المؤلفون: Vassilios P. Vassilikos, Georgios Giannopoulos, Nikolaos Fragakis, Antonis Billis, Michalis Efremidis, Konstantinos Letsas, Themistoklis Maounis, Anna Kostopoulou, Georgios Andrikopoulos, Sokratis Pastromas, Apostolos Katsivas, Charalambos Kossyvakis, Eleftherios Kallergis, Emmanouel Kanoupakis, Panagiotis Ioannidis, Stelios Tzeis, Dimosthenis Avramidis, Ioannis Papagiannis, Spyridon Deftereos, Eftychia Symeonidou, Dimitrios Tsiachris, George Theodorakis, Ioannis Rassias, Dimitrios Lysitsas, Eleni Chatzinikolaou, Nikolaos Mezilis, Stylianos Paraskevaidis, Spyros Kourouklis, Theodoros Apostolopoulos, Dimosthenis Katritsis, Sophia Chatzidou, Lilian Mantziari, Georgios Leventopoulos, Ioannis Chiladakis, George Kourgiannidis, George Stavropoulos, Sotirios Xydonas, Charilaos Ginos, Athanasios Kotsakis, Giannis Baltogiannis, Antonis S. Manolis, Skevos Sideris, Konstantinos Gatzoulis

المصدر: Hellenic Journal of Cardiology, Vol 67, Iss , Pp 76-78 (2022)

مصطلحات موضوعية: Diseases of the circulatory (Cardiovascular) system, RC666-701

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1109966622000951; https://doaj.org/toc/1109-9666

URL الوصول: https://doaj.org/article/d63a6577287243a59c6d68a99a11760f

المؤلفون: Vassilios P. Vassilikos, Antonis Billis, Michalis Efremidis, George Theodorakis, Georgios Andrikopoulos, Spyridon Defteraios, Apostolos Katsivas, Dimitrios Mouselimis, Anastasios Tsarouchas, Pantelis Baniotopoulos, Charalambos Kossyvakis, Emmanouel Kanoupakis, Panagiotis Ioannidis, Nikolaos Fragakis, Eleni Chatzinikolaou, Themistoklis Maounis, Stylianos Paraskevaidis, Konstantinos Gatzoulis, Demosthenes Katritsis, Dimitrios Lysitsas, Theodoros Apostolopoulos, Antonis S. Manolis, Dimosthenis Avramidis, Sophia Chatzidou, Efthymios Livanis, Ioannis Papagiannis, Dionysios Leftheriotis, Dimitrios Tsiachris, Stelios Tzeis, Ioannis Rassias, Stelios Rokas, Georgios Levendopoulos, George Kourgiannidis, Dionisios Kalpakos, George Stavropoulos, Ioannis Chiladakis, Stella Gaitanidou, Charilaos Ginos, Athanasios Kotsakis, Konstandinos Kappos, Theofilos Kolettis, Emmanuil Simantirakis, Antonios Sideris, Skevos Sideris

المصدر: Hellenic Journal of Cardiology, Vol 62, Iss 1, Pp 48-54 (2021)

مصطلحات موضوعية: Registry, Radiofrequency ablation, Arrhythmias, Tachycardias, Catheter ablation, Diseases of the circulatory (Cardiovascular) system, RC666-701

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1109966620301950; https://doaj.org/toc/1109-9666

