المؤلفون: Sumaya K. Al-Rawe, Daniil Baranov, Agnieszka K. Bronowska, Celine Cano, Michael A. Carroll, Paul G. Waddell

المصدر: Crystals, Vol 14, Iss 12, p 1070 (2024)

مصطلحات موضوعية: polymorphism, crystal packing, amide coupling, approximate symmetry, N-arylbenzamide, molecular dynamics simulations, Crystallography, QD901-999

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2073-4352/14/12/1070; https://doaj.org/toc/2073-4352

URL الوصول: https://doaj.org/article/3834db1a1c8441c9849c237651bc5b4a

المؤلفون: Duncan C. Miller, Suzannah J. Harnor, Mathew P. Martin, Richard A. Noble, Stephen R. Wedge, Celine Cano

المصدر: Journal of Medicinal Chemistry. 66:4491-4502

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c286d0f072a149458bea662b0d7df668
https://doi.org/10.1021/acs.jmedchem.3c00072

المؤلفون: Gianni Chessari (1541785), Ian R. Hardcastle (129314), Jong Sook Ahn (5614631), Burcu Anil (2530831), Elizabeth Anscombe (1859752), Ruth H. Bawn (2884739), Luke D. Bevan (10429825), Timothy J. Blackburn (129305), Ildiko Buck (10429828), Celine Cano (1859773), Benoit Carbain (1859755), Juan Castro (3448166), Ben Cons (10429831), Sarah J. Cully (10429834), Jane A. Endicott (1286214), Lynsey Fazal (1269375), Bernard T. Golding (129309), Roger J. Griffin (129311), Karen Haggerty (1859770), Suzannah J. Harnor (10429837), Keisha Hearn (1668085), Stephen Hobson (10429840), Rhian S. Holvey (10429843), Steven Howard (760049), Claire E. Jennings (3068733), Christopher N. Johnson (157130), John Lunec (2224543), Duncan C. Miller (6509135), David R. Newell (129326), Martin E. M. Noble (10429846), Judith Reeks (3068739), Charlotte H. Revill (2224558), Christiane Riedinger (2224555), Jeffrey D. St. Denis (10429849), Emiliano Tamanini (1541818), Huw Thomas (431643), Neil T. Thompson (5322431), Mladen Vinković (2396401), Stephen R. Wedge (2493652), Pamela A. Williams (572408), Nicola E. Wilsher (1541797), Bian Zhang (10429852), Yan Zhao (58882)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Plant Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, osteosarcoma xenograft model, vivo inhibitors, quantum mechanics ligand-based design, MDM 2 X-ray crystallography, SJSA, metabolite identification, Isoindolinone Inhibitors, Structure-Based Design, minute 2, reactivate p 53, representative compounds, MDM 2-p interaction, novel isoindolinone-based MDM 2 inh., tumor growth

Relation: https://figshare.com/articles/journal_contribution/Structure-Based_Design_of_Potent_and_Orally_Active_Isoindolinone_Inhibitors_of_MDM2-p53_Protein_Protein_Interaction/14298511

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02188.s004

المؤلفون: Duncan C. Miller, Tristan Reuillon, Lauren Molyneux, Timothy Blackburn, Simon J. Cook, Noel Edwards, Jane A. Endicott, Bernard T. Golding, Roger J. Griffin, Ian Hardcastle, Suzannah J. Harnor, Amy Heptinstall, Pamela Lochhead, Mathew P. Martin, Nick C. Martin, Stephanie Myers, David R. Newell, Richard A. Noble, Nicole Phillips, Laurent Rigoreau, Huw Thomas, Julie A. Tucker, Lan-Zhen Wang, Michael J. Waring, Ai-Ching Wong, Stephen R. Wedge, Martin E. M. Noble, Celine Cano

المصدر: Journal of Medicinal Chemistry. 65:6513-6540

مصطلحات موضوعية: Drug Discovery, Molecular Medicine, Pyrroles, Mitogen-Activated Protein Kinase 7, Cell Proliferation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a06ab562a276985938cc66414c34c2
https://doi.org/10.1021/acs.jmedchem.1c01756

المؤلفون: Nicola J. Curtin, Graeme C.M. Smith, David R. Newell, Niall M.B. Martin, Pia Thommes, Andrew Slade, Keith Menear, Roger J. Griffin, Liam Cornell, Julia Bardos, Jody Barbeau, Michele Tavecchio, Celine Cano, Caroline J. Richardson, Helen Jenkins, Yan Zhao, Michael A. Batey, Joanne M. Munck

