المؤلفون: Andrea M. Zuhl, Charles E. Nolan, Michael A. Brodney, Sherry Niessen, Kevin Atchison, Christopher Houle, David A. Karanian, Claude Ambroise, Jeffrey W. Brulet, Elizabeth M. Beck, Shawn D. Doran, Brian T. O’Neill, Christopher W. am Ende, Cheng Chang, Kieran F. Geoghegan, Graham M. West, Joshua C. Judkins, Xinjun Hou, David R. Riddell, Douglas S. Johnson

المصدر: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/5dfe4a29e6af43a49ee6c24207abc513

المؤلفون: Laigao Chen, Anabella Villalobos, Ryosuke Arakawa, Shawn D. Doran, Christer Halldin, Brian T. O’Neill, Akihiro Takano, Michael Aaron Brodney, Nahid Amini, Charles E. Nolan, Timothy J. McCarthy, Jason K. Dutra, Sangram Nag, Cheng Chang, Lei Zhang

المصدر: Journal of Nuclear Medicine. 60:992-997

مصطلحات موضوعية: 0303 health sciences, Chemistry, Pharmacology, medicine.disease, Effective dose (pharmacology), 03 medical and health sciences, 0302 clinical medicine, In vivo, Oral administration, Radioligand, medicine, Distribution (pharmacology), Radiology, Nuclear Medicine and imaging, Alzheimer's disease, Quantitative analysis (chemistry), 030217 neurology & neurosurgery, 030304 developmental biology, Distribution Volume

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::dc017d72ab0f8c8c2e3e286dc6ce3d29
https://doi.org/10.2967/jnumed.118.217372

المؤلفون: Kelly R. Bales, Anabella Villalobos, David Riddell, Shawn D. Doran, Christopher Ryan Butler, Bruce N. Rogers, Lorraine F. Lanyon, Karamjeet Pandher, Claude Ambroise, Ashley Robshaw, Gabriela Barreiro, Christopher Houle, Kevin Ogilvie, Brian T. O’Neill, Erik Alphie Lachapelle, Germaine Boucher, Xinjun Hou, Katherine Hales, David Karanian, Michael Aaron Brodney, Leanne M. Buzon, Kimberly Lapham, Lei Zhang, Luis Martinez-Alsina, Charles E. Nolan, Claire M. Steppan, Cathleen Gonzales, John C. Murray, Cheng Chang, Jason K. Dutra, Elizabeth Mary Beck

المصدر: Journal of Medicinal Chemistry. 61:4476-4504

مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Protein Conformation, Thiazines, Cathepsin D, Skin Pigmentation, Amyloid beta-Protein Precursor, Mice, 03 medical and health sciences, Dogs, 0302 clinical medicine, Protein structure, In vivo, Drug Discovery, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Humans, Protease Inhibitors, Cells, Cultured, Pyrans, Melanosome, Hypopigmentation, chemistry.chemical_classification, Molecular Structure, biology, Brain, Phenotype, Mice, Inbred C57BL, Thiazoles, 030104 developmental biology, Enzyme, chemistry, Biochemistry, Drug Design, biology.protein, Melanocytes, Molecular Medicine, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16220e824d55c04d1dd3342582ab393
https://doi.org/10.1021/acs.jmedchem.8b00246

المؤلفون: Felix Vajdos, Eric Benvenuti, Leanne M. Buzon, Brian T. O’Neill, Gabriela Barreiro, David Riddell, Kevin Atchison, Charles E. Nolan, Ashley Robshaw, Eric F. Johnson, Kevin D. Parris, Shawn D. Doran, Michael Aaron Brodney, Xinjun Hou, Luis Martinez-Alsina, Kimberly Lapham, Mei-Hui Hsu, Elizabeth Mary Beck, Christopher Ryan Butler, Kevin Ogilvie, Cathleen Gonzales, Lorraine F. Lanyon, Christopher John Helal

