المؤلفون: Christopher E. Mahoney, David Pirman, Victor Chubukov, Taryn Sleger, Sebastian Hayes, Zi Peng Fan, Eric L. Allen, Ying Chen, Lingling Huang, Meina Liu, Yingjia Zhang, Gabrielle McDonald, Rohini Narayanaswamy, Sung Choe, Yue Chen, Stefan Gross, Giovanni Cianchetta, Anil K. Padyana, Stuart Murray, Wei Liu, Kevin M. Marks, Joshua Murtie, Marion Dorsch, Shengfang Jin, Nelamangala Nagaraja, Scott A. Biller, Thomas Roddy, Janeta Popovici-Muller, Gromoslaw A. Smolen

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/27aeab8f4bce40e788924435c21f0b77

المؤلفون: Anil K. Padyana, Stefan Gross, Lei Jin, Giovanni Cianchetta, Rohini Narayanaswamy, Feng Wang, Rui Wang, Cheng Fang, Xiaobing Lv, Scott A. Biller, Lenny Dang, Christopher E. Mahoney, Nelamangala Nagaraja, David Pirman, Zhihua Sui, Janeta Popovici-Muller, Gromoslaw A. Smolen

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/13114a6254b94cd5a8f05eeabf842c50

المؤلفون: Eric L. Allen, Danielle B. Ulanet, David Pirman, Christopher E. Mahoney, John Coco, Yaguang Si, Ying Chen, Lingling Huang, Jinmin Ren, Sung Choe, Michelle F. Clasquin, Erin Artin, Zi Peng Fan, Giovanni Cianchetta, Joshua Murtie, Marion Dorsch, Shengfang Jin, Gromoslaw A. Smolen

المصدر: Cell Reports, Vol 17, Iss 3, Pp 876-890 (2016)

مصطلحات موضوعية: alpha-ketoglutarate dehydrogenase, oxoglutarate dehydrogenase, OGDH, citric acid cycle, TCA cycle, Krebs cycle, malate-aspartate shuttle, aspartate, cancer metabolism, target validation, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716312918; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/038a8ba083f6473f859242fde11df665

المؤلفون: Gromoslaw A. Smolen, Marcos Lahera, Raúl M. Luque, Rocío Letón, Graeme Eisenhofer, Lorena Maestre, Miguel Urioste, Javier Aller, Cristina Moreno-Rengel, Rafael Torres-Pérez, María Ángeles Gálvez, Giovanni Cianchetta, Belen Herraez, Javier Coloma, Emiliano Honrado, Maria Currás-Freixes, Christopher E. Mahoney, Bruna Calsina, Susan Richter, Laura Remacha, Mercedes Robledo, Oscar Llorca, Óscar García-Uriarte, David Pirman, Guillermo Pita, Cristina Rodríguez-Antona, Cristina Montero-Conde, Alberto Cascón

المصدر: The American Journal of Human Genetics. 104:651-664

مصطلحات موضوعية: DLST, Adult, Male, 0301 basic medicine, Carcinogenesis, Citric Acid Cycle, Adrenal Gland Neoplasms, Loss of Heterozygosity, Pheochromocytoma, Biology, medicine.disease_cause, Article, Germline, Paraganglioma, Loss of heterozygosity, 03 medical and health sciences, 0302 clinical medicine, Germline mutation, Catalytic Domain, Basic Helix-Loop-Helix Transcription Factors, Genetics, medicine, Humans, Genetic Predisposition to Disease, cancer susceptibility gene, TCA cycle, Gene, Germ-Line Mutation, Genetics (clinical), Gene Expression Profiling, Correction, High-Throughput Nucleotide Sequencing, Methylation, DNA Methylation, Middle Aged, medicine.disease, Phenotype, 030104 developmental biology, Gene Expression Regulation, 030220 oncology & carcinogenesis, Female, Acyltransferases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd586a03004b8250322c4b0219c4845
https://doi.org/10.1016/j.ajhg.2019.02.017

المؤلفون: Lingling Huang, Kevin Marks, Shengfang Jin, Sung Choe, Scott A. Biller, Joshua Murtie, Gromoslaw A. Smolen, Janeta Popovici-Muller, Eric L. Allen, Rohini Narayanaswamy, Stefan Gross, Yingjia Zhang, Wei Liu, Thomas P. Roddy, Gabrielle McDonald, Nelamangala Nagaraja, Marion Dorsch, Anil K. Padyana, Christopher E. Mahoney, Taryn Sleger, Meina Liu, Yue Chen, Stuart Murray, Victor Chubukov, Sebastian Hayes, Giovanni Cianchetta, Ying Chen, Zi Peng Fan, David Pirman

