المؤلفون: Roger Bone, Sj Amy Fujishige, I Charles A. Kettner, David A. Agard

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://util.ucsf.edu/agard/Publications/44-Agard-Biochem-1991.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.74.6144; http://util.ucsf.edu/agard/Publications/44-Agard-Biochem-1991.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.74.6144
http://util.ucsf.edu/agard/Publications/44-Agard-Biochem-1991.pdf

المؤلفون: Dagmar Ringe, Todd Holyoak, Robert S. Fuller, Charles A. Kettner, Gregory A. Petsko

المصدر: Biochemistry. 43:2412-2421

مصطلحات موضوعية: Furin, chemistry.chemical_classification, Cation binding, Proteases, Binding Sites, Saccharomyces cerevisiae Proteins, biology, Stereochemistry, Peptide, Plasma protein binding, Crystallography, X-Ray, Boronic Acids, Biochemistry, Substrate Specificity, Serine, Structure-Activity Relationship, chemistry, biology.protein, Structure–activity relationship, Proprotein Convertases, Binding site, Oligopeptides, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667e1983f582f96052899553f0bd5c2d
https://doi.org/10.1021/bi035849h

المؤلفون: Zhongren J. Wu, Daniel M. Camac, Peter J. Domaille, Zelda R. Wasserman, Sharon J. Archer, Lawrence J. Mersinger, Charles A. Kettner, Christopher J. Rizzo, Marina Bukhtiyarova, Sharada Jagannathan, Neil A. Farrow

المصدر: Chemistry & Biology. 9(1):79-92

مصطلحات موضوعية: inorganic chemicals, Magnetic Resonance Spectroscopy, medicine.medical_treatment, Clinical Biochemistry, Peptide, Hepacivirus, Viral Nonstructural Proteins, Crystallography, X-Ray, Biochemistry, Cofactor, chemistry.chemical_compound, Viral Proteins, Drug Discovery, medicine, Humans, Protease Inhibitors, Binding site, Molecular Biology, Histidine, chemistry.chemical_classification, Pharmacology, NS3, Protease, Binding Sites, biology, Intracellular Signaling Peptides and Proteins, General Medicine, Nuclear magnetic resonance spectroscopy, Boronic Acids, chemistry, biology.protein, Molecular Medicine, Carrier Proteins, Boronic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980d55bc9e3375bba9449a162ee65ea3

المؤلفون: Frank Jordan, Donghui Bao, and Charles A. Kettner, W. Phillip Huskey

المصدر: Journal of the American Chemical Society. 121:4684-4689

مصطلحات موضوعية: Chymotrypsin, biology, Chemistry, Hydrogen bond, Stereochemistry, Inorganic chemistry, Subtilisin, Active site, General Chemistry, Fractionation, Biochemistry, Catalysis, chemistry.chemical_compound, Colloid and Surface Chemistry, biology.protein, Proton NMR, Histidine, Boronic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6e5eaeb395c69f2807f2e7f9f3b36256
https://doi.org/10.1021/ja990180g

المؤلفون: Patricia C. Weber, Richard S. Alexander, Charles A. Kettner, Mimi L. Quan, Duncia John, Robert M. Knabb, Mary K. VanAtten, C. Anne Higley, Ruth R. Wexler, Santella Joseph B, Anne Y. Liauw, James Russell Pruitt

المصدر: Bioorganic & Medicinal Chemistry Letters. 8:775-780

مصطلحات موضوعية: Models, Molecular, inorganic chemicals, Steric effects, Molecular model, Clinical Biochemistry, Tetrazoles, Pharmaceutical Science, Peptide, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Thrombin, Drug Discovery, medicine, Organic chemistry, Molecular Biology, chemistry.chemical_classification, Binding Sites, Dipeptide, Molecular Structure, biology, Organic Chemistry, Stereoisomerism, Triazoles, Amides, Boronic Acids, Combinatorial chemistry, chemistry, Enzyme inhibitor, biology.protein, Pyrazoles, Molecular Medicine, Indicators and Reagents, Discovery and development of direct thrombin inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1866ef1bc5764c5e6734e8e5a035b696
https://doi.org/10.1016/s0960-894x(98)00104-8

المؤلفون: László Polgár, Fusheng Guo, Frank Jordan, Charles A. Kettner, Ferenc Felföldi, Ara Kahyaoglu, Khadijeh Haghjoo

المصدر: Journal of Biological Chemistry. 272:25547-25554

مصطلحات موضوعية: Proteases, Magnetic Resonance Spectroscopy, Protein Conformation, Swine, Stereochemistry, Hydrogen bond, Chemistry, Serine Endopeptidases, Low-barrier hydrogen bond, Subtilisin, Oligopeptidase, Hydrogen Bonding, Cell Biology, Hydrogen-Ion Concentration, Biochemistry, Catalysis, Serine, Active center, Kinetics, Animals, Antipain, Protease Inhibitors, Prolyl Oligopeptidases, Molecular Biology, Histidine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b249365bda1961cf0e151d5096af8c
https://doi.org/10.1074/jbc.272.41.25547

