المؤلفون: Ryan M. Esquejo, Christopher T. Salatto, Jake Delmore, Bina Albuquerque, Allan Reyes, Yuji Shi, Rob Moccia, Emily Cokorinos, Matthew Peloquin, Mara Monetti, Jason Barricklow, Eliza Bollinger, Brennan K. Smith, Emily A. Day, Chuong Nguyen, Kieran F. Geoghegan, John M. Kreeger, Alan Opsahl, Jessica Ward, Amit S. Kalgutkar, David Tess, Lynne Butler, Norimitsu Shirai, Timothy F. Osborne, Gregory R. Steinberg, Morris J. Birnbaum, Kimberly O. Cameron, Russell A. Miller

المصدر: EBioMedicine, Vol 31, Iss , Pp 122-132 (2018)

مصطلحات موضوعية: Medicine, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396418301373; https://doaj.org/toc/2352-3964

URL الوصول: https://doaj.org/article/3a6b1a8ecd964eee8550aafb2b27ef05

المؤلفون: Liuqing Wei, Jun Xiao, Joseph S. Warmus, Jeffrey R. Chabot, Robert Dullea, Christopher T. Salatto, David W. Piotrowski, Benjamin A. Thuma, Donna N. Petersen, Chris Limberakis, Julien Genovino, Steven B. Coffey, Michael W. Bolt, Kim F. McClure, Kevin D. Hesp, Spiros Liras, Jamie H. D. Cate, Nathanael G. Lintner, Allyn T. Londregan, Gary Erik Aspnes, Benjamin Reidich

المصدر: Journal of Medicinal Chemistry. 61:5704-5718

مصطلحات موضوعية: Male, 0301 basic medicine, 01 natural sciences, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, In vivo, Drug Discovery, Animals, Structure–activity relationship, Protease Inhibitors, 010405 organic chemistry, Chemistry, PCSK9, PCSK9 Inhibitors, Subtilisin, Hit to lead, Proprotein convertase, Small molecule, Rats, 0104 chemical sciences, 030104 developmental biology, Biochemistry, Drug Design, Molecular Medicine, Kexin, Safety

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46075104e513dd56e96e55dc41b689b9
https://doi.org/10.1021/acs.jmedchem.8b00650

المؤلفون: Jessica Ward, Jason Barricklow, Chuong Nguyen, Eliza Bollinger, Christopher T. Salatto, Bina Albuquerque, Mara Monetti, Norimitsu Shirai, Emily A. Day, Emily Cokorinos, Kieran F. Geoghegan, Gregory R. Steinberg, Rob Moccia, Matthew Peloquin, Ryan M. Esquejo, Morris J. Birnbaum, Russell A. Miller, Alan C. Opsahl, Brennan K. Smith, Jake Delmore, Kimberly O. Cameron, Timothy F. Osborne, Allan R. Reyes, John M. Kreeger, Lynne Butler, David A. Tess, Amit S. Kalgutkar, Yuji Shi

المصدر: EBioMedicine, Vol 31, Iss, Pp 122-132 (2018)
EBioMedicine

مصطلحات موضوعية: 0301 basic medicine, AMPK, Primates, medicine.medical_specialty, Indoles, lcsh:Medicine, Rodentia, AMP-Activated Protein Kinases, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, chemistry.chemical_compound, Liver disease, Non-alcoholic Fatty Liver Disease, Internal medicine, NAFLD, Medicine, Animals, Protein kinase A, ACC, lcsh:R5-920, business.industry, Activator (genetics), Cholesterol, Lipogenesis, lcsh:R, General Medicine, medicine.disease, 3. Good health, 030104 developmental biology, Endocrinology, Hyperlipidemia, chemistry, Liver, lipids (amino acids, peptides, and proteins), Steatohepatitis, business, Hepatic fibrosis, lcsh:Medicine (General), Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f1c5af9f8bcc8ab432732a5031a0fe
http://www.sciencedirect.com/science/article/pii/S2352396418301373

المؤلفون: Dennis O. Scott, Spiros Liras, Roger B. Ruggeri, Heather Eng, Adam S. Kamlet, Ryosuke Arakawa, David W. Piotrowski, Robert Dullea, Christopher T. Salatto, Karen Atkinson, Michael W. Bolt, Anne-Marie R. Dechert-Schmitt, Paul DaSilva-Jardine, Allyn T. Londregan, Brian Raymer, Kenneth Dahl, Daniel P. Canterbury, Donna N. Petersen, Paula M. Loria, Chris Limberakis, Emi Kimoto, Kim F. McClure, Kevin Beaumont, Liuqing Wei, Akihiro Takano, Kevin P. Maresca, Jun Xiao, Amanda King-Ahmad, Christer Halldin, Benjamin Reidich, Jeffrey R. Chabot

