المؤلفون: Trishnamoni Gautom, Dharmendra Dheeman, Colin Levy, Thomas Butterfield, Guadalupe Alvarez Gonzalez, Philip Le Roy, Lewis Caiger, Karl Fisher, Linus Johannissen, Neil Dixon

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/6e2c65ffe00d4ce4862774b49c4e7438

المؤلفون: Stephen A. Marshall, Karl A. P. Payne, Karl Fisher, Gabriel R. Titchiner, Colin Levy, Sam Hay, David Leys

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/f32b25ac38ee44d1bc567840faf9b7cd

المؤلفون: Mary Ortmayer, Florence J. Hardy, Matthew G. Quesne, Karl Fisher, Colin Levy, Derren J. Heyes, C. Richard A. Catlow, Sam P. de Visser, Stephen E. J. Rigby, Sam Hay, Anthony P. Green

المصدر: JACS Au, Vol 1, Iss 7, Pp 913-918 (2021)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2691-3704

URL الوصول: https://doaj.org/article/7b1ea1dfa43042aa99a9e11ae0aa8261

المؤلفون: Mary Ortmayer (8437401), Florence J. Hardy (10801578), Matthew G. Quesne (1298382), Karl Fisher (1740823), Colin Levy (2334499), Derren J. Heyes (110340), C. Richard A. Catlow (7163117), Sam P. de Visser (7860788), Stephen E. J. Rigby (8437413), Sam Hay (1982488), Anthony P. Green (1874023)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Evolutionary Biology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, code, porphyrin π- cation, site features, C c P W 191F compound, site Trp 51, reactivity manifests, Active Site Hydrogen Bond Controlli., Trp 51 tunes, Trp 191, noncanonical substitutions, ferryl heme states, metal-oxo coordination environments., activity increase, oxidative transformations, cytochrome c peroxidase, substrate binding site, metal-oxo structure, ferryl heme structure, C c P W 191F compound II, phenolic substrates, redox partner cyt c, function, Heme Peroxidase Nature

Relation: https://figshare.com/articles/journal_contribution/A_Noncanonical_Tryptophan_Analogue_Reveals_an_Active_Site_Hydrogen_Bond_Controlling_Ferryl_Reactivity_in_a_Heme_Peroxidase/14595822

الاتاحة: https://doi.org/10.1021/jacsau.1c00145.s001

المؤلفون: Richard B. Tunnicliffe, William K. Hu, Michele Y. Wu, Colin Levy, A. Paul Mould, Edward A. McKenzie, Rozanne M. Sandri-Goldin, Alexander P. Golovanov

المصدر: mBio, Vol 10, Iss 5 (2019)

مصطلحات موضوعية: phosphorylation, splicing, herpes simplex virus, structure, SR protein kinase, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2150-7511

URL الوصول: https://doaj.org/article/a3d1cf2d127e48568e7e7049c2934cf3

المؤلفون: Elizabeth L. Bell, Ross Smithson, Siobhan Kilbride, Jake Foster, Florence J. Hardy, Saranarayanan Ramachandran, Aleksander A. Tedstone, Sarah J. Haigh, Arthur A. Garforth, Philip J. R. Day, Colin Levy, Michael P. Shaver, Anthony P. Green

المصدر: Nature Catalysis. 5:673-681

مصطلحات موضوعية: Process Chemistry and Technology, Bioengineering, Biochemistry, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c7e1d2020fa56daaf4656cb9e083de41
https://doi.org/10.1038/s41929-022-00821-3

المؤلفون: Karl A. P. Payne, Gabriel R. Titchiner, David Leys, Sam Hay, Colin Levy, Karl Fisher, Stephen A Marshall

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications

مصطلحات موضوعية: Models, Molecular, Carboxy-Lyases, Flavin Mononucleotide, Stereochemistry, Decarboxylation, Science, Allosteric regulation, General Physics and Astronomy, Article, General Biochemistry, Genetics and Molecular Biology, Substrate Specificity, Enzyme catalysis, Structure-Activity Relationship, Bacterial Proteins, Protein Domains, Catalytic Domain, X-ray crystallography, Multidisciplinary, Aromatic acid, Cycloaddition Reaction, biology, Viscosity, Chemistry, Active site, Substrate (chemistry), General Chemistry, Cycloaddition, Enzymes, Oxygen, Kinetics, Protein Subunits, Carboxylation, Enzyme mechanisms, Biocatalysis, Solvents, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74886bdbb11f0000c25dd2eb8a91557
https://doaj.org/article/f32b25ac38ee44d1bc567840faf9b7cd