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Squalene monooxygenase, Science, Cell, Chemical biology, General Physics and Astronomy, Antineoplastic Agents, 02 engineering and technology, Neuroendocrine tumors, Biology, General Biochemistry, Genetics and Molecular Biology, Article, Gene Expression Regulation, Enzymologic, 03 medical and health sciences, Drug Delivery Systems, Cell Line, Tumor, medicine, Humans, lcsh:Science, Regulation of gene expression, Multidisciplinary, Cancer, General Chemistry, 021001 nanoscience & nanotechnology, medicine.disease, Gene Expression Regulation, Neoplastic, 030104 developmental biology, medicine.anatomical_structure, Cholesterol, Squalene Monooxygenase, Cell culture, Cancer cell, Cancer research, lcsh:Q, Drug Screening Assays, Antitumor, 0210 nano-technology, Gene Deletion

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b9963f98863abf7bfee5a9413bdfc9
https://doaj.org/article/27aeab8f4bce40e788924435c21f0b77

المؤلفون: Andrew J. Olaharski, Rohini Narayanaswamy, Janeta Popovici-Muller, Thomas P. Roddy, Lee Silverman, Raj Nagaraja, Gromoslaw A. Smolen, Stefan Gross, Christopher E. Mahoney, David Pirman

المصدر: Toxicology and applied pharmacology. 401

مصطلحات موضوعية: 0301 basic medicine, Male, Squalene monooxygenase, Drug Evaluation, Preclinical, Toxicology, 03 medical and health sciences, Squalene, chemistry.chemical_compound, 0302 clinical medicine, Dogs, Medicine, Animals, Squalene Epoxidase Inhibitors, Enzyme Inhibitors, Lung cancer, Skin, Pharmacology, chemistry.chemical_classification, Dose-Response Relationship, Drug, business.industry, Cholesterol, medicine.disease, Macaca fascicularis, 030104 developmental biology, Enzyme, chemistry, Squalene Monooxygenase, Cell culture, 030220 oncology & carcinogenesis, Toxicity, Cancer research, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43527cd1156cc4bf21aff21aac877d41
https://pubmed.ncbi.nlm.nih.gov/32522582

المؤلفون: Erin Artin, Lingling Huang, Joshua Murtie, Danielle Ulanet, Giovanni Cianchetta, Zi Peng Fan, Jinmin Ren, Eric L. Allen, Michelle Clasquin, David Pirman, Ying Chen, Christopher E. Mahoney, Sung Choe, Gromoslaw A. Smolen, Yaguang Si, Marion Dorsch, Shengfang Jin, John Coco

المصدر: Cell Reports, Vol 17, Iss 3, Pp 876-890 (2016)

مصطلحات موضوعية: 0301 basic medicine, oxoglutarate dehydrogenase, Cell Respiration, Malate-aspartate shuttle, cancer metabolism, Computational biology, Biology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Metabolomics, OGDH, Cell Line, Tumor, Neoplasms, alpha-ketoglutarate dehydrogenase, medicine, Animals, Humans, Ketoglutarate Dehydrogenase Complex, Enzyme Inhibitors, RNA, Small Interfering, TCA cycle, lcsh:QH301-705.5, chemistry.chemical_classification, Aspartic Acid, aspartate, Cancer, medicine.disease, Citric acid cycle, 030104 developmental biology, Enzyme, chemistry, Biochemistry, malate-aspartate shuttle, target validation, lcsh:Biology (General), Gene Knockdown Techniques, Cancer cell, citric acid cycle, Oxoglutarate dehydrogenase complex, Krebs cycle

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1abfa7781529d89e5650e094709755a
http://www.sciencedirect.com/science/article/pii/S2211124716312918

المؤلفون: Stephen Y. Chan, Bradley A. Maron, Joseph Loscalzo, Ying-Yi Zhang, Jane A. Leopold, Christopher E Mahoney, Diane E. Handy, Kevin P. White

المصدر: Circulation. 126:963-974

مصطلحات موضوعية: Male, medicine.medical_specialty, Nitric Oxide Synthase Type III, Hypertension, Pulmonary, Pulmonary Artery, Spironolactone, Nitric Oxide, Article, Nitric oxide, Rats, Sprague-Dawley, chemistry.chemical_compound, Mineralocorticoid receptor, Physiology (medical), Internal medicine, medicine, Animals, Humans, Familial Primary Pulmonary Hypertension, Cysteine, Pulmonary Wedge Pressure, Sulfhydryl Compounds, Pulmonary wedge pressure, Aldosterone, Cells, Cultured, Mineralocorticoid Receptor Antagonists, Endothelin-1, business.industry, Endothelial Cells, medicine.disease, Receptor, Endothelin B, Pulmonary hypertension, Endothelin 1, Rats, Disease Models, Animal, Oxidative Stress, Endocrinology, chemistry, Cardiology and Cardiovascular Medicine, Endothelin receptor, business, Oxidation-Reduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9d7dba2e626ff7ea3d72c43a17cd2d
https://doi.org/10.1161/circulationaha.112.094722