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c9f0d0e3e98828130b4f41f16e3e80
https://doi.org/10.1158/1535-7163.c.6535653.v1

المؤلفون: Nicola J. Curtin, Graeme C.M. Smith, David R. Newell, Niall M.B. Martin, Pia Thommes, Andrew Slade, Keith Menear, Roger J. Griffin, Liam Cornell, Julia Bardos, Jody Barbeau, Michele Tavecchio, Celine Cano, Caroline J. Richardson, Helen Jenkins, Yan Zhao, Michael A. Batey, Joanne M. Munck

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3174dc79b3c750b99d9eff50af83dd73
https://doi.org/10.1158/1535-7163.22497552

المؤلفون: Nicola J. Curtin, Graeme C.M. Smith, David R. Newell, Niall M.B. Martin, Pia Thommes, Andrew Slade, Keith Menear, Roger J. Griffin, Liam Cornell, Julia Bardos, Jody Barbeau, Michele Tavecchio, Celine Cano, Caroline J. Richardson, Helen Jenkins, Yan Zhao, Michael A. Batey, Joanne M. Munck

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2593b57508ee0ef2270374929c03d884
https://doi.org/10.1158/1535-7163.22497549

المؤلفون: Barbara W. Durkacz, Caroline A. Austin, Ian G. Cowell, Roger J. Griffin, Celine Cano-Soumillac, Andrew R. Pettitt, Robert Harris, Anthony Carter, Christopher Lowe, Fran O'Neill, Graham H. Jackson, Geoffrey P. Summerfield, Tryfonia Mainou-Fowler, Sarah L. Elliott, Elaine Willmore

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134f47c2cf25b662688cd8883181d12b
https://doi.org/10.1158/1078-0432.c.6517021.v1

المؤلفون: Barbara W. Durkacz, Caroline A. Austin, Ian G. Cowell, Roger J. Griffin, Celine Cano-Soumillac, Andrew R. Pettitt, Robert Harris, Anthony Carter, Christopher Lowe, Fran O'Neill, Graham H. Jackson, Geoffrey P. Summerfield, Tryfonia Mainou-Fowler, Sarah L. Elliott, Elaine Willmore

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406fd62e571ee5eb98ec0cf9f2b448f4
https://doi.org/10.1158/1078-0432.22439584

المؤلفون: Lan Z. Wang, Miller Duncan Charles, Bernard T. Golding, Ian Hickson, Martin E.M. Noble, Celine Cano, Suzannah J. Harnor, Michael J. Waring, Harry J Shrives, Shaimaa Khalifa, Jane Totobenazara, Stephen J. Hobson, Elaine Willmore, Hannah L Stewart, Mathew P. Martin, Susan J. Tudhope, Huw D. Thomas, Islam Al-Khawaldeh, Claire E. Jennings, João V de Souza, Max J. Temple, Jane A. Endicott, Cinzia Bordoni, Honorine Lebraud, Agnieszka K. Bronowska, Ian R. Hardcastle, Amy B. Heptinstall, Stephen R. Wedge, Christine Basmadjian, Gregory G Aldred, Julie A. Tucker, Mohammed J Al Yasiri

المصدر: Journal of Medicinal Chemistry. 64:10001-10018

مصطلحات موضوعية: chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Kinase, Active site, Protein Serine-Threonine Kinases, Structure-Activity Relationship, Residue (chemistry), Pyrimidines, Enzyme, Biochemistry, Covalent bond, Alkynes, Drug Discovery, Cancer cell, biology.protein, Humans, Molecular Medicine, Kinome, Cysteine, Protein Kinase Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56300566066f33b5e78d20a96b537040
https://doi.org/10.1021/acs.jmedchem.0c01249