المؤلفون: Anthony Green, Jonathan Trimble, Rebecca Crawshaw, Florence Hardy, Colin Levy, Murray Brown, Douglas Fuerst, Derren Heyes, Richard Obexer

المصدر: Research Square

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2539e268e5c5948449313dfdec159cc8
https://doi.org/10.26434/chemrxiv-2022-b4j5n

المؤلفون: Elizabeth Bell, Ross Smithson, Siobhan Kilbride, Jake Foster, Florence Hardy, Saranarayanan Ramachandran, Aleksander Tedstone, Sarah Haigh, Arthur Garforth, Philip Day, Colin Levy, Michael Shaver, Anthony Green

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c88c517ceca45333c7b0bcfe60835b9
https://doi.org/10.21203/rs.3.rs-1350765/v1

المؤلفون: Deepankar Gahloth, Karl Fisher, Karl A.P. Payne, Matthew Cliff, Colin Levy, David Leys

المصدر: Gahloth, D, Fisher, K, Payne, K A P, Cliff, M, Levy, C & Leys, D 2022, ' Structural and biochemical characterisation of the prenylated flavin mononucleotide-dependent indole-3-carboxylic acid decarboxylase ', Journal of Biological Chemistry, pp. 101771 . https://doi.org/10.1016/j.jbc.2022.101771

مصطلحات موضوعية: Models, Molecular, Structure-Activity Relationship, Carboxy-Lyases, Flavin Mononucleotide, Manchester Institute of Biotechnology, Cell Biology, ResearchInstitutes_Networks_Beacons/manchester_institute_of_biotechnology, Molecular Biology, Biochemistry, Protein Structure, Tertiary, Substrate Specificity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c34cebc3155e2a1c0847b69ed09453d
https://www.research.manchester.ac.uk/portal/en/publications/structural-and-biochemical-characterisation-of-the-prenylated-flavin-mononucleotidedependent-indole3carboxylic-acid-decarboxylase(1a645aa3-def4-4286-9fcc-5bca1aa0a7f5).html

المؤلفون: Craig A. Hutton, Harshwardhan Poddar, James A. Triccas, Kirsty J. McLean, Gayathri Nagalingam, Andrew W. Munro, Sunnia Rajput, Irwin Selvam, Colin Levy

المصدر: Journal of Medicinal Chemistry. 62:9792-9805

مصطلحات موضوعية: chemistry.chemical_classification, 0303 health sciences, biology, Stereochemistry, Cytochrome P450, Substrate (chemistry), 01 natural sciences, 0104 chemical sciences, 3. Good health, law.invention, Adduct, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, Protein structure, Enzyme, chemistry, law, Drug Discovery, biology.protein, Molecular Medicine, Structure–activity relationship, Electron paramagnetic resonance, Heme, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e010e8cb9dc0178b58f8c2f260ea7a96
https://doi.org/10.1021/acs.jmedchem.9b01199

المؤلفون: Shaowei Zhang, Robert Schwarcz, Derren J. Heyes, Carlo Breda, Christopher David Edlin, Flaviano Giorgini, Nigel S. Scrutton, Girdhar Singh Deora, Colin Levy, Kevin D. Read, Marina Wright Muelas, Douglas B. Kell, David Leys, Benjamin P. Ross, Philip J. R. Day, Alex D Klausing, Stephen O’Hagan, Michiyo Sakuma

المصدر: Communications Biology, Vol 2, Iss 1, Pp 1-10 (2019)
Zhang, S, Sakuma, M, Deora, G S, Levy, C, Klausing, A, Breda, C, Read, K D, Ross, B P, Wright Muelas, M, Day, P, O'Hagan, S, Kell, D, Schwarcz, R, Leys, D, Heyes, D, Giorgini, F & Scrutton, N 2019, ' A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites ', Communications Biology . https://doi.org/10.1038/s42003-019-0520-5
Communications Biology
COMMUNICATIONS BIOLOGY