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: Male, 0301 basic medicine, Patch-Clamp Techniques, Stereochemistry, Glycine, Article, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Tandem Mass Spectrometry, Drug Discovery, Animals, Moiety, Potency, Structure–activity relationship, Anilides, Amino Acid Sequence, Enzyme Inhibitors, Binding site, Structural motif, Chromatography, High Pressure Liquid, ADME, biology, Chemistry, Brain, 030104 developmental biology, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Crystallization, Linker, Amyloid precursor protein secretase, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded625eb28a2c9b897d6055a57557a14
https://doi.org/10.1021/acs.jmedchem.6b01451

المؤلفون: Akihiro, Takano, Laigao, Chen, Sangram, Nag, Michael A, Brodney, Ryosuke, Arakawa, Cheng, Chang, Nahid, Amini, Shawn D, Doran, Jason K, Dutra, Timothy J, McCarthy, Charles E, Nolan, Brian T, O'Neill, Anabella, Villalobos, Lei, Zhang, Christer, Halldin

المصدر: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 60(7)

مصطلحات موضوعية: Male, Fluorine Radioisotopes, Radiochemistry, Thiazines, Brain, Ligands, Models, Biological, Kinetics, Macaca fascicularis, Positron-Emission Tomography, Pyrazines, Animals, Female, Whole Body Imaging, Amyloid Precursor Protein Secretases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::07ab8a235067dc35f919a5196244d1ca
https://pubmed.ncbi.nlm.nih.gov/30530832

المؤلفون: Christopher John Helal, Kevin Atchison, Christopher Ryan Butler, Cathleen Gonzales, Ricardo Lira, Shawn D. Doran, Feng Pan, Felix Vajdos, Alison H. Varghese, Gabriela Barreiro, Michael Aaron Brodney, Jinlong Wang, Elizabeth Mary Beck, Luis Martinez-Alsina, Yong Zhang, Kevin D. Parris, David Riddell, Joseph Michael Young, Leanne M. Buzon, Ashley Robshaw, Kevin Ogilvie, Jason K. Dutra, Brian T. O’Neill, John C. Murray, Charles E. Nolan

المصدر: Journal of Medicinal Chemistry. 58:2678-2702

مصطلحات موضوعية: Male, Models, Molecular, Drug, media_common.quotation_subject, Amidines, Cathepsin D, Plaque, Amyloid, Pharmacology, Mice, Dogs, Alzheimer Disease, Oral administration, mental disorders, Drug Discovery, medicine, Animals, Aspartic Acid Endopeptidases, Humans, Potency, Sulfhydryl Compounds, Enzyme Inhibitors, Rats, Wistar, media_common, ADME, Amyloid beta-Peptides, Retinal pigment epithelium, biology, Chemistry, Brain, medicine.disease, Rats, medicine.anatomical_structure, Drug Design, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Alzheimer's disease, Amyloid precursor protein secretase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455eb0d85337e81623d88cc6b235a8b0
https://doi.org/10.1021/jm501833t

المؤلفون: Mark W. Bundesmann, David Riddell, Peter Mikochik, Leanne M. Buzon, Brian T. O’Neill, Subas M. Sakya, Jayvardhan Pandit, Christopher Ryan Butler, Xinjun Hou, Ashley Robshaw, Kevin D. Parris, Jason K. Dutra, Ricardo Lira, Loren M. Price, Charles E. Nolan, Elizabeth Mary Beck, Bruce N. Rogers, Gabriela Barreiro, Aijia Yu, Michael Aaron Brodney, Cathleen Gonzales, Erik Alphie Lachapelle, Shawn D. Doran, Luis Martinez-Alsina, Kevin E. Henegar, Ying Fan, Kevin Atchison, Eric F. Johnson, John C. Murray, Kevin Ogilvie, Yong Zhang