المصدر: Angewandte Chemie International Edition. 56:16218-16222

مصطلحات موضوعية: 0301 basic medicine, Drug, media_common.quotation_subject, Ribosome, Catalysis, Small Molecule Libraries, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Humans, media_common, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, PCSK9, PCSK9 Inhibitors, Subtilisin, General Medicine, General Chemistry, Prodrug, Proprotein convertase, Small molecule, 030104 developmental biology, Liver, Biochemistry, 030220 oncology & carcinogenesis, Hepatocytes, Kexin, Proprotein Convertase 9

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284063acd5910c34eb16ba576995a299
https://doi.org/10.1002/anie.201708744

المؤلفون: Paul DaSilva-Jardine, Jessica Ward, Katherine Cialdea, Matthew F. Calabrese, Marina Amaro, Harmeet Gandhok, Francis Rajamohan, Alan C. Opsahl, Mara Monetti, Kimberly O. Cameron, Tim Rolph, Eliza Bollinger, Benjamin S. Maciejewski, Ravi G. Kurumbail, Christopher T. Salatto, Timothy M. Coskran, David A. Tess, Aditi Jatkar, Nathan E. Genung, Emily Cokorinos, Allan R. Reyes, Morris J. Birnbaum, Germaine Boucher, John M. Kreeger, Andre Shavnya, David J. Edmonds, Russell A. Miller, Amit S. Kalgutkar

المصدر: Journal of Pharmacology and Experimental Therapeutics. 361:303-311

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Kidney, medicine.medical_specialty, business.industry, Kidney metabolism, Renal function, AMPK, medicine.disease, Diabetic nephropathy, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Endocrinology, Fibrosis, 030220 oncology & carcinogenesis, Internal medicine, medicine, Molecular Medicine, business, Protein kinase A, Kidney disease

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f66e0afa566f1f67e7eeedde3c3b2a37
https://doi.org/10.1124/jpet.116.237925

المؤلفون: Jane M. Withka, Daniel W. Kung, Russell A. Miller, Matthew S. Dowling, Aaron C. Smith, Angela Wolford, Heather Eng, Janice A. Brown, Jun Xiao, Kris A. Borzilleri, Ravi G. Kurumbail, David J. Edmonds, Jessica Ward, Amit S. Kalgutkar, Colin R. Rose, Tim F. Ryder, Meihua Tu, Dilinie P. Fernando, Emily Cokorinos, David Hepworth, James A. Landro, Kimberly O. Cameron, Matthew F. Calabrese, Christopher T. Salatto, Francis Rajamohan, Andre Shavnya, Markus Boehm, Yuxia Mao, Allan R. Reyes, Richard K. Frisbie, Nicole Caspers, Edward L. Conn, Samit Kumar Bhattacharya

المصدر: Journal of Medicinal Chemistry. 59:8068-8081

مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Adenosine monophosphate, Indazoles, Indoles, Protein Conformation, Administration, Oral, Enzyme Activators, AMP-Activated Protein Kinases, Crystallography, X-Ray, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, AMP-activated protein kinase, Drug Discovery, medicine, Animals, Humans, Diabetic Nephropathies, Protein kinase A, Indole test, Indazole, biology, Activator (genetics), Chemistry, AMPK, Adenosine, High-Throughput Screening Assays, Rats, Macaca fascicularis, 030104 developmental biology, Biochemistry, 030220 oncology & carcinogenesis, Injections, Intravenous, biology.protein, Molecular Medicine, Adsorption, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635e2459bb078e726c0e9a8f44099dcd
https://doi.org/10.1021/acs.jmedchem.6b00866

