المؤلفون: Alastair G. McEwen, Yassmine Chebaro, Valérie Lamour, Arnaud Vanden Broeck, Noëlle Potier

المساهمون: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Structural Biology and Genomics Platform [Illkirch], Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Substances naturelles/chimie moléculaire, Université Louis Pasteur - Strasbourg I-Ecole européenne de chimie, polymères et matériaux [Strasbourg]-Centre National de la Recherche Scientifique (CNRS)

المصدر: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2018, 62 (8), pp.4225-4231. ⟨10.1021/acs.jmedchem.8b01928⟩

مصطلحات موضوعية: Aminocoumarins, Stereochemistry, Isomerase, Molecular Dynamics Simulation, 01 natural sciences, DNA gyrase, 03 medical and health sciences, Adenosine Triphosphate, Drug Discovery, Escherichia coli, Protein Structure, Quaternary, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, Binding Sites, Chemistry, Thermus thermophilus, Hydrogen Bonding, SUPERFAMILY, Coumermycin A1, 0104 chemical sciences, 3. Good health, Protein Subunits, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], 010404 medicinal & biomolecular chemistry, DNA Gyrase, Molecular Medicine, Dimerization, Bacterial dna

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce8db4c358883e54698f6a06055937c
https://doi.org/10.1021/acs.jmedchem.8b01928

المؤلفون: Sugino, Akio, Higgins, N. Patrick, Brown, Patrick O., Peebles, Craig L., Cozzarelli, Nicholas R.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 1978 Oct 01. 75(10), 4838-4842.

URL الوصول: https://www.jstor.org/stable/69012

المؤلفون: Menzel, Rolf, Gellert, Martin

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 1987 Jun . 84(12), 4185-4189.

URL الوصول: https://www.jstor.org/stable/29944

المؤلفون: Xiaoqiu Xiao, Budbazar Enkhjargal, Yan Ding, Anatol Manaenko, Jiping Tang, Lei Gong, Lei Huang, Ruiming Fan, John H. Zhang, DevinW. McBride

المصدر: Neuropharmacology. 138:160-169

مصطلحات موضوعية: Male, 0301 basic medicine, Agonist, medicine.drug_class, Brain Edema, Inflammation, Pharmacology, Neuroprotection, Article, Rats, Sprague-Dawley, Random Allocation, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, stomatognathic system, Animals, Medicine, Collagenases, cardiovascular diseases, Osteopontin, Receptor, Cerebral Hemorrhage, Intracerebral hemorrhage, biology, business.industry, Integrin beta1, Brain, Janus Kinase 2, medicine.disease, Coumermycin A1, nervous system diseases, Disease Models, Animal, Glucose, Neuroprotective Agents, STAT1 Transcription Factor, 030104 developmental biology, Hyperglycemia, biology.protein, Encephalitis, Nasal administration, medicine.symptom, business, 030217 neurology & neurosurgery, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34b0d32fb47d3e87f44e845d27b4cf9
https://doi.org/10.1016/j.neuropharm.2018.06.009

المؤلفون: Dongxu Feng, Peng Yang, Yuan Yang, Aihua Zhang

المصدر: Archiv der PharmazieREFERENCES. 353(6)

مصطلحات موضوعية: medicine.drug_class, Antibiotics, Pharmaceutical Science, Microbial Sensitivity Tests, Gram-Positive Bacteria, 01 natural sciences, DNA gyrase, Microbiology, Structure-Activity Relationship, Coumarins, Drug Discovery, Gram-Negative Bacteria, medicine, heterocyclic compounds, Novobiocin, Clorobiocin, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, biology.organism_classification, Coumermycin A1, 0104 chemical sciences, Anti-Bacterial Agents, 010404 medicinal & biomolecular chemistry, DNA supercoil, Antibacterial activity, Bacteria, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95931ccf716086159cbc36797e60c496
https://pubmed.ncbi.nlm.nih.gov/32253782

