المؤلفون: C. Edwin Garner, Christopher J. Wegerski, Melanie Doyle-Eisele, Jacob D. McDonald, J. Michael Sanders, Benjamin C. Moeller, Suramya Waidyanatha

المصدر: Toxicology Reports, Vol 7, Iss , Pp 883-892 (2020)

مصطلحات موضوعية: Metabolism, Disposition, Distribution, Absorption, Toxicology. Poisons, RA1190-1270

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2214750020303516; https://doaj.org/toc/2214-7500

URL الوصول: https://doaj.org/article/ccfc7d63e08048ffa968a1f99f964164

المؤلفون: Kevin R. Webster, Siegfried H. Reich, Justin T. Ernst, Paul A. Sprengeler, Chinh Tran, Theodore Michels, Garrick K. Packard, Christian Nilewski, Alan Xiang, Samuel Sperry, Jeff Clarine, Andres Nevarez, Christopher J. Wegerski, Adina Gerson-Gurwitz, Gary G. Chiang, Jocelyn Staunton, Ana Parra, Eric Sung, Haleigh Howard, Maria Barrera, Joan Chen, Sarah Fish, Nathan P. Young, Boreth Eam, Peggy A. Thompson

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1650a320f50adfe95d94d63fa8b72d9e
https://doi.org/10.1158/1535-7163.c.6542892.v1

المؤلفون: Kevin R. Webster, Siegfried H. Reich, Justin T. Ernst, Paul A. Sprengeler, Chinh Tran, Theodore Michels, Garrick K. Packard, Christian Nilewski, Alan Xiang, Samuel Sperry, Jeff Clarine, Andres Nevarez, Christopher J. Wegerski, Adina Gerson-Gurwitz, Gary G. Chiang, Jocelyn Staunton, Ana Parra, Eric Sung, Haleigh Howard, Maria Barrera, Joan Chen, Sarah Fish, Nathan P. Young, Boreth Eam, Peggy A. Thompson

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b76301f84d3ad65de199ac1ded585c
https://doi.org/10.1158/1535-7163.22521054.v1

المؤلفون: Haleigh Howard, Eric Sung, Samuel Sperry, Christopher J. Wegerski, Tran Chinh Viet, Adina Gerson-Gurwitz, Gary G. Chiang, Garrick Packard, Andres Nevarez, Paul A. Sprengeler, Joan Chen, Jocelyn Staunton, Kevin R. Webster, Maria Barrera, Reich Siegfried Heinz, Ana Parra, Nathan P Young, Alan Xiang, Justin T. Ernst, Sarah Fish, Theodore Michels, Peggy A. Thompson, Christian Nilewski, Jeff Clarine, Boreth Eam

المصدر: Molecular Cancer Therapeutics. 20:26-36

مصطلحات موضوعية: 0301 basic medicine, Untranslated region, Cancer Research, Lymphoma, B-Cell, Mice, SCID, medicine.disease_cause, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Mice, Inbred NOD, In vivo, Cell Line, Tumor, Biomarkers, Tumor, medicine, Animals, Humans, PTEN, RNA, Messenger, EIF4B, Protein kinase B, PI3K/AKT/mTOR pathway, biology, EIF4G, TOR Serine-Threonine Kinases, PTEN Phosphohydrolase, Oncogenes, Xenograft Model Antitumor Assays, 030104 developmental biology, Oncology, chemistry, Drug Resistance, Neoplasm, Protein Biosynthesis, 030220 oncology & carcinogenesis, Eukaryotic Initiation Factor-4A, biology.protein, Cancer research, Female, Carcinogenesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14e9801128ca86bd9b7b59cc4c5bb4e
https://doi.org/10.1158/1535-7163.mct-19-0973

المؤلفون: Peggy A. Thompson, Garrick Kenneth Packard, Theodore Michels, Boreth Eam, Alan X. Xiang, Reich Siegfried Heinz, Sarah Fish, Christian Nilewski, Paul A. Sprengeler, Justin T. Ernst, Christopher J. Wegerski