URL الوصول: https://doaj.org/article/606b49015ce04cda8671bd4f60f9eac2

المؤلفون: S. Paraskevaidis, Antonios Sideris, Spyridon Defteraios, Charalambos Kossyvakis, Eleni Chatzinikolaou, Stella Gaitanidou, Dimitrios Mouselimis, Anastasios Tsarouchas, I. Chiladakis, George Kourgiannidis, Antonis S. Manolis, Demosthenes G. Katritsis, Konstantinos Gatzoulis, Georgios Levendopoulos, Stelios Tzeis, Charilaos Ginos, Ioannis Rassias, Ioannis Papagiannis, Apostolos Katsivas, Themistoklis Maounis, Stelios Rokas, Dimosthenis Avramidis, Dimitrios N. Lysitsas, Theodoros Apostolopoulos, Emmanuil Simantirakis, Dionisios Kalpakos, Sophia Chatzidou, Antonis Billis, Georgios Andrikopoulos, Panagiotis Ioannidis, Efthymios Livanis, George Stavropoulos, Konstandinos Kappos, Vassilios Vassilikos, Skevos Sideris, Pantelis Baniotopoulos, Dimitrios Tsiachris, Dionysios Leftheriotis, Emmanouel Kanoupakis, M Efremidis, Athanasios Kotsakis, George N. Theodorakis, Nikolaos Fragakis, Theofilos M. Kolettis

المصدر: Hellenic Journal of Cardiology, Vol 62, Iss 1, Pp 48-54 (2021)

مصطلحات موضوعية: medicine.medical_specialty, Registry, lcsh:Diseases of the circulatory (Cardiovascular) system, Radiofrequency ablation, medicine.medical_treatment, Patient demographics, Tachycardias, Cardiology, Catheter ablation, 030204 cardiovascular system & hematology, Arrhythmias, Nodal disease, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Internal medicine, Atrial Fibrillation, medicine, Humans, 030212 general & internal medicine, Registries, Retrospective Studies, Absolute number, Greece, business.industry, Atrial fibrillation, Ablation, medicine.disease, lcsh:RC666-701, Cardiology and Cardiovascular Medicine, Complication, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e67d8414fdcdb62d46141e89f63406a
http://www.sciencedirect.com/science/article/pii/S1109966620301950

المؤلفون: M Efremidis, Christos Angelidis, Andreas Kaoukis, Vasiliki Panagopoulou, Konstantinos Raisakis, Christodoulos Stefanadis, Michael W. Cleman, Konstantina Toli, Charalambos Kossyvakis, Andreas Theodorakis, Spyridon Deftereos, Ioannis Mantas, Panagiotis Zavitsanakis, Vlasios Pyrgakis, Georgios Giannopoulos

المصدر: Clinical Biochemistry. 46:1020-1025

مصطلحات موضوعية: Male, medicine.medical_specialty, medicine.medical_treatment, Clinical Biochemistry, Electric Countershock, Apoptosis, Cardioversion, TNF-Related Apoptosis-Inducing Ligand, Recurrence, Internal medicine, Atrial Fibrillation, medicine, Humans, Coronary sinus, Aged, Inflammation, business.industry, Atrial fibrillation, General Medicine, Venous blood, Middle Aged, medicine.disease, Peripheral, Solubility, Heart failure, Cardiology, Female, Tumor necrosis factor alpha, business, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ee30ee796670d3d74e04b5ca22df09
https://doi.org/10.1016/j.clinbiochem.2013.02.003

المؤلفون: Michael W. Cleman, George Hahalis, Vasileios Tzalamouras, Dimitrios Alexopoulos, Vlassios Pyrgakis, Spyridon Deftereos, Andreas Kaoukis, Christodoulos Stefanadis, Antonis S. Manolis, Sofia Karageorgiou, Konstantinos Raisakis, Vasiliki Panagopoulou, Georgios Giannopoulos, Konstantinos Toutouzas, Charalambos Kossyvakis, Dimitrios Avramides

المصدر: Journal of the American College of Cardiology. 61(19):1949-1955

مصطلحات موضوعية: medicine.medical_specialty, business.industry, medicine.medical_treatment, Contrast-induced nephropathy, Percutaneous coronary intervention, Stent, medicine.disease, Balloon, contrast, Surgery, acute kidney injury, conditioning, contrast-induced nephropathy, Internal medicine, Conventional PCI, medicine, Cardiology, Clinical endpoint, Number needed to treat, Myocardial infarction, business, Cardiology and Cardiovascular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224b5854a401acd47e896fe4b846b053

