المؤلفون: Clubb, James HA, Santos, Joao, Pakola, Santeri A, Van der Heijden, Mirte, Jirovec, Elise, Arias, Victor, Quixabeira, Dafne Alves, Kudling, Tatiana V, Block, Matthew, Mäenpää, Johanna, Cohen, Julia, Chisamore, Michael, Adamo, Daniel, Alanko, Tuomo, Sormunen, Jorma, Kononen, Juha, Haybout, Lyna, Havunen, Riikka, Goldfinch, John, Kistler, Claudia, Sorsa, Suvi, Cervera-Carrascon, Victor, Hemminki, Akseli

المصدر: Regular and Young Investigator Award Abstracts ; page A824-A824

الاتاحة: https://doi.org/10.1136/jitc-2024-sitc2024.0722
https://syndication.highwire.org/content/doi/10.1136/jitc-2024-SITC2024.0722

المؤلفون: Jirovec, Elise, Quixabeira, Dafne C.A., Clubb, James H.A., Pakola, Santeri A., Kudling, Tatiana, Arias, Victor, Haybout, Lyna, Jalkanen, Katriina, Alanko, Tuomo, Monberg, Tine, Khammari, Amir, Dreno, Brigitte, Svane, Inge Marie, Block, Matthew S., Adamo, Daniel A., Mäenpää, Johanna, Kistler, Claudia, Sorsa, Suvi, Hemminki, Otto, Kanerva, Anna, Santos, João M., Cervera-Carrascon, Victor, Hemminki, Akseli

المساهمون: Tampere University, Children's and Women's health, Diagnostic Medicine, Psychiatry, TAYS Cancer Centre

مصطلحات موضوعية: 3122 Cancers

وصف الملف: fulltext

Relation: 297; 43; https://trepo.tuni.fi/handle/10024/161860

الاتاحة: https://trepo.tuni.fi/handle/10024/161860
https://doi.org/10.1186/s13046-024-03219-0

المؤلفون: Basnet, Saru, Van der Heijden, Mirte, Quixabeira, Dafne C.A., Jirovec, Elise, Grönberg-Vähä-Koskela, Susanna A.M., Clubb, James H.A., Kanerva, Anna, Pakola, Santeri, Haybout, Lyna, Arias, Victor, Hemminki, Otto, Kudling, Tatiana, Zafar, Sadia, Cervera-Carrascon, Victor, Santos, Joao M., Hemminki, Akseli

المصدر: Molecular Therapy ; volume 32, issue 8, page 2800 ; ISSN 1525-0016

الاتاحة: https://doi.org/10.1016/j.ymthe.2024.07.009
https://api.elsevier.com/content/article/PII:S1525001624004647?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1525001624004647?httpAccept=text/plain

المؤلفون: Pakola, Santeri A., Peltola, Katriina J., Clubb, James H.A., Jirovec, Elise, Haybout, Lyna, Kudling, Tatiana V., Alanko, Tuomo, Korpisaari, Riitta, Juteau, Susanna, Jaakkola, Marjut, Sormunen, Jorma, Kemppainen, Jukka, Hemmes, Annabrita, Pellinen, Teijo, van der Heijden, Mirte, Quixabeira, Dafne C.A., Kistler, Claudia, Sorsa, Suvi, Havunen, Riikka, Santos, Joao M., Cervera-Carrascon, Victor, Hemminki, Akseli

المساهمون: University of Helsinki, TRIMM - Translational Immunology Research Program, Clinicum, HUS Comprehensive Cancer Center, Department of Oncology, Department of Pathology, HUSLAB, Institute for Molecular Medicine Finland, Faculty Common Matters (Faculty of Medicine), Precision Systems Medicine

