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1Academic Journal
المؤلفون: Chen, Deng, Osipyan, Angelina, Adriana, Jeaunice, Kader, Mohammed, Gureev, Maxim, Knol, Catharina W. J., Sigmund, Marie Cathérine, Xiao, Zhangping, van der Wouden, Petra E., Cool, Robbert H., Poelarends, Gerrit J., Dekker, Frank J.
المصدر: Chen , D , Osipyan , A , Adriana , J , Kader , M , Gureev , M , Knol , C W J , Sigmund , M C , Xiao , Z , van der Wouden , P E , Cool , R H , Poelarends , G J & Dekker , F J 2023 , ' Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos ' , Journal of Medicinal Chemistry , vol. 66 , no. 13 , pp. 8767-8781 . https://doi.org/10.1021/acs.jmedchem.3c00397
وصف الملف: application/pdf
الاتاحة: https://hdl.handle.net/11370/72670fcf-5cf0-4157-a8f9-3359f66fc9c5
https://research.rug.nl/en/publications/72670fcf-5cf0-4157-a8f9-3359f66fc9c5
https://doi.org/10.1021/acs.jmedchem.3c00397
https://pure.rug.nl/ws/files/756638837/acs.jmedchem.3c00397.pdf
http://www.scopus.com/inward/record.url?scp=85164376968&partnerID=8YFLogxK -
2Academic Journal
المؤلفون: Shao, Jinfeng, Kuiper, Bastiaan P, Thunnissen, Andy-Mark W H, Cool, Robbert H, Zhou, Liang, Huang, Chenxi, Dijkstra, Bauke W, Broos, Jaap
المصدر: Shao , J , Kuiper , B P , Thunnissen , A-M W H , Cool , R H , Zhou , L , Huang , C , Dijkstra , B W & Broos , J 2022 , ' The Role of Tryptophan in π Interactions in Proteins : An Experimental Approach ' , Journal of the American Chemical Society , vol. 144 , no. 30 , 04986 , pp. 13815-13822 . https://doi.org/10.1021/jacs.2c04986
وصف الملف: application/pdf
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3Academic Journal
المؤلفون: Xiao, Zhangping, Osipyan, Angelina, Song, Shanshan, Chen, Deng, Schut, Reinder A, van Merkerk, Ronald, van der Wouden, Petra E, Cool, Robbert H, Quax, Wim J, Melgert, Barbro N, Poelarends, Gerrit J, Dekker, Frank J
المصدر: Xiao , Z , Osipyan , A , Song , S , Chen , D , Schut , R A , van Merkerk , R , van der Wouden , P E , Cool , R H , Quax , W J , Melgert , B N , Poelarends , G J & Dekker , F J 2022 , ' Thieno[2,3- d]pyrimidine-2,4(1 H,3 H)-dione Derivative Inhibits d -Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells ' , Journal of Medicinal Chemistry , vol. 65 , no. 3 , pp. 2059-2077 . https://doi.org/10.1021/acs.jmedchem.1c01598
وصف الملف: application/pdf
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4Academic Journal
المؤلفون: Xiao, Zhangping, Chen, Deng, Mulder, Fabian, Song, Shanshan, van der Wouden, Petra E, Cool, Robbert H, Melgert, Barbro N, Poelarends, Gerrit J, Dekker, Frank J
المصدر: Xiao , Z , Chen , D , Mulder , F , Song , S , van der Wouden , P E , Cool , R H , Melgert , B N , Poelarends , G J & Dekker , F J 2022 , ' 4-Iodopyrimidine labeling reveals nuclear translocation and nuclease activity for both MIF and MIF2 ' , Chemistry , vol. 28 , no. 1 , e202103030 . https://doi.org/10.1002/chem.202103030
وصف الملف: application/pdf
الاتاحة: https://hdl.handle.net/11370/4380903a-9d91-4662-8ef1-9828d3a7c6bd
https://research.rug.nl/en/publications/4380903a-9d91-4662-8ef1-9828d3a7c6bd
https://doi.org/10.1002/chem.202103030
https://pure.rug.nl/ws/files/199259104/Chemistry_A_European_J_2021_Xiao_4_u2010Iodopyrimidine_Labeling_Reveals_Nuclear_Translocation_and_Nuclease_Activity_for_1_.pdf -
5Academic Journal
المؤلفون: Shao, Jinfeng, Kuiper, Bastiaan P., Thunnissen, Andy-Mark W. H., Cool, Robbert H., Zhou, Liang, Huang, Chenxi, Dijkstra, Bauke W., Broos, Jaap
المصدر: Journal of the American Chemical Society 144(30), 13815 - 13822 (2022). doi:10.1021/jacs.2c04986
مصطلحات موضوعية: info:eu-repo/classification/ddc/540
جغرافية الموضوع: DE