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: Drug, Male, Models, Molecular, CYP2D6, ERG1 Potassium Channel, media_common.quotation_subject, Molecular Sequence Data, Amyloidogenic Proteins, Mice, Inbred Strains, Pyrazole, Pharmacology, Crystallography, X-Ray, Article, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Animals, Aspartic Acid Endopeptidases, Humans, Drug Interactions, Protease Inhibitors, Amino Acid Sequence, media_common, chemistry.chemical_classification, biology, Potential risk, First generation, Ether-A-Go-Go Potassium Channels, 3. Good health, Enzyme, chemistry, Biochemistry, Cytochrome P-450 CYP2D6, Drug Design, biology.protein, Molecular Medicine, Pyrazoles, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8005f5cf17b6e63dea10eb5d783b7474
http://europepmc.org/articles/PMC4415909

المؤلفون: Charles E. Nolan, Christer Halldin, Anabella Villalobos, Kelly R. Bales, Klaas Schildknegt, Ryosuke Arakawa, Akihiro Takano, Lorraine F. Lanyon, Leanne M. Buzon, Shawn D. Doran, Nahid Amini, Laigao Chen, Brian T. O’Neill, Michael Aaron Brodney, Elizabeth Mary Beck, Lei Zhang, Timothy J. McCarthy, Sangram Nag, Jason K. Dutra

المصدر: Journal of medicinal chemistry. 61(8)

مصطلحات موضوعية: 0301 basic medicine, Male, Fluorine Radioisotopes, Thiazines, Cleavage (embryo), Ligands, 03 medical and health sciences, Mice, 0302 clinical medicine, In vivo, mental disorders, Drug Discovery, Amyloid precursor protein, Extracellular, medicine, Animals, Aspartic Acid Endopeptidases, Protease Inhibitors, chemistry.chemical_classification, biology, medicine.diagnostic_test, Brain, In vitro, 030104 developmental biology, Enzyme, chemistry, Biochemistry, Positron emission tomography, Positron-Emission Tomography, Pyrazines, Pet ligand, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Radiopharmaceuticals, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087651e6e72808da07b8c041e1b3d37c
https://pubmed.ncbi.nlm.nih.gov/29617136

المؤلفون: Kelly R. Bales, David Karanian, Michael Aaron Brodney, Shawn D. Doran, Cathleen Gonzales, Katherine Hales, Germaine Boucher, Lorraine F. Lanyon, Charles E. Nolan, Karamjeet Pandher, Christopher Houle, Claude Ambroise, Cheng Chang

المصدر: Alzheimer's & Dementia. 12

مصطلحات موضوعية: Epidemiology, Health Policy, Biology, Cell biology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Ultrastructure, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, Hypopigmentation, Melanosome

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::69664bc0d18a8c28039de61358dcc6fb
https://doi.org/10.1016/j.jalz.2016.06.854

المؤلفون: Douglas E. Wood, Robert B. Nelson, Barbara G. Sahagan, Xingrong Liu, Lei Zhang, Nikolay Pozdnyakov, Jeffrey Van Deusen, Karl E.G. Richter, James E. Finley, Christine P. Parker, Karen J. Coffman, Michael Aaron Brodney, Barbara-Anne Martin, David D. Auperin, Joel B. Schachter, Dane R. Liston, Michael J. Karmilowicz, Tracy M. Brown, Barbara Tate, Christine E. Oborski, Sharon A. Sokolowski, Stacey L. Becker, Bronk Brian Scott, Thomas A. Lanz, Carol D. Hicks, Charles E. Nolan, Kathleen M. Wood

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2637-2640

مصطلحات موضوعية: Tetrahydronaphthalenes, medicine.drug_class, Stereochemistry, Guinea Pigs, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Therapeutic index, In vivo, Amide, Drug Discovery, medicine, Amyloid precursor protein, Animals, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, Imidazoles, Valine, Enzyme Activation, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Biological Assay, Amyloid Precursor Protein Secretases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecedc3d6dd0ae90f3f64245736a002bc
https://doi.org/10.1016/j.bmcl.2010.12.118

