نتائج البحث - "Cdk8"

Relation: info:eu-repo/semantics/altIdentifier/wos/001336881000001; info:eu-repo/grantAgreement/SNF/Projektförderung in Biologie und Medizin (Abteilung III)/152814; http://hdl.handle.net/20.500.11850/715391

الاتاحة: https://hdl.handle.net/20.500.11850/715391
https://doi.org/10.3929/ethz-b-000700513

View record in BASE

7

Academic Journal

An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II

المؤلفون: Zhao, Haiyan, Li, Jiaqin, Xiang, Yufei, Malik, Sohail, Vartak, Supriya V, Veronezi, Giovana M B, Young, Natalie, Riney, McKayla, Kalchschmidt, Jens, Conte, Andrea, Jung, Seol Kyoung, Ramachandran, Srinivas, Roeder, Robert G, Shi, Yi, Casellas, Rafael, Asturias, Francisco J

المساهمون: Zhao, Haiyan, Li, Jiaqin, Xiang, Yufei, Malik, Sohail, Vartak, Supriya V, Veronezi, Giovana M B, Young, Natalie, Riney, Mckayla, Kalchschmidt, Jen, Conte, Andrea, Jung, Seol Kyoung, Ramachandran, Sriniva, Roeder, Robert G, Shi, Yi, Casellas, Rafael, Asturias, Francisco J

مصطلحات موضوعية: CDK8 kinase module, MED26, Mediator complex, RNA polymerase II CTD, activation, eukaryotic transcription, nuclear receptor, transcription regulation

Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:001281276300001; journal:MOLECULAR CELL; https://hdl.handle.net/11588/964666; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85198752363

الاتاحة: https://hdl.handle.net/11588/964666
https://doi.org/10.1016/j.molcel.2024.06.006

View record in BASE

8

Academic Journal

Highlighting the Major Role of Cyclin C in Cyclin-Dependent Kinase 8 Activity through Molecular Dynamics Simulations

المؤلفون: Ziada, Sonia, Diharce, Julien, Serillon, Dylan, Bonnet, Pascal, Aci-Sèche, Samia

المساهمون: Institut de Chimie Organique et Analytique (ICOA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), Biologie Intégrée du Globule Rouge (BIGR (UMR_S_1134 / U1134)), Institut National de la Transfusion Sanguine Paris (INTS)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre / Abymes Guadeloupe -Université des Antilles (UA)-Université Paris Cité (UPCité), Institut de Recherche Servier, FEDER-FSE 2014-2020-EX003677, CHemBio, Plateforme de Chémobiologie pour le développement de nouvelles méthodologies pour l'innovation thérapeutique, FEDER-FSE 2014-2020-EX003202, ValBioCosm, Valorisation de la Biodiversité en Cosmétique, FEDER-FSE 2014-2020-EX011313, TechSAB, Plateformes Technologiques, Synthèse, Analyse et Biochimie, APR-IA-PF 2021-00149467, QUALICHIM, ANR-11-LABX-0029,SYNORG,Synthèse Organique : des molécules au vivant(2011), ANR-11-LABX-0018,IRON,Radiopharmaceutiques Innovants en Oncologie et Neurologie(2011)

المصدر: ISSN: 1661-6596.

مصطلحات موضوعية: CDK8 cyclin C, protein-protein interaction, molecular dynamic simulation, free energy calculation, drug design, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]

الاتاحة: https://hal.science/hal-04662241
https://hal.science/hal-04662241v1/document
https://hal.science/hal-04662241v1/file/manuscript.v5.pdf
https://doi.org/10.3390/ijms25105411

View record in BASE

9

Academic Journal

Assessment of iridoids and their similar structures as antineoplastic drugs by in silico approach

المؤلفون: Prabhat Neupane, Jhashanath Adhikari Subin, Rameshwar Adhikari

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Anticancer, molecular dynamics simulations, CDK8 protein

Relation: https://figshare.com/articles/journal_contribution/Assessment_of_iridoids_and_their_similar_structures_as_antineoplastic_drugs_by_i_in_silico_i_approach/25205299

الاتاحة: https://doi.org/10.6084/m9.figshare.25205299.v1
https://figshare.com/articles/journal_contribution/Assessment_of_iridoids_and_their_similar_structures_as_antineoplastic_drugs_by_i_in_silico_i_approach/25205299

View record in BASE

10

Academic Journal

The discovery of a novel pyrrolo[2,3-b]pyridine as a selective CDK8 inhibitor offers a new approach against psoriasis

المؤلفون: Yao Yao Yan, Yu Meng Wang, Jun Hao Shen, Yu Jie Jian, Cen Cen Lei, Quan Wang, Chao Liu, Xing Xing Zhang, Xin Hua Liu

المصدر: Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116705- (2024)

مصطلحات موضوعية: Design, CDK8 inhibitor, Pyrrolo-pyridine, Psoriasis activity, Therapeutics. Pharmacology, RM1-950

Relation: http://www.sciencedirect.com/science/article/pii/S0753332224005894; https://doaj.org/toc/0753-3322; https://doaj.org/article/eada1e08a03049b191c7614dcce463b8

الاتاحة: https://doi.org/10.1016/j.biopha.2024.116705
https://doaj.org/article/eada1e08a03049b191c7614dcce463b8

View record in BASE

Full Text Finder

11

Academic Journal

Unveiling the noncanonical activation mechanism of CDKs: insights from recent structural studies

المؤلفون: Tao Li, Hui-Chi Tang, Kuang-Lei Tsai

المصدر: Frontiers in Molecular Biosciences, Vol 10 (2023)

مصطلحات موضوعية: CDK7, CDK8, MED12, kinase, T-loop, Y-loop, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2023.1290631/full; https://doaj.org/toc/2296-889X

