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1
المؤلفون: Srinivas K. Chunduru, Mark A. McKinlay, Yigong Shi, David Weng, Martin A. Graham, Matthew D. Alexander, Thomas Haimowitz, Yu-Hua Lee, Pavan K. Tirunahari, Mukta S. Hendi, Yijun Deng, Susan R. Rippin, Matthew G. LaPorte, Gurpreet S. Kapoor, Martin E. Seipel, Guangyao Yu, Stephen M. Condon, Eric M. Neiman, Jennifer M. Burns, Yasuhiro Mitsuuchi, Christopher A. Benetatos
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2
المؤلفون: Srinivas K. Chunduru, Mark A. McKinlay, Yigong Shi, David Weng, Martin A. Graham, Matthew D. Alexander, Thomas Haimowitz, Yu-Hua Lee, Pavan K. Tirunahari, Mukta S. Hendi, Yijun Deng, Susan R. Rippin, Matthew G. LaPorte, Gurpreet S. Kapoor, Martin E. Seipel, Guangyao Yu, Stephen M. Condon, Eric M. Neiman, Jennifer M. Burns, Yasuhiro Mitsuuchi, Christopher A. Benetatos
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3
المؤلفون: Srinivas K. Chunduru, Mark A. McKinlay, Yigong Shi, David Weng, Martin A. Graham, Matthew D. Alexander, Thomas Haimowitz, Yu-Hua Lee, Pavan K. Tirunahari, Mukta S. Hendi, Yijun Deng, Susan R. Rippin, Matthew G. LaPorte, Gurpreet S. Kapoor, Martin E. Seipel, Guangyao Yu, Stephen M. Condon, Eric M. Neiman, Jennifer M. Burns, Yasuhiro Mitsuuchi, Christopher A. Benetatos
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4
المؤلفون: Srinivas K. Chunduru, Mark A. McKinlay, Yigong Shi, David Weng, Martin A. Graham, Matthew D. Alexander, Thomas Haimowitz, Yu-Hua Lee, Pavan K. Tirunahari, Mukta S. Hendi, Yijun Deng, Susan R. Rippin, Matthew G. LaPorte, Gurpreet S. Kapoor, Martin E. Seipel, Guangyao Yu, Stephen M. Condon, Eric M. Neiman, Jennifer M. Burns, Yasuhiro Mitsuuchi, Christopher A. Benetatos
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5Academic Journal
المؤلفون: W. Ellingboe, Janis Upeslacis, Marc Collett, Tarek S, John F. O'connell, Anita Y. M. Howe, Johnathan Bloom, Carl J. Baldick, Christopher A. Benetatos, Huiming Cheng, Joel S, Srinivas K. Chunduru, Glen A. Coburn, Ariamala Gopalsamy, William P. Gorczyca, Stephen Johann, Xiaoqun Jiang, Michelle L, Girija Krisnamurthy, Matthew Olson, Steve Swanberg, Ian Thompson, Megan Thorn, Alfred Del Vecchio, Dorothy C. Young, Marja Van Zeijl, Joel S. Christensen, Boris Feld, Steve Herrmann, Michelle L. Kimberl, Mark Orlowski, John W. Ellingboe, Tarek S. Mansour, John F. O’connell
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.322.9608; http://aac.asm.org/content/48/12/4813.full.pdf
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6
المؤلفون: Randy W. Jackson, Matthew G. LaPorte, Torsten Herbertz, Tandy L. Draper, Janet A. Gaboury, Susan R. Rippin, Ravi Patel, Srinivas K. Chunduru, Christopher A. Benetatos, Dorothy C. Young, Christopher J. Burns, Stephen M. Condon
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3227-3231
مصطلحات موضوعية: Models, Molecular, Indoles, Molecular Structure, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Crystallography, X-Ray, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, Molecular Medicine, Enzyme Inhibitors, Molecular Biology, Allosteric Site, Pyrans
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7
المؤلفون: Eugene C. Amparo, Srinivas K. Chunduru, Ariamala Gopalsamy, Christopher A. Benetatos, Lori E. Miller, Tandy L. Draper, Christopher J. Burns, Matthew G. LaPorte, Lara K. Leister, Torsten Herbertz, Dorothy C. Young, Stephen M. Condon, Blackledge Charles W, Gerry Rhodes, Alison R. Hussey
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:2968-2973