المؤلفون: Kimberly O. Cameron, Kevin J. Filipski, Jana Polivkova, Matthew S. Dowling, Andre Shavnya, Gary Erik Aspnes, David Christopher Ebner, Allan R. Reyes, Qifang Li, Michael Herr, Jun Xiao, Jessica Ward, Shawn Cabral, Heather Eng, Sophie Y. Lavergne, Ravi G. Kurumbail, Jane M. Withka, Samit Kumar Bhattacharya, Dilinie P. Fernando, Meihua Tu, Edward L. Conn, Bo Feng, Janice A. Brown, Daniel W. Kung, Francis Rajamohan, Esther C.Y. Lee, Russell A. Miller, Emily Cokorinos, Christopher T. Salatto, Nicole Caspers, Nathan E. Genung, Jane Panteleev, Benjamin A. Thuma, Matthew F. Calabrese, Sumathy Mathialagan, Aaron C. Smith, Kris A. Borzilleri, David J. Edmonds, Amit S. Kalgutkar

المصدر: Journal of medicinal chemistry. 61(6)

مصطلحات موضوعية: 0301 basic medicine, Adenosine monophosphate, Male, Models, Molecular, Indoles, Organic anion transporter 1, Glucuronidation, Enzyme Activators, Pharmacology, AMP-Activated Protein Kinases, Organic Anion Transporters, Sodium-Independent, Kidney, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, In vivo, Drug Discovery, medicine, Animals, Humans, Rats, Wistar, Protein kinase A, biology, AMPK, Adenosine, Rats, Enzyme Activation, 030104 developmental biology, chemistry, Intestinal Absorption, Renal physiology, biology.protein, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ccac15ee02a34e6adc23a5d238341d
https://pubmed.ncbi.nlm.nih.gov/29466005

المؤلفون: Boris A. Chrunyk, Vincent Mascitti, Michael M. Baksh, Robert Dullea, Marc D. Roy, David Price, Cathy Préville, Carlos A. Sanhueza, Wen Lin, Elnaz Menhaji-Klotz, Meihua Tu, Amanda King-Ahmad, David F. Gebhard, Benjamin A. Thuma, Mark Ammirati, James E. Finley, Christopher T. Salatto, Spiros Liras, Sanjay Dutta, Shenping Liu, Benjamin Reidich, Kevin Beaumont, Ingrid A. Stock, Karen Atkinson, Rajesh Kumar, M. G. Finn

المصدر: Journal of the American Chemical Society. 139(9)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Biodistribution, Liver cytology, Polymers, Asialoglycoprotein Receptor, 010402 general chemistry, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Catalysis, Article, 03 medical and health sciences, chemistry.chemical_compound, Bridged Bicyclo Compounds, Colloid and Surface Chemistry, medicine, Humans, Drug Carriers, Ligand efficiency, Molecular Structure, Chemistry, Oxanorbornadiene, General Chemistry, Ketones, Ligand (biochemistry), 0104 chemical sciences, 030104 developmental biology, medicine.anatomical_structure, Liver, Hepatocyte, Hepatocytes, Asialoglycoprotein receptor, Conjugate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960308770c3c39141859f247dd5ef639
https://pubmed.ncbi.nlm.nih.gov/28230359

المؤلفون: Christopher T, Salatto, Russell A, Miller, Kimberly O, Cameron, Emily, Cokorinos, Allan, Reyes, Jessica, Ward, Matthew F, Calabrese, Ravi G, Kurumbail, Francis, Rajamohan, Amit S, Kalgutkar, David A, Tess, Andre, Shavnya, Nathan E, Genung, David J, Edmonds, Aditi, Jatkar, Benjamin S, Maciejewski, Marina, Amaro, Harmeet, Gandhok, Mara, Monetti, Katherine, Cialdea, Eliza, Bollinger, John M, Kreeger, Timothy M, Coskran, Alan C, Opsahl, Germaine G, Boucher, Morris J, Birnbaum, Paul, DaSilva-Jardine, Tim, Rolph

المصدر: The Journal of pharmacology and experimental therapeutics. 361(2)

مصطلحات موضوعية: Indoles, Aminopyridines, Enzyme Activators, AMP-Activated Protein Kinases, Kidney, Kidney Function Tests, Fibrosis, Rats, Enzyme Activation, Isoenzymes, Mice, Inbred C57BL, Macaca fascicularis, Oxidative Stress, Proteinuria, Species Specificity, Animals, Humans, Diabetic Nephropathies, Phosphorylation, Cell Size

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::dabb362de095f5aa2c5ef6849429242e
https://pubmed.ncbi.nlm.nih.gov/28289077

