المؤلفون: Ekaterina Tankisheva, Ping He, Michael Aaron Brodney, Robert Alexander, Richard Margolin, Claire Leurent, Jessica Mancuso, Ruolun Qiu, Danny Chen, Jae Eun Ahn

المصدر: Journal of Alzheimer's Disease

مصطلحات موضوعية: Male, 0301 basic medicine, Thiazines, Administration, Oral, Pharmacology, amyloid-β peptides, 0302 clinical medicine, Aspartic Acid Endopeptidases, Aged, 80 and over, Cross-Over Studies, General Neuroscience, Cerebral degeneration, General Medicine, Middle Aged, Healthy Volunteers, Psychiatry and Mental health, Clinical Psychology, Tolerability, Female, Alzheimer’s disease, pharmacokinetics, Research Article, medicine.drug, Adult, safety, Adolescent, Young Adult, 03 medical and health sciences, Phase I, Double-Blind Method, Pharmacokinetics, pharmacodynamics, medicine, Humans, Protease Inhibitors, Dosing, tolerability, Adverse effect, Aged, Pyrans, Amyloid beta-Peptides, business.industry, Drug interaction, Thiazoles, BACE1 protein-human, 030104 developmental biology, Pharmacodynamics, Midazolam, Amyloid Precursor Protein Secretases, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec86be9ff67e9a596041cc3d5a1abc14
https://doi.org/10.3233/jad-190228

المؤلفون: Claire Leurent, Jessica Mancuso, Charles Carrieri, Constantino Kantaridis, Laure Mendes da Costa, Ruolun Qiu, Richann Liu, Terence Fullerton, Jae Eun Ahn, Ping He, Fernando Dela Cruz, Eva Hajos-Korcsok

المصدر: Clinical Pharmacology and Therapeutics

مصطلحات موضوعية: Drug, Adult, Male, Adolescent, media_common.quotation_subject, Pharmacology, 030226 pharmacology & pharmacy, Models, Biological, Article, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Cerebrospinal fluid, Pharmacokinetics, Medicine, Humans, Pharmacology (medical), Adverse effect, media_common, Aged, Randomized Controlled Trials as Topic, Aged, 80 and over, Amyloid beta-Peptides, Clinical Trials, Phase I as Topic, Dose-Response Relationship, Drug, business.industry, Research, Articles, Middle Aged, Dose–response relationship, Tolerability, 030220 oncology & carcinogenesis, Pharmacodynamics, Biomarker (medicine), Female, Amyloid Precursor Protein Secretases, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16619e9beb2c58d9d896f6f3123afafe
https://pubmed.ncbi.nlm.nih.gov/31314925

المؤلفون: Martin M. Bednar, Claire Leurent, James A. Goodman, Steven M. Greenberg, Monica Lindsay, Eric E. Smith, Yao Zhang, Ping He, Usharbudh Shivraj Sohur, Mahmut Edip Gurol, Anand Viswanathan, Jonathan R. Polimeni, Linda Frattura

المصدر: Annals of Clinical and Translational Neurology, 6, 795-806
Annals of Clinical and Translational Neurology, 6, 4, pp. 795-806
Annals of Clinical and Translational Neurology

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, medicine.medical_specialty, Placebo, Antibodies, Monoclonal, Humanized, Asymptomatic, 03 medical and health sciences, 0302 clinical medicine, Ponezumab, Double-Blind Method, Alzheimer Disease, Internal medicine, medicine, Humans, Immunologic Factors, Research Articles, Aged, Cerebral Hemorrhage, Intracerebral hemorrhage, Aged, 80 and over, Amyloid beta-Peptides, business.industry, General Neuroscience, Middle Aged, medicine.disease, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], Magnetic Resonance Imaging, Migraine with aura, Peptide Fragments, Cerebral Amyloid Angiopathy, 030104 developmental biology, Treatment Outcome, Tolerability, Monoclonal, Cardiology, Female, Neurology (clinical), Cerebral amyloid angiopathy, Immunotherapy, medicine.symptom, business, 030217 neurology & neurosurgery, Research Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6dfcb4685279750ab544fa32f67e61
http://hdl.handle.net/2066/207168

المؤلفون: Sridhar Duvvuri, Robert Carr, Phil Iredale, Carolyn Rowinski, Athan Spiros, Patrick Roberts, Tracey L. Rapp, Timothy Nicholas, Hugo Geerts, Claire Leurent, David Raunig