المؤلفون: Vlasios Pyrgakis, Georgios Giannopoulos, George Hahalis, Dimitrios Alexopoulos, Spyridon Deftereos, Christodoulos Stefanadis, Charalambos Kossyvakis, Antonis S. Manolis, Michael W. Cleman, Vasiliki Panagopoulou, Andreas Kaoukis, Konstantinos Raisakis, Metaxia Driva

المصدر: Journal of the American College of Cardiology. 61:1679-1685

مصطلحات موضوعية: Adult, Male, Bare-metal stent, medicine.medical_specialty, medicine.medical_treatment, Coronary Angiography, intravascular ultrasound, Coronary Restenosis, Percutaneous Coronary Intervention, Double-Blind Method, Restenosis, Interquartile range, bare-metal stent(s), Internal medicine, medicine, Humans, Prospective Studies, Contraindication, Aged, Aged, 80 and over, diabetes, business.industry, hyperplasia, Percutaneous coronary intervention, Stent, Middle Aged, neointima, in-stent restenosis, medicine.disease, Coronary Vessels, Treatment Outcome, Diabetes Mellitus, Type 2, Conventional PCI, Cardiology, Number needed to treat, Female, Stents, Colchicine, Cardiology and Cardiovascular Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b9db7fb23051cf1f73617fa14273ef
https://doi.org/10.1016/j.jacc.2013.01.055

المؤلفون: Vasiliki Panagopoulou, Vlassios Pyrgakis, Spyridon Deftereos, Charalambos Kossyvakis, Georgios Giannopoulos, Andreas Kaoukis, Georgios Bouras, Michael W. Cleman

المصدر: Current Topics in Medicinal Chemistry. 13:231-240

مصطلحات موضوعية: medicine.medical_specialty, Heart disease, medicine.drug_class, Molecular Sequence Data, Myocardial Infarction, Disease, Copeptin, Predictive Value of Tests, Internal medicine, Drug Discovery, Natriuretic peptide, Humans, Medicine, Amino Acid Sequence, Myocardial infarction, Intensive care medicine, Heart Failure, business.industry, Glycopeptides, General Medicine, medicine.disease, Cardiovascular Diseases, Heart failure, Cardiology, Biomarker (medicine), Myocardial infarction diagnosis, business, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc423ef65de0076085f2a3c2d1590322
https://doi.org/10.2174/15680266113139990088

المؤلفون: Michael W. Cleman, Loukas K. Pappas, Charalambos Kossyvakis, Vlasios Pyrgakis, Georgios Giannopoulos, Dimitrios Avramides, Georgios Hahalis, Spyridon Deftereos, Christodoulos Stefanadis, Dimitrios Alexopoulos, Vasiliki Panagopoulou, Andreas Kaoukis, Konstantinos Raisakis

المصدر: JACC: Cardiovascular Interventions. 6(3):267-273

مصطلحات موضوعية: medicine.medical_specialty, Visual analogue scale, business.industry, medicine.medical_treatment, Sedation, Percutaneous coronary intervention, Surgery, law.invention, Fentanyl, Randomized controlled trial, law, medicine.artery, Anesthesia, medicine, Midazolam, Radial artery, medicine.symptom, Prospective cohort study, business, Cardiology and Cardiovascular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a239970feee9aab959b6ca1e5159e79

المؤلفون: Manolis Vavuranakis, Vlasios Pyrgakis, Dimitrios A. Vrachatis, Georgios Giannopoulos, Theodore G. Papaioannou, Stamatina Pagoni, Vasiliki Panagopoulou, Michael W. Cleman, Charalambos Kossyvakis, Spyridon Deftereos

المصدر: Current pharmaceutical design. 23(9)

مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, Rivaroxaban, business.industry, medicine.medical_treatment, Warfarin, Administration, Oral, Anticoagulants, Cryoablation, Catheter ablation, Atrial fibrillation, Heparin, medicine.disease, Surgery, Dabigatran, Internal medicine, Drug Discovery, Atrial Fibrillation, medicine, Cardiology, Catheter Ablation, Humans, Apixaban, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5287576c1668b704249f8592ad0b96
https://pubmed.ncbi.nlm.nih.gov/27917710

المؤلفون: Spyridon Deftereos, Konstantinos Doudoumis, Vlasios Pyrgakis, Georgios Giannopoulos, Georgios Bouras, Christos Angelidis, Metaxia Driva, Christodoulos Stefanadis, Vasiliki Panagopoulou, Michael Efremidis, Charalambos Kossyvakis, Andreas Theodorakis, Andreas Kaoukis, Konstantinos Raisakis

المصدر: Journal of the American College of Cardiology. 60:1790-1796

مصطلحات موضوعية: medicine.medical_specialty, biology, business.industry, Radiofrequency ablation, C-reactive protein, Atrial fibrillation, Odds ratio, medicine.disease, Placebo, Gastroenterology, law.invention, chemistry.chemical_compound, chemistry, Randomized controlled trial, law, Interquartile range, Internal medicine, Anesthesia, medicine, biology.protein, Colchicine, Cardiology and Cardiovascular Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156b788d9838aa0700959809fc6e6aaf
https://doi.org/10.1016/j.jacc.2012.07.031

المؤلفون: Christodoulos Stefanadis, Andreas Kaoukis, Georgios Bouras, Georgios Hatzis, Dimitris Tousoulis, Vasiliki Panagopoulou, Spyridon Deftereos, Charalambos Kossyvakis

المصدر: Current Clinical Pharmacology. 7:175-194

مصطلحات موضوعية: medicine.medical_specialty, medicine.drug_class, Administration, Oral, Dabigatran, medicine, Animals, Humans, Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics, Intensive care medicine, Rivaroxaban, business.industry, Anticoagulant, Warfarin, Anticoagulants, Venous Thromboembolism, General Medicine, medicine.disease, Thrombosis, Pulmonary embolism, Treatment Outcome, Clinical Trials, Phase III as Topic, Apixaban, Endothelium, Vascular, Pulmonary Embolism, business, medicine.drug, Discovery and development of direct thrombin inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f7a83520e34d98c10d8ff263a4043e
https://doi.org/10.2174/157488412800958703

المؤلفون: Spyridon Deftereos, Charalambos Kossyvakis, Anastasia Perpinia, Vlassios Pyrgakis, Alexandros Alexopoulos, Nikolaos Michelakakis

المصدر: Therapeutic Advances in Cardiovascular Disease. 4:295-299

مصطلحات موضوعية: Male, medicine.medical_specialty, Degeneration (medical), Left ventricular hypertrophy, Muscle hypertrophy, Risk Factors, Fibrosis, Internal medicine, medicine, Humans, Pharmacology (medical), In patient, Atrioventricular Block, Aged, Sick Sinus Syndrome, business.industry, Cardiac Pacing, Artificial, Middle Aged, medicine.disease, Echocardiography, Hypertension, Cardiology, Female, Hypertrophy, Left Ventricular, Electrical conduction system of the heart, Cardiology and Cardiovascular Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4995b7bba768572c1ec91b6ec1104117
https://doi.org/10.1177/1753944710381603

المؤلفون: Vasiliki Panagopoulou, Michael W. Cleman, Spyridon Deftereos, Dimitris Tousoulis, Charalambos Kossyvakis, Vlasios Pyrgakis, Andreas Kaoukis, Christodoulos Stefanadis, Konstantinos Raisakis, Georgios Giannopoulos, George Hahalis, Vasileios Tzalamouras

