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1Dissertation/ Thesis
المؤلفون: Fenollosa Artés, Felip
المساهمون: University/Department: Universitat Politècnica de Catalunya. Departament d'Enginyeria Mecànica
Thesis Advisors: Buj Corral, Irene, Gomà Ayats, Joan Ramon
المصدر: TDX (Tesis Doctorals en Xarxa)
مصطلحات موضوعية: This doctoral thesis has been focused on the challenge to obtain, using Additive Manufacturing (AM), models for surgical planning, under the premise that the equipment to obtain them should be accessible to the hospital field. The objective is to spread the use of prototypes as a surgical training tool, upgrading medical practice in the same way that technologies which enhanced radiographs at the time. The reason for using AM, instead of more traditional technologies, is its capacity to materialise, in a straight way, the digital data of the patient anatomy coming from three-dimensional scanning systems, making it possible to achieve personalised models. The results are basically the generation of new knowledge in order to create accessible multi-material 3D printing machines that would allow to obtain models mimicking living tissues. Related to the will to spread this technology, research has focused on open source technologies, mainly Fused Filament Fabrication (FFF), and similar technologies based on catalitzable liquids. This research is aligned with the development work related to AM at CIM UPC, and in this special field there is a close cooperation with Hospital Sant Joan de Déu in Barcelona (HSJD). The first section of the thesis includes a description of the state of the art, including the existing technologies and their application within the medical field. For the first time, basis have been laid for the characterisation of living tissues – primarily soft tissues – to support the selection of materials mimicking them in an AM process, so as to improve the surgical planning experience. The stiffness linked to most of the materials commonly used in 3D printing, makes them unhelpful to simulate tumours and other anatomic references. Then, parameters like density, viscoelasticity, soft materials industry characterisation, soft tissues and vessels elastic modulus, its hardness, mimicking blood and sterilisation requirements, are successively treated. The second section starts exploring FFF 3D printing. Processes are classified from the point of view of multi-materiality, a key factor for surgical planning models, telling multi-nozzle solutions from mixing printheads solutions. A study about probable useful materials (both filaments and liquids) to mimic soft tissues is included. It is stated how liquids, compared to filaments, are more demanding related to additive manufacturing processes, and different ways to print very soft materials are detailed. Finally, six real cases – in which the doctorate has participated in these last years –, involving collaboration with HSJD, are reported. In the origin it can be found the difficulty to perform tumour resection surgeries to children, like neuroblastoma type, and the initiative of Dr. Lucas Krauel. Finally, Section 3 is devoted to the exploration of many concepts (up to 8), activity performed along the last five years thanks to the technical resources of CIM UPC and the academic activity of the UPC students, related to their final degree thesis, therefore reaching the construction of several machines and mechanisms to test them. The wide and systematic research about these concepts makes closer the day to reach a desktop 3D printing multimaterial solution. It is found that the best way to progress is having a plurality of independent printheads in order to enable a 3D printer to integrate some of the researched concepts, thus materialising a possible solution. To sum up, it is raised how a 3D printer for surgical training models should be like, for the purpose of serving as a basis for new developments., Àrees temàtiques de la UPC::Enginyeria mecànica
وصف الملف: application/pdf
URL الوصول: http://hdl.handle.net/10803/667421
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2Dissertation/ Thesis
المؤلفون: Malki, Mustafa Adnan
المساهمون: Pearson, Ewan, Brown, Andrew
مصطلحات موضوعية: 615.1, Pharmacogenomics, Pharmacokinetics, Clinical pharmacology, Drug-gene interactions, Commonly used drug
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3Academic Journal
المؤلفون: Xi Liu, Suji Wang, Hongcheng Tang, Mengtian Li, Ping Gao, Xiong Peng, Maohua Chen
