المؤلفون: Danielle Denis, François G. Gervais, Rino Stocco, Stephen Lau, Birgit Kosjek, Michel Gallant, Vouy Linh Truong, Helmi Zaghdane, Dan Sørensen, Deborah Slipetz, Christophe Mellon, Gary P. O'Neill, Ernest E. Lee, Robert Houle, Yves Leblanc, Carl Berthelette, Daniel Guay, Carmela Molinaro, Jean-François Lévesque, Elizabeth Wong, Jin Wu, Yves Ducharme, Michael A. Crackower, John Colucci, Connie M. Krawczyk, Richard Friesen, Paul D. O’Shea, Nicole Sawyer, Susan Sillaots, Zhaoyin Wang, Christian Beaulieu, Daniel Simard, Chad Dalton, Wayne Mullet, Martine Hamel

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:288-293

مصطلحات موضوعية: Lung Diseases, Receptors, Prostaglandin, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, Animals, Humans, Structure–activity relationship, Receptors, Immunologic, Respiratory system, Receptor, Crth2 antagonist, Molecular Biology, Chemistry, Organic Chemistry, Antagonist, Macaca mulatta, In vitro, Rats, Immunology, Microsomes, Liver, Molecular Medicine, Prostaglandin D2, Carbolines

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62517a8c6d9944543c6229358efce07b
https://doi.org/10.1016/j.bmcl.2010.11.015

المؤلفون: Christophe Mellon, Nathalie Méthot, Deborah A. Nicoll-Griffith, Momar Ndao, Frédéric Massé, Christian Beaulieu, Angélique Fortier, Hyeram Park, W. Cameron Black, Elise Isabel, Doris Lee

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:7444-7449

مصطلحات موضوعية: Chagas disease, Proteases, Clinical Biochemistry, Protozoan Proteins, Pharmaceutical Science, Cruzipain, Cysteine Proteinase Inhibitors, Biochemistry, Structure-Activity Relationship, Cysteine Proteases, Drug Discovery, medicine, Humans, Structure–activity relationship, Chagas Disease, Trypanosoma cruzi, Molecular Biology, biology, Chemistry, Biphenyl Compounds, Organic Chemistry, Kinetoplastida, Valine, biology.organism_classification, medicine.disease, Cathepsins, Cysteine protease, Cysteine Endopeptidases, Drug development, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6582e07a38a94405e3fdc8c323756d1
https://doi.org/10.1016/j.bmcl.2010.10.015

المؤلفون: W. Cameron Black, Jean-François Lévesque, Denis Riendeau, Jean-Pierre Falgueyret, Kevin P. Bateman, M. David Percival, Elise Isabel, Tammy LeRiche, Vouy Linh Truong, Jacques Yves Gauthier, Michel Therien, Robert Zamboni, Sevgi B. Rodan, Sylvie Desmarais, Christophe Mellon, Deborah A. Nicoll-Griffith, Renata Oballa, Gregg Wesolowski, Sonia Lamontagne, Carmai Seto, Nathalie Chauret, Chun Sing Li, Robert N. Young, Frédéric Massé, Wanda Cromlish, Daniel J. McKay, Le T. Duong, Cheuk K. Lau, Serge Leger, Joel Robichaud, Gideon A. Rodan

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:887-892

مصطلحات موضوعية: Stereochemistry, Cathepsin K, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Cysteine Proteinase Inhibitors, Biochemistry, Stereocenter, chemistry.chemical_compound, Dogs, In vivo, Drug Discovery, Animals, Humans, Molecular Biology, biology, Biphenyl Compounds, Organic Chemistry, Macaca mulatta, In vitro, Rats, chemistry, Enzyme inhibitor, Hepatocytes, biology.protein, Molecular Medicine, Stereoselectivity, Rabbits, Glucuronide, Odanacatib

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ce075aa9949065722c92768a34c9f4
https://doi.org/10.1016/j.bmcl.2009.12.083

