المؤلفون: Wensheng Yu (2124583), Jian Liu (33711), Dane Clausen (9023702), Younong Yu (1398901), Joseph L. Duffy (1601548), Ming Wang (172316), Shouning Xu (10522207), Lin Deng (127858), Takao Suzuki (401012), Christine C. Chung (10522213), Robert W. Myers (3010719), Daniel J. Klein (316359), James I. Fells (10522216), M. Katharine Holloway (2094208), Jin Wu (216487), Guoxin Wu (2483092), Bonnie J. Howell (1843960), Richard J. O. Barnard (9023711), Joseph Kozlowski (2124589)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Evolutionary Biology, Cancer, Infectious Diseases, Chemical Sciences not elsewhere classified, selectivity, Reduced hERG Activity, 3 inhibitors, optimized serum shift, Minimum Cellular Potency Serum Shift, dog PK profiles, HIV Latency Reactivation, potency, HDACs 6

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Ethyl_Ketone-Based_Highly_Selective_HDACs_1_2_3_Inhibitors_for_HIV_Latency_Reactivation_with_Minimum_Cellular_Potency_Serum_Shift_and_Reduced_hERG_Activity/14368180

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02150.s001

المؤلفون: James I. Fells, Wensheng Yu, Younong Yu, Richard J. O. Barnard, Christine C. Chung, Bonnie J. Howell, Shouning Xu, Daniel J. Klein, Joseph A. Kozlowski, Joseph L. Duffy, Dane Clausen, Jian Liu, M. Katharine Holloway, Robert W. Myers, Guoxin Wu, Takao Suzuki, Lin Deng, Jin Wu, Ming Wang

المصدر: Journal of Medicinal Chemistry. 64:4709-4729

مصطلحات موضوعية: ERG1 Potassium Channel, Ketone, hERG, Drug Evaluation, Preclinical, Histone Deacetylase 2, Histone Deacetylase 1, 01 natural sciences, Histone Deacetylases, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Drug Discovery, Animals, Humans, Protein Isoforms, Potency, Latency (engineering), Oxazoles, 030304 developmental biology, Oxazole, chemistry.chemical_classification, 0303 health sciences, biology, Imidazoles, Ketones, Rats, 0104 chemical sciences, Histone Deacetylase Inhibitors, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, Biochemistry, HIV-1, biology.protein, Molecular Medicine, Virus Activation, Histone deacetylase, Selectivity, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c8b7b2d8a7b239d36c3d11df82ab88
https://doi.org/10.1021/acs.jmedchem.0c02150

المؤلفون: Dong-Ming Shen, Michael Wolff, Shirly Pinto, Deodial Guiadeen, Bindhu V. Karanam, James M. Balkovec, Arto D. Krikorian, Shuwen He, Maria Madeira, Donald M. Sperbeck, Andreas Verras, Judyann Wiltsie, Jian Liu, Jackie Shang, Tim Cernak, Beth Ann Murphy, Qingmei Hong, Christine C. Chung, Ravi P. Nargund, Kevin D. Dykstra, Judith N. Gorski, Robert J. DeVita, Sharon Tong, Tianying Jian, Lisa M. Sonatore, Jeffrey T. Kuethe, Jianying Xiao, Jinqi Liu, Zhong Lai, Zhicai Wu, Mikhail Reibarkh, Ginger X. Yang, Yang Yu

المصدر: Bioorganic & Medicinal Chemistry Letters. 29:1182-1186

مصطلحات موضوعية: Benzimidazole, Cyclohexane, Stereochemistry, Carboxylic acid, Clinical Biochemistry, Carboxylic Acids, Pharmaceutical Science, 01 natural sciences, Biochemistry, Mass Spectrometry, Inhibitory Concentration 50, Mice, chemistry.chemical_compound, Isomerism, In vivo, Drug Discovery, Animals, Humans, Moiety, Diacylglycerol O-Acyltransferase, Enzyme Inhibitors, Molecular Biology, Chromatography, High Pressure Liquid, Active metabolite, chemistry.chemical_classification, Cyclohexanones, 010405 organic chemistry, Chemistry, Organic Chemistry, In vitro, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Hepatocytes, Molecular Medicine, Benzimidazoles, Isomerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d804bc7e0890d2b1abe6ee34b194779
https://doi.org/10.1016/j.bmcl.2019.03.025