مصطلحات موضوعية: Indoles, Stereochemistry, Hepatitis C virus, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, Viral Nonstructural Proteins, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Biochemistry, Virus, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Enzyme Inhibitors, Binding site, Molecular Biology, Pyrans, chemistry.chemical_classification, Indole test, Binding Sites, biology, Organic Chemistry, virus diseases, digestive system diseases, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine
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8
المؤلفون: Daniel C. Pevear, Dorothy C. Young, Christopher A. Benetatos, Glen A. Coburn, Susan R. Rippin, Christopher J. Burns, Marc S. Collett, Christopher J. Rizzo, Joel S. Christensen, Tandy L. Draper, Tiejun Gao, John O'Connell, Stephen M. Condon, Kristin Galie, Alison R. Hussey, Srinivas K. Chunduru, Gerry Rhodes, Norman M. Kneteman, Janet A. Gaboury, Tarek S. Mansour, Randy W. Jackson, D. Lorne Tyrrell, Anita Y. M. Howe, Matthew G. LaPorte, Torsten Herbertz
المصدر: ChemMedChem. 3:1508-1515
مصطلحات موضوعية: Indoles, Allosteric regulation, Mice, Transgenic, Hepacivirus, Mice, SCID, Viral Nonstructural Proteins, Antiviral Agents, Biochemistry, Ns5b polymerase, Inhibitory Concentration 50, Mice, Allosteric Regulation, In vivo, Drug Discovery, Animals, General Pharmacology, Toxicology and Pharmaceutics, Pyrans, Pharmacology, Indole test, Chemistry, Organic Chemistry, RNA-Dependent RNA Polymerase, Virology, RNA, Viral, Molecular Medicine
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9
المؤلفون: John Silke, Stephen M. Condon, Christopher A. Benetatos, W. Wei-Lynn Wong, Nufail Khan, Pascal Schneider, Frank Koentgen, Bernard A. Callus, James E Vince, Mark A. McKinlay, Srinivas K. Chunduru, Diep Chau, Martin Leverkus, Afsar U. Ahmed, Vinay Tergaonkar, David L. Vaux, Rebecca Feltham, Robert Brink
المساهمون: University of Zurich, Silke, John
المصدر: Cell, vol. 131, no. 4, pp. 682-693
مصطلحات موضوعية: HUMDISEASE, Apoptosis, 10263 Institute of Experimental Immunology, Inhibitor of Apoptosis Proteins, Mice, 0302 clinical medicine, Benzoquinones, XIAP Deficiency, Enzyme Inhibitors, Caspase, Protein Synthesis Inhibitors, Caspase 8, 0303 health sciences, biology, Intracellular Signaling Peptides and Proteins, NF-kappa B, Caspase Inhibitors, 3. Good health, XIAP, Autocrine Communication, Receptors, Tumor Necrosis Factor, Type I, SIGNALING, 030220 oncology & carcinogenesis, biological phenomena, cell phenomena, and immunity, Signal Transduction, Proteasome Endopeptidase Complex, Lactams, Macrocyclic, Ripoptosome, 610 Medicine & health, Article, General Biochemistry, Genetics and Molecular Biology, Cell Line, Mitochondrial Proteins, Viral Proteins, 03 medical and health sciences, 1300 General Biochemistry, Genetics and Molecular Biology, Baculoviral IAP Repeat-Containing 3 Protein, Animals, Humans, Serpins, 030304 developmental biology, Brefeldin A, Tumor Necrosis Factor-alpha, Biochemistry, Genetics and Molecular Biology(all), Molecular Mimicry, TNF Receptor-Associated Factor 2, Apoptosis/physiology, Benzoquinones/metabolism, Brefeldin A/metabolism, Caspase 8/antagonists & inhibitors, Caspase 8/metabolism, Enzyme Inhibitors/metabolism, Inhibitor of Apoptosis Proteins/antagonists & inhibitors, Inhibitor of Apoptosis Proteins/genetics, Intracellular Signaling Peptides and Proteins/metabolism, Lactams, Macrocyclic/metabolism, Mitochondrial Proteins/metabolism, NF-kappa B/metabolism, Proteasome Endopeptidase Complex/metabolism, Protein Synthesis Inhibitors/metabolism, Receptors, Tumor Necrosis Factor, Type I/metabolism, Serpins/metabolism, Signal Transduction/physiology, TNF Receptor-Associated Factor 2/genetics, TNF Receptor-Associated Factor 2/metabolism, Tumor Necrosis Factor-alpha/metabolism, Viral Proteins/metabolism, biology.protein, Cancer research, 570 Life sciences, CELLBIO, Baculoviral IAP repeat-containing protein 3, Apoptosis Regulatory Proteins
