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1Academic Journal
المؤلفون: Huawei Qiu, Ronnie Wei, Julie Jaworski, Ekaterina Boudanova, Heather Hughes, Scott VanPatten, Anders Lund, Jaime Day, Yanfeng Zhou, Tracey McSherry, Clark Q. Pan, Rebecca Sendak
المصدر: mAbs, Vol 11, Iss 7, Pp 1266-1275 (2019)
مصطلحات موضوعية: Antibody engineering, deamidation, mutagenesis, developability, structure-function, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607
وصف الملف: electronic resource
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2
المؤلفون: Steve Roczniak, Sarah Hamren, Irene Tom, Clark Q. Pan, Mary DeRome
المصدر: Peptides. 29:479-486
مصطلحات موضوعية: medicine.medical_specialty, Lung Neoplasms, Receptors, Vasoactive Intestinal Polypeptide, Type I, Physiology, Molecular Sequence Data, Vasoactive intestinal peptide, Radioimmunoassay, CHO Cells, Plasma protein binding, Pharmacology, Biology, Biochemistry, Polyethylene Glycols, Structure-Activity Relationship, Cellular and Molecular Neuroscience, Cricetulus, Endocrinology, Cell Line, Tumor, Cricetinae, Internal medicine, medicine, Animals, Humans, Amino Acid Sequence, Receptor, Cell Proliferation, Sequence Homology, Amino Acid, Cell growth, Chinese hamster ovary cell, Immunogenicity, Cancer, medicine.disease, Peptide Fragments, Cell culture, Electrophoresis, Polyacrylamide Gel, Protein Binding, Vasoactive Intestinal Peptide
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3
المؤلفون: Huawei, Qiu, Denise M, Honey, Jonathan S, Kingsbury, Anna, Park, Ekaterina, Boudanova, Ronnie R, Wei, Clark Q, Pan, Tim, Edmunds
المصدر: Protein science : a publication of the Protein Society. 24(9)
مصطلحات موضوعية: Protein Folding, Structure-Activity Relationship, HEK293 Cells, alpha-Galactosidase, Mutagenesis, Site-Directed, Serine, Humans, Cysteine, Disulfides, Articles, Recombinant Proteins
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4
المؤلفون: Andrea Bell, Stephanie L. Yung, Ling Yang, Joanne M. Buxton, Clark Q. Pan, Thomas H. Claus, Hongxing Chen, James Whelan, Kevin B. Clairmont, Margit MacDougall, Irene Tom
المصدر: Journal of Biological Chemistry. 281:12506-12515
مصطلحات موضوعية: Blood Glucose, Male, Agonist, endocrine system, medicine.medical_specialty, medicine.drug_class, Molecular Sequence Data, Peptide, Biology, Biochemistry, Glucagon, Glucagon-Like Peptide-1 Receptor, Rats, Sprague-Dawley, Internal medicine, Receptors, Glucagon, medicine, Animals, Humans, Inverse agonist, Amino Acid Sequence, Rats, Wistar, Molecular Biology, Peptide sequence, Glucagon-like peptide 1 receptor, chemistry.chemical_classification, Sequence Homology, Amino Acid, digestive, oral, and skin physiology, Cell Biology, Rats, Endocrinology, Diabetes Mellitus, Type 2, chemistry, Drug Design, Peptides, Glucagon receptor, Glucagon receptor family, hormones, hormone substitutes, and hormone antagonists
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5
المؤلفون: Baisong Mei, Clark Q. Pan, Yaoqi Chen, Jianmin Chen, John E. Murphy
المصدر: Molecular Biotechnology. 34:165-178
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, animal diseases, Blotting, Western, Cell, bcl-X Protein, Enzyme-Linked Immunosorbent Assay, Bioengineering, Biology, Applied Microbiology and Biotechnology, Biochemistry, Cell Line, Flow cytometry, law.invention, law, hemic and lymphatic diseases, medicine, Humans, HSP70 Heat-Shock Proteins, Secretion, Molecular Biology, Factor VIII, medicine.diagnostic_test, HEK 293 cells, Flow Cytometry, Molecular biology, Recombinant Proteins, Gene expression profiling, Blot, medicine.anatomical_structure, Proto-Oncogene Proteins c-bcl-2, Cell culture, Recombinant DNA, Biotechnology
