المؤلفون: Souvik Banerjee (2015404), Shalini Yadav (6246062), Sourav Banerjee (3337731), Sayo O. Fakayode (1691464), Jyothi Parvathareddy (331384), Walter Reichard (11585491), Surekha Surendranathan (11585494), Foyez Mahmud (1497745), Ryan Whatcott (11585497), Joshua Thammathong (11585500), Bernd Meibohm (110267), Duane D. Miller (238777), Colleen B. Jonsson (132961), Kshatresh Dutta Dubey (1583317)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Cancer, Mental Health, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, md simulations identified, impressively high accuracy, find different indications, binding affinity significantly, acute viral pneumonia, rational drug design, 10 drug candidates, based drug design, drug bank database, based virtual screening, promising virtual hits, pro , 50 , 19 antiviral therapeutics, drug bank, based screening, promising hits, vitro <

Relation: https://figshare.com/articles/journal_contribution/Drug_Repurposing_to_Identify_Nilotinib_as_a_Potential_SARS-CoV_2_Main_Protease_Inhibitor_Insights_from_a_Computational_and_i_In_Vitro_i_Study/16836841

الاتاحة: https://doi.org/10.1021/acs.jcim.1c00524.s001

المؤلفون: Daniel W. Kneller (10357652), Hui Li (32376), Stephanie Galanie (3470420), Gwyndalyn Phillips (10357655), Audrey Labbé (11614634), Kevin L. Weiss (2181330), Qiu Zhang (239441), Mark A. Arnould (10925210), Austin Clyde (11614637), Heng Ma (240045), Arvind Ramanathan (198127), Colleen B. Jonsson (132961), Martha S. Head (2466190), Leighton Coates (1274958), John M. Louis (237589), Peter V. Bonnesen (2038771), Andrey Kovalevsky (1296192)

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Biotechnology, Infectious Diseases, Virology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, positively charged linker, maintaining correct geometry, established drug target, molecule antivirals specific, assisted structure analysis, ray structures demonstrated, pro , enzyme inhibition assays, binding subsites s1, 2 main protease, subsites s1, vitro <, protease inhibitors, neutron structure, molecule building, inhibitor binding, enzyme ’, virtual reality, protonation states, protonated his163, p1 group, noncovalent compounds

Relation: https://figshare.com/articles/journal_contribution/Structural_Electronic_and_Electrostatic_Determinants_for_Inhibitor_Binding_to_Subsites_S1_and_S2_in_SARS-CoV_2_Main_Protease/16891112

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01475.s001

المؤلفون: Shruti Bansal (11731343), Colleen B. Jonsson (132961), Shannon L. Taylor (11731346), Juan Manuel Figueroa (11731349), Andrea Vanesa Dugour (11731352), Carlos Palacios (11731355), Julio César Vega (11731358)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, urgent unmet need, preliminary finding needs, last year observed, health care personnel, global pandemic caused, provide early treatment, infection affecting millions, div >< p, controlled study showed, nasal spray may, xylitol inhibit sars, ml inhibits sars, nasal sprays, nasal cavity, target sars, vitro <, several countries, prevent transmission, initial replication

Relation: https://figshare.com/articles/journal_contribution/Residual_virus_titer_TCID50_mL_after_treatment_with_iota-carrageenan_solutions_in_Diluent_P1_sodium_chloride_9_mg_mL_adjusted_to_pH_6_7_/17051432

الاتاحة: https://doi.org/10.1371/journal.pone.0259943.s001

المؤلفون: Shruti Bansal (11731343), Colleen B. Jonsson (132961), Shannon L. Taylor (11731346), Juan Manuel Figueroa (11731349), Andrea Vanesa Dugour (11731352), Carlos Palacios (11731355), Julio César Vega (11731358)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, urgent unmet need, preliminary finding needs, last year observed, health care personnel, global pandemic caused, provide early treatment, infection affecting millions, div >< p, controlled study showed, nasal spray may, xylitol inhibit sars, ml inhibits sars, nasal sprays, nasal cavity, target sars, vitro <, several countries, prevent transmission, initial replication

Relation: https://figshare.com/articles/journal_contribution/Statistical_analysis_of_residual_virus_titers_determined_after_each_treatment_with_different_concentrations_of_iota-carrageenan_in_Diluent_P1_sodium_chloride_9_mg_mL_adjusted_to_pH_6_7_/17051435