المؤلفون: Filomena G. Ottaviano, Joseph Loscalzo, Jane A. Leopold, Christopher E Mahoney, Diane E. Handy, Kevin Croce, Richard C Jin, Shiow-Shih Tang, Ying-Yi Zhang, Laura Coleman Anderson

المصدر: Circulation. 123:1963-1973

مصطلحات موضوعية: Blood Platelets, medicine.medical_specialty, Bleeding Time, Genotype, Platelet Aggregation, P-selectin, GPX3, Antioxidants, Article, Mice, chemistry.chemical_compound, Risk Factors, Physiology (medical), Internal medicine, Extracellular, medicine, Animals, Platelet, Platelet activation, Cyclic GMP, Mice, Knockout, chemistry.chemical_classification, Glutathione Peroxidase, Reactive oxygen species, business.industry, Glutathione peroxidase, Infarction, Middle Cerebral Artery, Thrombosis, Glutathione, Adenosine Diphosphate, Disease Models, Animal, P-Selectin, Endocrinology, chemistry, Immunology, Endothelium, Vascular, Reactive Oxygen Species, Cardiology and Cardiovascular Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf954987a87bf02889fea156b9a5f91
https://doi.org/10.1161/circulationaha.110.000034

المؤلفون: Gromoslaw A. Smolen, Stefan Gross, Shengfang Jin, Scott A. Biller, Taryn Sleger, Sung Choe, Rohini Narayanaswamy, Joshua Murtie, Raj Nagaraja, Gabrielle McDonald, Thomas P. Roddy, Yu Chen, David Pirman, Giovanni Cianchetta, Christopher E. Mahoney, Sebastian Hayes, Zi Peng Fan, Anil K. Padyana, Stuart Murray, Victor Chubukov

المصدر: Cancer Research. 78:3504-3504

مصطلحات موضوعية: Cancer Research, Oncology, Neuroendocrine Cancer, Chemical biology, Vulnerability, Computational biology, Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ef2047d40d97cff8dce69aae5c12daf6
https://doi.org/10.1158/1538-7445.am2018-3504

المؤلفون: Joseph Loscalzo, Christopher E Mahoney, Djamel Lebeche, Diane E. Handy, Roger J. Hajjar, Joshua A Balderman, Sofia Annis, Kevin P. White, Jane A. Leopold, Hae-Young Lee

المصدر: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

مصطلحات موضوعية: Pathology, medicine.medical_specialty, Vascular smooth muscle, Myocytes, Smooth Muscle, Bone Morphogenetic Protein 2, Down-Regulation, Core Binding Factor Alpha 1 Subunit, Coronary Artery Disease, Real-Time Polymerase Chain Reaction, Bone morphogenetic protein 2, Vascular Medicine, Calcium in biology, Muscle, Smooth, Vascular, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Runx2, microRNA, medicine, Humans, Cells, Cultured, 030304 developmental biology, Original Research, 0303 health sciences, Messenger RNA, business.industry, medicine.disease, Cell biology, smooth muscle cells, MicroRNAs, Real-time polymerase chain reaction, vascular calcification, 030220 oncology & carcinogenesis, embryonic structures, Cardiology and Cardiovascular Medicine, business, Calcification

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3646ba68fb6898bb92ba814d1d682d
http://europepmc.org/articles/PMC3540659

المؤلفون: Christopher E Mahoney, Jay L. Zweier, Joseph Loscalzo, Ying Yi Zhang, Craig Hemann, Stephen Y. Chan

المصدر: Cell metabolism. 10(4)

مصطلحات موضوعية: Iron-sulfur cluster assembly, Iron-Sulfur Proteins, Cellular adaptation, Physiology, HUMDISEASE, Mitochondrion, Biology, Aconitase, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Oxygen Consumption, microRNA, medicine, Animals, Humans, Hypoxia, Molecular Biology, Psychological repression, Cells, Cultured, 030304 developmental biology, Regulation of gene expression, Caspase 7, Mice, Knockout, 0303 health sciences, Caspase 3, Endothelial Cells, Cell Biology, Hypoxia (medical), Cell biology, Mitochondria, MicroRNAs, Biochemistry, Gene Expression Regulation, Von Hippel-Lindau Tumor Suppressor Protein, 030220 oncology & carcinogenesis, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501eca1a8e84e2b215ee8689c949d17c
https://pubmed.ncbi.nlm.nih.gov/19808020

المؤلفون: Richard C Jin, Christopher E Mahoney, Laura Coleman, Filomena G Ottaviano, Yingyi Zhang, Diane E Handy, Joseph Loscalzo

المصدر: Circulation. 118

مصطلحات موضوعية: Physiology (medical), Cardiology and Cardiovascular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0692223e9add5f88f52a4dd2fbc2d75b
https://doi.org/10.1161/circ.118.suppl_18.s_552