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6
المؤلفون: Aaron, Moulin, Magali, Mathieu, Catherine, Lawrence, Russell, Bigelow, Mark, Levine, Christine, Hamel, Jean-Piere, Marquette, Josiane, Le Parc, Christophe, Loux, Paul, Ferrari, Cecile, Capdevila, Jacques, Dumas, Bruno, Dumas, Alexey, Rak, Julie, Bird, Huawei, Qiu, Clark Q, Pan, Tim, Edmunds, Ronnie R, Wei
المصدر: Protein science : a publication of the Protein Society. 23(12)
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Antibodies, Monoclonal, Articles, Antibodies, Monoclonal, Humanized, Crystallography, X-Ray, Antibodies, Neutralizing, Antigen-Antibody Reactions, Immunoglobulin Fab Fragments, Antibody Specificity, Transforming Growth Factor beta, Humans, Protein Isoforms, Single-Chain Antibodies
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7
المؤلفون: Tony H. Dodge, Robert A. Lazarus, Dana L. Baker, Clark Q. Pan, Dominick Sinicropi, William S. Prince
المصدر: Journal of Biological Chemistry. 273:18374-18381
مصطلحات موضوعية: Models, Molecular, Cystic Fibrosis, Protein Conformation, Mutant, Enzyme-Linked Immunosorbent Assay, Endogeny, Antigen-Antibody Complex, Biology, Protein Engineering, Biochemistry, chemistry.chemical_compound, medicine, Deoxyribonuclease I, Humans, Lupus Erythematosus, Systemic, Potency, Molecular Biology, Expectorants, chemistry.chemical_classification, Binding Sites, Lupus erythematosus, Sputum, Wild type, DNA, Cell Biology, medicine.disease, Molecular biology, Actins, Chromatin, Recombinant Proteins, Enzyme, chemistry, Exogenous DNA
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8
المؤلفون: Clark Q. Pan, Robert A. Lazarus
المصدر: Journal of Biological Chemistry. 273:11701-11708
مصطلحات موضوعية: chemistry.chemical_classification, Molecular mass, Mutant, Wild type, Cell Biology, Biology, Biochemistry, Molecular biology, Amino acid, chemistry.chemical_compound, Enzyme, Protein structure, chemistry, Structure–activity relationship, Molecular Biology, DNA
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9
المؤلفون: Qun Zhou, James E. Stefano, Charlene Manning, Josephine Kyazike, Bo Chen, Diego A. Gianolio, Anna Park, Michelle Busch, Julie Bird, Xiaoyang Zheng, Helene Simonds-Mannes, Jennifer Kim, Rick C. Gregory, Robert J. Miller, William H. Brondyk, Pradeep K. Dhal, Clark Q. Pan
المصدر: Bioconjugate chemistry. 25(3)
مصطلحات موضوعية: Glycan, Glycosylation, Cell Survival, Biomedical Engineering, Pharmaceutical Science, Bioengineering, Antineoplastic Agents, Mice, SCID, Antibodies, Monoclonal, Humanized, Antibodies, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Polysaccharides, Cell Line, Tumor, Moiety, Structure–activity relationship, Animals, Humans, Cell Proliferation, Pharmacology, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Effector, Organic Chemistry, Neoplasms, Experimental, Trastuzumab, Sialyltransferases, A-site, Biochemistry, biology.protein, Nucleic acid, Sialic Acids, Antibody, Drug Screening Assays, Antitumor, Biotechnology
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10
المؤلفون: Sabine Kraft, Barbara Krebs, Bodo Brocks, Michael Schauer, Clark Q. Pan, Stefan Zahn, Sabine Noll
