المؤلفون: Kristin L. Komschlies, Timothy T. Back, Theresa A. Gregorio, M. Eilene Gruys, Giovanna Damia, Robert H. Wiltrout, Connie R. Faltynek

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fe9f23a9c65ed8b9fb98da6e7c8fa265
https://doi.org/10.1201/9781003067245-12

المؤلفون: Molecular Pain, Jun Chen, Donghee Kim, Bruce R Bianchi, Eric J Cavanaugh, Connie R Faltynek, Philip R Kym, Regina M Reilly

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/e4/65/Mol_Pain_2009_Jan_21_5_3.tar.gz

وصف الملف: application/zip

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.358.7323

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.358.7323

المؤلفون: Molecular Pain, Torben R Neel, Michael F Jarvis, Ping Han, Connie R Faltynek, Carol S Surowy

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/85/6c/Mol_Pain_2005_Sep_28_1_28.tar.gz

وصف الملف: application/zip

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.5378

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.5378

المؤلفون: Victoria E. Scott, Mulugeta Mamo, Russell A. Judge, Connie R. Faltynek, C. Brent Putman, Ana L. Aguirre, Marian Namovic, Vincent S. Stoll, Karen Kage, Steven Cassar, Adrian D. Hobson, Janel M. Boyce-Rustay, Steve D. Pratt, Anil Vasudevan, Steven Swann, Gricelda H. Simler

المصدر: ChemBioChem. 19:613-621

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Phosphatase, Cell, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, Mechanical Hyperalgesia, 0302 clinical medicine, In vivo, Myosin, medicine, Humans, Transferase, Benzothiazoles, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, rho-Associated Kinases, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Chemistry, Organic Chemistry, 030104 developmental biology, medicine.anatomical_structure, Drug Design, Molecular Medicine, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e598a04cf2ca6f53d0c4aee341f0a73e
https://doi.org/10.1002/cbic.201700547

المؤلفون: Philip R. Kym, Arthur Gomtsyan, Gregory A. Gfesser, Bin Li, Regina M. Reilly, Bruce Clapham, Jerome F. Daanen, Rodger F. Henry, Torben R. Neelands, Pamela S. Puttfarcken, Susan M. Huang, Robert G. Schmidt, Robert J. Altenbach, S.K. Joshi, Huaqing Liu, Marlon D. Cowart, David N. Whittern, Phil B. Cox, Jill-Desiree Brederson, Michael J. Dart, Anurupa Shrestha, Donna Gauvin, Michael E. Kort, Erol K. Bayburt, Ping Song, Steve McGaraughty, Connie R. Faltynek, Heath A. McDonald, Patricia N. Banfor, Diana Schmidt, Eric A. Voight, Mohamad Shebley, Jason A. Segreti

المصدر: Journal of Medicinal Chemistry. 59:4926-4947

مصطلحات موضوعية: TRPV3, Pyridines, Molecular Conformation, TRPV Cation Channels, Pharmacology, 010402 general chemistry, 01 natural sciences, Structure-Activity Relationship, Transient receptor potential channel, Drug Discovery, medicine, Humans, Structure–activity relationship, Selective receptor modulator, ADME, Dose-Response Relationship, Drug, 010405 organic chemistry, Chemistry, Antagonist, Reserpine, 0104 chemical sciences, HEK293 Cells, Neuropathic pain, Molecular Medicine, Calcium, Cyclobutanes, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1b773984159dd5e2a719a0398228e6
https://doi.org/10.1021/acs.jmedchem.6b00287

المؤلفون: Charles Locke, Peter W. Reeh, W. Rachel Duan, Ahmed A. Othman, Klaus Schaffler, Connie R. Faltynek, Wolfram Nothaft, Andrea E. Best

المصدر: British Journal of Clinical Pharmacology. 75:404-414

مصطلحات موضوعية: Pharmacology, integumentary system, Laser-Evoked Potentials, business.industry, Antagonist, TRPV1, Placebo, Nociception, Anesthesia, Hyperalgesia, Medicine, Pharmacology (medical), Tramadol, medicine.symptom, business, Etoricoxib, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c3512370321050a2147fbafccf5e6a4c
https://doi.org/10.1111/j.1365-2125.2012.04377.x