مصطلحات موضوعية: Medicine, Genetics, Evolutionary Biology, Ecology, Hematology, Virology, Computational Biology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, stable binding interaction, insect detoxification system, glycosyltransferase rpugt344d38 contributes, uridine diphosphate, significantly increased, significantly increase, resistant strains, recombinant rpugt344d38, metabolize 50, lcr aphids, lcr )-, expression levels, comprehensive analysis, commonly used, better understanding
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4Academic Journal
المؤلفون: Fredrik Domhagen, Sarka Langer, Angela Sasic Kalagasidis
مصطلحات موضوعية: Biophysics, Ecology, Sociology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, various vocs documented, simplified analytical model, nonoccupant voc emissions, materials ’ emissions, model suggests, model resolutions, world applications, review introduces, new buildings, initially high, existing literature, emitting area, emission rates, conflicting results, commonly used, combining factors, approximately 0, also shown, 13 l
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5Academic Journal
المؤلفون: Samapika Sahu, Avinash Garg, Renu Saini, Ananya Debnath
مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Pharmacology, Cancer, Computational Biology, Environmental Sciences not elsewhere classified, Astronomical and Space Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, umbrella sampling technique, enhanced fluidity without, commonly used cryoprotectant, understanding cryoprotectant behavior, dmso concentration increases, model bilayer understanding, interface water leads, dmso crossing encounters, pore formation decreases, dimethyl sulfoxide crossing, interface water assists, water assists, dimethyl sulfoxide, crossing behavior, dmso crossing, pore formation, interface toward, dmso pores, various concentrations, transient pores
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6Academic Journal
المؤلفون: Kefu Liu, Gefan Wan, Yongcong Li, Zhenlong Liang, Yan Meng, Xiaozhou Yuan, Jinyan Duan
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Immunology, Marine Biology, Cancer, Hematology, Chemical Sciences not elsewhere classified, tandem mass tag, potential metabolic disorders, parallel reaction monitoring, high diagnostic area, differential protein profile, commonly used specimens, become particularly crucial, 32 identified deps, urinary proteomics, study demonstrates, spp2 exhibited, specifically displaying, shedding light, proteins apoa1, patients using, mucopolysaccharidosis type, irreversible nature, interventional treatment, expression levels, exploratory studies, enzyme α, early diagnosis
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7Academic Journal
المؤلفون: Chengdong Zhan, Liqin Lian, Chuming Pang, Liangzhi Hong
مصطلحات موضوعية: Medicine, Microbiology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Computational Biology, Space Science, Chemical Sciences not elsewhere classified, poor water solubility, membrane disruption mechanism, commonly used isothiazolinone, >- dimethylethyl methacrylate, thymol end group, incorporating natural thymol, hydrophilic pdmaema block, typical pathogenic bacteria, resistant bacteria, positive bacteria, typical gram, synergistic effect, poly (<, nonleaching fabrics, n <, much higher, kill 98, electrostatic interactions, create durable, cotton fabrics
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8Academic Journal
المؤلفون: Liu Yang, Yingrong Li, Tianhua Zou, Feng Xu
مصطلحات موضوعية: Biochemistry, Medicine, Evolutionary Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, oxygen reduction reaction, nanotube morphology exhibited, methanol oxidation reaction, commonly used electrocatalyst, 55 times higher, 33 times higher, poor catalyst durability, bind ptcu strongly, 2 , noncarbon composite support, c toward orr, c toward mor, noncarbon support, ptcu catalyst, composite oxide, carbon support, synergistic action, synergetic effect, specific activity, lower overpotential, high performance, easy corrosion, confinement effect, 000 cycles
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9Academic Journal
المؤلفون: Gaoqi Weng, Huifeng Zhao, Dou Nie, Haotian Zhang, Liwei Liu, Tingjun Hou, Yu Kang
مصطلحات موضوعية: Medicine, Genetics, Molecular Biology, Physiology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, garnered emerging attention, desired physicochemical properties, commonly used distribution, advancing generative models, rediscmol benchmark differ, rediscmol benchmark, remains insufficient, related metrics, previous evaluations, novel structures, learning metrics, greater ability, graphaf struggle, graphaf ), generate molecules, findings based, existing metrics, biological context, aspect despite, 5 kinase