المؤلفون: Kathleen M. Wood, Ping Du, Karen J. Coffman, Karl E.G. Richter, Sharon A. Sokolowski, Barbara-Anne Martin, Dane R. Liston, Barbara Tate, Douglas E. Wood, Tracy M. Brown, Michael Aaron Brodney, Carol D. Hicks, Charles E. Nolan, Nikolay Pozdnyakov, James E. Finley, Christine E. Oborski, Stacey L. Becker, Thomas A. Lanz, Kieran F. Geoghegan

المصدر: Journal of Pharmacology and Experimental Therapeutics. 334:269-277

مصطلحات موضوعية: Male, Tetrahydronaphthalenes, Guinea Pigs, Mice, Inbred Strains, Pharmacology, Transfection, Cell Line, Mice, Cerebrospinal fluid, Therapeutic index, Pharmacokinetics, In vivo, mental disorders, Escherichia coli, Animals, Humans, Potency, Tissue Distribution, Lymphocyte Count, Enzyme Inhibitors, Gamma secretase, B-Lymphocytes, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Brain, Valine, In vitro, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Pharmacodynamics, Molecular Medicine, Female, Amyloid Precursor Protein Secretases, Spleen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3da18b952deeed900e3aece6d23d62
https://doi.org/10.1124/jpet.110.167379

المؤلفون: Robert B. Nelson, Susan E. Drozda, Steve Faraci, Kim Verdries, Pat Seymour, Robert A. Volkmann, Weimin Qian, and Anabella Villalobos, Dane R. Liston, W. Frost White, Charles E. Nolan, John A. Lowe, Michael Majchrzak, Deane M. Nason, Karen M. Ward

المصدر: Journal of Medicinal Chemistry. 47:1575-1586

مصطلحات موضوعية: Male, Gene isoform, Tetrahydronaphthalenes, Central nervous system, Aminopyridines, Nitric Oxide Synthase Type I, Motor Activity, Chemical synthesis, Rats, Sprague-Dawley, Structure-Activity Relationship, In vivo, Cerebellum, Drug Discovery, medicine, Animals, Cyclic GMP, chemistry.chemical_classification, biology, Chemistry, In vitro, Rats, Nitric oxide synthase, medicine.anatomical_structure, Enzyme, nervous system, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Nitric Oxide Synthase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8883048ff2f6eb5be3dd0789c9cf1e
https://doi.org/10.1021/jm030519g

المؤلفون: Charles E. Nolan

المصدر: The Catholic Historical Review. 98:604-606

مصطلحات موضوعية: History, biology, General Arts and Humanities, media_common.quotation_subject, Local church, Context (language use), biology.organism_classification, Colonialism, language.human_language, Faith, Irish, Regionalism (international relations), language, Papal infallibility, Theology, Religious studies, Bishops, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8012fcd0454bc4cc810ca156fa2c1e65
https://doi.org/10.1353/cat.2012.0211

المؤلفون: Kimberly A. Verdries, Martin Sanders, Michelle Vanase, Peter John Whittle, Jolanta Nowakowski, W. Stephen Faraci, Shawn D. Doran, Mark H. Stefaniak, James Baxter, Dane R. Liston, Robert B. Nelson, Steven D. Heck, Stevin H. Zorn, Michael A. Ashton, Charles E. Nolan, Robert A. Volkmann, Weimin Qian, John A. Lowe, Karen M. Ward, Celeste Johnson

المصدر: Bioorganic & Medicinal Chemistry Letters. 9:2569-2572

مصطلحات موضوعية: Gene isoform, Clinical Biochemistry, Aminopyridines, Pharmaceutical Science, Nitric Oxide Synthase Type I, Biochemistry, Structure-Activity Relationship, In vivo, Drug Discovery, Animals, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Organic Chemistry, Biological activity, In vitro, Rats, body regions, Nitric oxide synthase, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Nitric Oxide Synthase, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e57b946192c2fe3b394f0a5498cb73f
https://doi.org/10.1016/s0960-894x(99)00432-1