المؤلفون: Sridhar Peddi, Diana L. Donnelly-Roberts, Connie R. Faltynek, Arturo Perez-Medrano, Derek W. Nelson, Tongmei Li, Alan S. Florjancic, William A. Carroll, Michael F. Jarvis, Marian T. Namovic

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3297-3300

مصطلحات موضوعية: Purinergic P2X Receptor Antagonists, Stereochemistry, Clinical Biochemistry, Tetrazoles, Pharmaceutical Science, Biochemistry, Chemical synthesis, Sulfone, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Moiety, Potency, Amines, Molecular Biology, Molecular Structure, Chemistry, organic chemicals, Organic Chemistry, Antagonist, In vitro, Rats, Benzyl group, Molecular Medicine, Amine gas treating, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683e04fd57c19abe464f0206f2e5483b
https://doi.org/10.1016/j.bmcl.2011.04.024

المؤلفون: Brett Antonio, Robert J. Gregg, Gricelda H. Simler, Matthew S Johnson, Yi Liu, Dong Liu, Marc J. C. Scanio, Prisca Honore, Alison Knox, James B. Thomas, Shailen K. Joshi, Mark L. Chapman, Brian E. Marron, Irene Drizin, Douglas S. Krafte, Connie R. Faltynek, Robert N. Atkinson, Xu-Feng Zhang, Michael J. Krambis, Kort Michael E, Michael F. Jarvis, Stephen Werness, Kennan C. Marsh, Lei Shi, Char-Chang Shieh

المصدر: Bioorganic & Medicinal Chemistry. 18:7816-7825

مصطلحات موضوعية: Clinical Biochemistry, Analgesic, Drug Evaluation, Preclinical, Administration, Oral, Pharmaceutical Science, Pharmacology, Biochemistry, Sodium Channels, NAV1.8 Voltage-Gated Sodium Channel, Structure-Activity Relationship, Sodium channel blocker, Oral administration, In vivo, Ganglia, Spinal, Microsomes, Drug Discovery, Animals, Humans, Molecular Biology, Neurons, Chemistry, Sodium channel, Organic Chemistry, Rats, Blockade, Disease Models, Animal, Nociception, Pyrazines, Neuropathic pain, Neuralgia, Molecular Medicine, Sodium Channel Blockers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebd1fee852efa5ef6ea85bd394f0b15
https://doi.org/10.1016/j.bmc.2010.09.057

المؤلفون: Rosemarie Roeloffs, Stephen Werness, Brian E. Marron, Chengmin Zhong, Brett Antonio, Ahmed H. Hakeem, Irene Drizin, Char-Chang Shieh, Mark L. Chapman, Joseph P. Mikusa, Marc J. C. Scanio, James B. Thomas, Shailen K. Joshi, Dong Liu, Mark A. Matulenko, Douglas S. Krafte, Robert N. Atkinson, Lei Shi, Kennan C. Marsh, Gricelda H. Simler, Matthew S Johnson, Michael J. Krambis, Kort Michael E, Michael F. Jarvis, Xu-Feng Zhang, Robert J. Gregg, Connie R. Faltynek, Matthew A. Secrest, Prisca Honore

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:6812-6815

مصطلحات موضوعية: Niacinamide, Stereochemistry, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Sodium channel blocker, Furan, Drug Discovery, Animals, Structure–activity relationship, Molecular Biology, Nicotinamide, Sodium channel, Organic Chemistry, Rats, Bioavailability, chemistry, Neuropathic pain, Molecular Medicine, Linker, Sodium Channel Blockers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0d6b9da5e44daf33aabb753a354c07
https://doi.org/10.1016/j.bmcl.2010.08.121

المؤلفون: Brian E. Marron, Kort Michael E, Michael F. Jarvis, Prisca Honore, Mark L. Chapman, Char-Chang Shieh, Ahmed H. Hakeem, Mark A. Matulenko, Xu-Feng Zhang, Connie R. Faltynek, Shailen K. Joshi, Douglas S. Krafte, Robert N. Atkinson