مصطلحات موضوعية: Kynurenine pathway, Metabolite, Medicine (miscellaneous), Pharmacology, Neuroprotection, Article, General Biochemistry, Genetics and Molecular Biology, Pathogenesis, Mice, 03 medical and health sciences, chemistry.chemical_compound, Kynurenine 3-Monooxygenase, 0302 clinical medicine, Manchester Institute of Biotechnology, medicine, Animals, Neurodegeneration, Enzyme Inhibitors, lcsh:QH301-705.5, X-ray crystallography, 030304 developmental biology, 0303 health sciences, Drug discovery, business.industry, Brain, Neurodegenerative Diseases, Hydrogen Peroxide, Prodrug, medicine.disease, ResearchInstitutes_Networks_Beacons/manchester_institute_of_biotechnology, Chemical biology, 3. Good health, chemistry, lcsh:Biology (General), Blood-Brain Barrier, General Agricultural and Biological Sciences, business, 030217 neurology & neurosurgery, Kynurenine

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cef15ca27e150c8aaa51693da774887
http://link.springer.com/article/10.1038/s42003-019-0520-5

المؤلفون: Matthew G. Quesne, Florence J. Hardy, Stephen E. J. Rigby, Sam Hay, C. Richard A. Catlow, Sam P. de Visser, Karl Fisher, Colin Levy, Anthony P. Green, Derren J. Heyes, Mary Ortmayer

المصدر: JACS Au, Vol 1, Iss 7, Pp 913-918 (2021)
JACS Au

مصطلحات موضوعية: Letter, proton-coupled electron transfer, Stereochemistry, tryptophan analogue, metal-oxo reactivity, 010402 general chemistry, 01 natural sciences, Redox, 03 medical and health sciences, chemistry.chemical_compound, Reactivity (chemistry), Expanded genetic code, Heme, QD1-999, 030304 developmental biology, 0303 health sciences, biology, Hydrogen bond, Cytochrome c peroxidase, cytochrome c peroxidase, Active site, hydrogen bonding, Porphyrin, 0104 chemical sciences, Chemistry, genetic code expansion, chemistry, biology.protein, heme enzyme

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea5cd79aab625181d24c7a852691fc9
https://orca.cardiff.ac.uk/id/eprint/143856/1/jacsau.1c00145.pdf

المؤلفون: Sarah L. Lovelock, Rebecca Crawshaw, Sophie Basler, Colin Levy, David Baker, Donald Hilvert, Anthony P. Green

المصدر: Nature. 606(7912)

مصطلحات موضوعية: Multidisciplinary, Biocatalysis, Proteins, Protein Engineering, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5cf58193b8a92b2d6d2f271265fc43
https://pubmed.ncbi.nlm.nih.gov/35650353

المؤلفون: Trishna Gautom, Dharmendra Dheeman, Colin Levy, Thomas Butterfield, Lewis Caiger, Karl Fisher, Linus Johannissen, Neil Dixon

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::61eec57259a6316d3a6e0433a069fc80
https://doi.org/10.21203/rs.3.rs-358367/v1

المؤلفون: Mark D, White, Laura, Dalle Carbonare, Mikel, Lavilla Puerta, Sergio, Iacopino, Martin, Edwards, Kate, Dunne, Elisabete, Pires, Colin, Levy, Michael A, McDonough, Francesco, Licausi, Emily, Flashman

المصدر: Proc Natl Acad Sci U S A

مصطلحات موضوعية: Oxygen, Arabidopsis Proteins, Gene Expression Regulation, Plant, fungi, Arabidopsis, Cysteine Dioxygenase, food and beverages, Biological Sciences, Oxidation-Reduction, Signal Transduction, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::6ea505c8b6861635b64234b70c84cffb
https://pubmed.ncbi.nlm.nih.gov/32868422

المؤلفون: Luis Bering, Jason Micklefield, Daniel Francis, Michael Winn, Colin Levy, Michael Rowlinson, Fanghua Wang

المصدر: Winn, M, Rowlinson, M, Wang, F, Bering, L, Francis, D, Levy, C & Micklefield, J 2021, ' Discovery, characterization and engineering of ligases for amide synthesis ', Nature, vol. 593, no. 7859, pp. 391-398 . https://doi.org/10.1038/s41586-021-03447-w