المؤلفون: Yasong Lu, Liming Zhang, David Riddell, Cathleen Gonzales, Antonia F. Stepan, Michael Aaron Brodney, Stephen Noell, Leslie R. Pustilnik, Charles E. Nolan, Eva Hajos-Korcsok, Christine E. Oborski, Kevin Atchison, Ivan Viktorovich Efremov, Claude Ambroise, Ashley Robshaw, Chakrapani Subramanyam

المصدر: Alzheimer's & Dementia. 9

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Amyloid, Epidemiology, In vivo, Chemistry, Health Policy, Neurology (clinical), Geriatrics and Gerontology, Pharmacology, Beta (finance), Gamma secretase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::adea9195a6e959c02150f073988a9f43
https://doi.org/10.1016/j.jalz.2013.05.1671

المؤلفون: Feng Pan, Joel W. Schwartz, Kevin Atchison, David Riddell, Eva Hajos-Korcsok, Charles E. Nolan, Cathleen Gonzales

المصدر: Alzheimer's & Dementia. 9

مصطلحات موضوعية: Pathology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Parenchyma, Medicine, Neurology (clinical), Geriatrics and Gerontology, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7963034491b877ae11609de2e7eb2ba7
https://doi.org/10.1016/j.jalz.2013.05.1049

المؤلفون: Michael Aaron Brodney, Kevin Atchison, Yao Zhang, Cheng Chang, Leslie R. Pustilnik, Yasong Lu, Sandra J. Engle, Stephen Noell, Kewa Mou, Ashley Robshaw, David Riddell, Charles E. Nolan, Christine E. Oborski

المصدر: Alzheimer's & Dementia. 9

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, In vivo, Chemistry, Health Policy, Neurology (clinical), Geriatrics and Gerontology, Pharmacology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7c91a0ff3e15138253e122a11041c4a0
https://doi.org/10.1016/j.jalz.2013.05.1684

المؤلفون: Andre Negahban, Kevin Atchison, Stephen Noell, Cathleen Gonzales, David Riddell, Leslie R. Pustilnik, Christopher Ryan Butler, Brian T. O’Neill, Cheng Chang, Shawn D. Doran, Feng Pan, Yasong Lu, Elizabeth Mary Beck, Jianhua Liu, Ashley Robshaw, Charles E. Nolan, Christine E. Oborski, Michael Aaron Brodney, Claude Ambroise, Eva Hajos-Korcsok

المصدر: Alzheimer's & Dementia. 9

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Amyloid, Epidemiology, Chemistry, Health Policy, Neurology (clinical), Geriatrics and Gerontology, Pharmacology, Multiple species, Beta (finance)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::763cd00940c0fd892ea9ab25dc1a4772
https://doi.org/10.1016/j.jalz.2013.05.1670

المؤلفون: Cheng Chang, Claude Ambroise, Kevin Atchison, David Riddell, Eva Hajos-Korcsok, Shawn D. Doran, Charles E. Nolan, Michael Aaron Brodney, Ashley Robshaw, Brian T. O’Neill, Cathleen Gonzales

المصدر: Alzheimer's & Dementia. 9

مصطلحات موضوعية: Drug, Amyloid, Epidemiology, business.industry, Health Policy, media_common.quotation_subject, Pharmacology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, Neurology (clinical), Geriatrics and Gerontology, Beta (finance), business, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::74c99c9b3d62f35c1f38aed2e04b3f1d
https://doi.org/10.1016/j.jalz.2013.05.1028

المؤلفون: ONeill Brian, Claude Ambroise, Michael Aaron Brodney, Christine E. Oborski, Kevin Atchison, David Riddell, Stephen Noell, Charles E. Nolan, Leslie R. Pustilnik

المصدر: Alzheimer's & Dementia. 9

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Terminal (electronics), Amyloid, Epidemiology, Chemistry, Health Policy, Neurology (clinical), Geriatrics and Gerontology, Beta (finance), Molecular biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1061963399b2c50e860667de488c88f0
https://doi.org/10.1016/j.jalz.2013.05.331