الاتاحة: https://doi.org/10.1371/journal.pone.0259943.s002

المؤلفون: Shruti Bansal (11731343), Colleen B. Jonsson (132961), Shannon L. Taylor (11731346), Juan Manuel Figueroa (11731349), Andrea Vanesa Dugour (11731352), Carlos Palacios (11731355), Julio César Vega (11731358)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, urgent unmet need, preliminary finding needs, last year observed, health care personnel, global pandemic caused, provide early treatment, infection affecting millions, div >< p, controlled study showed, nasal spray may, xylitol inhibit sars, ml inhibits sars, nasal sprays, nasal cavity, target sars, vitro <, several countries, prevent transmission, initial replication

Relation: https://figshare.com/articles/journal_contribution/Cell_viability_found_by_MTT_assay_after_treatment_with_diluent_P1_and_and_solutions_of_iota_carrageenan_obtained_from_sample_1_without_the_addition_of_virus_expressed_as_optical_density_and_statistical_analysis_compared_to_untreated_cells_/17051438

الاتاحة: https://doi.org/10.1371/journal.pone.0259943.s003

المؤلفون: Shruti Bansal (11731343), Colleen B. Jonsson (132961), Shannon L. Taylor (11731346), Juan Manuel Figueroa (11731349), Andrea Vanesa Dugour (11731352), Carlos Palacios (11731355), Julio César Vega (11731358)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, urgent unmet need, preliminary finding needs, last year observed, health care personnel, global pandemic caused, provide early treatment, infection affecting millions, div >< p, controlled study showed, nasal spray may, xylitol inhibit sars, ml inhibits sars, nasal sprays, nasal cavity, target sars, vitro <, several countries, prevent transmission, initial replication

Relation: https://figshare.com/articles/journal_contribution/Cell_viability_found_by_MTT_assay_after_treatment_with_diluent_P2_and_solutions_of_iota_carrageenan_obtained_from_sample_2_without_the_addition_of_virus_expressed_as_optical_density_and_statistical_analysis_compared_to_untreated_cells_/17051447

الاتاحة: https://doi.org/10.1371/journal.pone.0259943.s006

المؤلفون: Shruti Bansal (11731343), Colleen B. Jonsson (132961), Shannon L. Taylor (11731346), Juan Manuel Figueroa (11731349), Andrea Vanesa Dugour (11731352), Carlos Palacios (11731355), Julio César Vega (11731358)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, urgent unmet need, preliminary finding needs, last year observed, health care personnel, global pandemic caused, provide early treatment, infection affecting millions, div >< p, controlled study showed, nasal spray may, xylitol inhibit sars, ml inhibits sars, nasal sprays, nasal cavity, target sars, vitro <, several countries, prevent transmission, initial replication

Relation: https://figshare.com/articles/journal_contribution/Statistical_analysis_of_residual_virus_titers_determined_after_each_treatment_with_different_concentrations_of_iota-carrageenan_in_Diluent_P2_sodium_chloride_5_mg_mL_adjusted_to_pH_6_7_/17051444

الاتاحة: https://doi.org/10.1371/journal.pone.0259943.s005

المؤلفون: Shruti Bansal (11731343), Colleen B. Jonsson (132961), Shannon L. Taylor (11731346), Juan Manuel Figueroa (11731349), Andrea Vanesa Dugour (11731352), Carlos Palacios (11731355), Julio César Vega (11731358)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, urgent unmet need, preliminary finding needs, last year observed, health care personnel, global pandemic caused, provide early treatment, infection affecting millions, div >< p, controlled study showed, nasal spray may, xylitol inhibit sars, ml inhibits sars, nasal sprays, nasal cavity, target sars, vitro <, several countries, prevent transmission, initial replication

Relation: https://figshare.com/articles/journal_contribution/Residual_virus_titer_TCID_sub_50_sub_mL_after_treatment_with_iota-carrageenan_solutions_in_Diluent_P2_sodium_chloride_5_mg_mL_adjusted_to_pH_6_7_/17051441

الاتاحة: https://doi.org/10.1371/journal.pone.0259943.s004

المؤلفون: Shruti Bansal (11731343), Colleen B. Jonsson (132961), Shannon L. Taylor (11731346), Juan Manuel Figueroa (11731349), Andrea Vanesa Dugour (11731352), Carlos Palacios (11731355), Julio César Vega (11731358)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, urgent unmet need, preliminary finding needs, last year observed, health care personnel, global pandemic caused, provide early treatment, infection affecting millions, div >< p, controlled study showed, nasal spray may, xylitol inhibit sars, ml inhibits sars, nasal sprays, nasal cavity, target sars, vitro <, several countries, prevent transmission, initial replication