المؤلفون: David J. Hampson, Anders Franklin, Märit Pringle

المصدر: Antimicrobial Resistance in Bacteria of Animal Origin

مصطلحات موضوعية: biology, Clindamycin, Clostridium perfringens, medicine.disease_cause, biology.organism_classification, Antimicrobial, Virology, Coumermycin A1, Microbiology, Antibiotic resistance, Brachyspira, Clostridium, Brachyspira hyodysenteriae, medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1df7634551ae8007af86dc2b550af003
https://doi.org/10.1128/9781555817534.ch9

المؤلفون: Favourite N. Cele, Mahmoud E. S. Soliman, Hezekiel M. Kumalo

المصدر: Cell Biochemistry and Biophysics

مصطلحات موضوعية: Aminocoumarins, 0301 basic medicine, Stereochemistry, Biophysics, Hsp90, Molecular Dynamics Simulation, 01 natural sciences, Biochemistry, DNA gyrase, Hsp90 inhibitor, 03 medical and health sciences, Molecular dynamics, Heat shock protein, HSP90 Heat-Shock Proteins, Principal Component Analysis, Original Paper, C–A1, MD simulations, Binding Sites, biology, Drug discovery, Chemistry, Active site, Cell Biology, General Medicine, Ligand (biochemistry), Coumermycin A1, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Molecular docking, HIV-1, biology.protein, Thermodynamics, Dimerization, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13eca8ccd09cbaa000f1f606ea99bf6
https://doi.org/10.1007/s12013-016-0743-8

المؤلفون: Marian A. Corcoran, George A. Jacoby, David C. Hooper

المصدر: Antimicrobial Agents and Chemotherapy. 59:6689-6695

مصطلحات موضوعية: Aminocoumarins, Pyrrolidines, Pyridones, medicine.drug_class, Topoisomerase IV, Quinolones, Biology, DNA gyrase, chemistry.chemical_compound, Bacteriocins, Mechanisms of Resistance, Escherichia coli, medicine, Pharmacology (medical), Novobiocin, Quinazolinones, Pharmacology, Genetics, Escherichia coli Proteins, Topoisomerase, Microcin, Quinolone, Coumermycin A1, Infectious Diseases, chemistry, Biochemistry, DNA Gyrase, biology.protein, DNA, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d77e7c3a7ac2e16a9d0679a276a30d
https://doi.org/10.1128/aac.01292-15

المؤلفون: Jaroslav Spizek, Bertolt Gust, Lutz Heide, Jitka Novotna, Andreas Kulik

المصدر: Journal of Industrial Microbiology and Biotechnology. 40:915-925

مصطلحات موضوعية: Adenosine Triphosphatases, Aminocoumarins, biology, Streptomyces rishiriensis, Streptomyces coelicolor, Bioengineering, Protein Serine-Threonine Kinases, biology.organism_classification, Applied Microbiology and Biotechnology, Streptomyces, Coumermycin A1, Anti-Bacterial Agents, Biochemistry, Gene cluster, Dicarboxylic Acids, Pyrroles, Heterologous expression, Threonine, Kinase activity, Gene Deletion, Plasmids, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f773100dfb6e76965c386f63b9c30c2
https://doi.org/10.1007/s10295-013-1266-6

المؤلفون: Jae Kyung Sohng, Janardan Lamichhane, Dinesh Koju, Sushila Maharjan, Saurabh Bhattarai, Niraj Aryal

المصدر: Applied Microbiology and Biotechnology. 93:687-696

مصطلحات موضوعية: Proline, Stereochemistry, Streptomyces rishiriensis, Applied Microbiology and Biotechnology, Streptomyces, Acyl-CoA Dehydrogenase, Nocardia, Lactones, Polyketide, chemistry.chemical_compound, Adenosine Triphosphate, Transferases, Moiety, Pyrroles, Cloning, Molecular, Pyrrole, Clorobiocin, biology, Streptomyces coelicolor, General Medicine, biology.organism_classification, Coumermycin A1, Biosynthetic Pathways, chemistry, Biochemistry, Genes, Bacterial, Carrier Proteins, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3458004fc15a8f75e80a71a5172a13cc
https://doi.org/10.1007/s00253-011-3567-x

المؤلفون: Jeffrey M. Holzbeierlein, Brian S. J. Blagg, Laura B. Peterson, Huiping Zhao, George A. Vielhauer, Bhaskar Reddy Kusuma

