المؤلفون: Paolo Prontera, Orazio Palumbo, Massimo Carella, Corrado Zenesini, Giuseppe Damante, Laura Licchetta, Francesca Bisulli, Lorenzo Muccioli, Luca Vignatelli, Roberto Michelucci, Giuseppe D’Orsi, Elena Pasini, Maria Tappatà, Cinzia Costa, Raffaele Lodi, Serena Mazzone, Dustin Armstrong, Cosimo Altomare, Lidia Di Vito, Nicola Gambacorta, Paola Imbrici, Valentina Imperatore, Antonella Liantonio, Paola Mantuano

المصدر: BMJ Open, Vol 14, Iss 10 (2024)

مصطلحات موضوعية: Medicine

وصف الملف: electronic resource

Relation: https://bmjopen.bmj.com/content/14/10/e085062.full; https://doaj.org/toc/2044-6055

URL الوصول: https://doaj.org/article/9a4c3bd3835e4950ac862a864ce35aea

المؤلفون: Leonardo Pisani, Marco Catto, Giovanni Muncipinto, Orazio Nicolotti, Antonio Carrieri, Mariagrazia Rullo, Angela Stefanachi, Francesco Leonetti, Cosimo Altomare

المصدر: Frontiers in Chemistry, Vol 10 (2022)

مصطلحات موضوعية: cholinesterases, monoamine oxidases, coumarin, neurodegeneration, cancer, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fchem.2022.1002547/full; https://doaj.org/toc/2296-2646

URL الوصول: https://doaj.org/article/53ff1d25b4064b7f8ec8c3ec6647bf7d

المؤلفون: Flavio De Maio, Mariagrazia Rullo, Modesto de Candia, Rosa Purgatorio, Gianfranco Lopopolo, Giulia Santarelli, Valentina Palmieri, Massimiliano Papi, Gabriella Elia, Erica De Candia, Maurizio Sanguinetti, Cosimo Altomare

المصدر: Viruses; Volume 14; Issue 8; Pages: 1730

مصطلحات موضوعية: factor Xa, thrombin, anticoagulants, SARS-CoV-2, COVID-19

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: SARS-CoV-2 and COVID-19; https://dx.doi.org/10.3390/v14081730

الاتاحة: https://doi.org/10.3390/v14081730

المؤلفون: Annalisa Tosoni, Emanuele Cosimo Altomare, Marcella Brunetti, Pierpaolo Croce, Filippo Zappasodi, Giorgia Committeri

المصدر: Brain Sciences; Volume 11; Issue 11; Pages: 1506

مصطلحات موضوعية: affordances, walking locomotion, framing distance, event-related potentials, spatial environment

وصف الملف: application/pdf

Relation: Behavioral Neuroscience; https://dx.doi.org/10.3390/brainsci11111506

الاتاحة: https://doi.org/10.3390/brainsci11111506

المؤلفون: Rosa Purgatorio, Nicola Gambacorta, Marco Catto, Modesto de Candia, Leonardo Pisani, Alba Espargaró, Raimon Sabaté, Saverio Cellamare, Orazio Nicolotti, Cosimo Altomare

المصدر: Molecules; Volume 25; Issue 23; Pages: 5773

مصطلحات موضوعية: isatin hydrazones, indole derivatives, antiamyloid agents, multitarget-directed ligands, 3D-QSAR

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Medicinal Chemistry; https://dx.doi.org/10.3390/molecules25235773

الاتاحة: https://doi.org/10.3390/molecules25235773

المؤلفون: Marco Catto, Rosa Purgatorio, Maxim S. Kobzev, Alexander A. Titov, Elena A. Sorokina, Tatiana N. Borisova, Leonid G. Voskressensky, Elena V. Alexandrova, Alexey V. Varlamov, Cosimo Altomare

المصدر: Molecular Diversity. 26:1243-1247

مصطلحات موضوعية: 010405 organic chemistry, Chemistry, Stereochemistry, Allene, Organic Chemistry, General Medicine, 010402 general chemistry, 01 natural sciences, Acetylcholinesterase, Catalysis, 0104 chemical sciences, Inorganic Chemistry, chemistry.chemical_compound, Drug Discovery, Moiety, Physical and Theoretical Chemistry, Molecular Biology, Inhibition constant, Derivative (chemistry), Butyrylcholinesterase, Information Systems

