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المؤلفون: Ghadir A. Sindi, Daewoo Lee, Sazan Ismael, Robert A. Colvin
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: Light, human tau release, Mutation, Missense, primary neuronal culture, tau Proteins, Optogenetics, PI, phosphatase inhibitor, CSF, cerebrospinal fluid, Biochemistry, pSite, phosphorylation site, Pathogenesis, ATR, all-trans retinal, chemistry.chemical_compound, Alzheimer Disease, PRD, proline-rich domain, Lactate dehydrogenase, Pi, medicine, Animals, Humans, Premovement neuronal activity, Phosphorylation, Molecular Biology, Cells, Cultured, Neurons, LDH, lactate dehydrogenase, Chemistry, Neurodegeneration, Wild type, IP-CM, immunopurified conditioned media, PHF, paired helical filament, BL, blue light, Cell Biology, ChR2, channelrhodopsin 2, medicine.disease, DIV, days in vitro, Cell biology, Drosophila melanogaster, Amino Acid Substitution, activity-dependent release, hTau, human tau, Drosophila, AD, Alzheimer's disease, Research Article
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المؤلفون: Zhenghao Xu, Xiaohua Wu, Jianhong Luo, Yi Wang, Shihong Zhang, Zhong Chen, Xiangnan Zhang, Ying Wang, Cenglin Xu, Yi Guo, Bin Chen, Shumin Duan, Shuang Wang, Weiwei Hu
المصدر: EBioMedicine
مصطلحات موضوعية: 0301 basic medicine, Male, Deep Brain Stimulation, Hippocampus, V, ventral, Hippocampal formation, Epileptogenesis, Severity of Illness Index, Neuronal circuit, ADD, afterdischarge duration, Mice, 0302 clinical medicine, AAV, adeno-associated virus, LMOL, lacunosum-moleculare layer, GABAergic Neurons, ANOVA, analysis of variance, Neurons, Chemistry, Pyramidal Cells, IN, interneuron, SNR, substantia nigra pars reticulate, General Medicine, LFES, Low-frequency electrical stimulation, medicine.anatomical_structure, Kindling, VGAT, vesicular GABA transporter, Brain stimulation, Anesthesia, GABAergic, Research Paper, EC, entorhinal cortex, Interneuron, ChR2, Channelrhodopsin 2, Mice, Transgenic, Optogenetics, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, medicine, Animals, Humans, Entorhinal cortex, Epilepsy, PN, principal neuron, Proteins, HFES, High-frequency electrical stimulation, WT, wild-type, TLE, Temporal lobe epilepsy, Disease Models, Animal, 030104 developmental biology, nervous system, ML, mediolateral, eYFP, enhanced Yellow Fluorescent Protein, GST, generalized seizure threshold, AP, antero-posterior, Neuroscience, 030217 neurology & neurosurgery, ADT, afterdischarge threshold, CaMKIIα, Calcium/calmodulin-dependent protein kinase II alpha