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1Academic Journal
المؤلفون: Agata Butryn, Philipp S. Simon, Pierre Aller, Philip Hinchliffe, Ramzi N. Massad, Gabriel Leen, Catherine L. Tooke, Isabel Bogacz, In-Sik Kim, Asmit Bhowmick, Aaron S. Brewster, Nicholas E. Devenish, Jürgen Brem, Jos J. A. G. Kamps, Pauline A. Lang, Patrick Rabe, Danny Axford, John H. Beale, Bradley Davy, Ali Ebrahim, Julien Orlans, Selina L. S. Storm, Tiankun Zhou, Shigeki Owada, Rie Tanaka, Kensuke Tono, Gwyndaf Evans, Robin L. Owen, Frances A. Houle, Nicholas K. Sauter, Christopher J. Schofield, James Spencer, Vittal K. Yachandra, Junko Yano, Jan F. Kern, Allen M. Orville
المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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2Academic Journal
المؤلفون: Philip Hinchliffe, Catherine L. Tooke, Christopher R. Bethel, Benlian Wang, Christopher Arthur, Kate J. Heesom, Stuart Shapiro, Daniela M. Schlatzer, Krisztina M. Papp-Wallace, Robert A. Bonomo, James Spencer
المصدر: mBio, Vol 13, Iss 3 (2022)
مصطلحات موضوعية: enmetazobactam, AAI101, tazobactam, inhibitor, antibiotic resistance, CTX-M-15, Microbiology, QR1-502
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2150-7511
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3Academic Journal
المؤلفون: Anka Lucic, Tika R. Malla, Karina Calvopiña, Catherine L. Tooke, Jürgen Brem, Michael A. McDonough, James Spencer, Christopher J. Schofield
المصدر: Antibiotics, Vol 11, Iss 3, p 396 (2022)
مصطلحات موضوعية: carbapenems, antimicrobial resistance, metallo-β-lactamases, serine-β-lactamases, biapenem, Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
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4Academic Journal
المؤلفون: Ioannis Galdadas, Shen Qu, Ana Sofia F Oliveira, Edgar Olehnovics, Andrew R Mack, Maria F Mojica, Pratul K Agarwal, Catherine L Tooke, Francesco Luigi Gervasio, James Spencer, Robert A Bonomo, Adrian J Mulholland, Shozeb Haider
المصدر: eLife, Vol 10 (2021)
مصطلحات موضوعية: TEM-1, KPC-2, β-lactamase, Medicine, Science, Biology (General), QH301-705.5
Relation: https://elifesciences.org/articles/66567; https://doaj.org/toc/2050-084X; e66567; https://doaj.org/article/7aac1beac51a40888c31f6d01e330204
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المؤلفون: Catherine L. Tooke, Philip Hinchliffe, Michael Beer, Kirill Zinovjev, Charlotte K. Colenso, Christopher J. Schofield, Adrian J. Mulholland, James Spencer
المصدر: Tooke, C L, Hinchliffe, P, Beer, M, Zinovjev, K, Colenso, C K, Schofield, C J, Mulholland, A J & Spencer, J 2023, ' Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 β-Lactamase ', Journal of the American Chemical Society, vol. 145, no. 13, pp. 7166-7180 . https://doi.org/10.1021/jacs.2c12123
مصطلحات موضوعية: Colloid and Surface Chemistry, AMR, General Chemistry, Biochemistry, Catalysis
وصف الملف: application/pdf
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المؤلفون: Catherine L. Tooke, Philip Hinchliffe, Michael Beer, Kirill Zinovjev, Charlotte K. Colenso, Christopher J. Schofield, Adrian J. Mulholland, James Spencer
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المؤلفون: Thomas B. Clarke, Alan Armstrong, Thomas Webb, James Spencer, Lindsay E. Evans, Aishwarya Krishna, Dominic C Marshall, Yajing Ma, Catherine L. Tooke, Andrew M. Edwards
المساهمون: IP2IPO Innovations Limited, Wellcome Trust
المصدر: Evans, L E, Krishna, A, Ma, Y, Webb, T E, Marshall, D C, Tooke, C L, Spencer, J, Clarke, T B, Armstrong, A & Edwards, A M 2019, ' Exploitation of Antibiotic Resistance as a Novel Drug Target : Development of a β-Lactamase-Activated Antibacterial Prodrug ', Journal of Medicinal Chemistry, vol. 62, no. 9, pp. 4411-4425 . https://doi.org/10.1021/acs.jmedchem.8b01923
مصطلحات موضوعية: DUAL-MODE, Cephalosporin, Antibiotics, Chemistry, Medicinal, Drug resistance, 0305 Organic Chemistry, 01 natural sciences, Ciprofloxacin, Drug Discovery, Topoisomerase II Inhibitors, EPIDEMIOLOGY, Prodrugs, Pharmacology & Pharmacy, 0303 health sciences, Molecular Structure, biology, Chemistry, ESTERS, Drug Resistance, Microbial, Prodrug, HYDROLYSIS, MICROBIOTA, Anti-Bacterial Agents, ESCHERICHIA-COLI, Molecular Medicine, KLEBSIELLA-PNEUMONIAE, 1115 Pharmacology and Pharmaceutical Sciences, Life Sciences & Biomedicine, medicine.drug, medicine.drug_class, Medicinal & Biomolecular Chemistry, Secondary infection, QUINOLONE ACTION, Microbial Sensitivity Tests, beta-Lactamases, MECHANISMS, Microbiology, Structure-Activity Relationship, 03 medical and health sciences, Antibiotic resistance, Escherichia coli, medicine, CEPHALOSPORIN, 030304 developmental biology, Science & Technology, 0304 Medicinal and Biomolecular Chemistry, biology.organism_classification, Cephalosporins, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Bacteria