المؤلفون: Anne Marie Alarco, Dan Sørensen, Arjun H. Banskota, Emmanuel Zazopoulos, Mahmood Piraee, Christophe Mellon, Chris M. Farnet, Henriette Gourdeau, Ashraf S. Ibrahim, Mustapha Aouidate, James B. McAlpine, Pierre Falardeau

المصدر: The Journal of Antibiotics. 62:565-570

مصطلحات موضوعية: TLN-05223, Male, Methicillin-Resistant Staphylococcus aureus, Magnetic Resonance Spectroscopy, Stereochemistry, TLN-05220, Molecular Sequence Data, Mice, Nude, Locus (genetics), Microbial Sensitivity Tests, anticancer, Gram-Positive Bacteria, Micromonospora, Mass Spectrometry, Micromonospora echinospora, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Polycyclic Aromatic Hydrocarbons, Pharmacology, Antibiotics, Antineoplastic, biology, Carcinoma, Prostatic Neoplasms, Vancomycin Resistance, polycyclic aromatic, Nuclear magnetic resonance spectroscopy, biology.organism_classification, Anti-Bacterial Agents, Antibacterial, chemistry, Pyran, bravomicin, Antibacterial activity, Two-dimensional nuclear magnetic resonance spectroscopy, Enterococcus

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79a0d9e16cc2bed0225f57ac9043aaf
https://doi.org/10.1038/ja.2009.77

المؤلفون: Andre Giroux, Dita M. Rasper, Steven Xanthoudakis, Johanne Renaud, Rejean Fortin, Christophe Mellon, Erich L. Grimm, John P. Vaillancourt, John Tam, Renee Aspiotis, Yongxin Han, Sophie Roy, W. Cameron Black, John Colucci, Paul Tawa, Robert Zamboni, Elise Isabel, Donald W. Nicholson

المصدر: Bioorganic & Medicinal Chemistry Letters. 17:1671-1674

مصطلحات موضوعية: Programmed cell death, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Caspase 3, Biochemistry, Chemical synthesis, Catalysis, Mass Spectrometry, Cell Line, Structure-Activity Relationship, Drug Discovery, medicine, Humans, Protease Inhibitors, Molecular Biology, Chromatography, High Pressure Liquid, Amination, Caspase, chemistry.chemical_classification, Protease, biology, Chemistry, Organic Chemistry, Biological activity, Caspase Inhibitors, Recombinant Proteins, Enzyme, Pyrazines, biology.protein, Molecular Medicine, Indicators and Reagents, Palladium

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3ef3107740aa2248fa1a467ca00e24
https://doi.org/10.1016/j.bmcl.2006.12.110

المؤلفون: Paul Tawa, M. David Percival, Wanda Cromlish, Kathryn E. Bass, Sylvie Desmarais, Shankar Venkatraman, Sonia Lamontagne, W. Cameron Black, Gregg Wesolowski, Jean-Pierre Falgueyret, Sevgi B. Rodan, Denis Riendeau, Christophe Mellon

المصدر: Analytical Biochemistry. 335:218-227

مصطلحات موضوعية: Cathepsin L, Blotting, Western, Cathepsin K, Biophysics, Cathepsin E, Cathepsin F, Cysteine Proteinase Inhibitors, Biology, Biochemistry, Cathepsin A, Cathepsin B, Cathepsin C, Iodine Radioisotopes, Cathepsin O, Leucine, Cathepsin H, Cell Line, Tumor, Cathepsin L1, Animals, Humans, Molecular Biology, Biphenyl Compounds, Cell Biology, Cathepsins, Molecular biology, Cysteine Endopeptidases, Diazomethane, Autoradiography, Rabbits

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84040a1008f6fba5cc76af2791ce2db
https://doi.org/10.1016/j.ab.2004.09.005

المؤلفون: Mélissa Arbour, Gavin Chit Tsui, Jean-Pierre Falgueyret, Pierre-André Fournier, Yongxin Han, Michel Gallant, Patrick Lacombe, Daniel Dube, Daniel Simard, Elizabeth Cauchon, Austin Chen, Renee Aspiotis, Suzanna Liu, René St-Jacques, Christophe Mellon, Erich L. Grimm, Yeeman K. Ramtohul, Helene Juteau