مصطلحات موضوعية: Cancers

وصف الملف: application/pdf

Relation: We thank Minna Oksanen, Susanna Gr\u00F6nberg-V\u00E4h\u00E4-Koskela, and Sini Raatikainen for expert assistance. This study was supported by TILT Biotherapeutics Oy, Jane and Aatos Erkko Foundation, EU Horizon grant 811693 (UNLEASHAD), Finnish Cultural Foundation, EU Horizon 2020 Research and Innovation Program under the Marie Sk\u0142odowska-Curie Grant agreements (No 813453), HUCH Research Funds (VTR), Cancer Foundation Finland, Sigrid Juselius Foundation and the Finnish Red Cross Blood Service. We thank Albert Ehrnrooth and Karl Fazer for their research support. The authors would like to thank FIMM Digital Microscopy and Molecular Pathology Unit supported by HiLIFE and Biocenter Finland for IHC services. S.A. Pakola reports grants from Helsinki University Hospital Research Funds, Cancer Foundation Finland, Jane and Aatos Erkko Foundation, Red Cross Blood Service, and Sigrid Juselius Finland, other support from TILT Biotherapeutics Oy, and grants from the European Commission during the conduct of the study. K.J. Peltola reports other support from TILT Therapeutics during the conduct of the study and from Faron Pharmaceuticals outside the submitted work, as well as personal fees from BMS, MSD, IPSEN, Roche, Bayer, and Novartis. J.H.A. Clubb reports being employed and a shareholder at TILT Biotherapeutics. L. Haybout reports other support from TILT Biotherapeutics during the conduct of the study. T. Alanko reports other support from TILT Biotherapeutics during the conduct of the study; personal fees and non-financial support from AstraZeneca and MSD; personal fees and other support from Bristol Myers Squibb, Roche, and Incyte; personal fees, non-financial support, and other support from Pfizer; personal fees from Servier and Nordic Drugs; other support from AbbVie, Bayer, Boehringer Ingelheim, Lilly, Debiopharm Group, GlaxoSmithKline, and TILT Biotherapeutics; and non-financial support from Merck outside the submitted work. A. Hemmes reports other support from TILT Biotherapeutics during the conduct of the study. T. Pellinen reports grants from Roche Glycart AG outside the submitted work. D.C. Quixabeira reports personal fees from TILT Bio-therapeutics during the conduct of the study and outside the submitted work. C. Kistler reports other support from TILT Biotherapeutics and from TILT Bio-therapeutics during the conduct of the study. S. Sorsa reports grants from the European Innovation Council\u2014European Commission and personal fees from TILT Biotherapeutics during the conduct of the study. R. Havunen reports personal fees from TILT Biotherapeutics and other support from TILT Bio-therapeutics during the conduct of the study. J.M. Santos reports personal fees, non-financial support, and other support from TILT Biotherapeutics; grants from the European Innovation Council and Business Finland during the conduct of the study; and personal fees, non-financial support, and other support from TILT Biotherapeutics outside the submitted work. V. Cervera-Carrascon reports personal fees from TILT Biotherapeutics during the conduct of the study and outside the submitted work. A. Hemminki reports grants from Helsinki University Hospital Research funds, Cancer Foundation Finland, Jane and Aatos Erkko Foundation, Red Cross Blood Service, and Sigrid Juselius Finland; other support from TILT Biotherapeutics Oy; grants from the European Commission during the conduct of the study; personal fees and other support from TILT Biotherapeutics Oy and Aeruginosa Oy; and other support from Circio Holdings ASA outside the submitted work; in addition, A. Hemminki reports patents for Enhanced adoptive cell therapy licensed to TILT Biotherapeutics Oy, Oncolytic adenoviruses coding for BI-specific antibodies and methods and uses related thereto licensed to TILT Biotherapeutics Oy, Oncolytic adenovirus and checkpoint inhibitor combination therapy pending to TILT Biotherapeutics Oy; http://hdl.handle.net/10138/586098; 85200659427; 001304237400016

