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1
المؤلفون: Shen Z, Tom A. Comery, David Smith, Brian J. Platt, Terrance H. Andree, Zhang Minsheng, Magid Abou-Gharbia, Sukoff-Rizzo Sj, Havran Lm, Chong Dc, Natasha Kagan, Zoë A. Hughes, Kelly Sullivan, Bach Ac rd, Boyd L. Harrison, Wayne E. Childers, Magda Asselin, Sharon Rosenzweig-Lipson, Claudine Pulicicchio, Steven M. Grauer, Marathias, George Theodore Grosu, Mark Day, Bicksler Jj, Chad E. Beyer, Adedayo Adedoyin, Christine Huselton, Sabb Al, Suzan Aschmies, Ronald L. Magolda, Warren D. Hirst, Kleintop T, Albert J. Robichaud
المصدر: Journal of Medicinal Chemistry. 53:4066-4084
مصطلحات موضوعية: Serotonin, Administration, Oral, Biological Availability, Mice, Transgenic, CHO Cells, In Vitro Techniques, Serotonin 5-HT1 Receptor Antagonists, Pharmacology, Hippocampus, Piperazines, Amyloid beta-Protein Precursor, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Cognition, Cricetulus, Piperidines, Memory, Oral administration, Cricetinae, Fluoxetine, Drug Discovery, medicine, Animals, Potency, Maze Learning, Nootropic Agents, Cerebral Cortex, Chemistry, Penile Erection, Antagonist, Acetylcholine, Antidepressive Agents, Rats, Bioavailability, Piperazine, Microsomes, Liver, Quinolines, Arylalkylamine, Molecular Medicine, medicine.drug
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2
المؤلفون: Christine Huselton, David H. Kaufman, Annika Goos-Nilsson, Jay E. Wrobel, Irene Feingold, Ponnal Nambi, Ronald C. Bernotas, Elaine Quinet, Anna Wilhelmsson, Jeremy M. Travins
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:526-530
مصطلحات موضوعية: Agonist, Benzimidazole, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Cell Line, Sulfone, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, polycyclic compounds, medicine, Animals, Humans, Potency, Structure–activity relationship, RNA, Messenger, Sulfones, Liver X receptor, Molecular Biology, Liver X Receptors, Chemistry, Organic Chemistry, Biological activity, Orphan Nuclear Receptors, Rats, Microsomes, Liver, Microsome, Molecular Medicine, ATP-Binding Cassette Transporters, Benzimidazoles, lipids (amino acids, peptides, and proteins)
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3
المؤلفون: Paige Erin Mahaney, Elizabeth Koury, Thomas Kenney, Robert Emmett Mcdevitt, Richard C. Winneker, Gavin David Heffernan, Grace H. Johnston, Darlene C. Deecher, Eugene John Trybulski, Christine Huselton, Peter D. Alfinito, Jenifer A. Bray, Scott Cosmi, Albert J. Robichaud, Eric S. Manas, Yanfang Li, Coghlan Richard Dale
المصدر: Bioorganic & Medicinal Chemistry. 17:7802-7815
مصطلحات موضوعية: Indoles, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Cell Line, Norepinephrine (medication), Norepinephrine, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Neurotransmitter Uptake Inhibitors, Receptor, Serotonin, 5-HT2A, Neurotransmitter, Receptor, Molecular Biology, 5-HT receptor, Virtual screening, Chemistry, fungi, Organic Chemistry, Biological Transport, Serotonin 5-HT2 Receptor Antagonists, Catecholamine, Molecular Medicine, Serotonin Antagonists, Reuptake inhibitor, medicine.drug
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4
المؤلفون: Lloyd M. Garrick, John F. Mehlmann, Diane B. Hauze, Joshua E. Cottom, Daniel M. Green, Jeffrey C. Pelletier, Murty Chengalvala, Irene Feingold, Joseph T. Lundquist, John F. Rogers, Charles William Mann, Linda Shanno, Jay E. Wrobel, Christine Huselton, Wenling Kao, Kees Kenneth L
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:1986-1990