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::35648538934a8901057630462084de1e
https://doi.org/10.1007/s11030-021-10185-8

المؤلفون: Cosimo Altomare, Alexander A. Titov, Tatiana N. Borisova, Nunzio Denora, Leonid G. Voskressensky, Nicola Gambacorta, Marco Catto, Leonardo Pisani, Modesto de Candia, Alexey V. Varlamov, Orazio Nicolotti, Maxim S. Kobzev

المصدر: ACS Chemical Neuroscience. 12:340-353

مصطلحات موضوعية: Physiology, Stereochemistry, Chemistry, Cognitive Neuroscience, Allene, Neurodegeneration, Cell Biology, General Medicine, medicine.disease, Biochemistry, Neuroprotection, chemistry.chemical_compound, Docking (molecular), medicine, Molecule, Indene, Cytotoxicity, Butyrylcholinesterase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::83246f0780cd37d6babafad28460335f
https://doi.org/10.1021/acschemneuro.0c00706

المؤلفون: Modesto de Candia, Nunzio Denora, Leonid G. Voskressensky, Mariagrazia Rullo, Rosa Purgatorio, Marco Catto, Antonio Carrieri, Cosimo Altomare, Alisa A. Nevskaya, Leonardo Pisani

المصدر: ChemMedChem. 16:589-598

مصطلحات موضوعية: Models, Molecular, Cell Survival, Serum albumin, Mannich base, 01 natural sciences, Biochemistry, Mannich Bases, Structure-Activity Relationship, chemistry.chemical_compound, Alzheimer Disease, Oral administration, Cell Line, Tumor, Drug Discovery, medicine, Humans, Prodrugs, General Pharmacology, Toxicology and Pharmaceutics, Solubility, Cytotoxicity, Butyrylcholinesterase, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Neurotoxicity, Water, Prodrug, medicine.disease, Combinatorial chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Neuroprotective Agents, Acetylcholinesterase, biology.protein, Molecular Medicine, Cholinesterase Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475d80d0e8dd664905cd0919676cc366
https://doi.org/10.1002/cmdc.202000583

المؤلفون: Annalisa Tosoni, Emanuele Cosimo Altomare, Mauro Gianni Perrucci, Giorgia Committeri, Rosalia Di Matteo

المصدر: Psychological research.

مصطلحات موضوعية: Arts and Humanities (miscellaneous), Developmental and Educational Psychology, Experimental and Cognitive Psychology, General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce2a83429a5147583512ce76b7e25d8
https://pubmed.ncbi.nlm.nih.gov/35794247

المؤلفون: Leonardo Pisani, Roberta Farina, Ramon Soto-Otero, Nunzio Denora, Giuseppe Mangiatordi, Orazio Nicolotti, Estefania Mendez-Alvarez, Cosimo Altomare, Marco Catto, Angelo Carotti

المصدر: Molecules; Volume 21; Issue 3; Pages: 362

مصطلحات موضوعية: Alzheimer’s disease, cholinesterase inhibitors, coumarins, MAO inhibitors, multi-target-directed ligands

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Medicinal Chemistry; https://dx.doi.org/10.3390/molecules21030362

الاتاحة: https://doi.org/10.3390/molecules21030362

المؤلفون: Pierpaolo Croce, Annalisa Tosoni, Filippo Zappasodi, Marcella Brunetti, Emanuele Cosimo Altomare, Giorgia Committeri

المصدر: Brain Sciences, Vol 11, Iss 1506, p 1506 (2021)
Brain Sciences
Volume 11
Issue 11

مصطلحات موضوعية: medicine.diagnostic_test, General Neuroscience, affordances, Sensory system, Neurosciences. Biological psychiatry. Neuropsychiatry, Electroencephalography, Stimulus (physiology), walking locomotion, event-related potentials, Anticipation, Article, Event-related potential, Embodied cognition, medicine, spatial environment, Psychology, Affordance, Priming (psychology), framing distance, Cognitive psychology, RC321-571

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc89cf437dde0429fcc30770bee40c7
https://www.mdpi.com/2076-3425/11/11/1506

المؤلفون: Leonid G. Voskressensky, Maria D. Matveeva, Cosimo Altomare, Rosa Purgatorio

المصدر: Future Medicinal Chemistry. 11:2735-2755

مصطلحات موضوعية: Pharmacology, Scaffold, 010405 organic chemistry, Chemistry, Drug discovery, Tumor cells, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, chemistry.chemical_compound, Mechanism of action, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, Pharmacophore, medicine.symptom, Isoquinoline