المصدر: Organic Letters. 22:6257-6261

مصطلحات موضوعية: Biological Products, Eukaryotic Initiation Factor-4A, Scaffold, Binding Sites, Natural product, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Substituent, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences, chemistry.chemical_compound, Rocaglamide, Eukaryotic initiation factor-4, eIF4A, Humans, Surface modification, Physical and Theoretical Chemistry, Benzofurans

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c6c6ced9312dfa787e7deaa5389be5
https://doi.org/10.1021/acs.orglett.0c01944

المؤلفون: J. Michael Sanders, Jacob D. McDonald, Benjamin C. Moeller, Suramya Waidyanatha, Melanie Doyle-Eisele, C. Edwin Garner, Christopher J. Wegerski

المصدر: Toxicology Reports
Toxicology Reports, Vol 7, Iss, Pp 883-892 (2020)

مصطلحات موضوعية: Health, Toxicology and Mutagenesis, Clinical Sciences, Urine, Absorption (skin), 010501 environmental sciences, Pharmacology, Disposition, Distribution, Toxicology, 01 natural sciences, Absorption, Medicinal and Biomolecular Chemistry, 03 medical and health sciences, 0302 clinical medicine, lcsh:RA1190-1270, Oral administration, Medicine, Feces, lcsh:Toxicology. Poisons, 0105 earth and related environmental sciences, business.industry, Regular Article, Metabolism, Chemical used, Other Chemical Sciences, business, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f63b86461156a14666608432afce413
http://europepmc.org/articles/PMC7390853

المؤلفون: Christopher J. Wegerski, Jacob D. McDonald, Suramya Waidyanatha, Barry S. McIntyre, C. Edwin Garner, Melanie Doyle-Eisele, Esra Mutlu

المصدر: Xenobiotica

مصطلحات موضوعية: Health, Toxicology and Mutagenesis, Mice, Inbred Strains, Absorption (skin), Pharmacology, Toxicology, 030226 pharmacology & pharmacy, Biochemistry, Article, Rats, Sprague-Dawley, Excretion, Benzophenones, Mice, 03 medical and health sciences, Ingredient, chemistry.chemical_compound, 0302 clinical medicine, Sprague dawley rats, Animals, Humans, skin and connective tissue diseases, 2-hydroxy-4-methoxybenzophenone, Chemistry, General Medicine, Metabolism, Disposition, Rats, 030220 oncology & carcinogenesis, Oxybenzone, Sunscreening Agents, human activities

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6cd32be81d4d3ca85107ba1d4622ac5
https://doi.org/10.1080/00498254.2019.1680906

المؤلفون: Nathan P Young, Paul A. Sprengeler, Christopher J. Wegerski, Samuel Sperry, Tran Chinh Viet, Andres Nevarez, Kevin R. Webster, Jocelyn Staunton, Haleigh Howard, Gary G. Chiang, Jim R Appleman, Alan Xiang, Theodore Michels, Reich Siegfried Heinz, Jolene Molter, Garrick Packard, Jeff Clarine, Christian Nilewski, Sarah Fish, Justin T. Ernst, Peggy A. Thompson, Boreth Eam, Joan Chen

المصدر: Journal of medicinal chemistry. 63(11)

مصطلحات موضوعية: Mice, Nude, Breast Neoplasms, Computational biology, Molecular Dynamics Simulation, Crystallography, X-Ray, Ligands, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Protein structure, Rocaglamide, Cell Line, Tumor, Drug Discovery, Protein biosynthesis, Animals, Humans, RNA, Messenger, Gene, 030304 developmental biology, Benzofurans, 0303 health sciences, Messenger RNA, Binding Sites, Chemistry, RNA, RNA Helicase A, 0104 chemical sciences, Protein Structure, Tertiary, Rats, 010404 medicinal & biomolecular chemistry, eIF4A, Drug Design, Eukaryotic Initiation Factor-4A, Mutagenesis, Site-Directed, Molecular Medicine, Female, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66b781e59583b73ced8e0594522c507
https://pubmed.ncbi.nlm.nih.gov/32470302