المصدر: Advances in Alzheimer's Disease. :83-98

مصطلحات موضوعية: Agonist, Intrinsic activity, Synaptic cleft, Working memory, medicine.drug_class, medicine, Cognition, General Medicine, Serotonergic, Psychology, Neuroscience, Partial agonist, Systems pharmacology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ad88a8337c961b248204d554ed6a6075
https://doi.org/10.4236/aad.2013.23012

المؤلفون: Ruolun Qiu, Laure Mendes da Costa, Robert C. Alexander, Richann Liu, Eva Hajos-Korcsok, Anne-Marie Wills, Ping He, Claire Leurent

المصدر: Alzheimer's & Dementia. 12

مصطلحات موضوعية: 0301 basic medicine, Amyloid, Epidemiology, business.industry, Health Policy, Safety tolerability, Pharmacology, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 030104 developmental biology, 0302 clinical medicine, Developmental Neuroscience, Pharmacokinetics, Healthy volunteers, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Gamma secretase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::88bb7f8149803a3fca73576742c23605
https://doi.org/10.1016/j.jalz.2016.06.1213

المؤلفون: Claire Leurent, Sridhar Duvvuri, Eve H. Pickering, James Kupiec, James A. Goodman, Jerome Barakos, Derek Purcell, Ping He, Gregory Klein, Eddie Martucci, Robert C. Alexander, Scott Kellogg

المصدر: Alzheimer's & Dementia. 12

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Amyloid, Epidemiology, Health Policy, Cognitive learning, Neurology (clinical), Healthy elderly, Geriatrics and Gerontology, Psychology, Developmental psychology, Clinical psychology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::95782b51aae4eeaa3ef89cf83517b926
https://doi.org/10.1016/j.jalz.2016.06.2219

المؤلفون: Laszlo Tora, P. Anthony Weil, Steven L. Sanders, Christine Ruhlmann, Véronique Mallouh, Patrick Schultz, Doris B. Kirschner, Claire Leurent

المصدر: The EMBO Journal. 21:3424-3433

مصطلحات موضوعية: Models, Molecular, Saccharomyces cerevisiae Proteins, Multiprotein complex, Macromolecular Substances, Protein Conformation, Amino Acid Motifs, RNA polymerase II, Saccharomyces cerevisiae, Article, General Biochemistry, Genetics and Molecular Biology, Histones, Structure-Activity Relationship, Transcription Factors, TFII, Species Specificity, Protein Interaction Mapping, Image Processing, Computer-Assisted, Animals, Drosophila Proteins, Humans, Microscopy, Immunoelectron, Molecular Biology, Transcription factor, TATA-Binding Protein Associated Factors, General Immunology and Microbiology, biology, General Neuroscience, Precipitin Tests, Molecular biology, Protein Structure, Tertiary, Cell biology, Microscopy, Electron, TAF1, Multiprotein Complexes, Histone fold, Transcription Factor TFIID, biology.protein, Transcription factor II D, Dimerization, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a185e30272ea5b8ae415789127096766
https://doi.org/10.1093/emboj/cdf342

المؤلفون: Sridhar Duvvuri, Carolyn Rowinski, Jeremias Antinew, Tracey L. Rapp, Timothy Nicolas, Laura Zumpano, Joy Sieklucki, Michelle Bergeron, David Raunig, Hetal S. Kocinsky, Claire Leurent

المصدر: Alzheimer's & Dementia. 8

مصطلحات موضوعية: Epidemiology, business.industry, Health Policy, Cognition, Placebo, Double blind, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Anesthesia, Scopolamine, medicine, Neurology (clinical), Geriatrics and Gerontology, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d83337e5539ccd7635f5f9e97440c2dd
https://doi.org/10.1016/j.jalz.2012.05.1586

المؤلفون: Claire Leurent, Sridhar Duvvuri, Athan Spiros, Phillip Iredale, Timothy Nicholas, Patrick Roberts, Robert Carr, Hugo Geerts, David Raunig, Carolyn Rowinski, Tracey L. Rapp

المصدر: Alzheimer's & Dementia. 8

مصطلحات موضوعية: Saliva, Pathology, medicine.medical_specialty, Salmonella, biology, Epidemiology, business.industry, animal diseases, Health Policy, Antibody titer, Urine, medicine.disease_cause, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Titer, medicine.anatomical_structure, Developmental Neuroscience, Tonsil, medicine, biology.protein, Neurology (clinical), Geriatrics and Gerontology, Antibody, business, Feces