المؤلفون: Yan Weng, Christopher T. Salatto, Robert V. Stanton, Debra Moshinsky, Debra A. DiMattia, Mei Liu, John M. Kreeger, Robert Dullea, Jessie Qian, Marc D. Roy, Tracey Clark, Jeremy Little, Evan Walters, Simone Sciabola, Tracy Chen

المصدر: Nucleic Acid Therapeutics. 22:344-359

مصطلحات موضوعية: Male, Adenosine, Oligonucleotides, Context (language use), Cytidine, Biology, Kidney, Transfection, Biochemistry, Mice, Receptors, Glucocorticoid, In vivo, Cell Line, Tumor, Oxazines, Drug Discovery, Genetics, Gene Knockdown Techniques, Animals, Humans, Transition Temperature, RNA, Messenger, Locked nucleic acid, Molecular Biology, Gene knockdown, Base Sequence, Guanosine, Oligonucleotide, Kidney metabolism, Oligonucleotides, Antisense, Molecular biology, Mice, Inbred C57BL, Gene Expression Regulation, Liver, Molecular Medicine, Thymidine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7c8f19b047c941c55b125e110c3fdf
https://doi.org/10.1089/nat.2012.0366

المؤلفون: Beijing Tan, Stephen W. Wright, Karen Atkinson, Janice A. Brown, Angel Guzman-Perez, Kevin J. Filipski, John Litchfield, Mary Theresa Didiuk, Esther C.Y. Lee, Christopher T. Salatto, Jian-Cheng Li, David Christopher Ebner, Meihua Tu, Jeffrey A. Pfefferkorn, Jianwei Bian, Christian Perreault, Matthew F. Sammons, Benjamin D. Stevens

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:415-420

مصطلحات موضوعية: medicine.medical_specialty, Chemistry, Pharmaceutical, Clinical Biochemistry, Pharmaceutical Science, Pyrazole, Ether, Biochemistry, Glucagon, chemistry.chemical_compound, Dogs, Pharmacokinetics, Internal medicine, Diabetes mellitus, Drug Discovery, Diabetes Mellitus, Receptors, Glucagon, medicine, Animals, Humans, Receptor, Molecular Biology, Dose-Response Relationship, Drug, Organic Chemistry, Temperature, medicine.disease, Rats, Molecular Weight, Kinetics, Dose–response relationship, Glucose, Endocrinology, Models, Chemical, chemistry, Drug Design, Lipophilicity, Pyrazoles, Molecular Medicine, Glucagon receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e84026e85448c47076ca75b76b5fd9
https://doi.org/10.1016/j.bmcl.2011.10.113

المؤلفون: Sarah M. Snell, Kate T. Murphy, Kathryn S. Holden, James G. Ryall, Lawrence Nair, Gordon S. Lynch, Philip A. Krasney, Christopher T. Salatto, Paula M. Loria, René Koopman, Chikwendu Ibebunjo

المصدر: The American Journal of Pathology. 176:2425-2434

مصطلحات موضوعية: Male, Aging, Pathology, medicine.medical_specialty, Time Factors, Duchenne muscular dystrophy, Diaphragm, Muscle Fibers, Skeletal, Myostatin, Biology, Pathology and Forensic Medicine, Muscle hypertrophy, Inhibitory Concentration 50, Mice, medicine, Animals, Respiratory system, Muscular dystrophy, Mice, Inbred C3H, Skeletal muscle, Muscular Dystrophy, Animal, musculoskeletal system, medicine.disease, Pathophysiology, Mice, Inbred C57BL, medicine.anatomical_structure, Mice, Inbred mdx, biology.protein, medicine.symptom, Regular Articles, Muscle Contraction, Muscle contraction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d925ba44c63d0cb39c1c93d6ca6d8da
https://doi.org/10.2353/ajpath.2010.090932

المؤلفون: Hollis A. Simmons, Xiao-Ning Wang, David D. Thompson, Christopher T. Salatto, Patricia G. Cosgrove

المصدر: Menopause. 13:609-620

مصطلحات موضوعية: Selective Estrogen Receptor Modulators, medicine.medical_specialty, Pyrrolidines, Tetrahydronaphthalenes, Ovariectomy, Vaginal Diseases, Administration, Oral, Estrogen receptor, Ethinyl Estradiol, Vaginal mucus, Vaginal estrogen, Rats, Sprague-Dawley, Internal medicine, medicine, Animals, Estrogen Receptor beta, Raloxifene, Mucous Membrane, Dose-Response Relationship, Drug, business.industry, Uterus, Obstetrics and Gynecology, Lasofoxifene, Rats, Postmenopause, Androgen receptor, Disease Models, Animal, Tamoxifen, Endocrinology, Receptors, Androgen, Raloxifene Hydrochloride, Vagina, Female, Atrophy, business, Estrogen receptor alpha, hormones, hormone substitutes, and hormone antagonists, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01f88dcd3cc9d75b7f900e6f1182f87
https://doi.org/10.1097/01.gme.0000227337.73738.c9