الاتاحة: http://hdl.handle.net/10138/586098

المؤلفون: Pakola, Santeri, Quixabeira, Dafne C. A., Kudling, Tatiana V., Clubb, James H. A., Grönberg-Vähä-Koskela, Susanna, Basnet, Saru, Jirovec, Elise, Arias, Victor, Haybout, Lyna, Heiniö, Camilla, Santos, Joao M., Cervera-Carrascon, Victor, Havunen, Riikka, Anttila, Marjukka, Hemminki, Akseli

المساهمون: TRIMM - Translational Immunology Research Program, Research Programs Unit, Department of Oncology, HUS Comprehensive Cancer Center

مصطلحات موضوعية: Adenovirus, Chemotherapy, Immunotherapy, Interleukin 2, Oncolytic virus, 11832 Microbiology and virology

وصف الملف: application/pdf

Relation: Pakola , S , Quixabeira , D C A , Kudling , T V , Clubb , J H A , Grönberg-Vähä-Koskela , S , Basnet , S , Jirovec , E , Arias , V , Haybout , L , Heiniö , C , Santos , J M , Cervera-Carrascon , V , Havunen , R , Anttila , M & Hemminki , A 2023 , ' An oncolytic adenovirus coding for a variant interleukin 2 cytokine improves response to chemotherapy through enhancement of effector lymphocyte cytotoxicity, fibroblast compartment modulation and mitotic slippage ' , Frontiers in Immunology , vol. 14 . https://doi.org/10.3389/fimmu.2023.1171083; ORCID: /0000-0001-6235-8612/work/147398125; ORCID: /0000-0001-7103-8530/work/156151526; http://hdl.handle.net/10138/570978; 81060cea-ab58-4a0d-8f45-9aa4e302cfba; 001031238800001

الاتاحة: http://hdl.handle.net/10138/570978

المؤلفون: Basnet, Saru, Santos, Joao M., Quixabeira, Dafne C.A., Clubb, James H.A., Grönberg-Vähä-Koskela, Susanna A.M., Arias, Victor, Pakola, Santeri, Kudling, Tatiana V., Heiniö, Camilla, Havunen, Riikka, Cervera-Carrascon, Victor, Sorsa, Suvi, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli

المساهمون: orcid:0000-0003-4089-1357, Ruokavirasto, Finnish Food Authority

مصطلحات موضوعية: cancerous diseases, oncolytic viruses, adenoviruses, immunotherapy

وصف الملف: 59-73; application/pdf

Relation: Molecular Therapy - Oncolytics; 28; 94498; http://hdl.handle.net/10138/569414; URN:NBN:fi-fe202401051623

الاتاحة: http://hdl.handle.net/10138/569414

المؤلفون: Clubb, James H. A., Kudling, Tatiana V., Girych, Mykhailo, Haybout, Lyna, Pakola, Santeri, Hamdan, Firas, Cervera-Carrascon, Víctor, Hemmes, Annabrita, Grönberg-Vähä-Koskela, Susanna, Santos, João Manuel, Quixabeira, Dafne C. A., Basnet, Saru, Heiniö, Camilla, Arias, Victor, Jirovec, Elise, Kaptan, Shreyas, Havunen, Riikka, Sorsa, Suvi, Erikat, Abdullah, Schwartz, Joel, Anttila, Marjukka, Aro, Katri, Viitala, Tapani, Vattulainen, Ilpo, Cerullo, Vincenzo, Kanerva, Anna, Hemminki, Akseli

المساهمون: orcid:0000-0003-4089-1357, Ruokavirasto, Finnish Food Authority

مصطلحات موضوعية: adenoviruses, immunotherapy, oncolytic viruses

وصف الملف: application/pdf

Relation: Frontiers in Immunology; 14; 94496; http://hdl.handle.net/10138/569413; URN:NBN:fi-fe202401051620