المؤلفون: Joseph L. Duffy, James I. Fells, Younong Yu, Bonnie J. Howell, Hyunjin M. Kim, Wensheng Yu, Dane Clausen, M. Katharine Holloway, Christine C. Chung, Robert W. Myers, Jin Wu, Richard J. O. Barnard, Daniel J. Klein, Joseph A. Kozlowski, Steve S. Carroll, Guoxin Wu, Jian Liu, Joseph Kelly

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: Histone Acetyltransferases, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Lysine, Provirus, 01 natural sciences, Biochemistry, Jurkat cells, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Histone, In vivo, Acetylation, Drug Discovery, biology.protein, Cancer research

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525b4192080895b98514a52d14d59d11
https://europepmc.org/articles/PMC7357218/

المؤلفون: Jin Wu, Joseph A. Kozlowski, Bonnie J. Howell, Dane Clausen, James I. Fells, Guoxin Wu, Robert W. Myers, Wensheng Yu, Christine C. Chung, Daniel J. Klein, Joseph L. Duffy, Jian Liu, Richard J. O. Barnard, Kate Holloway

المصدر: Bioorganicmedicinal chemistry letters. 30(17)

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Clinical Biochemistry, Imine, Human immunodeficiency virus (HIV), Pharmaceutical Science, medicine.disease_cause, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Histone Deacetylases, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, medicine, HDAC inhibitor, Imidazole, Animals, Humans, Molecular Biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Imidazoles, Combinatorial chemistry, 0104 chemical sciences, Rats, Histone Deacetylase Inhibitors, Isoenzymes, 010404 medicinal & biomolecular chemistry, HIV-1, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec48bbfb23bb75c786357864cd360370
https://pubmed.ncbi.nlm.nih.gov/32738976

المؤلفون: Robert J. De Vita, Zhi-Cai Shi, Bindhu V. Karanam, Beth Ann Murphy, Shuwen He, Tianying Jian, Christine C. Chung, Maria Madeira, Qingmei Hong, Tim Cernak, Ravi P. Nargund, James M. Balkovec, Donald M. Sperbeck, Min Liu, Andreas Verras, Judyann Wiltsie, Jian Liu, Lisa M. Sonatore, Sharon Tong, Shirly Pinto, Deodial Guiadeen, Michael Wolff, Zhicai Wu, Dong-Ming Shen, Arto D. Krikorian, Yang Yu, Judith N. Gorski, Petr Vachal, Jianying Xiao, Jinqi Liu, Zhong Lai

المصدر: Bioorganicmedicinal chemistry letters. 29(11)

مصطلحات موضوعية: Library design, Benzimidazole, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Chemistry, Pharmaceutical, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, Medicinal chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Molecular Medicine, Humans, Benzimidazoles, Diacylglycerol O-Acyltransferase, Enzyme Inhibitors, Molecular Biology, Diacylglycerol kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0380ff27cfdf10ca6e079a9a149965
https://pubmed.ncbi.nlm.nih.gov/30952592

المؤلفون: Shirly Pinto, Deodial Guiadeen, David X. Yang, Tianying Jian, Ravi P. Nargund, Donald M. Sperbeck, Tim Cernak, Qingmei Hong, James M. Balkovec, Christine C. Chung, Dong-Ming Shen, Jeffrey T. Kuethe, Sharon Tong, Pauline C. Ting, Judyann Wiltsie, Jack Gibson, Lisa M. Sonatore, Zhicai Wu, Ginger X. Yang, Michael Wolff, Judith N. Gorski, Robert J. DeVita, Yang Yu, Jian Liu, JeanMarie Lisnock, Zhong Lai, Shuwen He, Jianying Xiao, Jinqi Liu, Bindhu V. Karanam, Arto D. Krikorian, Kevin D. Dykstra, Maria Madeira

المصدر: ACS Medicinal Chemistry Letters. 5:1082-1087

مصطلحات موضوعية: Benzimidazole, Stereochemistry, Metabolite, Organic Chemistry, Pharmacology, Cyclohexanecarboxylic acid, Biology, Biochemistry, Ames test, chemistry.chemical_compound, chemistry, Free fraction, Drug Discovery, Moiety, Epimer, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5736a4f35707b793d0b53f6a00a346de
https://doi.org/10.1021/ml5003426