المؤلفون: Nathan P. Young, Gary G. Chiang, Andres Nevarez, Joan Chen, Tran Chinh Viet, Reich Siegfried Heinz, Theodore Michels, Eric Sung, Haleigh Howard, Christopher J. Wegerski, Ana Parra, Gregory S. Parker, Boreth Eam, Alan Xiang, Samuel Sperry, Jocelyn Staunton, Maria Barrera, Christian Nilewski, Kevin R. Webster, Garrick Packard, Sarah Fish, Jeff Clarine, Paul A. Sprengeler, Peggy A. Thompson, Ivy Nj Hung, Justin T. Ernst

المصدر: Cancer Research. 78:DDT02-05

مصطلحات موضوعية: Untranslated region, Cancer Research, Messenger RNA, Oncogene, Eukaryotic Translation Initiation Factor 4F, Cancer, Translation (biology), EIF4A1, Biology, medicine.disease, Oncology, eIF4A, Cancer research, medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::23be4e92a65700d1d634cbd6a08772ef
https://doi.org/10.1158/1538-7445.am2018-ddt02-05

المؤلفون: C. Edwin Garner, Kristen Ryan, Christopher J. Wegerski, Suramya Waidyanatha, Jacob D. McDonald, Melanie Doyle-Eisle, J. Michael Sanders

المصدر: Toxicology and Applied Pharmacology. 339:151-160

مصطلحات موضوعية: Male, 0301 basic medicine, Cyanobacteria, medicine.medical_specialty, Neurotoxins, Administration, Oral, Rodentia, Urine, Toxicology, Drug Administration Schedule, Rats, Sprague-Dawley, Excretion, Mice, Random Allocation, 03 medical and health sciences, 0302 clinical medicine, Equivalent, Internal medicine, Excitatory Amino Acid Agonists, medicine, Animals, Neurotoxin, Tissue Distribution, Feces, Pharmacology, Alanine, chemistry.chemical_classification, Cyanobacteria Toxins, biology, Chemistry, Amino Acids, Diamino, biology.organism_classification, Rats, Amino acid, 030104 developmental biology, Endocrinology, Female, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea81a5cad39a8129c4c3e90e73b35978
https://doi.org/10.1016/j.taap.2017.12.008

المؤلفون: Christian Nilewski, Andres Nevarez, Sarah Fish, Boreth Eam, Alan X. Xiang, Paul A. Sprengeler, Peggy A. Thompson, Jeff Clarine, Garrick Kenneth Packard, Theodore Michels, Reich Siegfried Heinz, Christopher J. Wegerski, Justin T. Ernst, Samuel Sperry

المصدر: Bioorganic & Medicinal Chemistry Letters. 47:128111

مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Rocaglamide, Cell Line, Tumor, Drug Discovery, Humans, Mode of action, Molecular Biology, Ternary complex, Benzofurans, Cell Proliferation, ADME, Biological Products, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Translation (biology), Combinatorial chemistry, Triterpenes, In vitro, Drug Design, eIF4A, Eukaryotic Initiation Factor-4A, Molecular Medicine, Amine gas treating, Drug Screening Assays, Antitumor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3ae75bb8babfe7b1170140b02995a4
https://doi.org/10.1016/j.bmcl.2021.128111

المؤلفون: C.E. Garner, J. M. Sanders, Suramya Waidyanatha, K.A. Shipkowski, Christopher J. Wegerski, M. Doyle-Eisele, Jacob D. McDonald

المصدر: Toxicol Appl Pharmacol

مصطلحات موضوعية: 0301 basic medicine, Male, Administration, Oral, Absorption (skin), Urine, Pharmacology, Toxicology, Article, Choline, Dimethylnitrosamine, Excretion, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, In vivo, Animals, Tissue Distribution, Rats, Wistar, Carcinogen, ADME, Deanol, Metabolism, Rats, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Administration, Intravenous, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a823cfb2b7b606215af870955b082c50
https://europepmc.org/articles/PMC7252906/

المؤلفون: Joan Chen, Jeff Clarine, Craig R. Stumpf, Paul A. Sprengeler, Christopher J. Wegerski, Michels Theodore, Garrick Kenneth Packard, Christian Nilewski, Jocelyn Staunton, Eric Sung, Kaveri Urklalan, Alan Xiang, Takasuke Mukaiyama, Reich Siegfried Heinz, Ivy Nj Hung, Justin T. Ernst, Kevin R. Webster, Gary G. Chiang, Gregory S. Parker, Andreas Nevarez, Peggy A. Thompson, Samuel Sperry, Maria Barrera, Ana Parra