مصطلحات موضوعية: medicine.medical_specialty, Benzimidazole, Time Factors, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Gonadotropin-releasing hormone, Peptide hormone, Biochemistry, Piperazines, Structure-Activity Relationship, chemistry.chemical_compound, Heterocyclic Compounds, Oral administration, Internal medicine, Drug Discovery, medicine, Animals, Receptor, Molecular Biology, Volume of distribution, Chemistry, Organic Chemistry, Antagonist, Luteinizing Hormone, Rats, Bioavailability, Endocrinology, Models, Animal, Molecular Medicine, Benzimidazoles, Receptors, LHRH
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5
المؤلفون: William R. Adams, Irene Feingold, John F. Mehlmann, Cesario O Tio, Joshua E. Cottom, Jay E. Wrobel, Jeffrey C. Pelletier, Daniel M. Green, John F. Rogers, James W. Jetter, Murty Chengalvala, Joseph T. Lundquist, Charles William Mann, Linda Shanno, Ronald L. Magolda, Diane B. Hauze, Gregory S. Kopf, Christine Huselton
المصدر: Journal of Medicinal Chemistry. 52:2148-2152
مصطلحات موضوعية: Male, Stereochemistry, Administration, Oral, Biological Availability, In Vitro Techniques, Binding, Competitive, Chemical synthesis, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Quinoxaline, Oral administration, Quinoxalines, Drug Discovery, Animals, Humans, Structure–activity relationship, Receptor, Antagonist, Luteinizing Hormone, Rats, chemistry, Pituitary Gland, Microsomes, Liver, Molecular Medicine, Benzimidazoles, Pharmacophore, Orchiectomy, Receptors, LHRH, Gonadotropin-releasing hormone receptor, Half-Life
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6
المؤلفون: Christine Huselton, Steven M. Grauer, Zhi Liu, Karen L. Marquis, Amy Sung, Radka Graf, Sheree F. Logue, Rachel Navarra, Thomas A. Comery, Sharon Rosenzweig-Lipson, Gary Paul Stack
المصدر: Psychopharmacology. 204:37-48
مصطلحات موضوعية: Male, Agonist, Reflex, Startle, Indoles, Apomorphine, medicine.drug_class, medicine.medical_treatment, Atypical antipsychotic, Pharmacology, Catalepsy, Rats, Sprague-Dawley, Mice, Avoidance Learning, Haloperidol, medicine, Animals, Antipsychotic, Clozapine, Drug Synergism, Azepines, medicine.disease, Typical antipsychotic, Rats, Stereotypy (non-human), Drug Therapy, Combination, Dizocilpine Maleate, Stereotyped Behavior, Psychology, Serotonin 5-HT2 Receptor Agonists, Antipsychotic Agents, medicine.drug
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7
المؤلفون: Murty V. Chengalvala, Linda Shanno, Charles William Mann, Josh Cottom, Diane B. Hauze, Jay E. Wrobel, Irene Feingold, Jeffrey C. Pelletier, Gregory S. Kopf, Daniel M. Green, John A. Rogers, Wenling Kao, Christine Huselton, John F. Mehlmann, Joseph T. Lundquist, Lloyd M. Garrick, James W. Jetter
المصدر: Bioorganic & Medicinal Chemistry. 16:6617-6640
مصطلحات موضوعية: Male, endocrine system, medicine.medical_specialty, medicine.drug_class, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Gonadotropin-releasing hormone, Methylation, Biochemistry, Piperazines, Gonadotropin-releasing hormone antagonist, Rats, Sprague-Dawley, Structure-Activity Relationship, Prostate cancer, In vivo, Internal medicine, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Receptor, Piperazine, Molecular Biology, Leuteinizing hormone, Molecular Structure, Chemistry, Organic Chemistry, Antagonist, Luteinizing Hormone, medicine.disease, Glycolates, Rats, Cross-Linking Reagents, Endocrinology, Molecular Medicine, Benzimidazoles, Receptors, LHRH, hormones, hormone substitutes, and hormone antagonists
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8