المؤلفون: David Won-Shik Kim, Ravi P. Nargund, Zhicai Wu, Maria Madeira, Jian Liu, JeanMarie Lisnock, Tianying Jian, Jeffrey T. Kuethe, Bindhu V. Karanam, Qingmei Hong, Dong-Ming Shen, Michael Wolff, Sharon Tong, Jack Gibson, Zhong Lai, Shirly Pinto, Deodial Guiadeen, Yang Yu, Donald M. Sperbeck, Beth Ann Murphy, James M. Balkovec, Christine C. Chung, Dunlu Chen, Judyann Wiltsie, Jinqi Liu, Xiaoli Chen, Shuwen He, Arto D. Krikorian, Lisa M. Sonatore, Pauline C. Ting, Judith N. Gorski, Robert J. DeVita, Ginger X. Yang

المصدر: ACS Medicinal Chemistry Letters. 4:773-778

مصطلحات موضوعية: Benzimidazole, Stereochemistry, Metabolite, Organic Chemistry, Cyclohexanecarboxylic acid, Biology, Biochemistry, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, Moiety, Epimer, Selectivity, Active metabolite

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cc6718ba0c1555d5839bf034018f4f
https://doi.org/10.1021/ml400168h

المؤلفون: Jiaping Zhang, Andrew K.P. Taggart, Steven J. Stout, Shirly Pinto, Larissa Wilsie, Xun Chen, Xuelei S. Song, David G. McLaren, Jason E. Imbriglio, Margarita Garcia-Calvo, George H. Addona, Christine C. Chung, Lisa M. Sonatore, Oksana C. Palyha

المصدر: Journal of biomolecular screening. 21(2)

مصطلحات موضوعية: 0301 basic medicine, Chromatography, Chemistry, digestive, oral, and skin physiology, Mass spectrometry, Biochemistry, humanities, Mass Spectrometry, Analytical Chemistry, Cell Line, 03 medical and health sciences, 030104 developmental biology, Liquid chromatography–mass spectrometry, Sf9 Cells, Molecular Medicine, Animals, Humans, Diacylglycerol O-Acyltransferase, Enzyme Inhibitors, Triglycerides, Biotechnology, Chromatography, Liquid, Enzyme Assays

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a8c17dafb11e5453ff6e2222e4a4bf
https://pubmed.ncbi.nlm.nih.gov/26403520

المؤلفون: Michael J. Forrest, Matthew J. Wyvratt, Lex H.T. Van der Ploeg, Kajal Patel, Michael H. Fisher, Ann E. Weber, Jiafang He, Anthony Mastracchio, Emma R. Parmee, Michael R. Tota, Euan Macintyre, Scott D. Edmondson, Xinchun Tong, Naphtali A. O'Connor, Joseph M. Metzger, Jeff P. Varnerin, Christine C. Chung, Scott Hofsess

المصدر: Bioorganic & Medicinal Chemistry Letters. 13:3983-3987

مصطلحات موضوعية: Vinyl Compounds, Phosphodiesterase Inhibitors, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Amide, Drug Discovery, Molecular Biology, chemistry.chemical_classification, biology, Organic Chemistry, Cyclic Nucleotide Phosphodiesterases, Type 3, In vitro, Pyridazines, Kinetics, Enzyme, chemistry, 3',5'-Cyclic-AMP Phosphodiesterases, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Selectivity, Enone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a716655952e30da51f523a1480673a13
https://doi.org/10.1016/j.bmcl.2003.08.056

المؤلفون: Margaret Wu, Cai Li, Robert W. Myers, Michael R. Tota, Michael E. Lassman, Christine C. Chung, Maryann Powles, Corey N. Miller, Jun Wang, Bindhu V. Karanam, Gino Salituro, Sheo B. Singh, Kenneth P. Ellsworth, Bei B. Zhang, Sang Ho Lee

مصطلحات موضوعية: Platensimycin, Adamantane, Biology, Carbohydrate metabolism, chemistry.chemical_compound, Mice, Anti-Infective Agents, medicine, Diabetes Mellitus, Animals, Humans, Hypoglycemic Agents, Aminobenzoates, Anilides, Beta oxidation, Fatty acid synthesis, Multidisciplinary, Fatty liver, Fatty Acids, Biological Sciences, medicine.disease, Mice, Mutant Strains, Cerulenin, Fatty Liver, Fatty acid synthase, Disease Models, Animal, Sterols, Glucose, chemistry, Biochemistry, Liver, Lipogenesis, biology.protein, Fatty Acid Synthases, Oxidation-Reduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06a8a194f9234738800a07d3d73077d
https://europepmc.org/articles/PMC3069196/