وصف الملف: application/pdf
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10
المؤلفون: Srinivas K. Chunduru, John W. Ellingboe, Huiming Cheng, Boris Feld, John O'Connell, Carl J. Baldick, Matthew W. Olson, Ian J. Thompson, Tarek S. Mansour, Michelle L. Kimberland, Marja van Zeijl, Girija Krisnamurthy, Christopher A. Benetatos, Joel S. Christensen, Dorothy C. Young, Ariamala Gopalsamy, Mark Orlowski, Steve Swanberg, Glen A. Coburn, Megan Thorn, Alfred M. Del Vecchio, Johnathan Bloom, Xiaoqun Jiang, S V Johann, Janis Upeslacis, Marc S. Collett, William P. Gorczyca, Anita Y. M. Howe, Steve Herrmann
المصدر: Antimicrobial Agents and Chemotherapy
مصطلحات موضوعية: Indoles, Hepatitis C virus, Drug Evaluation, Preclinical, RNA-dependent RNA polymerase, DNA-Directed DNA Polymerase, Hepacivirus, Viral Nonstructural Proteins, Biology, medicine.disease_cause, Antiviral Agents, Virus, Substrate Specificity, chemistry.chemical_compound, Cytopathogenic Effect, Viral, RNA polymerase, Chlorocebus aethiops, Escherichia coli, medicine, Animals, Humans, Pharmacology (medical), Enzyme Inhibitors, Vero Cells, NS5B, Cells, Cultured, Polymerase, Pyrans, Pharmacology, Interferon-alpha, virus diseases, RNA, RNA-Dependent RNA Polymerase, Virology, Molecular biology, HIV Reverse Transcriptase, digestive system diseases, Reverse transcriptase, Spectrometry, Fluorescence, Infectious Diseases, chemistry, biology.protein, Replicon
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11
المؤلفون: Christopher A. Benetatos, Dorothy C. Young, Robert Jordan, Marc S. Collett, Guang Yang, Daniel C. Pevear, Srinivas K. Chunduru
المصدر: Journal of Virology. 78:10202-10205
مصطلحات موضوعية: Octoxynol, viruses, Hepatitis C virus, Immunology, Replication, Hepacivirus, Viral Nonstructural Proteins, Virus Replication, medicine.disease_cause, Microbiology, Cell Line, Polyethylene Glycols, Ribonucleases, Virology, Endopeptidases, medicine, Humans, Replicon, NS5A, Nuclease, biology, virus diseases, RNA, RNA virus, biology.organism_classification, Molecular biology, digestive system diseases, NS2-3 protease, Viral replication, Insect Science, biology.protein, RNA, Viral
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12
المؤلفون: Stephen M. Condon, Pavan Tirunahari Kumar, Eric M. Neiman, Yijun Deng, Thomas Haimowitz, Bodhi Bettjeman, Yu Hua Lee, Xiaochun Li, Gurpreet S. Kapoor, Mukta S. Hendi, Rebecca Feltham, Martin E. Seipel, Christopher A. Benetatos, Jiawei Wang, Guangyao Yu, Catherine L. Day, James E Vince, Matthew D Alexander, Susan R. Rippin, Jennifer M. Burns, John Silke, Matthew G. LaPorte, Yasuhiro Mitsuuchi, Nufail Khan, Yigong Shi, Mark A. McKinlay, Mathew H. Cumming, Martin A. Graham, Srinivas K. Chunduru
المصدر: Journal of medicinal chemistry. 57(9)
مصطلحات موضوعية: Models, Molecular, Indoles, Chemistry, Molecular Mimicry, Antagonist, Antineoplastic Agents, Dipeptides, Neoplasms, Experimental, Pharmacology, Smac mimetics, In vitro, XIAP, Mitochondrial Proteins, Mice, Tolerability, Hematologic Neoplasms, Drug Discovery, Molecular Medicine, Potency, Animals, Signal transduction, Apoptosis Regulatory Proteins, Carrier Proteins, Birinapant