المؤلفون: John Wityak, A. Y. Liauw, J. V. Duncia, Patricia C. Weber, M. J. Thoolen, Santella Joseph B, Charles A. Kettner, Mimi Lifen Quan, Christopher D. Ellis, Celia Dominguez, Ruth R. Wexler, Robert M. Knabb, Jeongsook M. Park

المصدر: Bioorganic & Medicinal Chemistry Letters. 7:1595-1600

مصطلحات موضوعية: chemistry.chemical_classification, Serine protease, congenital, hereditary, and neonatal diseases and abnormalities, biology, Stereochemistry, medicine.drug_class, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, In vitro, Enzyme, Thrombin, chemistry, Enzyme inhibitor, Drug Discovery, biology.protein, medicine, Molecular Medicine, Molecular Biology, circulatory and respiratory physiology, Discovery and development of direct thrombin inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fe3c574209e9e5d020592c4b65be0eb8
https://doi.org/10.1016/s0960-894x(97)00254-0

المؤلفون: Richard S. Alexander, Robert M. Knabb, David J. Carini, Celia Dominguez, Patricia C. Weber, Charles A. Kettner, Ruth R. Wexler

المصدر: Bioorganic & Medicinal Chemistry Letters. 7:79-84

مصطلحات موضوعية: Dipeptide, biology, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Combinatorial chemistry, Chemical synthesis, chemistry.chemical_compound, Thrombin, Enzyme inhibitor, Drug Discovery, medicine, Side chain, biology.protein, Molecular Medicine, Guanidine, Molecular Biology, Boronic acid, Discovery and development of direct thrombin inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e8d8737ccd0d5a7cd7a53e033b49f54c
https://doi.org/10.1016/s0960-894x(96)00584-7

المؤلفون: Brian L. Wells, Richard S. Alexander, Joseph Buriak, Joseph Cacciola, S.L. Lee, David J. Carini, Patricia C. Weber, Pieter F. W. Stouten, Matthew M. Abelman, John M. Fevig, Gregory Loyde Hillyer, Robert A. Galemmo, Ruth R. Wexler, Karen A. Rossi, Lori L. Bostrom, Charles A. Kettner, Richard Hilmer, Robert M. Knabb

المصدر: Bioorganic & Medicinal Chemistry Letters. 6:2913-2918

مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Chemistry, Aryl, Organic Chemistry, Clinical Biochemistry, Binding pocket, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, Thrombin, Orally active, Binding conformation, Drug Discovery, medicine, Molecular Medicine, Molecular Biology, Alkyl, Discovery and development of direct thrombin inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::69491b906e379ec101be8d95fd234caa
https://doi.org/10.1016/s0960-894x(96)00525-2

المؤلفون: Charles R. Sterling, Pablo C. Okhuysen, Charles A. Kettner, Cynthia L. Chappell

المصدر: Antimicrobial Agents and Chemotherapy. 40:2781-2784

مصطلحات موضوعية: Spores, Aminopeptidases, Microbiology, chemistry.chemical_compound, Aminopeptidase B, Amastatin, parasitic diseases, Animals, Protease Inhibitors, Pharmacology (medical), Chelation, Propidium iodide, Edetic Acid, Cryptosporidium parvum, Pharmacology, chemistry.chemical_classification, biology, fungi, biology.organism_classification, Boronic Acids, In vitro, Anti-Bacterial Agents, Infectious Diseases, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, biology.protein, Peptides, Research Article, Phenanthrolines

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5011a60d01dc35c9c9db1eeaa5e010bc
https://doi.org/10.1128/aac.40.12.2781

المؤلفون: Patricia C. Weber, Robert M. Knabb, Matthew M. Abelman, Charles A. Kettner, David R. Brittelli, John M. Fevig

المصدر: Bioorganic & Medicinal Chemistry Letters. 6:295-300

مصطلحات موضوعية: Cyclohexane, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Tryptophan, Pharmaceutical Science, Crystal structure, Ring (chemistry), Biochemistry, Pyrrolidine, chemistry.chemical_compound, Thrombin, Drug Discovery, medicine, Side chain, Molecular Medicine, Molecular Biology, medicine.drug, Discovery and development of direct thrombin inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d22d10d0435100f325a662a557694fc6
https://doi.org/10.1016/0960-894x(96)00015-7

المؤلفون: Richard S. Alexander, Robert M. Knabb, Joseph Cacciola, John M. Fevig, Patricia C. Weber, David R. Brittelli, Charles A. Kettner

المصدر: Bioorganic & Medicinal Chemistry Letters. 6:301-306

مصطلحات موضوعية: biology, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Active site, Biochemistry, Thrombin, Drug Discovery, biology.protein, medicine, Molecular Medicine, Molecular Biology, medicine.drug, Discovery and development of direct thrombin inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0ad822e21c031320db984d5008b8077b
https://doi.org/10.1016/0960-894x(96)00016-9

