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1Academic Journal
المؤلفون: Melissa Thaler, Tim P. Ofman, Ken Kok, Jurriaan J. A. Heming, Elisha Moran, Isabelle Pickles, Anouk A. Leijs, Adrianus M. C. H. van den Nieuwendijk, Richard J. B. H. N. van den Berg, Gijs Ruijgrok, Zachary Armstrong, Clarisse Salgado-Benvindo, Dennis K. Ninaber, Eric J. Snijder, Constant A. A. van Boeckel, Marta Artola, Gideon J. Davies, Herman S. Overkleeft, Martijn J. van Hemert
المصدر: ACS Central Science, Vol 10, Iss 8, Pp 1594-1608 (2024)
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2374-7951
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2Academic Journal
المؤلفون: Ming Jiang, Mirjam C. W. Huizenga, Jonah L. Wirt, Janos Paloczi, Avand Amedi, Richard J. B. H. N. van den Berg, Joerg Benz, Ludovic Collin, Hui Deng, Xinyu Di, Wouter F. Driever, Bogdan I. Florea, Uwe Grether, Antonius P. A. Janssen, Thomas Hankemeier, Laura H. Heitman, Tsang-Wai Lam, Florian Mohr, Anto Pavlovic, Iris Ruf, Helma van den Hurk, Anna F. Stevens, Daan van der Vliet, Tom van der Wel, Matthias B. Wittwer, Constant A. A. van Boeckel, Pal Pacher, Andrea G. Hohmann, Mario van der Stelt
المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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المؤلفون: Mario van der Stelt, Constant A. A. van Boeckel, Wouter P F Driever, Elliot D. Mock, Ioli Kotsogianni, Jelle M Vooijs, Carmen S Fonseca, Hans den Dulk
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: chemistry.chemical_classification, 0303 health sciences, Pyrimidine, Stereochemistry, Phospholipase D, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, Enzyme, chemistry, In vivo, Morpholine, Drug Discovery, Lipophilicity, Molecular Medicine, N-Acylphosphatidylethanolamine, Structure–activity relationship, 030304 developmental biology
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المؤلفون: Sebastian H. Grimm, Eelke B. Lenselink, Adriaan W. Tuin, Constant A. A. van Boeckel, Adrianus M. C. H. van den Nieuwendijk, Ruud H. Wijdeven, Jordi F. Keijzer, Mario van der Stelt, Herman S. Overkleeft, Jacques Neefjes, Nora Liu, Gerard J. P. van Westen, Berend Gagestein
المصدر: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, 27(5), 692-699مصطلحات موضوعية: Fms-like tyrosine kinase 3 (FLT3), Indoles, Acutemyeloidleukemia(AML), Clinical Biochemistry, Pharmaceutical Science, medicine.disease_cause, 01 natural sciences, Biochemistry, Structure-Activity Relationship, hemic and lymphatic diseases, Drug Discovery, Acute myeloid leukemia (AML), medicine, Humans, Structure–activity relationship, Receptor, Protein Kinase Inhibitors, Fms-liketyrosinekinase3(FLT3), Molecular Biology, Aza Compounds, Mutation, Binding Sites, Molecular Structure, Inhibitors, 010405 organic chemistry, Chemistry, Organic Chemistry, Cancer, Myeloid leukemia, Drug resistant mutants, medicine.disease, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, fms-Like Tyrosine Kinase 3, H-89analogs, Tyrosine Kinase 3, Cancer research, H-89 analogs, Molecular Medicine, Matched molecular pair analysis, Protein Binding
وصف الملف: application/pdf
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5Academic Journal
المؤلفون: Marie-José C, van Lierop, Wynand, Alkema, Anke J, Laskewitz, Rein, Dijkema, Hans M, van der Maaden, Martin J, Smit, Ralf, Plate, Paolo G M, Conti, Christan G J M, Jans, C Marco, Timmers, Constant A A, van Boeckel, Scott J, Lusher, Ross, McGuire, Rene C, van Schaik, Jacob, de Vlieg, Ruben L, Smeets, Claudia L, Hofstra, Annemieke M H, Boots, Marcel, van Duin, Benno A, Ingelse, Willem G E J, Schoonen, Aldo, Grefhorst, Theo H, van Dijk, Folkert, Kuipers, Wim H A, Dokter, Data Science for Life Science & Health
المصدر: PLoS ONE. 7(11)
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المؤلفون: Elliot D, Mock, Ioli, Kotsogianni, Wouter P F, Driever, Carmen S, Fonseca, Jelle M, Vooijs, Hans, den Dulk, Constant A A, van Boeckel, Mario, van der Stelt