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13
المؤلفون: Christopher A. Benetatos, Marc S. Collett, Daniel C. Pevear, Marty Seipel, Srinivas K. Chunduru, Siu Chi Chang Sun, Charles M. Rice, Scott G. Baginski
المصدر: Proceedings of the National Academy of Sciences. 97:7981-7986
مصطلحات موضوعية: Indoles, Genes, Viral, medicine.drug_class, viruses, RNA-dependent RNA polymerase, Viral transformation, Microbial Sensitivity Tests, Virus Replication, Antiviral Agents, Virus, chemistry.chemical_compound, Dogs, Viral entry, medicine, Animals, Diarrhea Virus 2, Bovine Viral, NS5B, Cells, Cultured, Multidisciplinary, Dose-Response Relationship, Drug, biology, Triazines, Diarrhea Virus 1, Bovine Viral, Pestivirus, Drug Resistance, Microbial, Biological Sciences, RNA-Dependent RNA Polymerase, biology.organism_classification, Virology, chemistry, Viral replication, Mutation, RNA, Viral, Antiviral drug
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14
المؤلفون: Christopher A. Benetatos, Martin E. Seipel, Pavan K. Tirunahari, Yu-Hua Lee, Thomas Haimowitz, Yijun Deng, Gurpreet S. Kapoor, Matthew D Alexander, Martin A. Graham, Srinivas K. Chunduru, Mukta S. Hendi, Eric M. Neiman, Jennifer M. Burns, Guangyao Yu, Stephen M. Condon, David E. Weng, Yasuhiro Mitsuuchi, Mark A. McKinlay, Susan R. Rippin, Matthew G. LaPorte, Yigong Shi
المصدر: Molecular cancer therapeutics. 13(4)
مصطلحات موضوعية: Cancer Research, TRAF2, Indoles, Mice, Nude, Antineoplastic Agents, Breast Neoplasms, Biology, Inhibitor of apoptosis, Receptors, Tumor Necrosis Factor, Inhibitor of Apoptosis Proteins, Mitochondrial Proteins, RIPK1, Cell Line, Tumor, Animals, Humans, Caspase 8, Drug Synergism, Dipeptides, TNF Receptor-Associated Factor 2, Molecular biology, XIAP, Gene Expression Regulation, Neoplastic, Oncology, Apoptosis, Cell culture, Cancer cell, Cancer research, Tumor necrosis factor alpha, Female, biological phenomena, cell phenomena, and immunity, Signal Transduction
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15
المصدر: The Prostate. 30:263-268
مصطلحات موضوعية: Pathology, medicine.medical_specialty, biology, Urology, Cancer, macromolecular substances, Hyperplasia, medicine.disease, Isotype, Prostate cancer, medicine.anatomical_structure, Oncology, Prostate, medicine, biology.protein, Adenocarcinoma, Immunohistochemistry, Antibody
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::49dfb096b03c247b9779efbf8abb827c
https://doi.org/10.1002/(sici)1097-0045(19970301)30:4<263::aid-pros6>3.0.co;2-m -
16
المؤلفون: Srinivas K. Chunduru, Katherine L. Nathanson, Adina Vultur, Yasuhiro Mitsuuchi, Meenhard Herlyn, Ravi K. Amaravadi, Xu He, Christopher A. Benetatos, Min Xiao, Mark A. McKinlay, Jessie Villanueva, Clemens Krepler, Eric M. Neiman, Molly B. Halloran, Hubert Pehamberger
المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research. 19(7)
مصطلحات موضوعية: Cancer Research, Indoles, Ubiquitin-Protein Ligases, Antineoplastic Agents, Biology, Inhibitor of apoptosis, Article, Inhibitor of Apoptosis Proteins, Mitochondrial Proteins, Mice, In vivo, Cell Line, Tumor, Spheroids, Cellular, medicine, Tumor Cells, Cultured, Animals, Humans, Viability assay, Melanoma, Cell Proliferation, Cell growth, Tumor Necrosis Factor-alpha, Molecular Mimicry, Intracellular Signaling Peptides and Proteins, Dipeptides, medicine.disease, Molecular biology, Xenograft Model Antitumor Assays, Baculoviral IAP Repeat-Containing 3 Protein, Tumor Burden, Disease Models, Animal, Oncology, Apoptosis, Cancer cell, Cutaneous melanoma, Cancer research, Apoptosis Regulatory Proteins