الاتاحة: http://hdl.handle.net/10138/569413

المؤلفون: Santos, Joao, Peltola, Katriina, Alanko, Tuomo, Pakola, Santeri A, Clubb, James, Jirovec, Elise, Haybout, Lyna, Kudling, Tatiana V, Korpisaari, Riitta, Juteau, Susanna, Jaakkola, Marjut, Sormunen, Jorma, Kononen, Juha, Quixabeira, Dafne CA, Kistler, Claudia, Sorsa, Suvi, Havunen, Riikka, Cervera-Carrascon, Victor, Hemminki, Akseli

المصدر: Late-Breaking Abstracts ; page A1743-A1743

الاتاحة: http://dx.doi.org/10.1136/jitc-2023-sitc2023.1518
https://syndication.highwire.org/content/doi/10.1136/jitc-2023-SITC2023.1518

المؤلفون: Clubb, James, Cervera-Carrascon, Victor, Peltola, Katriina, Alanko, Tuomo, Korpisaari, Riitta, Jaakkola, Marjut, Sormunen, Jorma, Kononen, Juha, Santos, Joao Manuel, Pakola, Santeri A, Jirovec, Elise, Kudling, Tatiana, Haybout, Lyna, Quixabeira, Dafne CA, Kistler, Claudia, Havunen, Riikka, Sorsa, Suvi, Hemminki, Akseli

المصدر: Regular and Young Investigator Award Abstracts ; page A806-A806

الاتاحة: http://dx.doi.org/10.1136/jitc-2023-sitc2023.0711
https://syndication.highwire.org/content/doi/10.1136/jitc-2023-SITC2023.0711

المؤلفون: Quixabeira, Dafne CA, Pakola, Santeri A, Clubb, James, Haybout, Lyna, Jirovec, Elise, Kudling, Tatiana, Santos, Joao, Cervera-Carrascon, Victor, Peltola, Katriina, Alanko, Tuomo, Sormunen, Jorma, Korpisaari, Riitta, Jaakkola, Marjut, Kononen, Juha, Juteau, Susanna, Kistler, Claudia, Sorsa, Suvi, Havunen, Riikka, Hemminki, Akseli

المصدر: Regular and Young Investigator Award Abstracts ; page A841-A841

الاتاحة: http://dx.doi.org/10.1136/jitc-2023-sitc2023.0745
https://syndication.highwire.org/content/doi/10.1136/jitc-2023-SITC2023.0745

المؤلفون: Kudling, Tatiana V, Clubb, James, Pakola, Santeri A, Quixabeira, Dafne Alves, Lähdeniemi, Iris, Heiniö, Camilla, Arias, Victor, Grönberg-Vähä-Koskela, Susanna AM, Havunen, Riikka, Cervera-Carrascon, Victor, Santos, Joao Manuel, Sutinen, Eva, Räsänen, Jari, Borenius, Kristian, Mäyränpää, Mikko, Altonen, Eero, Sorsa, Suvi, Hemminki, Otto, Kanerva, Anna, Verschuren, Emmy W, Ilonen, Ilkka, Hemminki, Akseli

المصدر: Regular and Young Investigator Award Abstracts ; page A912-A912

الاتاحة: http://dx.doi.org/10.1136/jitc-2023-sitc2023.0814
https://syndication.highwire.org/content/doi/10.1136/jitc-2023-SITC2023.0814

المؤلفون: Santos, Joao, Svane, Inge, Peltola, Katriina, Alanko, Tuomo, Korpisaari, Riitta, Juteau, Susanna, Jaakkola, Marjut, Sormunen, Jorma, Kononen, Juha, Ellebaek, Eva, Monberg, Tine, Donia, Marco, Khammari, Amir, Dreno, Brigitte, Pakola, Santeri A, Clubb, James, Jirovec, Elise, Quixabeira, Dafne CA, Kudling, Tatiana, Haybout, Lyna, Cervera-Carrascon, Victor, Kistler, Claudia, Sorsa, Suvi, Havunen, Riikka, Hemminki, Akseli