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Azospirillum lipoferum, Pectobacterium, Carboxylic Acids, Mutagenesis (molecular biology technique), Pseudomonas syringae, Cyclopentanes, 010402 general chemistry, 01 natural sciences, Ligases, 03 medical and health sciences, chemistry.chemical_compound, Biosynthesis, Manchester Institute of Biotechnology, Amide, Escherichia coli, Amino Acids, Isoleucine, chemistry.chemical_classification, Multidisciplinary, Chemistry, Herbicides, Coronatine, ResearchInstitutes_Networks_Beacons/manchester_institute_of_biotechnology, Highly selective, Amides, 0104 chemical sciences, Amino acid, Kinetics, 030104 developmental biology, Enzyme, Biochemistry, Indenes, Biocatalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4b38a4fbe6a532819dc35ef3e6dc67
https://pubmed.ncbi.nlm.nih.gov/34012085

المؤلفون: Colin Levy, Katharine Pike, Derren J. Heyes, M. Gordon Joyce, Krisztina Gabor, Hauke Smidt, John Van Der Oost, David Leys

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/85/8c/Mol_Microbiol_2008_Oct_20_70(1)_151-167.tar.gz

وصف الملف: application/zip

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.358.4401

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.358.4401

المؤلفون: Stephen E. J. Rigby, Kang Lan Tee, David Leys, Kirsty J. McLean, James Belcher, Sarah Matthews, Andrew W. Munro, Colin Levy, Richard T. Blankley, David A. Parker, Hazel M. Girvan

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, crystal structure, cytochrome P450, alkene, Stereochemistry, Decarboxylation, Protonation, Alkenes, Crystallography, X-Ray, Hydroxylation, Staphylococcaceae, Biochemistry, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Catalytic Domain, fatty acid hydroxylation, Organic chemistry, enzyme mechanism, Amino Acid Sequence, CYP152L1, Molecular Biology, Heme, fatty acid oxidation, Oxidative decarboxylation, chemistry.chemical_classification, biology, Alkene, Fatty Acids, Active site, Substrate (chemistry), product analysis, Cell Biology, Amino acid, 030104 developmental biology, Peroxidases, chemistry, Mutation, decarboxylase, Enzymology, biology.protein, Sequence Alignment, EPR spectroscopy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba3cf442f7f263bfef7f829b4a5f5e0
https://doi.org/10.1074/jbc.m116.762336

المؤلفون: Colin Levy, Lydia Tabernero, Eyong Egbe

المصدر: PLoS ONE, Vol 15, Iss 6, p e0235133 (2020)
Egbe, E, Levy, C W & Tabernero, L 2020, ' Computational and structure-guided design of phosphoinositide substrate specificity into the tyrosine specific LMW-PTP enzyme ', PLoS ONE, vol. 15, no. 6, pp. e0235133 . https://doi.org/10.1371/journal.pone.0235133
PLoS ONE

مصطلحات موضوعية: Protein Folding, Mutant, Protein tyrosine phosphatase, Phosphatidylinositols, Biochemistry, Protein Structure, Secondary, Substrate Specificity, Database and Informatics Methods, 0302 clinical medicine, Catalytic Domain, Macromolecular Structure Analysis, Tyrosine, chemistry.chemical_classification, 0303 health sciences, Crystallography, Multidisciplinary, biology, Physics, Condensed Matter Physics, Recombinant Proteins, Enzymes, Amino acid, Chemistry, Physical Sciences, Crystal Structure, Medicine, Sequence Analysis, Research Article, Chemical Elements, Protein Structure, Bioinformatics, Science, Phosphatase, Research and Analysis Methods, Phosphates, 03 medical and health sciences, Residue (chemistry), Manchester Institute of Biotechnology, Solid State Physics, Computer Simulation, Molecular Biology, 030304 developmental biology, Phosphatases, Chemical Compounds, Biology and Life Sciences, Proteins, Active site, ResearchInstitutes_Networks_Beacons/manchester_institute_of_biotechnology, Oxygen, Enzyme, Amino Acid Substitution, chemistry, Enzyme Structure, Enzymology, biology.protein, Protein Tyrosine Phosphatases, Sequence Alignment, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037097390bf017d565917ccd41cae73b
https://doaj.org/article/96c1e3c4d7184914af684d85e30ef290