المؤلفون: Liang Chen, Ponnal Nambi, Qiang-Yuan Liu, Rayomand J Unwalla, Valerie Clerin, Michael D Basso, Mathias Färnegårdh, Irene Feingold, Dawn A. Savio, James Carl Keith, Christopher P. Miller, Jay Wrobel, Anita R Halpern, Farooq Azam, Anna Wilhelmsson, Annika Goos-Nilsson, Robert R. Singhaus, Christine Resmini, Christine Huselton, Baihua Hu, Michael D. Collini, Elaine M. Quinet, Tomas Bonn, Cristofer Enroth
المصدر: Journal of Medicinal Chemistry. 49:6151-6154
مصطلحات موضوعية: Male, Models, Molecular, Transcriptional Activation, Biological Availability, Receptors, Cytoplasmic and Nuclear, In Vitro Techniques, Ligands, Cell Line, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Transactivation, Drug Stability, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Liver X receptor, Liver X Receptors, Phenylacetates, Binding Sites, Molecular Structure, biology, Anticholesteremic Agents, Quinoline, Biological activity, Atherosclerosis, Orphan Nuclear Receptors, Protein Structure, Tertiary, DNA-Binding Proteins, Mice, Inbred C57BL, Cholesterol, chemistry, Biochemistry, ABCA1, LDL receptor, Microsomes, Liver, Quinolines, biology.protein, Molecular Medicine, ATP-Binding Cassette Transporters, Female, lipids (amino acids, peptides, and proteins), ATP Binding Cassette Transporter 1
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9
المصدر: Brain Research. 1098:71-78
مصطلحات موضوعية: Serotonin, medicine.medical_specialty, Dopamine, Microdialysis, Ovariectomy, Rats, Sprague-Dawley, Stereotaxic Techniques, Norepinephrine, Norepinephrine reuptake inhibitor, Desvenlafaxine Succinate, Internal medicine, medicine, Animals, Molecular Biology, 5-HT receptor, Brain Chemistry, Adrenergic Uptake Inhibitors, Chemistry, General Neuroscience, Cyclohexanols, Preoptic Area, Rats, Desvenlafaxine, Endocrinology, Stereotaxic technique, Ovariectomized rat, Catecholamine, Female, Neurology (clinical), Reuptake inhibitor, Selective Serotonin Reuptake Inhibitors, Developmental Biology, medicine.drug
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10
المؤلفون: Latha Sridharan, Judy Lucas, Carlo Etienne, Craig Titsch, Inder Chaudhary, Christine Huselton, Diane H. Boschelli, Jennifer M. Golas, Carolyn Discafani, Erwin R. Boghaert, Frank Boschelli, K T Arndt, Jonathan Golas, Fei Ye, Fangbiao Li
المصدر: Cancer Research. 65:5358-5364
مصطلحات موضوعية: Cancer Research, Colorectal cancer, Administration, Oral, Mice, Nude, Antineoplastic Agents, Biology, Focal adhesion, Mice, In vivo, Nitriles, medicine, Animals, Humans, Phosphorylation, Protein Kinase Inhibitors, Aniline Compounds, ABL, Kinase, Autophosphorylation, HCT116 Cells, medicine.disease, Xenograft Model Antitumor Assays, In vitro, src-Family Kinases, Oncology, Colonic Neoplasms, Quinolines, Cancer research, Female, HT29 Cells, Proto-oncogene tyrosine-protein kinase Src
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11
المؤلفون: Michael Marella, Christine Huselton, Edward Melenski, Casey C. McComas, Richard C. Winneker, Cheryl Mugford, Jeffrey Cohen, Andrew Fensome, Matthew R. Yudt, Ov D. Slayden, Jay Wrobel
المصدر: Bioorganicmedicinal chemistry letters. 22(23)
مصطلحات موضوعية: Male, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Progesterone receptor modulators, Pharmacology, Biochemistry, Progesterone Antagonist, Ames test, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Progesterone receptor, Animals, Humans, Molecular Biology, Sulfonamides, Chemistry, Aryl, Organic Chemistry, Alkaline Phosphatase, Macaca mulatta, Rats, Molecular Medicine, Receptors, Progesterone, Half-Life
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12