Relation: info:eu-repo/semantics/altIdentifier/pmid/pmid:35868012; info:eu-repo/semantics/altIdentifier/issn/1943-2984; info:eu-repo/semantics/altIdentifier/issn/1520-5126; info:eu-repo/semantics/altIdentifier/wos/WOS:000885853200001; info:eu-repo/semantics/altIdentifier/issn/0002-7863; https://bib-pubdb1.desy.de/record/486059; https://bib-pubdb1.desy.de/search?p=id:%22PUBDB-2022-07059%22
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6Academic Journal
المؤلفون: Song, Shanshan, Liu, Bin, Habibie, Habibie, van den Bor, Jelle, Smit, Martine J, Gosens, Reinoud, Wu, Xinhui, Brandsma, Corry-Anke, Cool, Robbert H, Haisma, Hidde J, Poelarends, Gerrit J, Melgert, Barbro N
المصدر: Song , S , Liu , B , Habibie , H , van den Bor , J , Smit , M J , Gosens , R , Wu , X , Brandsma , C-A , Cool , R H , Haisma , H J , Poelarends , G J & Melgert , B N 2021 , ' D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling ' , EBioMedicine , vol. 68 , 103412 . https://doi.org/10.1016/j.ebiom.2021.103412
مصطلحات موضوعية: MIF, emphysema, alveolar epithelial cells, type II cells, COPD, CXCR7, MIGRATION INHIBITORY FACTOR, CELL-SURVIVAL, STEM-CELLS, ACTIVATION, ORGANOIDS, REGENERATION, EXPRESSION, APOPTOSIS, NICHE
وصف الملف: application/pdf
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7Academic Journal
المؤلفون: Xiao, Zhangping, Song, Shanshan, Chen, Deng, van Merkerk, Ronald, van der Wouden, Petra E., Cool, Robbert H., Quax, Wim J., Poelarends, Gerrit J., Melgert, Barbro N., Dekker, Frank J.
المساهمون: China Scholarship Council, Rijksuniversiteit Groningen
المصدر: Angewandte Chemie International Edition ; volume 60, issue 32, page 17514-17521 ; ISSN 1433-7851 1521-3773
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8Academic Journal
المؤلفون: Sinitski, Dzmitry, Gruner, Katrin, Brandhofer, Markus, Kontos, Christos, Winkler, Pascal, Reinstädler, Anja, Bourilhon, Priscila, Xiao, Zhangping, Cool, Robbert H, Kapurniotu, Aphrodite, Dekker, Frank J, Panstruga, Ralph, Bernhagen, Jürgen
المصدر: Sinitski , D , Gruner , K , Brandhofer , M , Kontos , C , Winkler , P , Reinstädler , A , Bourilhon , P , Xiao , Z , Cool , R H , Kapurniotu , A , Dekker , F J , Panstruga , R & Bernhagen , J 2020 , ' Cross-kingdom mimicry of the receptor signaling and leukocyte recruitment activity of a human cytokine by its plant orthologs ' , The Journal of Biological Chemistry , vol. 295 , no. 3 , pp. 850-867 . https://doi.org/10.1074/jbc.RA119.009716
مصطلحات موضوعية: CXC chemokine receptor type 4 (CXCR-4), chemokine, cellular immune response, migration, structure?function, inflammation, innate immunity, cytokine, protein conformation, plant defense, CD74, MIF, MIGRATION INHIBITORY FACTOR, PROTEIN SECONDARY STRUCTURE, D-DOPACHROME TAUTOMERASE, CIRCULAR-DICHROISM SPECTRA, CRYSTAL-STRUCTURE, CHEMOKINE RECEPTORS, STRUCTURAL DETERMINANTS, INTERNATIONAL UNION, FACTOR MIF, D-DT
وصف الملف: application/pdf
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9Academic Journal
المؤلفون: Xiao, Zhangping, Chen, Deng, Song, Shanshan, van der Vlag, Ramon, van der Wouden, Petra E, van Merkerk, Ronald, Cool, Robbert H, Hirsch, Anna K H, Melgert, Barbro N, Quax, Wim J, Poelarends, Gerrit J, Dekker, Frank J
المصدر: 63 ; 20 ; 11920 ; 11933 ; Journal of medicinal chemistry ; United States
Relation: http://hdl.handle.net/10033/623224; Journal of medicinal chemistry
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10Academic Journal
المصدر: Wang , Y , Setroikromo , R , van Merkerk , R , Cool , R H & Quax , W J 2019 , ' Creation of RANKL mutants with low affinity for decoy receptor OPG and their potential anti-fibrosis activity ' , Febs Journal , vol. 286 , no. 18 , pp. 3582-3593 . https://doi.org/10.1111/febs.14925
