المؤلفون: Wang, Jocelyn, Nakafuku, Kohki M., Ziff, Jeannie, Gelin, Christine F., Gholami, Hadi, Thompson, Aaron A., Karpowich, Nathan K., Limon, Luis, Coate, Heather R., Damm-Ganamet, Kelly L., Shih, Amy Y., Grant, Joanna C., Côte, Marjorie, Mak, Puiying A., Pascual, Heather A., Rives, Marie-Laure, Edwards, James P., Venable, Jennifer D., Venkatesan, Hariharan, Shi, Zhicai, Allen, Samantha J., Sharma, Sujata, Kung, Pei-Pei, Shireman, Brock T.

المصدر: Bioorganic & Medicinal Chemistry Letters ; volume 96, page 129492 ; ISSN 0960-894X

الاتاحة: http://dx.doi.org/10.1016/j.bmcl.2023.129492
https://api.elsevier.com/content/article/PII:S0960894X23003700?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0960894X23003700?httpAccept=text/plain

المؤلفون: Anne E. Fitzgerald, Tatiana Koudriakova, Kevin J. Coe, Anthony Ndifor, Cathy Preville, Christine Dugovic, Neelakandha S. Mani, Nicholas I. Carruthers, Michele C. Rizzolio, Timothy W. Lovenberg, Brock T. Shireman, Diane Nepomuceno, Coate Heather R, Daniel J. Pippel, Brian Lord, Allison Brett Douglas, Curt A. Dvorak, Pascal Bonaventure

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: 010405 organic chemistry, Chemistry, Sleep wake, digestive, oral, and skin physiology, Organic Chemistry, Antagonist, Neuropeptide, Pharmacology, 01 natural sciences, Biochemistry, Orexin receptor, 0104 chemical sciences, Orexin, 010404 medicinal & biomolecular chemistry, nervous system, mental disorders, Drug Discovery, Receptor, Mode of action, hormones, hormone substitutes, and hormone antagonists, psychological phenomena and processes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b157e2b40c4b8187c17e0918f6f2afc
https://doi.org/10.1021/acsmedchemlett.0c00085

المؤلفون: Thompson, Aaron A., Harbut, Michael B., Pei-Pei Kung, Karpowich, Nathan K., Branson, Jeffrey D., Grant, Joanna C., Hagan, Deborah, Pascual, Heather A., Guoyun Bai, Zavareh, Reza Beheshti, Coate, Heather R., Collins, Bernard C., Côte, Marjorie, Gelin, Christine F., Damm-Ganamet, Kelly L., Gholami, Hadi, Huff, Adam R., Limon, Luis, Lumb, Kevin J., Mak, Puiying A.

المصدر: Proceedings of the National Academy of Sciences of the United States of America; 5/2/2023, Vol. 120 Issue 18, p1-74, 74p

مصطلحات موضوعية: PROTEIN-protein interactions, LIGAND binding (Biochemistry), STRUCTURE-activity relationships, ALLOSTERIC regulation, SINGLE molecules

المؤلفون: Nicholas I. Carruthers, Lawrence Fourgeaud, Ning Qin, Sunil Sahdeo, Curt A. Dvorak, Anindya Bhattacharya, Brian Lord, Qi Wang, Natalie Taylor, Alan D. Wickenden, Reinhold Penner, Coate Heather R, John Starkus, Yingbo He, Timothy W. Lovenberg, Malika Faouzi

المصدر: European journal of pharmacology. 853

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_treatment, TRPM Cation Channels, Pharmacology, medicine.disease_cause, 03 medical and health sciences, Transient receptor potential channel, Mice, 0302 clinical medicine, In vivo, Drug Discovery, medicine, Animals, Humans, TRPM2, Microglia, Chemistry, Antagonist, Rats, 030104 developmental biology, medicine.anatomical_structure, Cytokine, HEK293 Cells, Pyrazoles, 030217 neurology & neurosurgery, Intracellular, Oxidative stress, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0748ef543777304f713bbc5f9b6b754b
https://pubmed.ncbi.nlm.nih.gov/30965058

المؤلفون: Chester Kuei, Changlu Liu, Curt A. Dvorak, Michelle Wennerholm, Timothy W. Lovenberg, Pascal Bonaventure, Coate Heather R, David Woody, Diane Nepomuceno, Nicholas I. Carruthers, Brian Lord

مصطلحات موضوعية: Agonist, Stereochemistry, medicine.drug_class, High-throughput screening, Organic Chemistry, Pharmacology, Biochemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Glycine, medicine, Receptor, Benzamide, EC50

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f062ad2194448196116d93aa5713ee
https://europepmc.org/articles/PMC4569879/

المؤلفون: Jiejun Wu, Nicholas I. Carruthers, Anthony Harrington, William A. Eckert, Grace Lee, Coate Heather R, Changlu Liu, Timothy W. Lovenberg, Steven W. Sutton, Victory Joseph, Chester Kuei, Sujin Yun, Diane Nepomuceno, Xiang Yao, Lynn Yieh, Qingqin Li, Christine Dugovic, Pascal Bonaventure, Curt A. Dvorak

المصدر: Molecular pharmacology. 88(5)

مصطلحات موضوعية: Agonist, Male, medicine.drug_class, Phenylalanine, Molecular Sequence Data, Guanosine, Nerve Tissue Proteins, Biology, Receptors, G-Protein-Coupled, Rats, Sprague-Dawley, chemistry.chemical_compound, Mice, Chlorocebus aethiops, medicine, Animals, Humans, Amino Acid Sequence, Receptor, Peptide sequence, Pharmacology, Orphan receptor, chemistry.chemical_classification, Habenula, Kinase, Tryptophan, Amino acid, Rats, HEK293 Cells, chemistry, Biochemistry, COS Cells, Molecular Medicine, Septum of Brain

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a403da982d84c8af8fa73e411bf06f
https://pubmed.ncbi.nlm.nih.gov/26349500

المؤلفون: Mulvihill, Mark J., Ji, Qun-Sheng, Coate, Heather R., Cooke, Andrew, Dong, Hanqing, Feng, Lixin, Foreman, Kenneth, Rosenfeld-Franklin, Maryland, Honda, Ayako, Mak, Gilda

المصدر: Bioorganic & Medicinal Chemistry ; volume 16, issue 3, page 1359-1375 ; ISSN 0968-0896

الاتاحة: http://dx.doi.org/10.1016/j.bmc.2007.10.061
https://api.elsevier.com/content/article/PII:S0968089607009273?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0968089607009273?httpAccept=text/plain