المصدر: Neuropharmacology. 59:201-207

مصطلحات موضوعية: Male, Niacinamide, Pain Threshold, Patch-Clamp Techniques, Sensory Receptor Cells, Morpholines, Biophysics, Tetrodotoxin, Pharmacology, Transfection, Sodium Channels, Membrane Potentials, NAV1.8 Voltage-Gated Sodium Channel, Rats, Sprague-Dawley, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Sodium channel blocker, Dorsal root ganglion, Ganglia, Spinal, medicine, Animals, Humans, Channel blocker, Patch clamp, Cells, Cultured, Spinal Cord Injuries, Membrane potential, Dose-Response Relationship, Drug, Chemistry, Sodium channel, Electric Stimulation, Rats, Disease Models, Animal, Allodynia, medicine.anatomical_structure, nervous system, Hyperalgesia, Neuralgia, medicine.symptom, Sodium Channel Blockers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b10f65e3d8c0358fb61cd6f1ed532df
https://doi.org/10.1016/j.neuropharm.2010.05.009

المؤلفون: Russell A. Judge, Anil Vasudevan, Victoria E. Scott, Gricelda H. Simler, Steve D. Pratt, Marian T. Namovic, C. Brent Putman, Ana Aguirre, Vincent S. Stoll, Mulugeta Mamo, Steven I. Swann, Steven C. Cassar, Connie R. Faltynek, Karen L. Kage, Janel M. Boyce-Rustay, Adrian D. Hobson

المصدر: ChemBioChem. 19:890-890

مصطلحات موضوعية: Organic Chemistry, Molecular Medicine, Molecular Biology, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::72c4a1e1ed0d515d90877f564abe154f
https://doi.org/10.1002/cbic.201800152

المؤلفون: Brian S. Brown, Connie R. Faltynek, Philip R. Kym, Steve McGaraughty, Jason A. Segreti, Ryan M. Fryer

المصدر: Brain Research. 1268:58-67

مصطلحات موضوعية: Male, Agonist, medicine.medical_specialty, Pyridines, medicine.drug_class, Resiniferatoxin, TRPV1, Action Potentials, TRPV Cation Channels, Biology, Body Temperature, Rats, Sprague-Dawley, chemistry.chemical_compound, Internal medicine, Abdomen, medicine, Animals, Premovement neuronal activity, Molecular Biology, Neurons, General Neuroscience, Temperature, Thermoregulation, Calcium Channel Blockers, Preoptic Area, Rats, Preoptic area, Calcium Channel Agonists, medicine.anatomical_structure, Endocrinology, Spinal Cord, nervous system, chemistry, Hypothalamus, Neurology (clinical), Neuron, Diterpenes, Body Temperature Regulation, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90ca66db294002044e7e0e13754f82f4
https://doi.org/10.1016/j.brainres.2009.02.018

المؤلفون: Jerome F. Daanen, Joseph P. Mikusa, Chih Hung Lee, Chengmin Zhong, Jason A. Segreti, Patrick W. Mantyh, Torben R. Neelands, Patricia N. Banfor, Michael F. Jarvis, Arthur Gomtsyan, Prasant Chandran, Molly A. Sevcik, Philip R. Kym, Donna M. Gauvin, Regina M. Reilly, Kennan C. Marsh, Michael E. Kort, Connie R. Faltynek, James P. Sullivan, Erol K. Bayburt, Carol S. Surowy, Joseph R. Ghilardi, Prisca Honore, Gricelda Hernandez, Ryan M. Fryer, Shailen K. Joshi

المصدر: Pain. 142:27-35

مصطلحات موضوعية: Male, Pain Threshold, Hyperthermia, Indazoles, Fever, Analgesic, TRPV1, Pain, TRPV Cation Channels, Bone Neoplasms, Motor Activity, Pharmacology, Body Temperature, Rats, Sprague-Dawley, Mice, Transient receptor potential channel, chemistry.chemical_compound, Osteoarthritis, Threshold of pain, Animals, Urea, Medicine, Drug Interactions, Pain Measurement, Inflammation, Analgesics, Mice, Inbred C3H, business.industry, Antagonist, medicine.disease, Rats, Disease Models, Animal, Anesthesiology and Pain Medicine, Nociception, Neurology, chemistry, Capsaicin, Calcium, Neurology (clinical), business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26cec77f1eb7a5454a08a328e395101
https://doi.org/10.1016/j.pain.2008.11.004

المؤلفون: Heath A. McDonald, Bruce R. Bianchi, Connie R. Faltynek, James S. Polakowski, Guo Zhu Zheng, Ryan G. Keddy, Kennan C. Marsh, Robert G. Schmidt, John R. Koenig, Prisca Honore, Brian S. Brown, Michael F. Jarvis, Chih-Hung Lee, Carol S. Surowy