المصدر: Regular and Young Investigator Award Abstracts ; page A845-A845

الاتاحة: http://dx.doi.org/10.1136/jitc-2023-sitc2023.0749
https://syndication.highwire.org/content/doi/10.1136/jitc-2023-SITC2023.0749

المؤلفون: Pakola, Santeri A, Cervera-Carrascon, Victor, Peltola, Katriina, Alanko, Tuomo, Korpisaari, Riitta, Jaakkola, Marjut, Sormunen, Jorma, Kononen, Juha, Clubb, James, Jirovec, Elise, Kudling, Tatiana, Haybout, Lyna, Quixabeira, Dafne CA, Kistler, Claudia, Santos, Joao, Sorsa, Suvi, Havunen, Riikka, Hemminki, Akseli

المصدر: Regular and Young Investigator Award Abstracts ; page A832-A832

الاتاحة: http://dx.doi.org/10.1136/jitc-2023-sitc2023.0739
https://syndication.highwire.org/content/doi/10.1136/jitc-2023-SITC2023.0739

المؤلفون: Arias, Victor, Kudling, Tatiana, Clubb, James, Haybout, Lyna, Jirovec, Elise, Pakola, Santeri A, Basnet, Saru, Quixabeira, Dafne CA, Hemminki, Otto, Grönberg-Vähä-Koskela, Susanna AM, Santos, Joao Manuel, Cervera-Carrascon, Victor, Hemminki, Akseli

المصدر: Regular and Young Investigator Award Abstracts ; page A903-A903

الاتاحة: http://dx.doi.org/10.1136/jitc-2023-sitc2023.0805
https://syndication.highwire.org/content/doi/10.1136/jitc-2023-SITC2023.0805

المؤلفون: Clubb, James H. A., Kudling, Tatiana V., Girych, Mykhailo, Haybout, Lyna, Pakola, Santeri, Hamdan, Firas, Cervera-Carrascon, Víctor, Hemmes, Annabrita, Grönberg-Vähä-Koskela, Susanna, Santos, João Manuel, Quixabeira, Dafne C. A., Basnet, Saru, Heiniö, Camilla, Arias, Victor, Jirovec, Elise, Kaptan, Shreyas, Havunen, Riikka, Sorsa, Suvi, Erikat, Abdullah, Schwartz, Joel, Anttila, Marjukka, Aro, Katri, Viitala, Tapani, Vattulainen, Ilpo, Cerullo, Vincenzo, Kanerva, Anna, Hemminki, Akseli

المصدر: Clubb , J H A , Kudling , T V , Girych , M , Haybout , L , Pakola , S , Hamdan , F , Cervera-Carrascon , V , Hemmes , A , Grönberg-Vähä-Koskela , S , Santos , J M , Quixabeira , D C A , Basnet , S , Heiniö , C , Arias , V , Jirovec , E , Kaptan , S , Havunen , R , Sorsa , S , Erikat , A , Schwartz , J , Anttila , M , Aro , K , Viitala , T , Vattulainen ....

مصطلحات موضوعية: PDAC, Syrian hamster, adenovirus, artificial intelligence, immune checkpoint inhibitor, immunotherapy, molecular simulations, oncolytic virus, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

الاتاحة: https://cris.vtt.fi/en/publications/011bcc08-ad08-460a-b682-963c7f974200
https://doi.org/10.3389/fimmu.2023.1060540
http://www.scopus.com/inward/record.url?scp=85148512770&partnerID=8YFLogxK

المؤلفون: Kudling, Tatiana V., Clubb, James H.A., Pakola, Santeri, Quixabeira, Dafne C.A., Lähdeniemi, Iris A.K., Heiniö, Camilla, Arias, Victor, Havunen, Riikka, Cervera-Carrascon, Victor, Santos, Joao M., Sutinen, Eva, Räsänen, Jari, Borenius, Kristian, Mäyränpää, Mikko I., Aaltonen, Eero, Sorsa, Suvi, Hemminki, Otto, Kanerva, Anna, Verschuren, Emmy W., Ilonen, Ilkka, Hemminki, Akseli