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::30b3941b54c369b5abe8ccbe883f81ae
https://doi.org/10.1016/j.jalz.2012.05.1110

المؤلفون: Sridhar Duvvuri, Joanne Bell, Tracey L. Rapp, James P. Mancuso, Grace M. Vandal, Anna Plotka, James Kupiec, Hifan Huang, Clare B. Billing, David Raunig, Claire Leurent

المصدر: Alzheimer's & Dementia. 8

مصطلحات موضوعية: Psychomotor learning, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Crossover, Cognition, Clinical study, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Physical medicine and rehabilitation, Developmental Neuroscience, medicine, Scopolamine, Neurology (clinical), Geriatrics and Gerontology, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::72a498ec78e28780e90a83af21d91e9e
https://doi.org/10.1016/j.jalz.2013.08.104

المؤلفون: Carolyn Rowinski, David Raunig, Sridhar Duvvuri, Elias Schwam, Anna Plotka, Sarah Grimwood, Claire Leurent, Timothy Nicholas, Tracey L. Rapp

المصدر: Alzheimer's & Dementia. 8

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, business.industry, Health Policy, Medicine, Neurology (clinical), Geriatrics and Gerontology, Pharmacology, business, Partial agonist, PK/PD models

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::001a7b8f05bef0d4c0a597d490e27244
https://doi.org/10.1016/j.jalz.2012.05.778

المؤلفون: Jason Barricklow, Christine K. Taylor, Louis Leung, Cheng Chang, Robin Roof, Keri E. Cannon, Laura McDowell, Todd Wisialowski, Rathna Iyer, Claire Leurent, Betty Pettersen, Julie Cianfrogna, Allen J. Duplantier, Faith Prior, Michael Aaron Brodney

المصدر: Alzheimer's & Dementia. 7

مصطلحات موضوعية: Epidemiology, Mechanism (biology), business.industry, Health Policy, Symptomatic treatment, Antagonist, Disease, Pharmacology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Nociceptin receptor, Developmental Neuroscience, Medicine, Neurology (clinical), Geriatrics and Gerontology, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0193b7c3175c689a56b04e3c5417106c
https://doi.org/10.1016/j.jalz.2011.05.2207

المؤلفون: Robin Roof, Faith Prior, Michael Aaron Brodney, Laura McDowell, Bradley Snyder, Elizabeth C. Arnold, Rathna Iyer, Allen J. Duplantier, Claire Leurent, Panayiotis Zagouras

المصدر: Alzheimer's & Dementia. 7

مصطلحات موضوعية: Epidemiology, Mechanism (biology), business.industry, Health Policy, Disease, Bioinformatics, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Beneficial effects, Depressive symptoms

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::02883701e24f9290329cf5633b0a678f
https://doi.org/10.1016/j.jalz.2011.05.2211

المؤلفون: Carolyn Rowinski, Sridhar Duvvuri, Timothy Nicholas, Michelle Bergeron, Claire Leurent, Yo-sub Park, Anna Plotka, David Raunig, Sarah Grimwood, Elias Schwam, Tracey L. Rapp

المصدر: Alzheimer's & Dementia. 7

مصطلحات موضوعية: Epidemiology, business.industry, Health Policy, Disease, Pharmacology, Partial agonist, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Pharmacokinetics, Tolerability, Medicine, Neurology (clinical), Geriatrics and Gerontology, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3e4565a5c17665b6e8368c3d791ccac2
https://doi.org/10.1016/j.jalz.2011.05.2259

المؤلفون: Michelle Vanase-Frawley, Michael Aaron Brodney, Robin Roof, Faith Prior, Laura McDowell, Allen J. Duplantier, Rouba Kozak, Julie Cianfrogna, Patricia A. Seymour, Dina McGinnis, Chester J. Siok, Cheng Chang, Louis Leung, Claire Leurent, Mihály Hajós, Rathna Iyer

المصدر: Alzheimer's & Dementia. 7

مصطلحات موضوعية: Epidemiology, business.industry, Health Policy, Antagonist, Cognition, Hippocampal function, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Nociceptin receptor, Developmental Neuroscience, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9004b8a9274e5bb126af30de53b93dd7
https://doi.org/10.1016/j.jalz.2011.05.2220

