر: The FASEB Journal. 26(1):192-202
وصف الملف: electronic
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5Academic Journal
المساهمون: Wellcome Trust, RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
المصدر: Journal of Biological Chemistry ; volume 293, issue 34, page 13090-13099 ; ISSN 0021-9258
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6Academic Journal
المؤلفون: El-Khoury, Riyad, Kaulio, Eveliina, Lassila, Katariina A., Crowther, Damian C., Jacobs, Howard T., Rustin, Pierre
المساهمون: Institute of Biotechnology, Research Programme for Molecular Neurology
مصطلحات موضوعية: Mitochondria, Neurodegeneration, Oxidative stress, Dementia, Alzheimer's disease, HIGHER-PLANT MITOCHONDRIA, CYTOCHROME-C-OXIDASE, ALZHEIMERS-DISEASE, LIFE-SPAN, ENDOPLASMIC-RETICULUM, NADH DEHYDROGENASE, DROSOPHILA-MELANOGASTER, PRECURSOR PROTEIN, GENE-EXPRESSION, Biomedicine
وصف الملف: application/pdf
Relation: We thank Eric Dufour and Marten Szibor for useful discussions, and Tea Tuomela, Essi Kiviranta and Outi Kuronen for technical assistance. AMMi (Association contre les Maladies Mitochondriales) and ANR (Grant number ANR-12-BSV1-0010) for financial support to RE-K and PR, Academy of Finland (Grant number 283157), European Research Council (Grant number 232738), Tampere University Hospital Medical Research Fund and Sigrid Juselius Foundation for financial support to HTJ, EK and KL.; El-Khoury , R , Kaulio , E , Lassila , K A , Crowther , D C , Jacobs , H T & Rustin , P 2016 , ' Expression of the alternative oxidase mitigates beta-amyloid production and toxicity in model systems ' , Free Radical Biology & Medicine , vol. 96 , pp. 57-66 . https://doi.org/10.1016/j.freeradbiomed.2016.04.006; http://hdl.handle.net/10138/224236; c6943ae5-be08-4fa0-85d3-ea8e7b3cf434; 84964345925; 000377619600006
الاتاحة: http://hdl.handle.net/10138/224236
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7Academic Journal
المؤلفون: Thornton, Peter, Sevalle, Jean, Deery, Michael J., Fraser, Graham, Zhou, Ye, Ståhl, Sara, Franssen, Elske H., Dodd, Roger B., Qamar, Seema, Gomez Perez-Nievas, Beatriz, Nicol, Louise S.C., Eketjäll, Susanna, Revell, Jefferson, Jones, Clare, Billinton, Andrew, St George-Hyslop, Peter H., Chessell, Iain, Crowther, Damian C.
المصدر: Thornton , P , Sevalle , J , Deery , M J , Fraser , G , Zhou , Y , Ståhl , S , Franssen , E H , Dodd , R B , Qamar , S , Gomez Perez-Nievas , B , Nicol , L S C , Eketjäll , S , Revell , J , Jones , C , Billinton , A , St George-Hyslop , P H , Chessell , I & Crowther , D C 2017 , ' TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant ....
مصطلحات موضوعية: genetic risk, microglia, neurodegeneration, neuroinflammation
وصف الملف: application/pdf
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8Academic Journal
المؤلفون: Pavel, Mariana, Imarisio, Sara, Menzies, Fiona M., Jimenez-Sanchez, Maria, Siddiqi, Farah H., Wu, Xiaoting, Renna, Maurizio, O'Kane, Cahir J., Crowther, Damian C., Rubinsztein, David C.
المصدر: Pavel , M , Imarisio , S , Menzies , F M , Jimenez-Sanchez , M , Siddiqi , F H , Wu , X , Renna , M , O'Kane , C J , Crowther , D C & Rubinsztein , D C 2016 , ' CCT complex restricts neuropathogenic protein aggregation via autophagy ' , Nature Communications , vol. 7 , 13821 . https://doi.org/10.1038/ncomms13821
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9Academic Journal
المصدر: Ott , S , Vishnivetskaya , A , Malmendal , A & Crowther , D C 2016 , ' Metabolic changes precede proteostatic dysfunction in a Drosophila model of Abeta peptide toxicity ' , Neurobiology of Aging , vol. 41 , pp. 39-52 . https://doi.org/10.1016/j.neurobiolaging.2016.01.009
وصف الملف: application/pdf
الاتاحة: https://curis.ku.dk/portal/da/publications/metabolic-changes-precede-proteostatic-dysfunction-in-a-drosophila-model-of-abeta-peptide-toxicity(a90fc720-7894-4496-9b50-604a967c5077).html
https://doi.org/10.1016/j.neurobiolaging.2016.01.009
https://curis.ku.dk/ws/files/176889431/1_s2.0_S0197458016000105_main_1_.pdf -
10Academic Journal
المصدر: Scientific Reports ; volume 6, issue 1 ; ISSN 2045-2322
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11Academic Journal
المؤلفون: Lim, Jung Yeon, Reighard, Charles P., Crowther, Damian C.