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Structure-Activity Relationship, Pyrimidines, Phospholipases, Phosphatidylethanolamines, Carboxylic Acids, Enzyme Inhibitors, Amides, Article
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المؤلفون: Ozge Gunduz-Cinar, Laura I. Castillo, Antonius P A Janssen, Helma van den Hurk, Marjolein Soethoudt, Andrew Holmes, Resat Cinar, Cristina Miliano, Annelot C. M. van Esbroeck, Colleen M Donovan, Pal Pacher, Elliot D. Mock, Aron H. Lichtman, Alexander T Bakker, Jesse Wat, Matthew W. Buczynski, Anouk M F van der Gracht, Tom van der Wel, Ioli Kotsogianni, Vasudev Kantae, Tiemen J Wendel, Xinyu Di, Thomas Hankemeier, Matthias B. Wittwer, Matthew N. Hill, János Pálóczi, Gavin N. Petrie, Uwe Grether, Joshua K. Park, Andrea Martella, Zoltán Varga, Ming Jiang, Daisuke Ogasawara, Giulia Donvito, Benjamin F. Cravatt, Constant A. A. van Boeckel, Bogdan I. Florea, Mario van der Stelt, Mohammed A. Mustafa
المصدر: Nature Chemical Biology, 16(6), 667-675
Nat Chem Biolمصطلحات موضوعية: Male, Cannabinoid receptor, Nape, medicine.medical_treatment, Drug Evaluation, Preclinical, Article, Amidohydrolases, 03 medical and health sciences, chemistry.chemical_compound, Mice, Fatty acid amide hydrolase, Cell Line, Tumor, Lipidomics, medicine, Phospholipase D, Animals, Humans, Enzyme Inhibitors, Receptors, Cannabinoid, Molecular Biology, Cannabinoid Receptor Antagonists, 030304 developmental biology, 0303 health sciences, Behavior, Animal, Molecular Structure, Chemistry, Phosphatidylethanolamines, 030302 biochemistry & molecular biology, Brain, Cell Biology, Anandamide, Blood Proteins, Fear, Lipid Metabolism, Endocannabinoid system, Cell biology, Mice, Inbred C57BL, medicine.anatomical_structure, lipids (amino acids, peptides, and proteins), Cannabinoid, Signal Transduction
وصف الملف: application/pdf
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المؤلفون: Christoph Driessen, Eva J. van Rooden, Charlotte M J Wesseling, David Ward, Herman S. Overkleeft, Gerjan de Bruin, Constant A. A. van Boeckel, Bogdan I. Florea, Mario van der Stelt, Alexei F. Kisselev, Adrianus M. C. H. van den Nieuwendijk
المصدر: European Journal of Organic Chemistry. 2017:5921-5934
مصطلحات موضوعية: chemistry.chemical_classification, Oligopeptide, 010405 organic chemistry, Chemistry, Peptidomimetic, Stereochemistry, Organic Chemistry, Lysine, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Amino acid, Proteasome, Proteasome inhibitor, medicine, Moiety, Physical and Theoretical Chemistry, Histidine, medicine.drug
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المؤلفون: Jure Loboda, Huib Ovaa, Elma Mons, Jill Hermans, Martijn Verdoes, Peter A. van Veelen, Boris Turk, Ineke D. C. Jansen, Dušan Turk, Bjorn R. van Doodewaerd, Constant A. A. van Boeckel
المساهمون: Parodontologie (OII, ACTA), Periodontology
المصدر: Journal of the American Chemical Society, 141(8), 3507-3514. American Chemical Society
Journal of the American Chemical Society
Mons, E, Jansen, I D C, Loboda, J, van Doodewaerd, B R, Hermans, J, Verdoes, M, van Boeckel, C A A, van Veelen, P A, Turk, B, Turk, D & Ovaa, H 2019, ' The alkyne moiety as a latent electrophile in irreversible covalent small molecule inhibitors of Cathepsin K ', Journal of the American Chemical Society, vol. 141, no. 8, pp. 3507-3514 . https://doi.org/10.1021/jacs.8b11027
Journal of the American Chemical Society, 141, 8, pp. 3507-3514
Journal of the American Chemical Society, 141, 3507-3514