المؤلفون: Ken Zasadny, Claire Leurent, Emily Miller, Carolyn Rowinski, Michael Aaron Brodney, Evan D. Morris, Karen J. Coffman, Adam Ogden, Beata Planeta-Wilson, Richard E. Carson, David Raunig, Marc B. Skaddan, Yi Wang, Tracey L. Rapp, Sarah Grimwood, Timothy Nicholas, Jim Ropchan, Yo-sub Park, Yu-Shin Ding, Elyse Katz, Sridhar Duvvuri, Elena M. Drummond, Aarti Sawant

المصدر: Alzheimer's & Dementia. 7

مصطلحات موضوعية: medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Partial agonist, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Endocrinology, Developmental Neuroscience, Internal medicine, Healthy volunteers, medicine, Neurology (clinical), Geriatrics and Gerontology, business, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::78d0acfea9b6776cccd7e03713ed0bfc
https://doi.org/10.1016/j.jalz.2011.05.1875

المؤلفون: Karl Rickels, Sudharshan K. Padmanabhan, Claire Leurent, J. D. Guelfi, Jean-Michael Germain, Claudine Brisard, Bruno Pitrosky, Stuart Montgomery, Karen A. Tourian

المصدر: Journal of clinical psychopharmacology. 30(1)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Population, Relapse prevention, Placebo, law.invention, Randomized controlled trial, Double-Blind Method, law, Internal medicine, Desvenlafaxine Succinate, medicine, Secondary Prevention, Humans, Pharmacology (medical), education, Psychiatry, Psychiatric Status Rating Scales, education.field_of_study, Depressive Disorder, Major, Dose-Response Relationship, Drug, Hamilton Rating Scale for Depression, Cyclohexanols, Antidepressive Agents, Discontinuation, Desvenlafaxine, Psychiatry and Mental health, Treatment Outcome, Female, Psychology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77af6ebd8748b43373de239102abaa34
https://pubmed.ncbi.nlm.nih.gov/20075643

المؤلفون: Marjorie Brand, Claire Leurent, Laszlo Tora, Patrick Schultz, Véronique Mallouh

المصدر: Science. 286:2151-2153

مصطلحات موضوعية: Models, Molecular, Protein Folding, Protein Conformation, genetic processes, information science, RNA polymerase II, macromolecular substances, Transcription Factors, TFII, chemistry.chemical_compound, Protein structure, Image Processing, Computer-Assisted, Humans, Transcription factor, TATA-Binding Protein Associated Factors, Genetics, Multidisciplinary, biology, Protein Structure, Tertiary, DNA-Binding Proteins, Microscopy, Electron, PCAF, chemistry, Transcription Factor TFIID, health occupations, Biophysics, biology.protein, Transcription factor II D, DNA, HeLa Cells, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8ae78dac88e224f4ab5675d722d9702
https://doi.org/10.1126/science.286.5447.2151

المؤلفون: Claire Leurent, Jay Graepel, Karen A. Tourian, Philip T. Ninan

المصدر: Primary care companion to the Journal of clinical psychiatry. 12(1)

مصطلحات موضوعية: Fluoxetine, medicine.medical_specialty, business.industry, Weight change, Venlafaxine, Articles, Desvenlafaxine, Psychiatry and Mental health, Weight loss, Internal medicine, medicine, Antidepressant, medicine.symptom, business, Psychiatry, Weight gain, Desvenlafaxine Succinate, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6681454dd532c3d1c2f0eb92a0173bc9
https://pubmed.ncbi.nlm.nih.gov/20582292

المؤلفون: Christine Ruhlmann, Laszlo Tora, P. Anthony Weil, Patrick Schultz, Claire Leurent, Krassimira A. Garbett, Steven L. Sanders, Máté Á. Demény

المصدر: The EMBO journal. 23(4)

مصطلحات موضوعية: Models, Molecular, TATA box, genetic processes, macromolecular substances, Biology, General Biochemistry, Genetics and Molecular Biology, Article, Fungal Proteins, Microscopy, Electron, Transmission, Acetyltransferases, Protein Structure, Quaternary, Molecular Biology, Histone Acetyltransferases, TATA-Binding Protein Associated Factors, General Immunology and Microbiology, General Neuroscience, TATA-Box Binding Protein, TAF7, Molecular biology, Recombinant Proteins, Cell biology, Protein Structure, Tertiary, TAF1, TAF4, Transcription Factor TFIID, health occupations, RNA Polymerase II, Transcription factor II A

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a323c2ac3cb8924b7385457bb55573f1
https://pubmed.ncbi.nlm.nih.gov/14765106