Relation: https://figshare.com/articles/journal_contribution/Cell_viability_found_by_MTT_assay_after_treatment_with_diluents_and_solutions_of_iota_carrageenan_without_the_addition_of_virus_expressed_as_optical_density_and_statistical_analysis_compared_to_untreated_cells_/17051456

الاتاحة: https://doi.org/10.1371/journal.pone.0259943.s009

المؤلفون: Shruti Bansal (11731343), Colleen B. Jonsson (132961), Shannon L. Taylor (11731346), Juan Manuel Figueroa (11731349), Andrea Vanesa Dugour (11731352), Carlos Palacios (11731355), Julio César Vega (11731358)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, urgent unmet need, preliminary finding needs, last year observed, health care personnel, global pandemic caused, provide early treatment, infection affecting millions, div >< p, controlled study showed, nasal spray may, xylitol inhibit sars, ml inhibits sars, nasal sprays, nasal cavity, target sars, vitro <, several countries, prevent transmission, initial replication

Relation: https://figshare.com/articles/journal_contribution/Statistical_analysis_of_residual_virus_titers_determined_after_each_treatment_with_different_concentrations_of_iota-carrageenan_in_Diluent_P3_xylitol_50_mg_mL_adjusted_to_pH_6_7_/17051453

الاتاحة: https://doi.org/10.1371/journal.pone.0259943.s008

المؤلفون: Shruti Bansal (11731343), Colleen B. Jonsson (132961), Shannon L. Taylor (11731346), Juan Manuel Figueroa (11731349), Andrea Vanesa Dugour (11731352), Carlos Palacios (11731355), Julio César Vega (11731358)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, urgent unmet need, preliminary finding needs, last year observed, health care personnel, global pandemic caused, provide early treatment, infection affecting millions, div >< p, controlled study showed, nasal spray may, xylitol inhibit sars, ml inhibits sars, nasal sprays, nasal cavity, target sars, vitro <, several countries, prevent transmission, initial replication

Relation: https://figshare.com/articles/journal_contribution/Residual_virus_titer_TCID50_mL_after_treatment_with_iota-carrageenan_solutions_in_Diluent_P3_xylitol_50_mg_mL_adjusted_to_pH_6_7_/17051450

الاتاحة: https://doi.org/10.1371/journal.pone.0259943.s007

المؤلفون: Mariah K. Taylor (5580026), Evan P. Williams (9516728), Thidathip Wongsurawat (160440), Piroon Jenjaroenpun (5212082), Intawat Nookaew (163890), Colleen B. Jonsson (132961)

مصطلحات موضوعية: Clinical Microbiology, Medical Bacteriology, Medical Infection Agents (incl. Prions), Medical Virology, hantavirus, Orthohantavirus, NGS, next generation sequencing, MinION, illumina MiSeq, single nucleotide polymorphism, SNP

Relation: https://figshare.com/articles/dataset/Table_1_Amplicon-Based_Next-Generation_Sequencing_Approaches_to_Characterize_Single_Nucleotide_Polymorphisms_of_Orthohantavirus_Species_XLSX/18989741

الاتاحة: https://doi.org/10.3389/fcimb.2020.565591.s001

المؤلفون: Daniel W. Kneller (10357652), Hui Li (32376), Stephanie Galanie (3470420), Gwyndalyn Phillips (10357655), Audrey Labbé (11614634), Kevin L. Weiss (2181330), Qiu Zhang (239441), Mark A. Arnould (10925210), Austin Clyde (11614637), Heng Ma (240045), Arvind Ramanathan (198127), Colleen B. Jonsson (132961), Martha S. Head (2466190), Leighton Coates (1274958), John M. Louis (237589), Peter V. Bonnesen (2038771), Andrey Kovalevsky (1296192)

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Biotechnology, Infectious Diseases, Virology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, positively charged linker, maintaining correct geometry, established drug target, molecule antivirals specific, assisted structure analysis, ray structures demonstrated, pro , enzyme inhibition assays, binding subsites s1, 2 main protease, subsites s1, vitro <, protease inhibitors, neutron structure, molecule building, inhibitor binding, enzyme ’, virtual reality, protonation states, protonated his163, p1 group, noncovalent compounds