المؤلفون: Alexander Pasternak, Paul Mazur, Michael R. Tota, Stephen D. Goble, Lihu Yang, Donna L. Hreniuk, Andrew D. Howard, Reynalda deJesus, Sander G. Mills, Christine C. Chung, Scott D. Feighner

المصدر: Bioorganicmedicinal chemistry letters. 19(21)

مصطلحات موضوعية: Male, genetic structures, Drug Inverse Agonism, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Somatotropin-releasing factor, Chemical synthesis, Cell Line, Rats, Sprague-Dawley, Structure-Activity Relationship, Drug Discovery, Inverse agonist, Animals, Humans, Obesity, Receptor, Receptors, Ghrelin, Molecular Biology, Sulfonamides, Chemistry, digestive, oral, and skin physiology, Organic Chemistry, Antagonist, Rats, Drug Design, Benzene derivatives, Molecular Medicine, Ghrelin, Anti-Obesity Agents, Enantiomer, hormones, hormone substitutes, and hormone antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfcd1b4cde935121608bb1f09ea58b2
https://pubmed.ncbi.nlm.nih.gov/19767208

المؤلفون: Amy Chang, Kenji Ohwaki, Erica Stec, Jeffrey P Varnerin, Toshimitsu Takagi, Berta Strulovici, Peter Hodder, Jun Kusunoki, Jonathan Schneeweis, Marc Ferrer, Oleg Kornienko, Paul N. Goudreau, Michael R. Tota, James Inglese, Christine C. Chung, Jason Cassaday, Lihu Yang, Takeru Yamakawa

المصدر: Assay and drug development technologies. 6(3)

مصطلحات موضوعية: chemistry.chemical_classification, biology, High-throughput screening, Coenzyme A, Fatty acid, Enzyme assay, Fluorescence, Rats, Fatty Acid Synthase, Type I, chemistry.chemical_compound, Fatty acid synthase, Enzyme, chemistry, Biochemistry, Drug Discovery, Thiol, biology.protein, Molecular Medicine, Animals, Humans, Sulfhydryl Compounds, Enzyme Inhibitors, Fatty acid synthesis, Acetyl-CoA Carboxylase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5962497b90e5494bbf0b96aeef46439e
https://pubmed.ncbi.nlm.nih.gov/18452391

المؤلفون: Christine C. Chung, Terry M. Pederson, Grant A. Krafft, David A. Egan, Thomas F. Holzman, Annemarie Rueter, Rohinton Edalji, Gary T. Wang, Gail Howard, Lana K. Yang, Earl J. Gubbins

المصدر: Journal of Protein Chemistry. 9:663-672

مصطلحات موضوعية: Molecular Sequence Data, Gene Expression, Biology, Transfection, Biochemistry, Cell Line, law.invention, Tissue culture, Cricetulus, law, Cricetinae, Complementary DNA, Renin, Animals, Humans, Amino Acid Sequence, Cloning, Molecular, Proprotein, Chromatography, High Pressure Liquid, Enzyme Precursors, Expression vector, Base Sequence, Chinese hamster ovary cell, fungi, DNA Restriction Enzymes, Molecular biology, Recombinant Proteins, Cell culture, Recombinant DNA, Expression cassette, Oligonucleotide Probes, Plasmids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9fbd11ca0fab8953b773404a84488de
https://doi.org/10.1007/bf01024761

المؤلفون: Alexey Rivkin, Yoona R. Kim, Mark T. Goulet, Nicole Ginanni, Jeffrey P Varnerin, Amy Chang, Nathan Bays, Michael R. Tota, Peter Strack, Stefan Krauss, Nancy E. Kohl, Armetta D. Hill, Christine C. Chung, Benito Munoz, Ilona Kariv, Paul N. Goudreau

المصدر: Bioorganicmedicinal chemistry letters. 16(17)

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Potency, Animals, Humans, Enzyme Inhibitors, Microwaves, Molecular Biology, chemistry.chemical_classification, Bicyclic molecule, biology, Molecular Structure, Aryl, Organic Chemistry, Malonates, Rats, Fatty acid synthase, Enzyme, chemistry, Enzyme inhibitor, Lactam, biology.protein, Hydroxyquinolines, Quinolines, Molecular Medicine, Fatty Acid Synthases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcea5d95422dd09d2b4c0390903bf3d
https://pubmed.ncbi.nlm.nih.gov/16784844