المصدر: Journal of Medicinal Chemistry. 54:6234-6253

مصطلحات موضوعية: Aminocoumarins, Stereochemistry, Dimer, Antineoplastic Agents, Stereoisomerism, Article, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Heat shock protein, Drug Discovery, Humans, Structure–activity relationship, HSP90 Heat-Shock Proteins, biology, Combinatorial chemistry, Hsp90, Small molecule, Coumermycin A1, chemistry, SKBR3, Drug Design, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor, Protein Multimerization, Dimerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d28517c542496ed21dea158c3ae93a3e
https://doi.org/10.1021/jm200553w

المؤلفون: Lutz Heide

المصدر: Biotechnology Advances. 27:1006-1014

مصطلحات موضوعية: Aminocoumarins, Clorobiocin, Bioengineering, General Medicine, Biology, biology.organism_classification, Applied Microbiology and Biotechnology, Streptomyces, DNA gyrase, Coumermycin A1, Anti-Bacterial Agents, Metabolic engineering, Biochemistry, Coumarins, Gene cluster, medicine, Cloning, Molecular, Genetic Engineering, Novobiocin, Biotechnology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8023be67b2419f36b584f1015dccd3ac
https://doi.org/10.1016/j.biotechadv.2009.05.017

المؤلفون: Sophie Ziai, Shun-Chii Tang, Hoang-Thanh Le, Olivier Wellman-Labadie, Thuy-Tiên Trinh, Simon Lemaire, Maxwell T. Hincke

المصدر: FEBS Journal. 275:5286-5297

مصطلحات موضوعية: chemistry.chemical_classification, Antimicrobial peptides, Peptide, Cell Biology, Biology, Antimicrobial, medicine.disease_cause, Biochemistry, Molecular biology, DNA gyrase, Coumermycin A1, chemistry.chemical_compound, chemistry, medicine, DNA supercoil, Molecular Biology, Escherichia coli, DNA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::155ca3b7264f73cadf5baa4147eb427d
https://doi.org/10.1111/j.1742-4658.2008.06659.x

المؤلفون: Bernd Kammerer, Bertolt Gust, Lutz Heide, Manuel Wolpert

المصدر: ChemBioChem. 9:603-612

مصطلحات موضوعية: Aminocoumarins, Gene Expression, Heterologous, Biochemistry, Mass Spectrometry, Databases, Genetic, Gene cluster, Molecular Biology, Chromatography, High Pressure Liquid, Genetics, Clorobiocin, Molecular Structure, biology, Organic Chemistry, Streptomyces coelicolor, Methyltransferases, biology.organism_classification, Streptomyces, Coumermycin A1, Anti-Bacterial Agents, Gene Expression Regulation, Multigene Family, Methyltransferase Gene, Mutation, Cosmid, Molecular Medicine, Heterologous expression, Genetic Engineering, Bacillus subtilis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45e73096b0e8a6e441d6a35a86cb63e
https://doi.org/10.1002/cbic.200700483

المؤلفون: Michał Piotr Marszałł, Ruin Moaddel, Krzysztof Jozwiak, Irving W. Wainer, Michel Bernier

المصدر: Analytical Biochemistry. 373:313-321

مصطلحات موضوعية: Adenosine Triphosphatases, Chromatography, biology, C-terminus, Biophysics, Cell Biology, Online Systems, Biochemistry, Hsp90, Article, Coumermycin A1, Radicicol, N-terminus, Inhibitory Concentration 50, chemistry.chemical_compound, chemistry, Affinity chromatography, Heat shock protein, biology.protein, medicine, HSP90 Heat-Shock Proteins, Molecular Biology, Novobiocin, Chromatography, Liquid, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6594796f4fb5dc80d60ef7ff6cc32587
https://doi.org/10.1016/j.ab.2007.11.001