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::82dcd542fe4e890f18bc8a51158113b9
https://doi.org/10.4155/fmc-2019-0136

المؤلفون: Maxim S. Kobzev, Alexander A. Titov, Saverio Cellamare, Modesto de Candia, Alexey V. Varlamov, Mauro Niso, Tatiana N. Borisova, Leonid G. Voskressensky, Nicola Antonio Colabufo, Leonardo Pisani, Cosimo Altomare

المصدر: Future Medicinal Chemistry. 11:2095-2106

مصطلحات موضوعية: Allene, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Neoplasms, Drug Discovery, medicine, Humans, Doxorubicin, ATP Binding Cassette Transporter, Subfamily B, Member 1, Cytotoxicity, Cell Proliferation, 030304 developmental biology, P-glycoprotein, Pharmacology, Aza Compounds, 0303 health sciences, P-glycoprotein Inhibitor, Antibiotics, Antineoplastic, biology, Chemistry, Molecular biology, Drug Resistance, Multiple, In vitro, Alkadienes, Multiple drug resistance, Cyclization, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Multidrug Resistance-Associated Protein 1, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb6da2de720f4de3840b4d151cc7946
https://doi.org/10.4155/fmc-2019-0037

المؤلفون: Leonardo Pisani, Rosa Purgatorio, Cosimo Altomare, Marco Catto, Mariagrazia Rullo, Orazio Nicolotti, Nicola Gambacorta, Modesto de Candia

المصدر: Molecules
Volume 26
Issue 17
Molecules, Vol 26, Iss 5208, p 5208 (2021)

مصطلحات موضوعية: Aché, Pharmaceutical Science, Organic chemistry, Pharmacology, isonipecotamides, Article, Analytical Chemistry, Structure-Activity Relationship, chemistry.chemical_compound, Thrombin, QD241-441, Piperidines, Alzheimer Disease, Drug Discovery, medicine, Animals, Humans, Potency, Physical and Theoretical Chemistry, Receptor, Butyrylcholinesterase, Cholinesterase, chemistry.chemical_classification, biology, acetylcholinesterase, Acetylcholinesterase, antithrombotic agents, language.human_language, Molecular Docking Simulation, Enzyme, chemistry, Chemistry (miscellaneous), Factor Xa, butyrylcholinesterase, language, biology.protein, Molecular Medicine, Cattle, Cholinesterase Inhibitors, Alzheimer’s disease, Factor Xa Inhibitors, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc804f4d39259642caf612fccf11ceb

المؤلفون: Bartolo Gabriele, Ida Ziccarelli, Antonio Palumbo Piccionello, Luca Frattaruolo, Orazio Nicolotti, Cosimo Altomare, Anna Rita Cappello, Raffaella Mancuso, Matteo Brindisi, Marco Catto

المساهمون: Brindisi, Matteo, Frattaruolo, Luca, Mancuso, Raffaella, Palumbo Piccionello, Antonio, Ziccarelli, Ida, Catto, Marco, Nicolotti, Orazio, Altomare, Cosimo D, Gabriele, Bartolo, Rita Cappello, Anna

المصدر: Biochemical pharmacology. 190

مصطلحات موضوعية: 0301 basic medicine, Lactams, Cell Survival, Antineoplastic Agents, Apoptosis, Breast Neoplasms, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, PI3K/AKT signaling pathway, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, breast cancer, Cytotoxic T cell, Humans, α-methylene-γ-lactams, α,β-unsaturated lactams, Cytotoxicity, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Pharmacology, chemistry.chemical_classification, Biological Products, Molecular Structure, Chemistry, Cell growth, Akt/PKB signaling pathway, Cell Cycle, Epithelial Cells, 030104 developmental biology, Enzyme, Gene Expression Regulation, 030220 oncology & carcinogenesis, Cancer research, Lactam, cytotoxicity, Female, Proto-Oncogene Proteins c-akt

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5135217f9ab8a5a7131e8de82dc71714
https://pubmed.ncbi.nlm.nih.gov/34147489

المؤلفون: Cosimo Altomare, A. Falcicchio, Bartolo Gabriele, Anna Rita Cappello, Ida Ziccarelli, N. Della Ca, Raffaella Mancuso, Luca Frattaruolo, Matteo Brindisi