Journal of the American Chemical Society, 141(8), 3507-3514مصطلحات موضوعية: Models, Molecular, SDG 16 - Peace, Stereochemistry, medicine.medical_treatment, Cathepsin K, Alkyne, Cysteine Proteinase Inhibitors, 010402 general chemistry, 01 natural sciences, Biochemistry, Catalysis, Article, Small Molecule Libraries, All institutes and research themes of the Radboud University Medical Center, Colloid and Surface Chemistry, medicine, Moiety, Humans, chemistry.chemical_classification, Protease, Molecular Structure, SDG 16 - Peace, Justice and Strong Institutions, General Chemistry, Small molecule, Justice and Strong Institutions, 0104 chemical sciences, chemistry, Covalent bond, Alkynes, Electrophile, Nanomedicine Radboud Institute for Molecular Life Sciences [Radboudumc 19], Cysteine
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34621c0b43c4eedbb885bb9f31641ab6
https://dare.uva.nl/personal/pure/en/publications/the-alkyne-moiety-as-a-latent-electrophile-in-irreversible-covalent-small-molecule-inhibitors-of-cathepsin-k(c6648de6-11fb-4e6e-b618-732d075f73d1).html -
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المؤلفون: Mario van der Stelt, Ruud H. Wijdeven, Sebastian H. Grimm, Eelke B. Lenselink, Gerard J. P. van Westen, Constant A. A. van Boeckel, Jacques Neefjes, Antonius P A Janssen
المصدر: Journal of Chemical Information and Modeling, 59(3), 1221-1229
Journal of Chemical Information and Modelingمصطلحات موضوعية: Models, Molecular, Protein family, Computer science, Protein Conformation, General Chemical Engineering, Library and Information Sciences, Machine learning, computer.software_genre, 01 natural sciences, Article, Machine Learning, 0103 physical sciences, Drug Discovery, Kinome, Independent data, Protein Kinase Inhibitors, 010304 chemical physics, Drug discovery, business.industry, Kinase Family, General Chemistry, computer.file_format, 0104 chemical sciences, Computer Science Applications, Visualization, 010404 medicinal & biomolecular chemistry, fms-Like Tyrosine Kinase 3, Tyrosine Kinase 3, Artificial intelligence, Executable, business, computer, Protein Kinases, Protein Binding
وصف الملف: application/pdf
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المؤلفون: Saskia Scheij, Richard J. B. H. N. van den Berg, Wilma E. Donker-Koopman, Mark Leemhuis, Anneke Strijland, Tom Wennekes, Saleem S Butt, Amar B. T. Ghisaidoobe, Gijsbert A. van der Marel, Herman S. Overkleeft, Arnold van Loevezijn, Mario van der Stelt, Constant A. A. van Boeckel, Gerrit-Jan Koomen, Adrianus M. C. H. van den Nieuwendijk, Johannes M. F. G. Aerts
المساهمون: Amsterdam Gastroenterology Endocrinology Metabolism, Medical Biochemistry, Amsterdam Cardiovascular Sciences
المصدر: Journal of medicinal chemistry, 57(21), 9096-9104. American Chemical Society
مصطلحات موضوعية: 1-Deoxynojirimycin, Stereochemistry, Chemistry, beta-Glucosidase, Biphenyl Compounds, Glucosylceramide synthase, Lysosomal storage disorders, Metabolic stability, Imino Sugars, Glucosylceramidase, Biochemistry, Glucosyltransferases, Drug Discovery, Humans, Molecular Medicine, Enzyme Inhibitors
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المؤلفون: Jeffry A. J. Wisse, Maurice Petitou, Vanessa Nancy-Portebois, D.G. Meuleman, Martin de Kort, Constant A. A. van Boeckel, Gerard M. T. Vogel, Vincent Motte, Guy Dubreucq
المساهمون: Chemical Biology
المصدر: Thrombosis and Haemostasis, 102(5), 804-810. Schattauer GmbH
مصطلحات موضوعية: Stereochemistry, Idraparinux, Antithrombin III, Biotin, Oligosaccharides, Fondaparinux, Structure-Activity Relationship, Thrombin, Polysaccharides, medicine, Animals, Humans, Structure–activity relationship, Binding Sites, Molecular Structure, Heparin, Chemistry, Antithrombin, Rational design, Anticoagulants, Heparin Antagonists, Thrombosis, Hematology, Avidin, Direct thrombin inhibitor, Drug Design, Rabbits, Factor Xa Inhibitors, medicine.drug
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المصدر: Drug Discovery Today. 10:769-779