Relation: https://figshare.com/articles/dataset/Structural_Electronic_and_Electrostatic_Determinants_for_Inhibitor_Binding_to_Subsites_S1_and_S2_in_SARS-CoV_2_Main_Protease/16891115

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01475.s002

المؤلفون: Shruti Bansal (11731343), Colleen B. Jonsson (132961), Shannon L. Taylor (11731346), Juan Manuel Figueroa (11731349), Andrea Vanesa Dugour (11731352), Carlos Palacios (11731355), Julio César Vega (11731358)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, urgent unmet need, preliminary finding needs, last year observed, health care personnel, global pandemic caused, provide early treatment, infection affecting millions, div >< p, controlled study showed, nasal spray may, xylitol inhibit sars, ml inhibits sars, nasal sprays, nasal cavity, target sars, vitro <, several countries, prevent transmission, initial replication

Relation: https://figshare.com/articles/figure/SARS-CoV-2_viral_titer_after_treatment_with_Samples_1_and_P1_/17051459

الاتاحة: https://doi.org/10.1371/journal.pone.0259943.g001

المؤلفون: Shruti Bansal (11731343), Colleen B. Jonsson (132961), Shannon L. Taylor (11731346), Juan Manuel Figueroa (11731349), Andrea Vanesa Dugour (11731352), Carlos Palacios (11731355), Julio César Vega (11731358)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, urgent unmet need, preliminary finding needs, last year observed, health care personnel, global pandemic caused, provide early treatment, infection affecting millions, div >< p, controlled study showed, nasal spray may, xylitol inhibit sars, ml inhibits sars, nasal sprays, nasal cavity, target sars, vitro <, several countries, prevent transmission, initial replication

Relation: https://figshare.com/articles/figure/SARS-CoV-2_viral_titer_after_treatment_with_Samples_3_and_P3_/17051465

الاتاحة: https://doi.org/10.1371/journal.pone.0259943.g003

المؤلفون: Shruti Bansal (11731343), Colleen B. Jonsson (132961), Shannon L. Taylor (11731346), Juan Manuel Figueroa (11731349), Andrea Vanesa Dugour (11731352), Carlos Palacios (11731355), Julio César Vega (11731358)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, urgent unmet need, preliminary finding needs, last year observed, health care personnel, global pandemic caused, provide early treatment, infection affecting millions, div >< p, controlled study showed, nasal spray may, xylitol inhibit sars, ml inhibits sars, nasal sprays, nasal cavity, target sars, vitro <, several countries, prevent transmission, initial replication

Relation: https://figshare.com/articles/figure/SARS-CoV-2_viral_titer_after_treatment_with_Samples_2_and_P2_/17051462

الاتاحة: https://doi.org/10.1371/journal.pone.0259943.g002

المؤلفون: Shruti Bansal (11731343), Colleen B. Jonsson (132961), Shannon L. Taylor (11731346), Juan Manuel Figueroa (11731349), Andrea Vanesa Dugour (11731352), Carlos Palacios (11731355), Julio César Vega (11731358)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, urgent unmet need, preliminary finding needs, last year observed, health care personnel, global pandemic caused, provide early treatment, infection affecting millions, div >< p, controlled study showed, nasal spray may, xylitol inhibit sars, ml inhibits sars, nasal sprays, nasal cavity, target sars, vitro <, several countries, prevent transmission, initial replication

Relation: https://figshare.com/articles/dataset/Composition_of_samples_used_as_diluents_samples_without_iota-carrageenan_/17051471

الاتاحة: https://doi.org/10.1371/journal.pone.0259943.t002

المؤلفون: Shruti Bansal (11731343), Colleen B. Jonsson (132961), Shannon L. Taylor (11731346), Juan Manuel Figueroa (11731349), Andrea Vanesa Dugour (11731352), Carlos Palacios (11731355), Julio César Vega (11731358)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, urgent unmet need, preliminary finding needs, last year observed, health care personnel, global pandemic caused, provide early treatment, infection affecting millions, div >< p, controlled study showed, nasal spray may, xylitol inhibit sars, ml inhibits sars, nasal sprays, nasal cavity, target sars, vitro <, several countries, prevent transmission, initial replication

Relation: https://figshare.com/articles/dataset/Composition_of_samples_containing_iota-carrageenan_/17051468

الاتاحة: https://doi.org/10.1371/journal.pone.0259943.t001