المصدر: Molecular Cancer Research. 18:B33-B33

مصطلحات موضوعية: MAPK/ERK pathway, Cancer Research, Oncology, In vivo, Apoptosis, EIF4E, Cancer research, mTORC1, Biology, Signal transduction, Molecular Biology, Gene, PI3K/AKT/mTOR pathway

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b48a35231b256c9fb1609092631b6f6d
https://doi.org/10.1158/1557-3125.pi3k-mtor18-b33

المؤلفون: Joan Chen, Melissa Neal, Katti Jessen, Gregory S. Parker, Reich Siegfried Heinz, Michael B. Shaghafi, Edward Z. R. Han, Ivy Nj Hung, Justin T. Ernst, James R. Appleman, Tran Chinh Viet, Qing Han, Douglas E. Murphy, Craig R. Stumpf, Christopher J. Wegerski, Vera Huang, Jolene Molter, Paul A. Sprengeler, Peggy A. Thompson, Jocelyn Staunton, Gary G. Chiang, Vikas K Goel, Jeff Clarine, Samuel Sperry, Boreth Eam, Kevin R. Webster, Adriana L. Jemison, Stephen E. Webber, Hong Zheng

المصدر: Journal of medicinal chemistry. 61(8)

مصطلحات موضوعية: 0301 basic medicine, Pyridines, Pyridones, Antineoplastic Agents, Protein Serine-Threonine Kinases, 03 medical and health sciences, Mice, Catalytic Domain, Cell Line, Tumor, Drug Discovery, Serine, Animals, Humans, Spiro Compounds, Phosphorylation, Protein kinase A, Protein Kinase Inhibitors, biology, Molecular Structure, Effector, Kinase, Chemistry, EIF4E, Intracellular Signaling Peptides and Proteins, Translation (biology), Xenograft Model Antitumor Assays, Cell biology, Rats, 030104 developmental biology, Eukaryotic Initiation Factor-4E, Pyrimidines, Mitogen-activated protein kinase, Drug Design, biology.protein, Molecular Medicine, Signal transduction, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04cce3bf4928b41080e47e6b530276e
https://pubmed.ncbi.nlm.nih.gov/29526098

المؤلفون: Samuel Sperry, Nathan P Young, Gregory S. Parker, Adina Gerson-Gurwitz, Reich Siegfried Heinz, Boreth Eam, Maria Barrera, Gary G. Chiang, Vikas K Goel, Eric Sung, Craig R. Stumpf, Joan Chen, Christopher J. Wegerski, Kevin R. Webster, Jocelyn Staunton, Peggy A. Thompson, Sarah Fish

المصدر: Molecular Cancer Therapeutics. 18:B133-B133

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Cancer Research, Oncogene, Chemistry, EIF4G, EIF4E, EIF4A1, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Cancer research, Signal transduction, Protein kinase B, PI3K/AKT/mTOR pathway

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8a70bc7c125b072eab8efc9871d36f4d
https://doi.org/10.1158/1535-7163.targ-19-b133

المؤلفون: Alan Xiang, Andreas Nevarez, Kaveri Urkalan, Peggy A. Thompson, Paul A. Sprengeler, Ana Parra, Christian Nilewski, Ivy Nj Hung, Justin T. Ernst, Joan Chen, Garrick Packard, Eric Sung, Gary G. Chiang, Gregory S. Parker, Reich Siegfried Heinz, Maria Barrera, Samuel Sperry, Craig R. Stumpf, Christopher J. Wegerski, Michels Theodore, Cody Parker, Jocelyn Staunton, Takasuke Mukaiyama, Vikas K. Goel, Kevin R. Webster, Jeff Clarine

