يعرض 1 - 20 نتائج من 104 نتيجة بحث عن '"Clinical consequences"', وقت الاستعلام: 0.64s تنقيح النتائج
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    المصدر: International Journal of Environmental Research and Public Health; Volume 19; Issue 9; Pages: 5400

    جغرافية الموضوع: agris

    وصف الملف: application/pdf

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    المؤلفون: E. Sánchez Gómez, Y. Arco Prados

    المصدر: Farmacia Hospitalaria, Vol 38, Iss 4, Pp 338-363 (2014)

    مصطلحات موضوعية: Abstract: Objective: To identify the pharmacologic interactions of oral anti-cancer drugs provided at an outpatient clinic. Material and methods: Anti-cancer drugs included in the Phamacotherapeutic Guideline of the Hospital were identified. A literature search was carried out on the pharmacologic interactions in MEDLINE® and EMBASE® (with the filer language English or Spanish, and the descriptors: “name of the anti-cancer drug” AND (“drug interactions” OR “pharmacokinetic”)), Up-to-date®, MICROMEDEX® and the drug information sheet for the EMA and the FDA. Information was also gathered from the abstract presented to European and Spanish scientific meetings for the last 4 years. When an interaction was analyzed and had clinical relevance, the best pharmacotherapeutic interaction-free alternative was sought. Results: Twenty-three drugs were identified, of which Chlorambucil, Fludarabine, Lenalidomide, Melphalan, and Thalidomide were the active compounds with the lowest likelihood of producing a pharmacologic interaction. Tyrosine kinase inhibitors (particularly Erlotinib, Imatinib, Lapatinib, and Pazopanib) are the drugs with highest number of pharmacologic interactions described, many of them with severe clinical consequences, with increases and decreases of the plasma levels of anti-cancer drugs. The active compounds identified that may have pharmacologic interactions with anticancer drugs were mainly: Allopurinol, Amiodarone, Carbamazepine, Dabigatran, Digoxin, Spironolactone, Phenytoin, Itraconazol, Repaglinide, Silodosin, Tamoxifen, Verapamil, and Warfarin. Pharmacologic interactions through the cytochrome P450 1A2, 2D6, 2C8, 2C9, 3A4 were the most important for tyrosine kinase inhibitors. Other non-pharmacologic compounds, with an important potential of producing relevant pharmacologic interaction were immunomodulators (Echinacea extracts) and Hypericum perforatum. Conclusions: Oral anticancer drugs have numerous pharmacologic interactions that should be monitored during pharmacotherapy. Given its position, Pharmacokinetics, Pharmacologic interaction, Out-patients, Oral chemotherapy, Pharmacy Department, Pharmacy and materia medica, RS1-441, Therapeutics. Pharmacology, RM1-950

    وصف الملف: electronic resource

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    المصدر: Kremers , R M W , Kleinegris , M-C , Ninivaggi , M , de Laat , B , ten Cate , H , Koek , G H , Wagenvoord , R J & Hemker , H C 2017 , ' Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis ' , PLOS ONE , vol. 12 , no. 5 , 0177020 . https://doi.org/10.1371/journal.pone.0177020

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    المؤلفون: Petrović, Dejan

    المصدر: PONS - medicinski časopis (2015) 12(2):68-74 ; ISSN: 1820-2411

    وصف الملف: application/pdf; txt

    Relation: info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175014/RS//; http://scindeks.ceon.rs/article.aspx?artid=1820-24111502068P

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    المؤلفون: Nespolo, Massimo1 massimo.nespolo@univ-lorraine.fr

    المصدر: Acta Crystallographica: Section D, Structural Biology. Nov2017, Vol. 73 Issue 11, p952-954. 2p.

    مصطلحات موضوعية: *IRON metabolism, *MOLECULAR biology, *NONFICTION

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