المساهمون: TRIMM - Translational Immunology Research Program, Research Programs Unit, University of Helsinki, Lung Cancer Model Systems, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, Digital Precision Cancer Medicine (iCAN), HUS Comprehensive Cancer Center, CAN-PRO - Translational Cancer Medicine Program, HUS Heart and Lung Center, Department of Medicine, INDIVIDRUG - Individualized Drug Therapy, Keuhkosairauksien yksikkö, III kirurgian klinikka, HUSLAB, Department of Pathology, Medicum, Clinicum, HUS Abdominal Center, Urologian yksikkö, HUS Gynecology and Obstetrics, Akseli Eetu Hemminki / Principal Investigator, Department of Obstetrics and Gynecology, Research Group Verschuren Emmy, Department of Surgery, Department of Oncology

مصطلحات موضوعية: adenovirus, checkpoint inhibitors, Immunotherapy, intravenous administration, Cancers

وصف الملف: application/pdf

Relation: This study was supported by the Doctoral Program in Clinical Research (University of Helsinki), Jane and Aatos Erkko Foundation, Finnish Cultural Foundation, Ida Montinin Foundation, Orion Foundation, K. Albin Johansson Foundation, HUCH Research Funds (VTR), Finnish Cancer Organizations, Sigrid Juselius Foundation, Novo Nordisk Foundation, Päivikki and Sakari Sohlberg Foundation, Finnish Red Cross Blood Service, and TILT Biotherapeutics Ltd. This study received funding from the European Union’s Horizon 2020 Research and Innovation Programme under Marie Skłodowska-Curie grant agreement No 813453. We thank Albert Ehrnrooth and Karl Fazer for their support. Part of this work was carried out with the support of the HiLIFE Laboratory Animal Center Core Facility, University of Helsinki. We thank Minna Oksanen and Susanna Grönberg-Vähä-Koskela for expert experimental and administrative assistance. We also thank Mikko Räsänen, Lotta Ahlfors and Laboratory Animal Center (LAC, University of Helsinki, Helsinki, Finland), Biomedicum Flow Cytometry Unit (University of Helsinki, Helsinki, Finland) and Biomedicum Imaging Unit (University of Helsinki, Helsinki, Finland). Open access funded by the Helsinki University Library (University of Helsinki, Finland). We thank Minna Oksanen and Susanna Grönberg-Vähä-Koskela for expert experimental and administrative assistance. We also thank Mikko Räsänen, Lotta Ahlfors and Laboratory Animal Center (LAC, University of Helsinki, Helsinki, Finland), Biomedicum Flow Cytometry Unit (University of Helsinki, Helsinki, Finland) and Biomedicum Imaging Unit (University of Helsinki, Helsinki, Finland). Open access funded by the Helsinki University Library (University of Helsinki, Finland).; Kudling , T V , Clubb , J H A , Pakola , S , Quixabeira , D C A , Lähdeniemi , I A K , Heiniö , C , Arias , V , Havunen , R , Cervera-Carrascon , V , Santos , J M , Sutinen , E , Räsänen , J , Borenius , K , Mäyränpää , M I , Aaltonen , E , Sorsa , S , Hemminki , O , Kanerva , A , Verschuren , E W , Ilonen , I & Hemminki , A 2023 , ' Effective intravenous delivery of adenovirus armed with TNFα and IL-2 improves anti-PD-1 checkpoint blockade in non-small cell lung cancer ' , OncoImmunology , vol. 12 , no. 1 , 2241710 . https://doi.org/10.1080/2162402X.2023.2241710; ORCID: /0000-0002-0877-9640/work/141186180; ORCID: /0000-0001-5771-9129/work/141186273; ORCID: /0000-0001-6235-8612/work/141186428; ORCID: /0000-0002-8149-3550/work/141186513; ORCID: /0000-0001-6684-3666/work/141186990; ORCID: /0000-0001-7103-8530/work/156151368; http://hdl.handle.net/10138/564127; c5174aed-f4ea-45ba-b96a-b555b27737ce; 85166781615; 001041332800001