المصدر: International Journal of Cardiology. 164:373-375

مصطلحات موضوعية: Male, Coronary angiography, Cardiac Catheterization, medicine.medical_specialty, medicine.medical_treatment, education, Psychological intervention, Coronary Vasospasm, Flow mediated dilation, Coronary Artery Disease, Coronary Angiography, Arterial spasm, Ulnar Artery, Predictive Value of Tests, Coronary Circulation, medicine.artery, Internal medicine, Humans, Medicine, Angioplasty, Balloon, Coronary, Ulnar artery, Aged, Cardiac catheterization, business.industry, General surgery, Medical school, Percutaneous coronary intervention, Middle Aged, humanities, Vasodilation, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, human activities

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c46915df2d601fe5e4c8b2a882fe61d
https://doi.org/10.1016/j.ijcard.2012.08.004

المؤلفون: Vasiliki Panagopoulou, Georgios Bobotis, Aggeliki Mavrogianni, Charalambos Kossyvakis, Spyridon Deftereos, Olga Ntzouvara, Andreas Kaoukis, Dimitris Tousoulis, Konstantinos Raisakis, Nikolaos Michelakakis, Vlasios Pyrgakis, Konstantinos Toutouzas, Georgios Giannopoulos, Christodoulos Stefanadis, Michael W. Cleman

المصدر: International Journal of Cardiology. 149:398-400

مصطلحات موضوعية: medicine.medical_specialty, business.industry, medicine.medical_treatment, General surgery, Angioplasty, medicine, Medical school, Percutaneous coronary intervention, General hospital, Cardiology and Cardiovascular Medicine, business, Surgery, Cardiac catheterization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2fc87c41b013f18618f9c79f7085b2e3
https://doi.org/10.1016/j.ijcard.2011.03.028

المؤلفون: Spyridon, Deftereos, Georgios, Giannopoulos, Konstantinos, Raisakis, Georgios, Hahalis, Andreas, Kaoukis, Charalambos, Kossyvakis, Dimitrios, Avramides, Loukas, Pappas, Vasiliki, Panagopoulou, Vlasios, Pyrgakis, Dimitrios, Alexopoulos, Christodoulos, Stefanadis, Michael W, Cleman

المصدر: JACC. Cardiovascular interventions. 6(3)

مصطلحات موضوعية: Male, Time Factors, Midazolam, Conscious Sedation, Pain, Arterial Occlusive Diseases, Coronary Angiography, Patient Readmission, Percutaneous Coronary Intervention, Predictive Value of Tests, Risk Factors, Odds Ratio, Humans, Hypnotics and Sedatives, Prospective Studies, Aged, Chi-Square Distribution, Greece, Incidence, Length of Stay, Middle Aged, Analgesics, Opioid, Fentanyl, Logistic Models, Treatment Outcome, Radial Artery, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::5d0af14134ae0182ad2c11eaacc760d0
https://pubmed.ncbi.nlm.nih.gov/24262625

المؤلفون: Spyridon Deftereos, Vlasios Pyrgakis, Christodoulos Stefanadis, Michael W. Cleman, Georgios Giannopoulos, Vasileios Tzalamouras, Maria Mavri, Charalambos Kossyvakis, Andreas Kaoukis, Konstantinos Raisakis, Vasiliki Panagopoulou

المصدر: Cardiology. 123(2)

مصطلحات موضوعية: Neointima, Male, medicine.medical_specialty, Inverse Association, medicine.medical_treatment, Coronary Restenosis, TNF-Related Apoptosis-Inducing Ligand, Percutaneous Coronary Intervention, Internal medicine, medicine, Humans, Pharmacology (medical), Aged, Neointimal hyperplasia, Analysis of Variance, Hyperplasia, business.industry, Graft Occlusion, Vascular, Stent, Drug-Eluting Stents, Ligand (biochemistry), medicine.disease, Cross-Sectional Studies, Apoptosis, Cancer research, Cardiology, Tumor necrosis factor alpha, Female, In stent restenosis, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503fba3d05c30b9ed75c8f89c9bcaa62
https://pubmed.ncbi.nlm.nih.gov/23018637