المؤلفون: Benoit Carbain, Keisha Hearn, Ildiko Maria Buck, Burcu Anil, Sarah J. Cully, Gianni Chessari, Jane A. Endicott, John Lunec, Neil T. Thompson, Juan Castro, Roger J. Griffin, Rhian S. Holvey, Karen Haggerty, Charlotte H. Revill, Ruth H. Bawn, Stephen R. Wedge, Christiane Riedinger, Christopher N. Johnson, Bernard T. Golding, Lynsey Fazal, Ian R. Hardcastle, Mladen Vinkovic, Claire E. Jennings, Jong Sook Ahn, Bian Zhang, Pamela A. Williams, Celine Cano, Suzannah J. Harnor, Ben Cons, Stephen J. Hobson, E. Anscombe, Jeffrey D. St. Denis, Steven Howard, David R. Newell, Emiliano Tamanini, Nicola E. Wilsher, Miller Duncan Charles, Huw D. Thomas, Timothy J. Blackburn, Martin E.M. Noble, Judith Reeks, Yan Zhao, Luke Bevan

المصدر: Journal of Medicinal Chemistry. 64:4071-4088

مصطلحات موضوعية: Male, Metabolite, Mice, Nude, Antineoplastic Agents, Bone Neoplasms, Isoindoles, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Stability, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, neoplasms, Cell Proliferation, 030304 developmental biology, Mice, Inbred BALB C, Osteosarcoma, 0303 health sciences, Molecular Structure, biology, Chemistry, Proto-Oncogene Proteins c-mdm2, Ligand (biochemistry), Xenograft Model Antitumor Assays, Cytostasis, Small molecule, In vitro, 0104 chemical sciences, Macaca fascicularis, 010404 medicinal & biomolecular chemistry, Microsomes, Liver, biology.protein, Molecular Medicine, Mdm2, Female, Protein Multimerization, Tumor Suppressor Protein p53, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2c962765a3d64c4d7d02d50fd31b0d
https://doi.org/10.1021/acs.jmedchem.0c02188

المؤلفون: Bernard T. Golding, Celine Cano, Amy B. Heptinstall, Michael J. Waring, Edwige M. H. Picazo, David Matthew Wilson

المصدر: Journal of Heterocyclic Chemistry

مصطلحات موضوعية: Chemistry, Nucleophilic aromatic substitution, Intramolecular force, Organic Chemistry, Biological activity, Articles, Alkylation, Combinatorial chemistry, Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97fc5e137c7699049e20602d53c5927
https://doi.org/10.1002/jhet.4228

المؤلفون: Chitra Bhatia, Katherine H. Carr, Sharon Yeoh, Corine Mas-Droux, Richard Bayliss, Rory F. Cunnison, Matthew J. Byrne, Nazia Nasir, Celine Cano, Christine Basmadjian

المصدر: 'Biochemical Journal ', vol: 477, pages: 1525-1539 (2020)
Biochemical Journal

مصطلحات موضوعية: Protein Conformation, Stereochemistry, Mutant, Substituent, Biochemistry, Catalysis, Serine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Structural Biology, Chemical Biology, Humans, NIMA-Related Kinases, Enzyme Inhibitors, Molecular Biology, Research Articles, 030304 developmental biology, 0303 health sciences, Chemistry, Kinase, protein engineering, Cell Biology, Protein engineering, Small molecule, Kinetics, small molecules, kinases, 030220 oncology & carcinogenesis, Mutation, Multipolar spindles, Cytokinesis, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d9a93b8caa7633c58a85a48c53e0fc
https://doi.org/10.1042/bcj20200128

المؤلفون: Moe Ishihara, Junhui Hu, Celine Cano-Ruiz, Maia Jackson, Aimee Wu, Stuart Conway, Robert D. Damoiseaux, Lily Wu

المصدر: Cancer Research. 83:1611-1611

مصطلحات موضوعية: Cancer Research, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0df8922827bfe823d6653cb25a471840
https://doi.org/10.1158/1538-7445.am2023-1611

المؤلفون: Deborah F. Mitcheson, Andrew R. Bottrill, Katherine Carr, Christopher R. Coxon, Celine Cano, Bernard T. Golding, Roger J. Griffin, Andrew M. Fry, Christian Doerig, Richard Bayliss, Andrew B. Tobin

مصطلحات موضوعية: Uncategorized, Chemical genetics, Covalent modification, Mass spectrometry, NIMA-related protein kinase (Nek), Plasmodium falciparum

Relation: 2381/39786; https://figshare.com/articles/journal_contribution/A_new_tool_for_the_chemical_genetic_investigation_of_the_Plasmodium_falciparum_Pfnek-2_NIMA-related_kinase/10226606

الاتاحة: https://figshare.com/articles/journal_contribution/A_new_tool_for_the_chemical_genetic_investigation_of_the_Plasmodium_falciparum_Pfnek-2_NIMA-related_kinase/10226606