مصطلحات موضوعية: fibrosis, liver, lung, OPG, RANK, KAPPA-B LIGAND, OSTEOPROTEGERIN OPG, CRYSTAL-STRUCTURE, ACTIVATOR, IMMUNE
وصف الملف: application/pdf
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11Academic Journal
المؤلفون: Mahalingam, Devalingam, Carew, Jennifer S, Espitia, Claudia M, Cool, Robbert H, Giles, Francis J, de Jong, Steven, Nawrocki, Steffan T
المصدر: Mahalingam , D , Carew , J S , Espitia , C M , Cool , R H , Giles , F J , de Jong , S & Nawrocki , S T 2019 , ' Heightened JNK Activation and Reduced XIAP Levels Promote TRAIL and Sunitinib-Mediated Apoptosis in Colon Cancer Models ' , Cancers , vol. 11 , no. 7 , 895 . https://doi.org/10.3390/cancers11070895
وصف الملف: application/pdf
الاتاحة: https://hdl.handle.net/11370/b8aea194-e27c-442c-a802-a01e337576d4
https://research.rug.nl/en/publications/b8aea194-e27c-442c-a802-a01e337576d4
https://doi.org/10.3390/cancers11070895
https://pure.rug.nl/ws/files/97044975/Heightened_JNK_Activation_and_Reduced_XIAP_Levels_Promote_TRAIL_and_Sunitinib_Mediated_Apoptosis_in_Colon_Cancer_Models.pdf -
12Academic Journal
المصدر: Kok , T , Wasiel , A A , Dekker , F J , Poelarends , G J & Cool , R H 2018 , ' High yield production of human invariant chain CD74 constructs fused to solubility-enhancing peptides and characterization of their MIF-binding capacities ' , Protein Expression and Purification , vol. 148 , pp. 46-53 . https://doi.org/10.1016/j.pep.2018.03.008
مصطلحات موضوعية: Journal Article
وصف الملف: application/pdf
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13Academic Journal
المؤلفون: Kok, Tjie, Wasiel, Anna A, Cool, Robbert H, Melgert, Barbro N, Poelarends, Gerrit J, Dekker, Frank J
المصدر: Kok , T , Wasiel , A A , Cool , R H , Melgert , B N , Poelarends , G J & Dekker , F J 2018 , ' Small-molecule inhibitors of macrophage migration inhibitory factor (MIF) as an emerging class of therapeutics for immune disorders ' , Drug Discovery Today , vol. 23 , no. 11 , pp. 1910-1918 . https://doi.org/10.1016/j.drudis.2018.06.017
مصطلحات موضوعية: TAUTOMERASE INHIBITORS, STRUCTURAL FEATURES, ENZYMATIC-ACTIVITY, IN-VITRO, CANCER, CYTOKINE, TARGET, DISCOVERY, GROWTH, ANTAGONISTS
وصف الملف: application/pdf
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14Academic Journal
المؤلفون: Kok, Tjie, Wapenaar, Hannah, Wang, Kan, Neochoritis, Constantinos G, Zarganes-Tzitzikas, Tryfon, Proietti, Giordano, Eleftheriadis, Nikolaos, Kurpiewska, Katarzyna, Kalinowska-Tłuścik, Justyna, Cool, Robbert H, Poelarends, Gerrit J, Dömling, Alexander, Dekker, Frank J
المصدر: Kok , T , Wapenaar , H , Wang , K , Neochoritis , C G , Zarganes-Tzitzikas , T , Proietti , G , Eleftheriadis , N , Kurpiewska , K , Kalinowska-Tłuścik , J , Cool , R H , Poelarends , G J , Dömling , A & Dekker , F J 2018 , ' Discovery of chromenes as inhibitors of macrophage migration inhibitory factor ' , Bioorganic & Medicinal Chemistry , vol. 26 , no. 5 , pp. 999-1005 . https://doi.org/10.1016/j.bmc.2017.12.032
مصطلحات موضوعية: Journal Article
وصف الملف: application/pdf
الاتاحة: https://hdl.handle.net/11370/f9c76e75-82bc-4289-b8f3-635b06050e76
https://research.rug.nl/en/publications/f9c76e75-82bc-4289-b8f3-635b06050e76
https://doi.org/10.1016/j.bmc.2017.12.032
https://pure.rug.nl/ws/files/54368675/Discovery_of_chromenes_as_inhibitors_of_macrophage_migration_inhibitory_factor.pdf -
15Academic Journal
المؤلفون: Koch, Gudrun, Nadal-Jimenez, Pol, Reis, Carlos R., Muntendam, Remco, Bokhove, Marcel, Melillo, Elena, Dijkstra, Bauke W., Cool, Robbert H., Quax, Wim J.
المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2014 Jan . 111(4), 1568-1573.
URL الوصول: https://www.jstor.org/stable/23769085
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16Academic Journal
المؤلفون: Wang, Yizhou, van Assen, Aart H G, Dos Reis, Carlos Ricardo Rodrigues, Setroikromo, Rita, van Merkerk, Ronald, Boersma, Ykelien L, Cool, Robbert H., Quax, Wim J
المصدر: Wang , Y , van Assen , A H G , Dos Reis , C R R , Setroikromo , R , van Merkerk , R , Boersma , Y L , Cool , R H & Quax , W J 2017 , ' Novel RANKL DE-loop mutants antagonize RANK-mediated osteoclastogenesis ' , Febs Journal , vol. 284 , no. 15 , pp. 2501-2512 . https://doi.org/10.1111/febs.14142
مصطلحات موضوعية: antagonist, bone homeostasis, osteoporosis, RANK, RANKL, TUMOR-NECROSIS-FACTOR, KAPPA-B LIGAND, CRYSTAL-STRUCTURE, RECEPTOR ACTIVATOR, INDUCED ARTHRITIS, BONE LOSS, COMPLEX, DEATH, TNF, SPECIFICITY
وصف الملف: application/pdf
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17Academic Journal
المؤلفون: van der Sloot, Almer M., Tur, Vicente, Szegezdi, Eva, Mullally, Margaret M., Cool, Robbert H., Samali, Afshin, Serrano, Luis, Quax, Wim J.
المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2006 Jun 01. 103(23), 8634-8639.
URL الوصول: https://www.jstor.org/stable/30050241
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18Academic Journal
المصدر: Journal of Drug Targeting ; volume 25, issue 4, page 360-369 ; ISSN 1061-186X 1029-2330
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19Academic Journal
المؤلفون: Song, Shanshan, Liu, Bin, Habibie, Habibie, Van den Bor, Jelle, Smit, Martine. J., Gosens, Reinoud, Wu, Xinhui, Brandsma, Corry-Anke, Cool, Robbert. H., Haisma, Hidde J., Poelarends, Gerrit J., Melgert, Barbro N.
المصدر: Song , S , Liu , B , Habibie , H , Van den Bor , J , Smit , M J , Gosens , R , Wu , X , Brandsma , C-A , Cool , R H , Haisma , H J , Poelarends , G J & Melgert , B N 2021 , ' D-dopachrome tautomerase contributes to lung epithelial repair via ACKR3-dependent Akt signaling ' , European Respiratory Journal , vol. 58 . https://doi.org/10.1183/13993003.congress-2021.OA2700
مصطلحات موضوعية: COPD, Lung growth/development, Epithelial cell
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20Academic Journal
المؤلفون: Xiao, Zhangping, Chen, Deng, Mulder, Fabian, Song, Shanshan, van der Wouden, Petra E., Cool, Robbert H., Melgert, Barbro N., Poelarends, Gerrit J., Dekker, Frank J.
المصدر: Chemistry
مصطلحات موضوعية: Research Articles, stat, archeo
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