المؤلفون: Ian Chopra, Anna A. Vickers, Alex J. O'Neill

المصدر: Journal of Antimicrobial Chemotherapy. 60:269-273

مصطلحات موضوعية: DNA Topoisomerase IV, DNA, Bacterial, Microbiology (medical), Staphylococcus aureus, Genotype, Topoisomerase IV, Microbial Sensitivity Tests, medicine.disease_cause, DNA gyrase, Microbiology, Coumarins, Drug Resistance, Bacterial, medicine, Pharmacology (medical), Novobiocin, Antibacterial agent, Pharmacology, Genetics, Mutation, biology, Reverse Transcriptase Polymerase Chain Reaction, Coumermycin A1, Anti-Bacterial Agents, Drug Combinations, Infectious Diseases, DNA Gyrase, biology.protein, Type II topoisomerase, Fluoroquinolones, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85592a78497bad53206151abfd20e354
https://doi.org/10.1093/jac/dkm191

المؤلفون: Anthony Stapon, Christopher T. Walsh, Daniel Kahne, Sylvie Garneau-Tsodikova

المصدر: Biochemistry. 45:8568-8578

مصطلحات موضوعية: Aminocoumarins, Clorobiocin, Antibiotics, Antineoplastic, Chemistry, Stereochemistry, Genes, Fungal, Biochemistry, DNA gyrase, Adenosine Monophosphate, Catalysis, Recombinant Proteins, Streptomyces, Coumermycin A1, Kinetics, chemistry.chemical_compound, Biosynthesis, Acyltransferases, Acyltransferase, Escherichia coli, Moiety, Cloning, Molecular, Pharmacophore, Novobiocin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2532483fa5f229d478789c3d90404a1c
https://doi.org/10.1021/bi060784e

المؤلفون: Thomas Ratajczak, Bryan K. Ward, Rudi K. Allan, Danny Mok

المصدر: Journal of Biological Chemistry. 281:7161-7171

مصطلحات موضوعية: C-terminus, Cell Biology, Biology, Biochemistry, Hsp90, Coumermycin A1, Tetratricopeptide, Immunophilins, Chaperone (protein), polycyclic compounds, Biophysics, medicine, biology.protein, Binding site, Molecular Biology, Novobiocin, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::67693afff13f98041b0cf86f53d2a070
https://doi.org/10.1074/jbc.m512406200

المؤلفون: Paul D. Straight, Pieter C. Dorrestein, Daniel J. Edwards, William H. Gerwick, Neil L. Kelleher, Michael A. Fischbach, Christopher T. Walsh, Shaun McLaughlin, Myat T. Lin, Sylvie Garneau-Tsodikova, Jonathan R. Blackhall, Roberto Kolter

المصدر: Biochemistry. 45:1537-1546

مصطلحات موضوعية: Aminocoumarins, Biology, Mass spectrometry, Biochemistry, Yersiniabactin, Mass Spectrometry, Article, Fourier transform ion cyclotron resonance, Enterobactin, Substrate Specificity, chemistry.chemical_compound, Adenosine Triphosphate, Phenols, Nonribosomal peptide, Catalytic Domain, Sulfhydryl Compounds, Peptide Synthases, chemistry.chemical_classification, Clorobiocin, Substrate (chemistry), Bromine, Combinatorial chemistry, Pyrrolidinones, Coumermycin A1, Thiazoles, Aminoglycosides, chemistry, Multigene Family, Novobiocin, Bacillus subtilis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd003c74c7df69fad569647a2d2c4cf
https://doi.org/10.1021/bi052333k

المؤلفون: Andrea Porzel, Shu-Ming Li, Jürgen Schmidt, Marion Steffensky, Elisabeth Schmutz, Lutz Heide

المصدر: European Journal of Biochemistry. 270:4413-4419

مصطلحات موضوعية: Aminocoumarins, Stereochemistry, Streptomyces rishiriensis, Molecular Sequence Data, Biology, Biochemistry, Mixed Function Oxygenases, Substrate Specificity, chemistry.chemical_compound, Biosynthesis, Coumarins, Multienzyme Complexes, Amide, medicine, Amino Acid Sequence, Cloning, Molecular, Novobiocin, chemistry.chemical_classification, Clorobiocin, Sequence Homology, Amino Acid, Streptomyces, Coumermycin A1, Amino acid, Kinetics, Dicarboxylic acid, chemistry, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973df90a729d63d6af5ac14c07d5ffe8
https://doi.org/10.1046/j.1432-1033.2003.03830.x