مصطلحات موضوعية: Pharmacology, medicine.drug_mechanism_of_action, Anticoagulant drug, Heparin, Chemistry, Antithrombin, Factor Xa Inhibitor, Anticoagulants, Fondaparinux, Thrombocytopenia, Structure-Activity Relationship, Thrombin, Biochemistry, Drug Discovery, medicine, Humans, Platelet factor 4, Factor Xa Inhibitors, circulatory and respiratory physiology, medicine.drug, Discovery and development of direct thrombin inhibitors
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المؤلفون: Constant A. A. van Boeckel, Maurice Petitou
المساهمون: Chemical Biology
المصدر: Angewandte Chemie-International Edition, 43(24), 3118-3133. Wiley
مصطلحات موضوعية: Drug, media_common.quotation_subject, Idraparinux, Antithrombin III, Molecular Sequence Data, Pharmacology, Catalysis, Structure-Activity Relationship, Thrombin, Polysaccharides, Antithrombotic, medicine, Mode of action, media_common, Serine protease, biology, Heparin, Chemistry, Serine Endopeptidases, Antithrombin, Anticoagulants, General Medicine, General Chemistry, Carbohydrate Sequence, Fondaparinux, Biochemistry, biology.protein, medicine.drug
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المؤلفون: Maurice Petitou, Constant A. A. van Boeckel
المصدر: Angewandte Chemie. 116:3180-3196
مصطلحات موضوعية: General Medicine
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المؤلفون: Herman S. Overkleeft, Tom Wennekes, Lisette Magnee, Steven H. L. Verhelst, Constant A. A. van Boeckel, Gijsbert A. van der Marel, Wouter Wiedenhof, Jacques H. van Boom
المصدر: European Journal of Organic Chemistry. 2004:2404-2410
مصطلحات موضوعية: chemistry.chemical_compound, Glycosylation, Stereochemistry, Chemistry, Cyclitol, Organic Chemistry, Aminoglycoside, General Medicine, Physical and Theoretical Chemistry, Neamine
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المؤلفون: Tom Wennekes, Jacques H. van Boom, Gijsbert A. van der Marel, Constant A. A. van Boeckel, Herman S. Overkleeft, Steven H. L. Verhelst
المصدر: Tetrahedron. 60:2813-2822
مصطلحات موضوعية: Allylic rearrangement, Chemistry, Stereochemistry, Organic Chemistry, Aminoglycoside, Leaving group, chemistry.chemical_element, General Medicine, Metathesis, Biochemistry, Catalysis, Nucleophile, Drug Discovery, Organic chemistry, Amination, Palladium
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المؤلفون: Jacques H. van Boom, Constant A. A. van Boeckel, Hans van den Elst, Dmitri V. Filippov, Cornelia M. Tromp, Gijs A. van der Marel, Herman S. Overkleeft
المصدر: Synlett. :0773-0778
مصطلحات موضوعية: Fucosyltransferase, biology, Chemistry, Stereochemistry, Organic Chemistry, Lysine, complex mixtures, Combinatorial chemistry, Glycopeptide, chemistry.chemical_compound, Solid-phase synthesis, Peptide synthesis, biology.protein, bacteria
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المؤلفون: Remy E. J. N. Litjens, Herman S. Overkleeft, Constant A. A. van Boeckel, Gijs A. van der Marel, Leendert J. van den Bos, Jeroen D. C. Codée, Jacques H. van Boom
المصدر: Tetrahedron. 60:1057-1064
مصطلحات موضوعية: Glycosylation, Sulfonium, Stereochemistry, Organic Chemistry, General Medicine, Combinatorial chemistry, Biochemistry, Acceptor, carbohydrates (lipids), chemistry.chemical_compound, chemistry, Reagent, Drug Discovery, Activator (phosphor), lipids (amino acids, peptides, and proteins), Trifluoromethanesulfonate
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المساهمون: Chemical Biology
المصدر: Drug Discovery Today: Technologies, 8(7), 297-306. Elsevier
مصطلحات موضوعية: Drug, media_common.quotation_subject, Computational biology, Biology, Drug Discovery, Animals, Humans, RNA, Messenger, Gene, Antibacterial agent, media_common, Pharmacology, Messenger RNA, Binding Sites, business.industry, Drug discovery, RNA-Binding Proteins, RNA, Ribosomal RNA, Anti-Bacterial Agents, Biotechnology, RNA, Bacterial, Aminoglycosides, Gene Expression Regulation, Drug development, RNA, Ribosomal, Drug Design, Nucleic Acid Conformation, RNA, Viral, business
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