المصدر: Bioorganic & Medicinal Chemistry. 16:8516-8525

مصطلحات موضوعية: Pyridines, Dopamine, Clinical Biochemistry, Analgesic, TRPV1, Administration, Oral, TRPV Cation Channels, Pharmaceutical Science, Arachidonic Acids, Pharmacology, Biochemistry, Rats, Sprague-Dawley, Structure-Activity Relationship, Transient receptor potential channel, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Receptor, Molecular Biology, Pain Measurement, Analgesics, Dose-Response Relationship, Drug, Chemistry, Organic Chemistry, Antagonist, Hydrogen-Ion Concentration, Rats, Disease Models, Animal, Hyperalgesia, Capsaicin, Molecular Medicine, Calcium, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f448fc511e60c32bec5d4c117e9c376a
https://doi.org/10.1016/j.bmc.2008.08.005

المؤلفون: Matthew S Johnson, Dong Liu, Robert J. Gregg, Irene Drizin, Michael F. Gross, Gricelda Hernandez, Kennan C. Marsh, James B. Thomas, Mark L. Chapman, Chang Z. Zhu, Brian E. Marron, Connie R. Faltynek, Shailen K. Joshi, Prisca Honore, Stephen Werness, Michael E. Kort, Douglas S. Krafte, Robert N. Atkinson, Rosemarie Roeloffs, William A. Carroll, Marc J. C. Scanio, Xu-Feng Zhang, Donna M. Gauvin, Michael J. Krambis, Michael F. Jarvis, Char-Chang Shieh, Lei Shi, Joseph P. Mikusa

المصدر: Bioorganic & Medicinal Chemistry. 16:6379-6386

مصطلحات موضوعية: Male, Clinical Biochemistry, Analgesic, Pharmaceutical Science, Lamotrigine, Pharmacology, Biochemistry, Piperazines, Sodium Channels, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Sodium channel blocker, Mexiletine, Drug Discovery, medicine, Animals, Humans, Potency, Furans, Molecular Biology, Voltage-gated ion channel, Chemistry, Sodium channel, Organic Chemistry, Analgesics, Non-Narcotic, Ether-A-Go-Go Potassium Channels, Rats, Neuropathic pain, Neuralgia, Molecular Medicine, Sodium Channel Blockers, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdfd333e1e1c8103d37b0c3b7e0a15f
https://doi.org/10.1016/j.bmc.2008.05.003

المؤلفون: Carol S. Surowy, Katharine L. Chu, Prisca Honore, Rachid El Kouhen, Connie R. Faltynek, Bruce R. Bianchi, Ping Han, James P. Sullivan, Steve McGaraughty, Wende Niforatos, Arthur Gomtsyan, Erol K. Bayburt, Chih-Hung Lee, Torben R. Neelands, Heath A. McDonald, Melissa H. Vos, Michael F. Jarvis

المصدر: Journal of Pharmacology and Experimental Therapeutics. 326:879-888

مصطلحات موضوعية: Male, Agonist, Hot Temperature, Indazoles, medicine.drug_class, TRPV1, Action Potentials, TRPV Cation Channels, Pharmacology, TRPV, Cell Line, Rats, Sprague-Dawley, Transient receptor potential channel, chemistry.chemical_compound, Dorsal root ganglion, medicine, Animals, Humans, Urea, Receptor, Cells, Cultured, Dose-Response Relationship, Drug, Rats, Posterior Horn Cells, medicine.anatomical_structure, nervous system, chemistry, Competitive antagonist, Capsaicin, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d345e34dd8700b32db5ac00c4d0fbd47
https://doi.org/10.1124/jpet.108.138511

المؤلفون: George K. Grayson, Kathy Sarris, Prisca Honore, Derek W. Nelson, Michael F. Jarvis, Marian T. Namovic, Connie R. Faltynek, Diana L. Donnelly-Roberts, Douglas Kalvin, William A. Carroll, Richard R. Harris

المصدر: Journal of Medicinal Chemistry. 51:3030-3034

مصطلحات موضوعية: medicine.medical_treatment, Interleukin-1beta, Pain, Peritonitis, Carbohydrazide, Cell Line, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Calcium flux, Purinergic P2 Receptor Antagonists, medicine, Animals, Humans, Structure–activity relationship, Receptor, Peritoneal Cavity, Pain Measurement, Analgesics, Antagonist, Peripheral Nervous System Diseases, Isoquinolines, Recombinant Proteins, In vitro, Rats, Hydrazines, Cytokine, chemistry, Biochemistry, Quinolines, Molecular Medicine, Calcium, Receptors, Purinergic P2X7