المصدر: Bioorganicmedicinal chemistry letters. 22(5)

مصطلحات موضوعية: Transgene, Clinical Biochemistry, hERG, Pharmaceutical Science, Biological Availability, Pharmacology, Biochemistry, Plasma renin activity, Rats, Sprague-Dawley, Structure-Activity Relationship, Dogs, Piperidines, Drug Discovery, Renin–angiotensin system, Renin, Structure–activity relationship, Animals, Cytochrome P-450 CYP3A, Humans, Animal species, Molecular Biology, Antihypertensive Agents, Cytochrome P-450 CYP3A Inhibitors, biology, Chemistry, Organic Chemistry, Ether-A-Go-Go Potassium Channels, Bioavailability, Rats, Hypertension, biology.protein, Molecular Medicine, Rats, Transgenic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bbcef3547c253b1c7b45e16084feb3
https://pubmed.ncbi.nlm.nih.gov/22325946

المؤلفون: Elise Isabel, Christophe Mellon, Michael J. Boyd, Nathalie Chauret, Denis Deschênes, Sylvie Desmarais, Jean-Pierre Falgueyret, Jacques Yves Gauthier, Karine Khougaz, Cheuk K. Lau, Serge Léger, Dorothy A. Levorse, Chun Sing Li, Frédéric Massé, M. David Percival, Bruno Roy, John Scheigetz, Michel Thérien, Vouy Linh Truong, Gregg Wesolowski, Robert N. Young, Robert Zamboni, W. Cameron Black

المصدر: Bioorganicmedicinal chemistry letters. 21(3)

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Cathepsin K, Pharmaceutical Science, Administration, Oral, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Dogs, Amide, Drug Discovery, Ethylamines, Animals, Protease Inhibitors, Molecular Biology, Cathepsin, biology, Organic Chemistry, Biphenyl Compounds, Active site, Amides, Rats, Biphenyl compound, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Odanacatib

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f7ac2065bec9654d54655621ebfc7a4
https://pubmed.ncbi.nlm.nih.gov/21232956

المؤلفون: M. David Percival, Alain Veilleux, W. Cameron Black, Jean-Pierre Falgueyret, Paul Tawa, Jacques Yves Gauthier, Christophe Mellon

المصدر: Analytical biochemistry. 411(1)

مصطلحات موضوعية: Time Factors, Blotting, Western, Cathepsin K, Biophysics, Cell Separation, Biology, Biochemistry, Western blot, Leucine, White blood cell, medicine, Leukocytes, Animals, Humans, Cysteine, Molecular Biology, Whole blood, Cathepsin S, Cathepsin, medicine.diagnostic_test, Monocyte, Biphenyl Compounds, Cell Biology, Molecular biology, Cathepsins, Macaca mulatta, Circadian Rhythm, Protein Transport, medicine.anatomical_structure, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd6919f67d5fc42e6190d5270955dd2
https://pubmed.ncbi.nlm.nih.gov/21094118

المؤلفون: Erika Vigneault, Rino Stocco, Julie Farand, Daigen Xu, Marc Blouin, Steve Rowland, Marie-Claude Mathieu, Mireille Gaudreault, Jean-François Lévesque, Yongxin Han, Alex G. Therien, Jason Burch, R. W. Friesen, Danielle Denis, Yves Ducharme, Mark Wrona, Patsy Clark, Christophe Mellon, Gary P. O'Neill

المصدر: Journal of medicinal chemistry. 53(5)

مصطلحات موضوعية: Cyclopropanes, Male, Magnetic Resonance Spectroscopy, Prostaglandin Antagonists, medicine.drug_class, Stereochemistry, Pain, Inflammation, Thiophenes, Benzoates, Rats, Sprague-Dawley, chemistry.chemical_compound, Structure-Activity Relationship, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Receptors, Prostaglandin E, Prostaglandin E2, Benzoic acid, Analgesics, Trifluoromethyl, Antagonist, Receptor antagonist, Rats, chemistry, Tolerability, Molecular Medicine, medicine.symptom, medicine.drug, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aae4dd330bf132835f31b8767df9cc2
https://pubmed.ncbi.nlm.nih.gov/20163116