المصدر: Human Molecular Genetics ; volume 24, issue 14, page 3929-3938 ; ISSN 1460-2083 0964-6906
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12
المؤلفون: Fabre, Kristin M., Delsing, Louise, Hicks, Ryan, Colclough, Nicola, Crowther, Damian C., Ewart, Lorna
المصدر: Advanced Drug Delivery Reviews. 140:129-135
مصطلحات موضوعية: Blood brain barrier, Drug development, iPSC, Microphysiological systems, Organs-on-chips, Pharmaceutical, Stem cells, Tissue chips, Blood, Drug products, Neurodegenerative diseases, Blood-brain barrier, Induced pluripotent stem cells, On chips, Pharmaceutical company, Pharmaceutical industry, Physiological response, Physiological models, Bioinformatik, Bioinformatics, INF502 Biomarkers, INF502 Biomarkörer
وصف الملف: print
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13Book
المؤلفون: Lomas, David A., Belorgey, Didier, Mallya, Meera, Onda, Maki, Kinghorn, Kerri J., Sharp, Lynda K., Phillips, Russell L., Page, Richard, Miranda, Elena, Crowther, Damian C.
المصدر: Amyloid and Amyloidosis ; page 388-390 ; ISBN 9780429125249
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14Academic Journal
المؤلفون: Khabirova, Eleonora, Moloney, Aileen, Marciniak, Stefan J., Williams, Julie, Lomas, David A., Oliver, Stephen G., Favrin, Giorgio, Sattelle, David B., Crowther, Damian C.
وصف الملف: application/pdf
Relation: https://orca.cardiff.ac.uk/id/eprint/79588/1/journal.pone.0102985.pdf; Khabirova, Eleonora, Moloney, Aileen, Marciniak, Stefan J., Williams, Julie https://orca.cardiff.ac.uk/view/cardiffauthors/A0156904.html orcid:0000-0002-4069-0259 orcid:0000-0002-4069-0259, Lomas, David A., Oliver, Stephen G., Favrin, Giorgio, Sattelle, David B. and Crowther, Damian C. 2014. The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans. PLoS ONE 9 (7) , e102985. 10.1371/journal.pone.0102985 https://doi.org/10.1371/journal.pone.0102985 file https://orca.cardiff.ac.uk/id/eprint/79588/1/journal.pone.0102985.pdf
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15Academic Journal
المؤلفون: Acerra, Nicola, Kad, Neil M., Griffith, Douglas A., Ott, Stanislav, Crowther, Damian C., Mason, Jody M.