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5a17fd1b46d8eda98cabfc139dca9d
https://doi.org/10.1021/jm701516f

المؤلفون: Prisca Honore, Connie R. Faltynek, James P. Sullivan, Jill M. Wetter, Arthur Gomtsyan, Michael F. Jarvis, Carol S. Surowy, Steven M. Hannick, Robert G. Schmidt, Erol K. Bayburt, Chih-Hung Lee, Kennan C. Marsh, Heath A. McDonald

المصدر: Journal of Medicinal Chemistry. 51:392-395

مصطلحات موضوعية: Indazoles, Stereochemistry, Analgesic, TRPV1, Administration, Oral, Biological Availability, Pain, TRPV Cation Channels, In Vitro Techniques, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, Animals, Humans, Urea, Structure–activity relationship, Analgesics, musculoskeletal, neural, and ocular physiology, Antagonist, Stereoisomerism, Biological activity, Haplorhini, Rats, Indenes, nervous system, chemistry, Discovery and development of TRPV1 antagonists, Capsaicin, Microsomes, Liver, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65762e92fd878ae91ff241f6133f0ff1
https://doi.org/10.1021/jm701007g

المؤلفون: William A Carroll, Chengmin Zhong, Stephen Werness, Jinrong Liu, Matthew S Johnson, Lei Shi, Michael F Jarvis, James B. Thomas, Xu-Feng Zhang, Mark L. Chapman, Michael F. Gross, Shailen Joshi, Michael E. Kort, Marc J. C. Scanio, Dong Liu, Robert J Gregg, Rosemarie Roeloffs, Prisca Honore, Gricelda Hernandez, Gregory J Pacofsky, Douglas S. Krafte, Robert N. Atkinson, Brian E. Marron, Irene I. Drizin, Kennan C Marsh, Joseph P Mikusa, Michael J. Krambis, Bernard P Murray, Char-Chang Shieh, Connie R. Faltynek

المصدر: Journal of Medicinal Chemistry. 51:407-416

مصطلحات موضوعية: Male, Patch-Clamp Techniques, Stereochemistry, Analgesic, hERG, Pain, Nerve Tissue Proteins, Inflammation, In Vitro Techniques, Pharmacology, Sodium Channels, Cell Line, NAV1.8 Voltage-Gated Sodium Channel, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Cricetulus, Sodium channel blocker, Cricetinae, Ganglia, Spinal, Drug Discovery, medicine, Animals, Humans, Furans, Neurons, Analgesics, biology, Chemistry, Sodium channel, Anti-Inflammatory Agents, Non-Steroidal, Chronic pain, Peripheral Nervous System Diseases, medicine.disease, Amides, Recombinant Proteins, Rats, Neuropathic pain, Systemic administration, biology.protein, Molecular Medicine, medicine.symptom, Sodium Channel Blockers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4dee5ae6db88bda78289080d9f0fe12
https://doi.org/10.1021/jm070637u

المؤلفون: Sriajan N. Vaidyanathan, Bruce R. Bianchi, Torben R. Neelands, Robert B. Moreland, Bruce Surber, Carol S. Surowy, Rachid El Kouhen, Michael F. Jarvis, Chih-Hung Lee, Shirish N. Raja, Connie R. Faltynek, Arthur Gomtsyan, Heath A. McDonald, Pamela S. Puttfarcken

المصدر: Journal of Pharmacology and Experimental Therapeutics. 323:285-293

مصطلحات موضوعية: Stereochemistry, TRPV1, TRPV Cation Channels, CHO Cells, Ligands, Transfection, Tritium, Binding, Competitive, Calcium in biology, Radioligand Assay, Cricetulus, Cricetinae, Ganglia, Spinal, Radioligand, Animals, Humans, Urea, Calcium Signaling, Neurons, Afferent, Binding site, Receptor, Pharmacology, Molecular Structure, Chemistry, Chinese hamster ovary cell, Cell Membrane, Antagonist, Stereoisomerism, Isoquinolines, Recombinant Proteins, Rats, Competitive antagonist, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d56c87efa9cefdc29bae60c6ca62103
https://doi.org/10.1124/jpet.107.124305