المؤلفون: Christodoulos Stefanadis, Vasiliki Panagopoulou, Spyridon Deftereos, Vlasios Pyrgakis, Georgios Giannopoulos, Georgios Bouras, Charalambos Kossyvakis

المصدر: Current clinical pharmacology. 7(3)

مصطلحات موضوعية: medicine.medical_specialty, Ximelagatran, Morpholines, Administration, Oral, Thiophenes, Dabigatran, chemistry.chemical_compound, Rivaroxaban, Internal medicine, Antithrombotic, Drug Discovery, medicine, Animals, Humans, Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics, Acute Coronary Syndrome, Clinical Trials as Topic, business.industry, Darexaban, Warfarin, Anticoagulants, General Medicine, Treatment Outcome, chemistry, Anesthesia, Factor Xa, Apixaban, business, medicine.drug, Discovery and development of direct thrombin inhibitors, Factor Xa Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab52d1918692e07cdd59673458d9e5e5
https://pubmed.ncbi.nlm.nih.gov/22564121

المؤلفون: Spyridon, Deftereos, Georgios, Giannopoulos, Charalambos, Kossyvakis, Vasiliki, Panagopoulou, Konstantinos, Raisakis, Andreas, Kaoukis, Konstantinos, Doudoumis, Vlasios, Pyrgakis, Antonis S, Manolis, Christodoulos, Stefanadis

المصدر: Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese. 53(1)

مصطلحات موضوعية: Male, Pulmonary Veins, Atrial Fibrillation, Catheter Ablation, Humans, Female, Heart Atria, Middle Aged, Ultrasonography, Interventional, Aged

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::5ef201b390495b308db83812952648ae
https://pubmed.ncbi.nlm.nih.gov/22275738

المؤلفون: Konstantinos Doudoumis, Spyridon Deftereos, Charalambos Kossyvakis, Vlasios Pyrgakis, Andreas Kaoukis, Vasiliki Panagopoulou, Georgios Giannopoulos, Konstantinos Raisakis, Christodoulos Stefanadis

المصدر: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing. 34(2)

مصطلحات موضوعية: Male, medicine.medical_specialty, Visual analogue scale, Pain, Hematoma, Physiology (medical), Catheterization, Peripheral, Medicine, Fluoroscopy, Humans, Coronary sinus, medicine.diagnostic_test, business.industry, Coronary Sinus, Middle Aged, medicine.disease, Peripheral, Surgery, Catheter, Treatment Outcome, Pneumothorax, Anesthesia, Feasibility Studies, Female, Cardiology and Cardiovascular Medicine, business, Electrophysiologic Techniques, Cardiac, Subclavian vein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d0b0449ac1b763aaa02896783061fa
https://pubmed.ncbi.nlm.nih.gov/22119856

المؤلفون: Spyridon, Deftereos, Georgios, Giannopoulos, Konstantinos, Raisakis, Andreas, Kaoukis, Charalambos, Kossyvakis, Loukas, Pappas, Vasiliki, Panagopoulou, Aggeliki-Despoina, Mavrogianni, Andreas, Theodorakis, Anastasia, Perpinia, Nikolaos, Michelakakis, Georgios, Bobotis, Vlasios, Pyrgakis

المصدر: Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese. 52(2)

مصطلحات موضوعية: Male, Treatment Outcome, Patient Selection, Catheterization, Peripheral, Radial Artery, Myocardial Infarction, Humans, Female, Angioplasty, Balloon, Coronary, Length of Stay, Middle Aged, Aged, Retrospective Studies

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::3d1a6d66c3af2c6acabc3331855a1f6b
https://pubmed.ncbi.nlm.nih.gov/21478120