الاتاحة: http://hdl.handle.net/10138/564127

المؤلفون: Basnet, Saru, Santos, Joao M., Quixabeira, Dafne C. A., Clubb, James H. A., Grönberg-Vähä-Koskela, Susanna A. M., Arias, Victor, Pakola, Santeri, Kudling, Tatiana V., Heiniö, Camilla, Havunen, Riikka, Cervera-Carrascon, Victor, Sorsa, Suvi, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli

المساهمون: TRIMM - Translational Immunology Research Program, Research Programs Unit, HUS Helsinki and Uusimaa Hospital District, HUS Comprehensive Cancer Center, HUS Gynecology and Obstetrics, Akseli Eetu Hemminki / Principal Investigator, Clinicum, Department of Obstetrics and Gynecology, Department of Oncology

مصطلحات موضوعية: Cancer, Therapy, Antibodies, Efficacy, Improves, Antigen, Marker, Cancers

وصف الملف: application/pdf

Relation: http://hdl.handle.net/10138/565407; 85146071632; 001058602600001

الاتاحة: http://hdl.handle.net/10138/565407

المؤلفون: Pakola, Santeri, Quixabeira, Dafne C. A., Kudling, Tatiana V., Clubb, James H. A., Grönberg-Vähä-Koskela, Susanna, Basnet, Saru, Jirovec, Elise, Arias, Victor, Haybout, Lyna, Heiniö, Camilla, Santos, Joao M., Cervera-Carrascon, Victor, Havunen, Riikka, Anttila, Marjukka, Hemminki, Akseli

المصدر: Frontiers in Immunology ; volume 14 ; ISSN 1664-3224

الاتاحة: http://dx.doi.org/10.3389/fimmu.2023.1171083
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1171083/full

المؤلفون: Clubb, James H. A., Kudling, Tatiana V., Heinioe, Camilla, Basnet, Saru, Pakola, Santeri, Cervera Carrascon, Victor, Santos, Joao Manuel, Quixabeira, Dafne C. A., Havunen, Riikka, Sorsa, Suvi, Zheng, Vincent, Salo, Tuula, Bäck, Leif, Aro, Katri, Tulokas, Sanni, Loimu, Venla, Hemminki, Akseli

المساهمون: Medicum, TRIMM - Translational Immunology Research Program, Research Programs Unit, Faculty of Medicine, HUS Comprehensive Cancer Center, HUSLAB, Department of Oral and Maxillofacial Diseases, Clinicum, Department of Oncology, HUS Head and Neck Center, Korva-, nenä- ja kurkkutautien klinikka

مصطلحات موضوعية: adenovirus, immune checkpoint inhibitor, head and neck cancer, immunotherapy, tertiary lymphoid neogenesis, TNFa, IL2, oncolytic virotherapy, SQUAMOUS-CELL CARCINOMA, INTRAEPITHELIAL NEOPLASIA GRADE-2, TNF-ALPHA, THERAPY, RECURRENT, RESISTANCE, SURVIVAL, RISK, Biomedicine, Cancers