المؤلفون: Sharon Rosenzweig-Lipson, Tim Lock, Deborah L. Smith, Robert H. Ring, Paul Jeffrey Dollings, Jean Zhang, Sarah K. Leonard, Susanna Y. Tse, Andrew D. Randall, Stacey J. Sukoff Rizzo, Sarah J. Neal, Li Di, Adam M. Gilbert, Dianne Kowal, John Dunlop, Meiyi Zhang, John A. Butera, Angela Kramer, Jason M. Dwyer, Christine Huselton, Corey N. Bender, Karthick Vishwanathan, Zoë A. Hughes, Brian J. Platt
المصدر: The Journal of pharmacology and experimental therapeutics. 338(1)
مصطلحات موضوعية: Agonist, Male, Allosteric modulator, medicine.drug_class, CHO Cells, Pharmacology, Receptors, Metabotropic Glutamate, Rats, Sprague-Dawley, chemistry.chemical_compound, Mice, Cricetulus, AMN082, Allosteric Regulation, Cricetinae, medicine, Animals, Humans, Biogenic Monoamines, Benzhydryl Compounds, Metabotropic glutamate receptor 5, Chemistry, Metabotropic glutamate receptor 7, Rats, HEK293 Cells, Molecular Medicine, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 3, Metabotropic glutamate receptor 2, Protein Binding
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13
المؤلفون: Charles W. Young, Francis DeGrazia, Prudence A. Francis, John P. Orazem, Christine Huselton, Mark G. Kris, Josephia R. F. Muindi, James R. Rigas, Raymond P. Warrell
المصدر: JNCI Journal of the National Cancer Institute. 85:1921-1926
مصطلحات موضوعية: Acute promyelocytic leukemia, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Population, Tretinoin, Leukemia, Promyelocytic, Acute, Pharmacokinetics, Drug tolerance, Carcinoma, Non-Small-Cell Lung, Neoplasms, Internal medicine, Cytochrome P-450 Enzyme Inhibitors, Humans, Medicine, Drug Interactions, education, Lung cancer, education.field_of_study, Dose-Response Relationship, Drug, business.industry, Area under the curve, Drug Tolerance, medicine.disease, Dose–response relationship, Ketoconazole, Endocrinology, Oncology, business, medicine.drug
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14
المؤلفون: Zoe A. Hughes, Thomas A. Comery, Lo Jennifer Rebecca, Ronald C. Bernotas, Jean Y. Zhang, Kevin G. Liu, Dianne Kowal, Deborah L. Smith, Guo Ming Zhang, Lee E. Schechter, Christine Huselton, Meiyi Zhang, Yinfa Yan, Robichaud Albert Jean
المصدر: Journal of medicinal chemistry. 53(21)
مصطلحات موضوعية: Indazoles, Chemistry, Biological Availability, Brain, Glutamic Acid, Pharmacology, Ligands, Acetylcholine, Piperazines, Rats, Structure-Activity Relationship, Receptors, Serotonin, Drug Discovery, Molecular Medicine, Animals, Humans, Serotonin Antagonists, Sulfones, Receptor, Nootropic Agents, HeLa Cells
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15
المؤلفون: Jean Zhang, Peter H. Reinhart, Deborah L. Smith, Zoë A. Hughes, Geraldine Ruth Mcfarlane, Dianne Kowal, Mei-Yi Zhang, Angela Kramer, Michael M. Monaghan, Guoming Zhang, Al J. Robichaud, Suzan Aschmies, Menelas N. Pangalos, Simon Haydar, Thomas A. Comery, Christine Huselton
المصدر: Alzheimer's & Dementia. 6
مصطلحات موضوعية: Epidemiology, medicine.drug_class, Stereochemistry, Chemistry, Health Policy, Receptor antagonist, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Amine gas treating, Neurology (clinical), Serotonin, Geriatrics and Gerontology
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16
المؤلفون: Jennifer Leiter, Kevin D. Burroughs, Eugene John Trybulski, Douglas John Jenkins, Grace H. Johnston, Darlene C. Deecher, Jenifer A. Bray, Lori Krim Gavrin, Douglas M. Ho, Lisa Nogle, Christine Huselton, Paige Erin Mahaney, Scott Cosmi, Peter D. Alfinito, Cheryl A. Mugford