المؤلفون: Jeffrey P Varnerin, Emma R. Parmee, Anthony Mastracchio, Scott D. Edmondson, Joseph W. Becker, Sangita B. Patel, Lex H.T. Van der Ploeg, Giovanna Scapin, Michael R. Tota, Christine C. Chung, Suresh B. Singh

المصدر: Biochemistry. 43(20)

مصطلحات موضوعية: Models, Molecular, Phosphodiesterase Inhibitors, Phosphodiesterase 3, Mutagenesis (molecular biology technique), Biology, Crystallography, X-Ray, Biochemistry, Substrate Specificity, Cyclic nucleotide, chemistry.chemical_compound, Protein structure, 1-Methyl-3-isobutylxanthine, Catalytic Domain, Lipolysis, Humans, Cyclic GMP, chemistry.chemical_classification, CGMP binding, Molecular Structure, Phosphodiesterase, Cyclic Nucleotide Phosphodiesterases, Type 3, Protein Structure, Tertiary, Isoenzymes, Enzyme, chemistry, 3',5'-Cyclic-AMP Phosphodiesterases, Mutagenesis, Site-Directed, Dimerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd2967da056f76a7f409e4db31a507b
https://pubmed.ncbi.nlm.nih.gov/15147193

المؤلفون: Michael R. Tota, Jeffrey P Varnerin, Suresh B. Singh, Douglas J. MacNeil, Lex H.T. Van der Ploeg, Christine C. Chung, Giovanna Scapin, Sangita B. Patel, Nancy R. Morin

المصدر: Biochemical and biophysical research communications. 307(4)

مصطلحات موضوعية: Models, Molecular, IBMX, Phosphodiesterase Inhibitors, Molecular Sequence Data, Biophysics, Biology, Quinolones, medicine.disease_cause, Biochemistry, Inclusion bodies, chemistry.chemical_compound, 1-Methyl-3-isobutylxanthine, Catalytic Domain, medicine, Escherichia coli, Animals, Humans, Amino Acid Sequence, Tyrosine, Molecular Biology, Cyclic GMP, Mutation, Cilostamide, Binding Sites, Tryptophan, Substrate (chemistry), Cell Biology, Cyclic Nucleotide Phosphodiesterases, Type 3, Kinetics, chemistry, 3',5'-Cyclic-AMP Phosphodiesterases, COS Cells, Sequence Alignment, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d58983e3d84b37e303cd42589361b6
https://pubmed.ncbi.nlm.nih.gov/12878217

المؤلفون: Thomas F. Holzman, Christine C. Chung, Rohinton Edalji, David A. Egan, Margaret Martin, Earl J. Gubbins, Grant A. Krafft, Gary T. Wang, A. Mitchel Thomas, Saul H. Rosenberg, Charles Hutchins

المصدر: Journal of protein chemistry. 10(5)

مصطلحات موضوعية: Peptidomimetic, Stereochemistry, Swine, Kinetics, Molecular Sequence Data, Angiotensinogen, Cleavage (embryo), Biochemistry, law.invention, Substrate Specificity, law, Renin–angiotensin system, Enzyme Stability, Renin, Bioorganic chemistry, Animals, Humans, Amino Acid Sequence, Histidine, Fluorescent Dyes, chemistry.chemical_classification, Enzyme Precursors, Molecular Structure, Hydrogen-Ion Concentration, Peptide Fragments, Recombinant Proteins, Enzyme, chemistry, Recombinant DNA, Thermodynamics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c876abb934cb725099a62437e61bae48
https://pubmed.ncbi.nlm.nih.gov/1799412

المؤلفون: Christine C. Chung, Kenji Ohwaki, Jonathan E. Schneeweis, Erica Stec, Jeffrey P. Varnerin, Paul N. Goudreau, Amy Chang, Jason Cassaday, Lihu Yang, Takeru Yamakawa, Oleg Kornienko, Peter Hodder, James Inglese, Marc Ferrer, Berta Strulovici, Jun Kusunoki, Michael R. Tota, Toshimitsu Takagi

المصدر: Assay & Drug Development Technologies; Jun2008, Vol. 6 Issue 3, p361-374, 14p

مصطلحات موضوعية: ENZYMES, TARGETED drug delivery, OBESITY, CANCER, FATTY acids