المصدر: Human antibodies. 15(4)
مصطلحات موضوعية: Liver Cirrhosis, Immunology, Molecular Sequence Data, Antibody Affinity, Breast Neoplasms, Matrix metalloproteinase, Pharmacology, Antibodies, Affinity maturation, Immunoglobulin Fab Fragments, In vivo, Fibrosis, Peptide Library, medicine, Immunology and Allergy, Potency, Animals, Combinatorial Chemistry Techniques, Humans, Amino Acid Sequence, Metalloproteinase, Tissue Inhibitor of Metalloproteinase-1, biology, Carcinoma, General Medicine, Tissue inhibitor of metalloproteinase, medicine.disease, Complementarity Determining Regions, Rats, biology.protein, Mutagenesis, Site-Directed, Antibody, Biotechnology
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11
المؤلفون: Nicole Barucci, Astrid A Ortiz, Jennifer C Reynolds, Clark Q. Pan, Thomas H. Claus, Steve Roczniak, Joanne M. Buxton, James Whelan, Kevin B. Clairmont, Ling Yang, Michael Burns, James N Livingston
المصدر: The Journal of endocrinology. 192(2)
مصطلحات موضوعية: Agonist, Blood Glucose, Male, endocrine system, medicine.medical_specialty, medicine.drug_class, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Glucagon, Glucagon-Like Peptide-1 Receptor, Diabetes Mellitus, Experimental, Polyethylene Glycols, Mice, Endocrinology, Internal medicine, Diabetes mellitus, medicine, Receptors, Glucagon, Animals, Insulin, Obesity, Rats, Wistar, Receptor, Glucagon-like peptide 1 receptor, Glucose tolerance test, Mice, Inbred BALB C, medicine.diagnostic_test, Chemistry, digestive, oral, and skin physiology, Glucose Tolerance Test, medicine.disease, Mice, Mutant Strains, Peptide Fragments, Rats, Mice, Inbred C57BL, Diabetes Mellitus, Type 2, Intercellular Signaling Peptides and Proteins, Female, Gastrointestinal Motility, Peptides, Glucagon receptor, hormones, hormone substitutes, and hormone antagonists
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12
المؤلفون: Stephanie L. Yung, Y. John Wang, James Whelan, Dumas Michael L, Steve Roczniak, Fugang Li, Clark Q. Pan, Thomas H. Claus, Wayne A. Froland, Yaxin Li, Irene Tom, Wei Wang
المصدر: The Journal of pharmacology and experimental therapeutics. 320(2)
مصطلحات موضوعية: Agonist, Blood Glucose, Male, medicine.drug_class, Molecular Sequence Data, Peptide, CHO Cells, Polyethylene Glycols, Mice, Cricetulus, Drug Stability, In vivo, Cricetinae, PEG ratio, medicine, Animals, Hypoglycemic Agents, Amino Acid Sequence, Rats, Wistar, Deamidation, Pharmacology, chemistry.chemical_classification, Mice, Inbred BALB C, Chemistry, Peptide Fragments, Rats, Glutamine, Biochemistry, Molecular Medicine, Receptors, Vasoactive Intestinal Peptide, Type II, Secretagogue, Cysteine, Vasoactive Intestinal Peptide
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13
المؤلفون: Clark Q. Pan, Sheryl Martin-Moe, Laszlo L. Musza, Y. John Wang, Wei Wang
المصدر: International journal of pharmaceutics. 351(1-2)
مصطلحات موضوعية: chemistry.chemical_classification, Aqueous solution, Chemistry, Dimer, Drug Storage, Pharmaceutical Science, Protonation, Peptide, Hydrogen-Ion Concentration, Combinatorial chemistry, Solvent, chemistry.chemical_compound, Nucleophile, Chlorides, Drug Stability, Zinc Compounds, Solvents, Organic chemistry, Pituitary Adenylate Cyclase-Activating Polypeptide, Deamidation, Imide, Dimerization
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14