المصدر: Catalysts, Vol 11, Iss 227, p 227 (2021)
Catalysts
Volume 11
Issue 2
Catalysts 11 (2021): 1–18. doi:10.3390/catal11020227
info:cnr-pdr/source/autori:Mancuso R.; Ziccarelli I.; Brindisi M.; Altomare C.D.; Frattaruolo L.; Falcicchio A.; Della Ca' N.; Cappello A.R.; Gabriele B./titolo:A stereoselective, multicomponent catalytic carbonylative approach to a new class of ?,?-unsaturated ?-lactam derivatives/doi:10.3390%2Fcatal11020227/rivista:Catalysts/anno:2021/pagina_da:1/pagina_a:18/intervallo_pagine:1–18/volume:11

مصطلحات موضوعية: multicomponent reaction, oxidative carbonylation, chemistry.chemical_element, Homogeneous catalysis, carbonylation, 010402 general chemistry, lcsh:Chemical technology, 01 natural sciences, Catalysis, pyrrolidinones, lcsh:Chemistry, chemistry.chemical_compound, lcsh:TP1-1185, Physical and Theoretical Chemistry, Alkyl, homopropargylic amines, chemistry.chemical_classification, γ-lactams, heterocycles, 010405 organic chemistry, palladium, Combinatorial chemistry, homogeneous catalysis, 0104 chemical sciences, chemistry, lcsh:QD1-999, Lactam, steroselective synthesis, Stereoselectivity, Carbonylation, Carbon monoxide, Palladium

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3099b7d80247ed1cad18b6ce3c6a06fa
https://www.mdpi.com/2073-4344/11/2/227

المؤلفون: Orazio Nicolotti, Roman S. Borisov, Modesto de Candia, Cosimo Altomare, Elena Yu. Nevskaya, Leonardo Pisani, Aleksey V. Varlamov, Lada V. Anikina, Tatiana N. Borisova, Leonid G. Voskressensky, Marco Catto, Rosa Purgatorio, Almira R. Miftyakhova, Alisa A. Nevskaya

المصدر: Molecules
Volume 26
Issue 2
Molecules, Vol 26, Iss 359, p 359 (2021)

مصطلحات موضوعية: Monoamine Oxidase Inhibitors, Stereochemistry, Cell Survival, Pharmaceutical Science, Mixed inhibition, pyrrolo[2,1-a]isoquinolines, 01 natural sciences, Article, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, chemistry.chemical_compound, lcsh:Organic chemistry, β-amyloid aggregation, Alzheimer Disease, Cell Line, Tumor, Neoplasms, Drug Discovery, Moiety, Humans, Physical and Theoretical Chemistry, Isoquinoline, Cytotoxicity, IC50, Monoamine Oxidase, Schiff Bases, 030304 developmental biology, 0303 health sciences, Schiff base, Amyloid beta-Peptides, Cell Death, Organic Chemistry, anti-Alzheimer’s disease agents, Isoquinolines, Acetylcholinesterase, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Kinetics, chemistry, Chemistry (miscellaneous), acetylcholinesterase inhibitors, Butyrylcholinesterase, Molecular Medicine, cytotoxicity, Cholinesterase Inhibitors

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e532bcc5e1c3fc009c2749f59b3a0f

المؤلفون: Nicola Giangregorio, Saverio Cellamare, Antón L. Martínez, Cosimo Altomare, María Isabel Loza, Sara Sablone, Marco Catto, Isabella Bolognino, Annamaria Tonazzi

المصدر: ChemMedChem
16 (2021): 2807–2816. doi:10.1002/cmdc.202100209
info:cnr-pdr/source/autori:Bolognino, Isabella; Giangregorio, Nicola; Tonazzi, Annamaria; Martinez, Anton L.; Altomare, Cosimo D.; Loza, Maria, I; Sablone, Sara; Cellamare, Saverio; Catto, Marco/titolo:Synthesis and Biological Evaluation of Dantrolene-Like Hydrazide and Hydrazone Analogues as Multitarget Agents for Neurodegenerative Diseases/doi:10.1002%2Fcmdc.202100209/rivista:ChemMedChem (Print)/anno:2021/pagina_da:2807/pagina_a:2816/intervallo_pagine:2807–2816/volume:16
Chemmedchem