URL الوصول: https://doaj.org/article/a73e571672d24787a01c89b76b989862

View record in DOAJ

Full Text Finder

12

Academic Journal

Discovery of 4‑Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity

المصدر: ACS Medicinal Chemistry Letters. 11(2)

URL الوصول: https://escholarship.org/uc/item/4cz02519

View record in eScholarship

13

Academic Journal

Regulation of Skn7-dependent, oxidative stress-induced genes by the RNA polymerase II-CTD phosphatase, Fcp1, and Mediator kinase subunit, Cdk8, in yeast

المؤلفون: Aristizabal, Maria J, Dever, Kristy, Negri, Gian Luca, Shen, Mary, Hawe, Nicole, Benschop, Joris J, Holstege, Frank CP, Krogan, Nevan J, Sadowski, Ivan, Kobor, Michael S

المصدر: Journal of Biological Chemistry. 294(44)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Biotechnology, Genetics, Underpinning research, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Aetiology, Generic health relevance, Cancer, Cyclin-Dependent Kinase 8, DNA-Binding Proteins, Gene Expression Regulation, Fungal, Oxidative Stress, Peroxidases, Phosphoprotein Phosphatases, Protein Stability, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Thioredoxins, Transcription Factors, Transcriptional Activation, transcription factor, transcription regulation, transcriptomics, yeast transcription, transcription, gene regulation, Cdk8, Fcp1, Mediator complex, Skn7, transcription repression, RNA polymerase II, oxidative stress, Chemical Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Chemical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/23g2m1hg
https://escholarship.org/content/qt23g2m1hg/qt23g2m1hg.pdf

View record in eScholarship

14

Academic Journal

马鹿 CDK8 基因生物信息学分析与组织表达

المؤلفون: 唐成怡, 吴玄烨, 吴尽, 杨帆, 刘学东

المصدر: 野生动物学报, Vol 44, Pp 572-579 (2023)

مصطلحات موضوعية: 鹿茸, CDK8, 生物信息学, 组织表达, Zoology, QL1-991

Relation: http://ysdw.nefu.edu.cn/thesisDetails#10.12375/ysdwxb.20230312; https://doaj.org/toc/2310-1490; https://doaj.org/article/2d7f9eb6ae674096a0a608aacaadcd1b

الاتاحة: https://doaj.org/article/2d7f9eb6ae674096a0a608aacaadcd1b

View record in BASE

15

Academic Journal

CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium

المؤلفون: Prieto, Susana, Dubra, Geronimo, Camasses, Alain, Aznar, Ana Bella, Begon-Pescia, Christina, Simboeck, Elisabeth, Pirot, Nelly, Gerbe, François, Angevin, Lucie, Jay, Philippe, Krasinska, Liliana, Fisher, Daniel

المساهمون: Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Ligue Nationale Contre le Cancer (LNCC), Institut régional de Cancérologie de Montpellier (ICM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Réseau d'histologie expérimentale de Montpellier (RHEM), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)

المصدر: ISSN: 1469-221X.

مصطلحات موضوعية: CDK19, CDK8, CFTR, intestinal epithelium, Mediator, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.CAN]Life Sciences [q-bio]/Cancer

Relation: info:eu-repo/semantics/altIdentifier/pmid/36545778; PUBMED: 36545778

الاتاحة: https://hal.science/hal-03911208
https://hal.science/hal-03911208v1/document
https://hal.science/hal-03911208v1/file/CDK8%20and%20CDK19%20act%20redundantly%20to%20control%20the%20CFTR%20pathway%20in%20the%20intestinal%20epithelium%20Prieto%20EMBO%20Reports%202022.pdf
https://doi.org/10.15252/embr.202154261

View record in BASE

16

Academic Journal

CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants

المساهمون: Department of Medical and Clinical Genetics, University of Helsinki, Medicum, HUSLAB, Tutkimusryhmä Anna-Elina Lehesjoki, Neuroscience Center, Helsinki University Hospital Area

مصطلحات موضوعية: MEDIATOR COMPLEX, PROTEIN, SEQUENCE, GENES, MED12, CDK8, Biomedicine

وصف الملف: application/pdf

Relation: Part of this work was supported by the Ministry of Education, Culture, Sports, Science and Technology (MEXT KAKENHI; grant numbers 24118003 and 25131704 to Y.O. and grant numbers 20K21502 and 20H05365 to T.I.), the Japanese Society for the Promotion of Science (JSPS) (KAKENHI; grant numbers 20570162 and 17K07282 to Y.H.), and Japan Agency for Medical Research and Development (JP18ek0109288h0002 and JP19ek0109288h003 to T.I.).; Zarate , Y A , Uehara , T , Abe , K , Oginuma , M , Harako , S , Ishitani , S , Lehesjoki , A-E , Bierhals , T , Kloth , K , Ehmke , N , Horn , D , Holtgrewe , M , Anderson , K , Viskochil , D , Edgar-Zarate , C L , Sacoto , M J G , Schnur , R E , Morrow , M M , Sanchez-Valle , A , Pappas , J , Rabin , R , Muona , M , Anttonen , A-K , Platzer , K , Luppe , J , Gburek-Augustat , J , Kaname , T , Okamoto , N , Mizuno , S , Kaido , Y , Ohkuma , Y , Hirose , Y , Ishitani , T & Kosaki , K 2021 , ' CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants ' , Genetics In medicine , vol. 23 , no. 6 , pp. 1050-1057 . https://doi.org/10.1038/s41436-020-01091-9; http://hdl.handle.net/10138/353316; 242bf5f7-79ce-4649-8e37-fca9fcc07ea0; 000611490600003

الاتاحة: http://hdl.handle.net/10138/353316

View record in BASE