المؤلفون: Kate Murphy, James G Ryall, Sarah M Snell, Lawrence Nair, René Koopman, Philip A Krasney, Chikwendu Ibebunjo, Kathryn S Holden, Paula M Loria, Christopher T Salatto, Gordon S Lynch

مصطلحات موضوعية: Biomedical and clinical sciences, Medical physiology, Health sciences, Aging, Animals, Diaphragm, Inhibitory Concentration 50, Male, Mice, Inbred C3H, Inbred C57BL, Inbred mdx, Muscle Contraction, Muscle Fibers, Skeletal, Muscular Dystrophy, Animal, Myostatin, Time Factors

Relation: http://hdl.handle.net/10779/DRO/DU:26801767.v1

الاتاحة: http://hdl.handle.net/10779/DRO/DU:26801767.v1
https://figshare.com/articles/journal_contribution/Antibody-Directed_Myostatin_Inhibition_Improves_Diaphragm_Pathology_in_Young_but_not_Adult_Dystrophic_mdx_Mice/26801767

المؤلفون: Michael Marconi, Karl E.G. Richter, Christopher T. Salatto, Anthony R. Semproni, Frederick R. Nelson, Kari Schmidt, Thomas A. Lanz, Joel B. Schachter, Tracy M. Brown

المصدر: Biochemical pharmacology. 75(5)

مصطلحات موضوعية: Male, medicine.medical_specialty, medicine.medical_treatment, Tau protein, Mice, Transgenic, Biochemistry, Cell Line, Myoblasts, Rats, Sprague-Dawley, Mice, Degenerative disease, Dogs, Western blot, Pharmacokinetics, Growth hormone secretagogue, In vivo, Internal medicine, mental disorders, medicine, Animals, Humans, Insulin-Like Growth Factor I, Rats, Wistar, Pharmacology, Amyloid beta-Peptides, medicine.diagnostic_test, biology, Myosin Heavy Chains, business.industry, Growth factor, Brain, medicine.disease, Recombinant Proteins, Rats, Endocrinology, biology.protein, Female, Alzheimer's disease, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80e59edc3bbbfd0694eb073e3727e42
https://pubmed.ncbi.nlm.nih.gov/18076866

المؤلفون: Terri A. Swanson, Theresa Tuthill, Alan C. Opsahl, Christopher T. Salatto, Benjamin S. Maciejewski

المصدر: Ultrasound in Medicine & Biology. 41:S14

مصطلحات موضوعية: medicine.medical_specialty, Acoustics and Ultrasonics, Radiological and Ultrasound Technology, business.industry, Ultrasound, Biophysics, Quantitative assessment, Medicine, Radiology, Nuclear Medicine and imaging, Myocardial fibrosis, Radiology, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1c22ea731ccb73a42a6dbc46a788e22b
https://doi.org/10.1016/j.ultrasmedbio.2014.12.105

المؤلفون: Christopher T Salatto, Russell A Miller, Kimberly O Cameron, Emily Cokorinos, Allan Reyes, Jessica Ward, Matt Calabrese, Ravi Kurumbail, Francis Rajamohan, Amit S Kalgutkar, David A Tess, Andre Shavnya, Nathan E Genung, David J Edmonds, Aditi Jatkar, Benjamin S Maciejewski, Marina Amaro, Harmeet Gandhok, Mara Monetti, Katherine Cialdea, Eliza Bollinger, John M Kreeger, Timothy M Coskran, Alan C Opsahl, Germaine G Boucher, Morris J Birnbaum, Paul Dasilva-Jardine, Tim Rolph

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://jpet.aspetjournals.org/content/jpet/early/2017/03/13/jpet.116.237925.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1046.9897; http://jpet.aspetjournals.org/content/jpet/early/2017/03/13/jpet.116.237925.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1046.9897
http://jpet.aspetjournals.org/content/jpet/early/2017/03/13/jpet.116.237925.full.pdf