مصطلحات موضوعية: Hydrazone, Pharmacology, Hydrazide, 01 natural sciences, Biochemistry, Neuroprotection, Dantrolene, acylcarnitine carrier, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, medicine, Humans, General Pharmacology, Toxicology and Pharmaceutics, Enzyme Inhibitors, hydrazide and hydrazone derivatives, Monoamine Oxidase, chemistry.chemical_classification, Full Paper, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Hydrazones, carnitine, Neurodegenerative Diseases, dantrolene analogues, Full Papers, Alzheimer's disease, Acetylcholinesterase, 0104 chemical sciences, multitarget activity, 010404 medicinal & biomolecular chemistry, Monoamine neurotransmitter, Hydrazines, Neuroprotective Agents, chemistry, Lipophilicity, Molecular Medicine, carnitine/acylcarnitine carrier, Pharmacophore, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0403ff1d651425e03a18fa1c6e9a3608
https://publications.cnr.it/doc/466106

المؤلفون: Alba Espargaró, Marco Catto, Leonardo Pisani, Raimon Sabaté, Rosa Purgatorio, Saverio Cellamare, Cosimo Altomare, Orazio Nicolotti, Nicola Gambacorta, Modesto de Candia

المصدر: Molecules, Vol 25, Iss 5773, p 5773 (2020)
Dipòsit Digital de la UB
Universidad de Barcelona
Molecules
Volume 25
Issue 23

مصطلحات موضوعية: Isatin, Indoles, Molecular Conformation, Quantitative Structure-Activity Relationship, Pharmaceutical Science, Chemistry Techniques, Synthetic, Ligands, Aggregation (Chemistry), Analytical Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, indole derivatives, Compostos heterocíclics, 0303 health sciences, Training set, Molecular Structure, Chemistry, Alzheimer's disease, antiamyloid agents, Molecular Docking Simulation, Chemistry (miscellaneous), Agregació (Química), Molecular Medicine, Pèptids, Heterocyclic compounds, Pharmacophore, Quantitative structure–activity relationship, Amyloid, Stereochemistry, Molecular Dynamics Simulation, Article, lcsh:QD241-441, Protein Aggregates, 03 medical and health sciences, isatin hydrazones, lcsh:Organic chemistry, Alzheimer Disease, Humans, Potency, multitarget-directed ligands, Physical and Theoretical Chemistry, Beta (finance), 3D-QSAR, 030304 developmental biology, Indole test, Amyloid beta-Peptides, Organic Chemistry, Peptide Fragments, Malaltia d'Alzheimer, Cytoprotection, Drug Design, Peptides, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394461c859fa3ed4ae2c172574d1366f
https://www.mdpi.com/1420-3049/25/23/5773

المؤلفون: Laura Del Coco, Cosimo Altomare, Angelina Boccarelli, María Majellaro, Francesco Paolo Fanizzi, Saverio Cellamare

المساهمون: Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares, Universidade de Santiago de Compostela. Departamento de Química Orgánica, Coco, L. D., Majellaro, M., Boccarelli, A., Cellamare, S., Altomare, C. D., Fanizzi, F. P.

المصدر: Molecules
Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela
Universidad de Santiago de Compostela (USC)
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname
Molecules, Vol 25, Iss 3502, p 3502 (2020)
Volume 25
Issue 15

مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Cell division, Cell, Pharmaceutical Science, Antiproliferative activity, Pharmacology, Analytical Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Breast cancer, Drug Discovery, 0303 health sciences, Principal Component Analysis, Chemistry, Discriminant Analysis, MVA, metabolomics, Vinblastine, medicine.anatomical_structure, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, MCF-7 Cells, Metabolome, Molecular Medicine, medicine.symptom, medicine.drug, antiproliferative activity, Niacinamide, Metabolomic, Article, lcsh:QD241-441, 03 medical and health sciences, breast cancer, NMR spectroscopy, lcsh:Organic chemistry, medicine, Metabolomics, Humans, Physical and Theoretical Chemistry, Least-Squares Analysis, IC50, Biaryl nicotinamide, 030304 developmental biology, Cell Proliferation, Cisplatin, Nicotinamide, Organic Chemistry, Biphenyl Compounds, biaryl nicotinamide, Mechanism of action, MCF-7

وصف الملف: application/pdf; ELETTRONICO

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb4c576ae02b560235f33850ab98cf8
http://europepmc.org/articles/PMC7435671