المؤلفون: Lawrence J. Mersinger, Charles A. Kettner, Vicki L. Nienaber

المصدر: Biochemistry. 35:9690-9699

مصطلحات موضوعية: Models, Molecular, chemistry.chemical_classification, Binding Sites, Hydrogen bond, Ligand, Stereochemistry, Molecular Sequence Data, Thrombin, Hydrogen Bonding, Peptide, Crystallography, X-Ray, Ligands, Biochemistry, Hydrophobic effect, Kinetics, Structure-Activity Relationship, Protein structure, chemistry, Electrochemistry, Humans, Amino Acid Sequence, Binding site, Oxyanion hole, Oligopeptides, Peptide sequence

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9215dc3f57528909c67b8fd6fd07bcc6
https://doi.org/10.1021/bi952164b

المؤلفون: Herbert Angliker, Charles A. Kettner

المصدر: The Biochemist. 26:59-61

مصطلحات موضوعية: General Biochemistry, Genetics and Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f0100a92299db128df0a953f225121fd
https://doi.org/10.1042/bio02603059

المؤلفون: Sheng Zhong, Frank Jordan, Khadijah Haghjoo, Charles A. Kettner

المصدر: Journal of the American Chemical Society. 117:7048-7055

مصطلحات موضوعية: Chymotrypsin, biology, Chemistry, General Chemistry, Slow binding, Solvent accessibility, Biochemistry, Catalysis, Proton magnetic resonance, Active center, Crystallography, Colloid and Surface Chemistry, biology.protein, Organic chemistry, Histidine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f81bf7bc55cf6634a047b6629e67634d
https://doi.org/10.1021/ja00132a002

المؤلفون: Charles A. Kettner, Matthew M. Abelman, Barbara N. Fisher, Goss S. Kauffman, Richard A. Earl, Philip Ma, John Wityak, Yvonne B. Bethel, Janice L. McMillan

المصدر: The Journal of Organic Chemistry. 60:3717-3722

مصطلحات موضوعية: Thrombin, Chemistry, Organic Chemistry, dup, medicine, Pharmacology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::510ffc9a6fa81358d99d1a6829cea9ef
https://doi.org/10.1021/jo00117a024

المؤلفون: Lawrence J. Mersinger, Munir A. Hussain, Michael B. Maurin, Charles A. Kettner

المصدر: International Journal of Pharmaceutics. 117:181-188

مصطلحات موضوعية: chemistry.chemical_classification, biology, Stereochemistry, Pharmaceutical Science, Mucous membrane of nose, Peptide, Aminopeptidase, Amino acid, Hydrolysis, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, otorhinolaryngologic diseases, biology.protein, Microsome

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ca0568a47f74d71eafa9c2a697c056b8
https://doi.org/10.1016/0378-5173(94)00328-3

المؤلفون: Chong-Hwan Chang, Patricia C. Weber, Francis A. Lewandowski, Charles A. Kettner, S.L. Lee, Margaret C. Schadt

المصدر: Biochemistry. 34:3750-3757

مصطلحات موضوعية: Boron Compounds, Ornithine, Stereochemistry, Molecular Sequence Data, Amidines, Crystallography, X-Ray, Biochemistry, Serine, Amidine, chemistry.chemical_compound, Aspartic acid, Side chain, Amino Acid Sequence, biology, Lysine, Thrombin, Active site, Tetrahedral molecular geometry, Ligand (biochemistry), Boronic Acids, Kinetics, chemistry, Solvents, biology.protein, Oligopeptides, Boronic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d22a0882882f83467433dc158d41f3
https://doi.org/10.1021/bi00011a033

المؤلفون: Elisabeth Tsilikounas, Charles A. Kettner, William W. Bachovchin

المصدر: Biochemistry. 32:12651-12655

مصطلحات موضوعية: inorganic chemicals, Magnetic Resonance Spectroscopy, Stereochemistry, medicine.medical_treatment, Molecular Sequence Data, chemistry.chemical_element, Biochemistry, Adduct, Serine, chemistry.chemical_compound, Gram-Negative Bacteria, medicine, Chymotrypsin, Histidine, Amino Acid Sequence, Boron, Protease, biology, Serine Endopeptidases, Nuclear magnetic resonance spectroscopy, Boronic Acids, chemistry, biology.protein, Oligopeptides, Boronic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d13b9b31effa220524e044def822c9
https://doi.org/10.1021/bi00210a013

المؤلفون: Marguerita S. L. Lim, Charles A. Kettner, Eric R. Johnston

المصدر: Journal of Medicinal Chemistry. 36:1831-1838

مصطلحات موضوعية: Boron Compounds, Models, Molecular, Magnetic Resonance Spectroscopy, Protein Conformation, Stereochemistry, Peptide, Tripeptide, Drug Discovery, Side chain, Peptide bond, Protein secondary structure, chemistry.chemical_classification, biology, Chemistry, Thrombin, Active site, Stereoisomerism, Nuclear magnetic resonance spectroscopy, Solutions, Models, Chemical, biology.protein, Thermodynamics, Molecular Medicine, Oligopeptides, Two-dimensional nuclear magnetic resonance spectroscopy, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca98e1d3d8517b01c483fa2ac12cdd5f
https://doi.org/10.1021/jm00065a005