وصف الملف: application/pdf

Relation: This study received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 813453. This study was supported by Jane and Aatos Erkko Foundation, HUCH Research Funds (VTR), Finnish Cancer Organizations, University of Helsinki, Novo Nordisk Foundation, Paivikki and Sakari Sohlberg Foundation, TILT Biotherapeutics Ltd. We thank Albert Ehrnrooth and Karl Fazer for research support. The funders were not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.; Clubb , J H A , Kudling , T V , Heinioe , C , Basnet , S , Pakola , S , Cervera Carrascon , V , Santos , J M , Quixabeira , D C A , Havunen , R , Sorsa , S , Zheng , V , Salo , T , Bäck , L , Aro , K , Tulokas , S , Loimu , V & Hemminki , A 2022 , ' Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer ' , Frontiers in Immunology , vol. 13 , 794251 . https://doi.org/10.3389/fimmu.2022.794251; ORCID: /0000-0001-6039-0088/work/112288101; ORCID: /0000-0001-6235-8612/work/113990064; ORCID: /0009-0009-8379-1584/work/134969188; ORCID: /0000-0001-7103-8530/work/156151436; http://hdl.handle.net/10138/352146; 656f4466-22fe-4ab0-9bc5-dae704b6e895; 000773608000001

الاتاحة: http://hdl.handle.net/10138/352146

المؤلفون: Zafar, Sadia, Basnet, Saru, Launonen, Inga-Maria, Quixabeira, Dafne Carolina Alves, Santos, Joao, Hemminki, Otto, Malmstedt, Minna, Cervera-Carrascon, Victor, Aronen, Pasi, Kalliokoski, Riikka, Havunen, Riikka, Rannikko, Antti, Mirtti, Tuomas, Matikainen, Mika, Kanerva, Anna, Hemminki, Akseli

المساهمون: HUS Comprehensive Cancer Center, Department of Oncology, TRIMM - Translational Immunology Research Program, University of Helsinki, Research Programs Unit, Department of Pathology, Clinicum, HUS Helsinki and Uusimaa Hospital District, Medicum, HUS Abdominal Center, Urologian yksikkö, Department of Surgery, Helsinki University Hospital Area, Research Program in Systems Oncology, HUSLAB, University Management, HUS Gynecology and Obstetrics, Akseli Eetu Hemminki / Principal Investigator

مصطلحات موضوعية: adenovirus 3, CD40 ligand, dendritic cells (DCs), prostate cancer, tumor microenvironment, PHASE-I, IMMUNE-RESPONSE, GENE-TRANSFER, DESMOGLEIN 2, IMMUNOTHERAPY, LIGAND, DIFFERENTIATION, PROGRESSION, VACCINATION, MECHANISMS, 11832 Microbiology and virology, Medical biotechnology, Genetics, developmental biology, physiology

وصف الملف: application/pdf

Relation: This study was supported by KLTO (Doctoral School for Clinical Research programme at the University of Helsinki), by Jane and Aatos Erkko Foundation, HUCH Research Funds (VTR), Sigrid Juselius Foundation, Finnish Cancer Organizations, University of Helsinki, Novo Nordisk Foundation, Paivikki and Sakari Sohlberg Foundation, and TILT Biotherapeutics Ltd. We thank Albert Ehrnrooth and Karl Fazer for research support.; Zafar , S , Basnet , S , Launonen , I-M , Quixabeira , D C A , Santos , J , Hemminki , O , Malmstedt , M , Cervera-Carrascon , V , Aronen , P , Kalliokoski , R , Havunen , R , Rannikko , A , Mirtti , T , Matikainen , M , Kanerva , A & Hemminki , A 2021 , ' Oncolytic Adenovirus Type 3 Coding for CD40L Facilitates Dendritic Cell Therapy of Prostate Cancer in Humanized Mice and Patient Samples ' , Human Gene Therapy , vol. 32 , no. 3-4 , pp. 192-202 . https://doi.org/10.1089/hum.2020.222; ORCID: /0000-0003-0455-9891/work/91247092; ORCID: /0000-0002-4261-3484/work/91248374; ORCID: /0000-0001-7103-8530/work/156151591; http://hdl.handle.net/10138/339799; 2eaefc4a-dd1d-4bbf-a655-68da1e489798; 000613083700001

الاتاحة: http://hdl.handle.net/10138/339799