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15
المؤلفون: Manami, Tsutsumi, Thomas H, Claus, Yin, Liang, Yaxin, Li, Ling, Yang, Jian, Zhu, Fernando, Dela Cruz, Xianbu, Peng, Hongxing, Chen, Stephanie L, Yung, Sarah, Hamren, James N, Livingston, Clark Q, Pan
المصدر: Diabetes. 51(5)
مصطلحات موضوعية: Diarrhea, Receptors, Vasoactive Intestinal Polypeptide, Type I, Injections, Subcutaneous, Molecular Sequence Data, Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Blood Pressure, Hormones, Peptide Fragments, Rats, Islets of Langerhans, Glucose, Diabetes Mellitus, Type 2, Heart Rate, Injections, Intravenous, Insulin Secretion, Animals, Humans, Insulin, Receptors, Vasoactive Intestinal Peptide, Receptors, Vasoactive Intestinal Peptide, Type II, Amino Acid Sequence, Receptors, Pituitary Hormone, Rats, Wistar, Cells, Cultured, Vasoactive Intestinal Peptide
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16
المؤلفون: Clark Q. Pan, Lazarus Ra, Ulmer Jana S, Andrea Herzka
المصدر: Protein science : a publication of the Protein Society. 7(3)
مصطلحات موضوعية: Models, Molecular, Cations, Divalent, DNA Mutational Analysis, Biology, Biochemistry, Catalysis, chemistry.chemical_compound, Structure-Activity Relationship, Species Specificity, Animals, Deoxyribonuclease I, Humans, Histidine, Binding site, Site-directed mutagenesis, Molecular Biology, Binding Sites, Hydrogen Bonding, Molecular biology, Recombinant Proteins, DNA-Binding Proteins, chemistry, Metals, DNase I hypersensitive site, Cattle, DNase footprinting assay, Hypersensitive site, DNA, Plasmids, Research Article
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17
المؤلفون: Robert A. Lazarus, Clark Q. Pan
المصدر: Biochemistry. 36(22)
مصطلحات موضوعية: Models, Molecular, DNA Ligases, DNA Repair, DNA repair, Sodium Chloride, Protein Engineering, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Plasmid, Deoxyribonuclease I, Humans, Magnesium, Klenow fragment, chemistry.chemical_classification, DNA ligase, biology, DNA, Superhelical, Hydrolysis, Mutagenesis, DNA, DNA Polymerase I, Kinetics, chemistry, biology.protein, Mutagenesis, Site-Directed, Calcium, DNA polymerase I, Plasmids
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18
المؤلفون: Gary J. Jesmok, Clark Q. Pan, Baisong Mei, Mohan Parmathi, Hendri Tjandra, John E. Murphy, Michael A. Fournel, James Newgren, Klaus-Peter Radtke, Haiyan Jiang, Kyle Landskroner, Liang Tang, Joanne Severs, Pamela Esmon, Jonathan S. Strauss, John Teare
المصدر: Blood. 108:1606-1606
مصطلحات موضوعية: Chemistry, Immunology, In vitro toxicology, Cell Biology, Hematology, Protein engineering, Pharmacology, Biochemistry, Coagulation, In vivo, hemic and lymphatic diseases, PEG ratio, PEGylation, Receptor, Cysteine
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19
المؤلفون: Clark Q. Pan, Thomas Barnett, Michael Fournel, J. E. Murphy, Baisong Mei, Harpartap Atwal, Liang Tang, Jennifer Nixon
المصدر: Blood. 108:4017-4017
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, biology, medicine.drug_class, Chemistry, animal diseases, Immunology, Mutagenesis, Cell Biology, Hematology, Polyethylene glycol, Pharmacology, Monoclonal antibody, Biochemistry, Virology, chemistry.chemical_compound, hemic and lymphatic diseases, mental disorders, PEG ratio, medicine, PEGylation, biology.protein, Binding site, Antibody, Cysteine
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