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10Academic Journal
المؤلفون: Logan M. Wilder, Keenan Wyatt, Christopher A. Skangos, W. Ellis Klein, Makenzie R. Parimuha, Jaclyn L. Katsirubas, James L. Young, Elisa M. Miller
مصطلحات موضوعية: Biophysics, Microbiology, Pharmacology, Biotechnology, Immunology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, present critical insight, nitrate reduction reactions, commonly used cation, free ammonia synthesis, study present aems, show negligible nh, rr electrolyzer studies, measurement error due, electrochemical ammonia synthesis, 3 , anion exchange membranes, preventing ammonia crossover, measurement error, exchange membrane, electrochemical nitrogen, select membranes, membranes matter, − 1, useful alternative, rr research, rr electrolyzers
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11Academic Journal
المؤلفون: Dong Wang, Jialiang Chen, Zhenghai Tang, Ruoyan Huang, Yilin Xiao, Jiadong Chen, Panchao Yin, Baochun Guo, Liqun Zhang
مصطلحات موضوعية: Medicine, Physiology, Biotechnology, Sociology, Inorganic Chemistry, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, via inverse vulcanization, many intractable issues, low modification efficiency, high fuel economy, environmentally friendly solution, creating molecular linkages, commonly used ssca, 3 -( triethoxysilyl, volatile organic compound, superior mechanical properties, spve readily react, filled rubber composite, organic solvents, comprehensive properties, thereby leading, spve exhibits, silanol groups, saving tires, main component, interfacial adhesion, functionalized polysulfide, facile synthesis, engineered polysulfide
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12Academic Journal
المؤلفون: Shuaike Wang, Zhaoyang Ding, Shaoyan Wang, Bingwen Hu, E Wu, Chengjie Xia, Mengdi Chen
مصطلحات موضوعية: Biochemistry, Cell Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, utilized image analysis, lamm equation phenomenologically, inverse boycott effect, differential centrifugation method, commonly used methods, combining image analysis, sedimentation coefficient distributions, overall sedimentation efficiency, entire sedimentation process, abnormal sedimentation process, analytical ultracentrifugation centrifugation, preparative centrifuge tube, preparative centrifuge experiments, effective sedimentation coefficient, preparative centrifuge, droplet sedimentation, effective fractionation, analytical ultracentrifuge, work builds, various systems, simply results, significantly reduced, quantitative results, primarily due, mostly conducted, intermediate phase
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13Academic Journal
المؤلفون: Linshan Luo, Zhefei Sun, Yiwei You, Xiang Han, Chaofei Lan, Shanpeng Pei, Pengfei Su, Zhiyong Zhang, Yahui Li, Shaowen Xu, Shengshi Guo, Dingqu Lin, Guangyang Lin, Cheng Li, Wei Huang, Shunqing Wu, Ming-Sheng Wang, Songyan Chen
مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Sociology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, Information Systems not elsewhere classified, unstable interfacial problem, high current density, g ., gaps, best cycling performance, higher electronic conductivity, achieve ultrastable cycling, state lithium batteries, li dendrite penetration, commonly used strategy, 3 , thereby stabilizing latp, term cycling, ultrastable cyclability, stabilizing latp, electronic states, well protect, usually neglected, strictly inhibited, significantly accelerates, side reactions, negative impact
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14Academic Journal
المؤلفون: Grzegorz Sowa, Agnieszka J. Bednarska, Ryszard Laskowski
مصطلحات موضوعية: Microbiology, Biotechnology, Ecology, Cancer, Science Policy, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, treated oilseed rape, repeated topical exposure, repeated insecticide treatments, exposed three times, either stochastic processes, poecilus cupreus beetles, poecilus cupreus, second treatments, organisms exposed, stochastic death, stochastic mortality, next two, natural selection, much higher, marginally better, individual tolerance, guts analysis, guts ), conclusively identify, commonly used, )
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15Academic Journal
المؤلفون: Meek Yang, Nourhan Mansour, Tengxiang Huang, Darby Heffer, Yuchen Pei, Wenyu Huang, Jieming Li, Bin Dong, Ning Fang
مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Ecology, Immunology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, mesoporous silica pore, low fluorescence background, high spatial precision, commonly used two, large interparticle inhomogeneity, better separation performance, adsorption versus diffusion, three times larger, molecule level uncovers, intraparticle inhomogeneity, ensemble level, separation science, separation application, diffusion rates, diffusion coefficients, molecule tracking, taking advantage, situ conditions, residence time, quantitatively analyzed
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16Academic Journal
المؤلفون: Zhizhen Zhang, Alessandro Sangion, Shenghong Wang, Todd Gouin, Trevor Brown, Jon A. Arnot, Li Li
مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Developmental Biology, Inorganic Chemistry, Chemical Sciences not elsewhere classified, range transport potential, predictive tool ’, academic chemical inventories, chemicals containing fluorine, commonly used qsprs, organic chemicals registered, limited ad coverage, chemical space covered, chemicals registered, predicted chemical, chemical assessments, ad coverage, training chemicals, chemicals studied, chemicals depends, warrants knowledge, structural features, significant number, semiempirical relationships, reactivity properties, often predicted, nonionizable ones, least one, findings show
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17Academic Journal
المؤلفون: Felix Rauh, Johannes Dittloff, Moritz Thun, Martin Stutzmann, Ian D. Sharp
مصطلحات موضوعية: Biophysics, Biotechnology, Ecology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, low sheet resistance, fully established monolayer, different orientations relative, commonly used structures, biased aqueous conditions, nanostructured black silicon, mean molecular area, average molecular orientation, enhancing structure based, using electrochemical potential, single adsorption mode, rc time constant, employ black si, black si reduces, situ electrochemical atr, black si, molecular axis, situ analysis, based substrates, electrochemical phenomena, electrochemical interfaces, electrochemical cell, coated si, vibrational modes
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18Academic Journal
المؤلفون: Yeping Ma, Wing Suet Tang, Sylvia Yang Liu, Bee Luan Khoo, Song Lin Chua
مصطلحات موضوعية: Medicine, Microbiology, Pharmacology, Ecology, Infectious Diseases, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, wound infection model, effective treatment strategies, cystic fibrosis patients, pqsr active site, potent inhibitory effects, commonly used antibiotic, clinical isolates collected, juglone provides insights, juglone could inhibit, aeruginosa also possesses, pqs signaling response, pqs signaling molecule, based qs systems, novel natural compound, biofilms pseudomonas aeruginosa, pseudomonas aeruginosa pqs, natural compound, aeruginosa biofilms, qs signaling, pqsr receptor, combinatorial effects
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19Academic Journal
المؤلفون: Chengmei Liu, Yu Mei, Haifeng Yang, Qian Zhang, Ke Zheng, Peng Zhang, Caifeng Ding
مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Physiology, Pharmacology, Biotechnology, Immunology, Developmental Biology, Cancer, Chemical Sciences not elsewhere classified, red fluorescence signal, important biological process, senescence biomedical research, commonly used biomarker, ratiometric fluorescent probe, obvious ratiometric probe, hep g2 cells, low detection limit, locate lysosomes accurately, induced senescence imaging, important application value, detect endogenous senescence, p1 , living cell senescence, induced senescence, living cells, successfully used, detect β, senescent cells, normal cells
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20Academic Journal
مصطلحات موضوعية: Biochemistry, Medicine, Biotechnology, Evolutionary Biology, Infectious Diseases, Plant Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, viable synthetic route, quinone derivatives studied, poor redox reactivity, observed specific capacities, measurable battery performance, commonly used super, address common concerns, p conductive carbon, one variant derived, ion battery architectures, ion batteries, facile one, conductive matrix, traditional metal, thereby offering, theoretical predictions, sustainable pathway, sustainable approach, suggesting limitations, substituted quinones, study introduces, step synthesis