المؤلفون: Joel Robichaud, Donald B. Kimmel, Elise Isabel, Christophe Mellon, Renata Oballa, W. Cameron Black, M. David Percival, Serge Leger, Gregg Wesolowski, Jean-Pierre Falgueyret, Christopher I. Bayly, Frédéric Massé, Sylvie Desmarais, Sheldon Crane, Michel Therien, Julie Paquet, Qingping Wang, Daniel J. McKay

المصدر: Journal of medicinal chemistry. 51(20)

مصطلحات موضوعية: Models, Molecular, Nitrile, Molecular model, Stereochemistry, Cathepsin K, Cysteine Proteinase Inhibitors, Chemical synthesis, Sulfone, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Drug Discovery, Nitriles, Animals, Sulfones, chemistry.chemical_classification, biology, Molecular Structure, Cathepsins, Macaca mulatta, Rats, Disease Models, Animal, Kinetics, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Osteoporosis, Pyrazoles, Female, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd3a950739b4d0ca4005d863ba3bfe6
https://pubmed.ncbi.nlm.nih.gov/18811135

المؤلفون: Sophie Roy, Christophe Mellon, Christopher I. Bayly, Andre Giroux, Steven Xanthoudakis, John P. Vaillancourt, Robert Zamboni, Donald W. Nicholson, Elise Isabel, Renee Aspiotis, Nancy A. Thornberry, Cameron Black, Daniel J. McKay, Dita M. Rasper, Yongxin Han, Erich L. Grimm, John Tam

المصدر: Bioorganicmedicinal chemistry letters. 15(17)

مصطلحات موضوعية: Ketone, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Caspase 3, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Structure-Activity Relationship, Valine, Drug Discovery, medicine, Combinatorial Chemistry Techniques, Humans, Enzyme Inhibitors, Molecular Biology, Caspase, chemistry.chemical_classification, Aspartic Acid, Protease, biology, Organic Chemistry, Hydrogen Bonding, Dipeptides, Ketones, Caspase Inhibitors, Recombinant Proteins, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Hydrophobic and Hydrophilic Interactions

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e375d90c6bb647c0ea21dc42b57d7b31
https://pubmed.ncbi.nlm.nih.gov/16023344

المؤلفون: Joel Robichaud, Christophe Mellon, Sevgi B. Rodan, Christopher I. Bayly, Renata Oballa, Peppi Prasit, Jean-Pierre Falgueyret, Gregg Wesolowski, M. David Percival

المصدر: ChemInform. 35

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Cathepsin K, Clinical Biochemistry, Pharmaceutical Science, Cysteine Proteinase Inhibitors, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Drug Discovery, Potency, Moiety, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Chemistry, Aryl, Organic Chemistry, Rational design, Aromatic amine, Hydrogen Bonding, General Medicine, Cathepsins, Enzyme inhibitor, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49caa7f7ba4e86c9209eea78a512fd52
https://doi.org/10.1002/chin.200450161

المؤلفون: Sylvie Desmarais, Shankar Venkatraman, Wanda Cromlish, W. Cameron Black, Christophe Mellon, Paul Tawa, Sevgi B. Rodan, Jean-Pierre Falgueyret, Kathryn E. Bass, Gregg Wesolowski, Sonia Lamontagne, M. David Percival, Denis Riendeau

المصدر: Analytical Biochemistry. 340:380

مصطلحات موضوعية: Cathepsin, Protease, Biochemistry, Chemistry, medicine.medical_treatment, Biophysics, medicine, Cell Biology, Molecular Biology, Molecular biology, Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::928eeb6532648d5f28214a916130708b
https://doi.org/10.1016/j.ab.2005.01.033