مصطلحات موضوعية: biology, Chemistry, Organic Chemistry, Transporter, Pharmacology, Biochemistry, Norepinephrine transporter, Norepinephrine reuptake inhibitor, Dopamine, Drug Discovery, biology.protein, medicine, Potency, Serotonin, Serotonin transporter, Dopamine transporter, medicine.drug
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17
المؤلفون: Heedong Yun, James F. Mattes, Simon Haydar, Jean Zhang, Lee E. Schechter, Deborah L. Smith, Radka Graf, Thomas A. Comery, Christine Huselton, Albert J. Robichaud, Angela Kramer, Suzan Aschmies, Andrae Patrick M
المصدر: Journal of medicinal chemistry. 53(6)
مصطلحات موضوعية: Indazoles, Pharmacology, Binding, Competitive, Structure-Activity Relationship, Pharmacokinetics, Drug Discovery, Receptor, Serotonin, 5-HT2B, Serotonin 5-HT2 Receptor Antagonists, Structure–activity relationship, Animals, Humans, Sulfones, Novel object recognition, Serotonin Antagonists, Receptor, Habituation, Psychophysiologic, Molecular Structure, Chemistry, Brain, Recognition, Psychology, Rats, Models, Chemical, Receptors, Serotonin, 5-HT6 receptor, Exploratory Behavior, Molecular Medicine, Amine gas treating
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18
المؤلفون: Ronald C. Bernotas, Irene Feingold, James W. Jetter, Christofer Enroth, Anna Wilhelmsson, Robert W Morris, Christine Huselton, Annika Goos-Nilsson, John W. Ullrich, Jay E. Wrobel, Ponnal Nambi, Elaine Quinet, Rayomand J. Unwalla, Jeremy M. Travins
المصدر: Bioorganicmedicinal chemistry letters. 20(9)
مصطلحات موضوعية: Agonist, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Sulfone, Cell Line, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Microsomes, Drug Discovery, medicine, Potency, Structure–activity relationship, Animals, Humans, Computer Simulation, Sulfones, Binding site, Liver X receptor, Molecular Biology, Binding selectivity, Liver X Receptors, Mice, Knockout, Binding Sites, Organic Chemistry, Quinoline, Atherosclerosis, Orphan Nuclear Receptors, Rats, Lipoproteins, LDL, chemistry, Quinolines, Molecular Medicine, lipids (amino acids, peptides, and proteins)
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19
المؤلفون: Joseph F. Grippo, Gary Allenby, Thomas Bosakowski, Laurie J. Sturzenbecker, Michael Rosenberger, Arthur A. Levin, Cl. Kratzeisen, Allen John Lovey, Christine Huselton, J Speck, Sonja Kazmer
المصدر: Annals of the New York Academy of Sciences. 669:70-85
مصطلحات موضوعية: Vitamin, Genetics, chemistry.chemical_compound, History and Philosophy of Science, chemistry, General Neuroscience, Biology, General Biochemistry, Genetics and Molecular Biology
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20
المؤلفون: Jackson Christopher M, Laurent Djandjighian, Stephen J. Gardell, John Michael Janusz, Manoj Samuel, Christine Huselton, Benjamin E. Blass, James K. Hennan, Eugene John Trybulski, Irene Feingold, Ronald L. Magolda, Andrew Fensome, Douglas M. Ho, Kun Liu
المصدر: Journal of medicinal chemistry. 52(21)
مصطلحات موضوعية: medicine.medical_specialty, Patch-Clamp Techniques, Heart disease, medicine.medical_treatment, Antiarrhythmic agent, In Vitro Techniques, Imidazolidines, Cell Line, Kv1.5 Potassium Channel, Structure-Activity Relationship, Cricetulus, Dogs, Internal medicine, Cricetinae, Drug Discovery, Atrial Fibrillation, medicine, Atrial effective refractory period, Animals, Humans, cardiovascular diseases, Sulfonamides, Chemistry, Cardiac arrhythmia, Atrial fibrillation, Stereoisomerism, 2-imidazolidinone, medicine.disease, Blockade, Endocrinology, Solubility, cardiovascular system, Cardiology, Microsomes, Liver, Molecular Medicine, Anti-Arrhythmia Agents