المصدر: Acerra , N , Kad , N M , Griffith , D A , Ott , S , Crowther , D C & Mason , J M 2014 , ' Retro-inversal of intracellular selected β-amyloid-interacting peptides : Implications for a novel Alzheimer’s disease treatment ' , Biochemistry , vol. 53 , no. 13 , pp. 2101-2111 . https://doi.org/10.1021/bi5001257
وصف الملف: application/pdf
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16Academic Journal
المؤلفون: Wacker, Jessica, Rönicke, Raik, Westermann, Martin, Wulff, Melanie, Reymann, Klaus G, Dobson, Christopher M, Horn, Uwe, Crowther, Damian C, Luheshi, Leila M, Fändrich, Marcus
المصدر: Acta Neuropathologica Communications ; volume 2, issue 1 ; ISSN 2051-5960
الاتاحة: http://dx.doi.org/10.1186/2051-5960-2-43
http://link.springer.com/content/pdf/10.1186/2051-5960-2-43.pdf
http://link.springer.com/article/10.1186/2051-5960-2-43/fulltext.html
http://link.springer.com/content/pdf/10.1186/2051-5960-2-43
https://link.springer.com/content/pdf/10.1186/2051-5960-2-43.pdf -
17Academic Journal
المؤلفون: Roussel, Benoit D, Newton, Timothy M, Malzer, Elke, Simecek, Nikol, Haq, Imran, Thomas, Sally E, Burr, Marian L, Lehner, Paul J, Crowther, Damian C, Marciniak, Stefan J, Lomas, David A
مصطلحات موضوعية: Animals, Cells, Cultured, Cholesterol, Disease Models, Animal, Drosophila melanogaster, Endoplasmic Reticulum, Epilepsies, Myoclonic, HeLa Cells, Heredodegenerative Disorders, Nervous System, Humans, Mice, Mutant Proteins, Neurons, Neuropeptides, Polymers, Protein Unfolding, Serpins, Signal Transduction, Ubiquitin-Conjugating Enzymes, Ubiquitin-Protein Ligases, Unfolded Protein Response, Neuroserpin
وصف الملف: Print-Electronic; application/pdf
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18Academic Journal
المؤلفون: Roussel, Benoit D, Kruppa, Antonina J, Miranda, Elena, Crowther, Damian C, Lomas, David A, Marciniak, Stefan J
مصطلحات موضوعية: Amyloid beta-Peptides, Animals, Endoplasmic Reticulum, Humans, Nervous System Diseases, Protein Folding, Signal Transduction, Unfolded Protein Response
وصف الملف: Print; application/pdf
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19Academic Journal
المؤلفون: Kruppa, Antonina J, Ott, Stanislav, Chandraratna, Dhia S, Irving, James A, Page, Richard M, Speretta, Elena, Seto, Tiffany, Camargo, Luiz Miguel, Marciniak, Stefan J, Lomas, David A, Crowther, Damian C
مصطلحات موضوعية: Alzheimer, Amyloid, Autophagy, Proteolysis, Puromycin-sensitive aminopeptidase, Alzheimer Disease, Aminopeptidases, Amyloid beta-Peptides, Animals, Genetically Modified, Blotting, Western, Brain, Drosophila melanogaster, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Fluorescent Antibody Technique, Humans, Immunoenzyme Techniques, Neuroblastoma, Neurons, Puromycin, RNA, Messenger, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Tumor Cells, Cultured
وصف الملف: Print-Electronic; application/pdf
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20Academic Journal
المؤلفون: Roussel, Benoit D., Kruppa, Antonina, J, Miranda, Elena, Crowther, Damian, C, Lomas, David, A, Marciniak, Stefan, J
المساهمون: University of Cambridge UK (CAM), Sérine protéases et physiopathologie de l'unité neurovasculaire, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Biology and Biotechnology "Charles Darwin", Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Università degli Studi di Roma "La Sapienza" = Sapienza University Rome (UNIROMA), The laboratories of DCC, DAL, and SJM are funded by grants from the UK Medical Research Council (MRC) and Alzheimer’s Research UK (formerly Alzheimer’s Research Trust), and by Papworth NHS Trust. AJK is a Wellcome Trust PhD student and SJM is an MRC Senior Clinical Fellow (G1002610). DCC is an Alzheimer’s Research UK Senior Research Fellow and is supported by the MRC (G0700990) and the UK Engineering and Physical Sciences Research Council. EM is funded by the Institut Pasteur–Cenci Bolognetti Foundation and by the Telethon Foundation.
المصدر: ISSN: 1474-4422.
مصطلحات موضوعية: MESH: Amyloid beta-Peptides, MESH: Animals, MESH: Endoplasmic Reticulum, MESH: Humans, MESH: Nervous System Diseases, MESH: Protein Folding, MESH: Signal Transduction, MESH: Unfolded Protein Response, [SDV.BC]Life Sciences [q-bio]/Cellular Biology
Relation: info:eu-repo/semantics/altIdentifier/pmid/23237905; PUBMED: 23237905
الاتاحة: https://inserm.hal.science/inserm-01296824
https://inserm.hal.science/inserm-01296824v1/document
https://inserm.hal.science/inserm-01296824v1/file/THELANCETNEUROLOGY-D-12-00012R3.pdf
https://inserm.hal.science/inserm-01296824v1/file/Roussel%20LancetNeuro2013.pdf
https://doi.org/10.1016/S1474-4422(12)70238-7