المصدر: Cancer Research. 79:1302-1302

مصطلحات موضوعية: Cancer Research, Oncology, Downregulation and upregulation, Hormone receptor, EIF4E, Cancer research, mTORC1, Biology, Gene, PI3K/AKT/mTOR pathway, In vitro, Hormone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9e552bcfa1908a77341e1bb9ff36e43d
https://doi.org/10.1158/1538-7445.am2019-1302

المؤلفون: Christian Nilewski, Tran Chinh Viet, Jeff Clarine, Eric Sung, Christopher J. Wegerski, Andres Nevarez, Gary G. Chiang, Maria Barrera, Jocelyn Staunton, Haleigh Howard, Peggy A. Thompson, Alan Xiang, Paul A. Sprengeler, Theodore Michels, Samuel Sperry, Ana Parra, Justin T. Ernst, Boreth Eam, Sarah Fish, Nathan P. Young, Kevin R. Webster, Garrick Packard, Reich Siegfried Heinz, Joan Chen

المصدر: Cancer Research. 79:2698-2698

مصطلحات موضوعية: 0301 basic medicine, Untranslated region, Cancer Research, Messenger RNA, EIF4G, RNA, 03 medical and health sciences, chemistry.chemical_compound, Eukaryotic initiation factor 4F, 030104 developmental biology, 0302 clinical medicine, Oncology, chemistry, 030220 oncology & carcinogenesis, eIF4A, Translational regulation, Cancer research, PI3K/AKT/mTOR pathway

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b6e3a6698acfa6241fc59b2da1986d9c
https://doi.org/10.1158/1538-7445.am2019-2698

المؤلفون: Daniel J. Kramer, Ling-Jen Chen, J. Michael Sanders, Leslie A. Thomas, Jacob D. McDonald, Christopher J. Wegerski, Kelly J. Dix

المصدر: Drug Metabolism and Disposition. 39:498-509

مصطلحات موضوعية: Male, Cumene, medicine.medical_specialty, Propanols, Metabolite, Administration, Oral, Pharmaceutical Science, Kidney, Intestinal absorption, Styrenes, Excretion, Mice, chemistry.chemical_compound, Glucuronides, Species Specificity, Pharmacokinetics, Microsomes, Internal medicine, Benzene Derivatives, medicine, Animals, Bile, Tissue Distribution, Lung, Enterohepatic circulation, Pharmacology, Sex Characteristics, Chemistry, Central Nervous System Depressants, Kidney metabolism, Articles, Rats, Inbred F344, Rats, Endocrinology, medicine.anatomical_structure, Intestinal Absorption, Liver, Organ Specificity, Injections, Intravenous, Carcinogens, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb609aa38b84812e6a4a9440fa815a0
https://doi.org/10.1124/dmd.110.034769

المؤلفون: Teatulohi Matainaho, Joshua Hammond, Christopher J. Wegerski, Phillip Crews, Karen Tenney

المصدر: Journal of Natural Products. 70:89-94

مصطلحات موضوعية: Stereochemistry, Pharmaceutical Science, Peptides, Cyclic, Pentapeptide repeat, Article, Analytical Chemistry, Drug Discovery, Photography, Animals, Nuclear Magnetic Resonance, Biomolecular, Pharmacology, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, Diastereomer, Theonella swinhoei, biology.organism_classification, Cyclic peptide, Amino acid, Sponge, Complementary and alternative medicine, chemistry, Proton NMR, Molecular Medicine, Cyclic pentapeptide, Theonella

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6dc25c71d9cd195bc37759d4afff68
https://doi.org/10.1021/np060464w

المؤلفون: Rachel N. Sonnenschein, Teatulohi Matainaho, Frederick A. Valeriote, Christopher J. Wegerski, Phillip Crews, Freddy Cabriales

المصدر: Tetrahedron. 62:10393-10399

مصطلحات موضوعية: Amorphinopsis, biology, Stereochemistry, Organic Chemistry, Halichondrida, Diastereomer, biology.organism_classification, Sesquiterpene, Biochemistry, Terpene, chemistry.chemical_compound, chemistry, Drug Discovery, Organic chemistry, Antibacterial activity, Solid tumor, Indo-Pacific

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cbde768a7707bf2e9bf2da0408a225d7
https://doi.org/10.1016/j.tet.2006.08.070