المؤلفون: Christopher R. Coxon, Christopher Wong, Richard Bayliss, Kathy Boxall, Katherine H. Carr, Andrew M. Fry, Ian R. Hardcastle, Christopher J. Matheson, David R. Newell, Mangaleswaran Sivaprakasam, Huw Thomas, David Turner, Sharon Yeoh, Lan Z. Wang, Roger J. Griffin, Bernard T. Golding, Céline Cano

مصطلحات موضوعية: Uncategorized, Nek2, cancer, small molecule inhibitors, structure-guided design

Relation: 2381/40168; https://figshare.com/articles/journal_contribution/Structure-guided_design_of_purine-based_probes_for_selective_Nek2_inhibition/10221548

الاتاحة: https://figshare.com/articles/journal_contribution/Structure-guided_design_of_purine-based_probes_for_selective_Nek2_inhibition/10221548

المؤلفون: Elizabeth Anscombe, Elisa Meschini, Regina Mora-Vidal, Mathew P Martin, David Staunton, Matthis Geitmann, U Helena Danielson, Will A Stanley, Lan Z Wang, Tristan Reuillon, Bernard T Golding, Celine Cano, David R Newell, Martin E M Noble, Stephen R Wedge, Jane A Endicott, Roger J Griffin

مصطلحات موضوعية: Uncategorised value

Relation: 10779/uos.23426561.v1; https://figshare.com/articles/journal_contribution/Identification_and_characterization_of_an_irreversible_inhibitor_of_CDK2/23426561

الاتاحة: https://figshare.com/articles/journal_contribution/Identification_and_characterization_of_an_irreversible_inhibitor_of_CDK2/23426561

المؤلفون: Celine Cano, Adam Potts, Shl Thomas, SL Hill

المصدر: Clinical Toxicology. 58:82-98

مصطلحات موضوعية: Cannabinoid Receptor Agonists, Cannabinoid receptor, Molecular Structure, Databases, Pharmaceutical, Chemical nomenclature, 030208 emergency & critical care medicine, General Medicine, Computational biology, Toxicology, Designer Drugs, Receptor, Cannabinoid, CB2, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Receptor, Cannabinoid, CB1, Drug control, Terminology as Topic, Cannabinoid receptor type 2, Animals, Humans, Identification (biology), 030212 general & internal medicine, Pharmacophore, Nomenclature

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8ee6a588400f24584221f0f0f6b7d4
https://doi.org/10.1080/15563650.2019.1661425

المؤلفون: Ian R. Hardcastle, Celine Cano, Mathew P. Martin, Leanne E Knight, Michael J. Waring, Islam Al-Khawaldeh, J. Daniel Lopez-Fernandez, Miller Duncan Charles, Jane A. Endicott, Martin E.M. Noble, Shengying Lin, D.J. Wood, Conghao Gai

المصدر: Journal of Medicinal Chemistry. 62:3741-3752

مصطلحات موضوعية: Binding Sites, Halogenation, Chemistry, Drug discovery, Allosteric regulation, Drug Evaluation, Preclinical, Druggability, Computational biology, Crystallography, X-Ray, Ligands, Small Molecule Libraries, Drug Discovery, Molecular Medicine, Binding site, Pharmacophore

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e9fdc992cdd6269599895e959c267e
https://doi.org/10.1021/acs.jmedchem.9b00304

المؤلفون: Andrew Kalusa, Paul Andrew Clarke, Keith Jones, Rob Van Montfort, Sylvain Couty, Isaac M. Westwood, Celine Cano, Jon Travers, Kathy Boxall, Chiau Ling Chow, Sam Burns, Jessica Schmitt, Lisa Pickard, Caterina Barillari, P. Craig Mcandrew, Paul A. Clarke, Spiros Linardopoulos, Roger J. Griffin, G. Wynne Aherne, Florence I. Raynaud, Paul Workman

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: https://www.researchgate.net/profile/Keith_Jones8/publication/257135788_The_discovery_of_potent_ribosomal_S6_kinase_inhibitors_by_high-throughput_screening_and_structure-guided_drug_design/links/0f31753270913a3cf6000000.pdf?origin%3Dpublication_detail.

مصطلحات موضوعية: S6 kinase, P70S6K, cancer, inhibitor

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1025.8308

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1025.8308