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17
المؤلفون: Tencho Tenev, Maurice Darding, John Silke, Christopher A. Benetatos, Rebecca Feltham, Katiuscia Bianchi, Pascal Meier
المساهمون: The Breakthrough Toby Robins Breast Cancer Research Centre, The Breakthrough Toby Robins Breast Cancer Research Centre [London]
المصدر: Cell Death and Differentiation
Cell Death and Differentiation, Nature Publishing Group, 2011, ⟨10.1038/cdd.2011.10⟩مصطلحات موضوعية: Smac mimetic, SMAC mimetics, TRAF2, Programmed cell death, Ubiquitin-Protein Ligases, Biology, Inhibitor of Apoptosis Proteins, Mitochondrial Proteins, Mice, ubiquitin, TNFα, Baculoviral IAP Repeat-Containing 3 Protein, Ring finger, medicine, Animals, Humans, cancer, RNA, Small Interfering, Molecular Biology, Mice, Knockout, Regulation of gene expression, Original Paper, Tumor Necrosis Factor-alpha, HEK 293 cells, Intracellular Signaling Peptides and Proteins, NF-kappa B, Cell Biology, Fibroblasts, IAP, TNF Receptor-Associated Factor 2, NFKB1, Neoplasm Proteins, Cell biology, cIAP1, HEK293 Cells, medicine.anatomical_structure, cell death, Gene Expression Regulation, Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein, Caspases, Cancer cell, cIAP2, Apoptosis Regulatory Proteins
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18
المؤلفون: Christopher A. Benetatos, Thomas S. Griffith, Michael A. O’Donnell, Mark A. McKinlay, Tamara A. Kucaba, Stephen M. Condon, Srinivas K. Chunduru, Jennifer M. Burns
المصدر: Apoptosis : an international journal on programmed cell death. 16(1)
مصطلحات موضوعية: Cancer Research, Clinical Biochemistry, Pharmaceutical Science, Gene Expression, Apoptosis, X-Linked Inhibitor of Apoptosis Protein, Biology, Inhibitor of apoptosis, Mitochondrial Proteins, TNF-Related Apoptosis-Inducing Ligand, Mice, Antineoplastic Combined Chemotherapy Protocols, medicine, Tumor Cells, Cultured, Animals, Humans, RNA, Small Interfering, Sensitization, Pharmacology, Bladder cancer, Biochemistry (medical), Antagonist, Intracellular Signaling Peptides and Proteins, Cancer, Drug Synergism, Cell Biology, Ligand (biochemistry), medicine.disease, Molecular biology, Recombinant Proteins, XIAP, Protein Structure, Tertiary, medicine.anatomical_structure, Urinary Bladder Neoplasms, Caspases, Cancer research, Apoptosis Regulatory Proteins, Protein Binding, Signal Transduction
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19
المؤلفون: C. Glenn Begley, Christopher A. Benetatos, Jennifer M. Burns, Angeline C. Mufalli, Gurpreet S. Kapoor, Yasuhiro Mitsuuchi, Martin E. Seipel, Yijun Deng, Thomas Haimowitz, Stephen M. Condon
المصدر: Cancer Research. 74:1806-1806
مصطلحات موضوعية: Cancer Research, Programmed cell death, biology, Cell growth, Inhibitor of apoptosis, Caspase 8, RIPK1, Oncology, Apoptosis, Cancer cell, Immunology, biology.protein, Cancer research, Caspase
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20
المؤلفون: Gurpreet S. Kapoor, Christopher A. Benetatos, Jennifer M. Burns, Stephen M. Condon, Eric M. Neiman, Srinivas K. Chunduru, Guangyao Yu, Yasuhiro Mitsuuchi, John Silke, Mark A. McKinlay
المصدر: Cancer Research. 74:2278-2278
مصطلحات موضوعية: Cancer Research, Oncology, Apoptosis, Kinase, Cancer cell, Tumor necrosis factor alpha, Biology, Inhibitor of apoptosis, Caspase 8, Autocrine signalling, Molecular biology, MAPK14