وصف الملف: application/pdf
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المؤلفون: Nicholas K. Sauter, Pauline A. Lang, Philipp S. Simon, Nicholas E. Devenish, Philip Hinchliffe, Vittal K. Yachandra, Junko Yano, Julien Orlans, Jürgen Brem, Gabriel Leen, Pierre Aller, Allen M. Orville, John H. Beale, James Spencer, Jos J. A. G. Kamps, A. Butryn, Catherine L. Tooke, Robin L. Owen, Ramzi N. Massad, Frances A. Houle, Kensuke Tono, Bradley Davy, Patrick Rabe, Jan Kern, Aaron S. Brewster, A. Ebrahim, Asmit Bhowmick, Tiankun Zhou, Gwyndaf Evans, Selina L. S. Storm, Shigeki Owada, Christopher J. Schofield, Isabel Bogacz, Danny Axford, Rie Tanaka, In-Sik Kim
المساهمون: Biologie Fonctionnelle, Insectes et Interactions (BF2I), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
المصدر: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-24757-7⟩
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Nature communications, vol 12, iss 1
Spencer, J, Hinchliffe, P, Tooke, C L, Kern, J F & Orville, A M 2021, ' An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography ', Nature Communications, vol. 12, no. 1, 4461 . https://doi.org/10.1038/s41467-021-24757-7مصطلحات موضوعية: Models, Molecular, Materials science, Science, [SDV]Life Sciences [q-bio], Optical spectroscopy, General Physics and Astronomy, 02 engineering and technology, Crystallography, X-Ray, Article, beta-Lactamases, General Biochemistry, Genetics and Molecular Biology, Avian Proteins, 03 medical and health sciences, Bacterial Proteins, Models, Catalytic Domain, Computational models, Animals, X-ray crystallography, 030304 developmental biology, 0303 health sciences, Crystallography, Multidisciplinary, Drop (liquid), Protein dynamics, Molecular, Equipment Design, General Chemistry, 021001 nanoscience & nanotechnology, Ligand (biochemistry), Small molecule, Recombinant Proteins, Enzymes, Structural biology, Temporal resolution, Femtosecond, X-Ray, Biocatalysis, Muramidase, Generic health relevance, 0210 nano-technology, Chickens, Macromolecule
وصف الملف: application/pdf
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المؤلفون: Ioannis Galdadas, Shen Qu, Ana Sofia F Oliveira, Edgar Olehnovics, Andrew R Mack, Maria F Mojica, Pratul K Agarwal, Catherine L Tooke, Francesco Luigi Gervasio, James Spencer, Robert A Bonomo, Adrian J Mulholland, Shozeb Haider
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10
المؤلفون: Shen Qu, Ana Sofia F Oliveira, Francesco Luigi Gervasio, Edgar Olehnovics, Catherine L. Tooke, Shozeb Haider, Pratul K Agarwal, Andrew R Mack, Adrian J. Mulholland, Ioannis Galdadas, Robert A. Bonomo, James Spencer, Maria F. Mojica
المصدر: eLife, Vol 10 (2021)
Galdadas, I, Oliveira, A S F, Tooke, C L, Spencer, J, Mulholland, A J, Haider, S & al., E 2021, ' Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics ', eLife, vol. 10, e66567 . https://doi.org/10.7554/eLife.66567
eLifeمصطلحات موضوعية: 0301 basic medicine, Shape change, Protein Conformation, Structural Biology and Molecular Biophysics, Antibiotics, 01 natural sciences, Biology (General), chemistry.chemical_classification, biology, General Neuroscience, β lactamases, General Medicine, Amino acid, Biochemistry, Medicine, Signal transduction, Research Article, medicine.drug_class, QH301-705.5, Science, Allosteric regulation, BrisSynBio, Computational biology, Molecular Dynamics Simulation, 010402 general chemistry, beta-Lactamases, General Biochemistry, Genetics and Molecular Biology, KPC-2, 03 medical and health sciences, Antibiotic resistance, Drug Resistance, Bacterial, medicine, TEM-1, General Immunology and Microbiology, Mechanism (biology), Bristol BioDesign Institute, Active site, β-lactamase, 0104 chemical sciences, Coupling (electronics), 030104 developmental biology, Enzyme, Amino Acid Substitution, Structural biology, chemistry, biology.protein, Other
وصف الملف: application/pdf
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المؤلفون: Timothy Armistead, Karina Calvopiña, Michael A. McDonough, Catherine L. Tooke, Patrick Rabe, James Spencer, Tika R. Malla, Allen M. Orville, Christopher J. Schofield, Philip Hinchliffe, Anka Lucic, Christopher T Lohans, Jürgen Brem
المصدر: Eur J Med Chem
Lucic, A, Hinchliffe, P, Malla, T R, Tooke, C L, Brem, J, Calvopiña, K, Lohans, C T, Rabe, P, McDonough, M A, Armistead, T, Orville, A M, Spencer, J & Schofield, C J 2021, ' Faropenem reacts with serine and metallo-β-lactamases to give multiple products ', European Journal of Medicinal Chemistry, vol. 215, 113257 . https://doi.org/10.1016/j.ejmech.2021.113257مصطلحات موضوعية: Stereochemistry, Stenotrophomonas maltophilia, Imine, Crystal structure, Ring (chemistry), Crystallography, X-Ray, beta-Lactams, 01 natural sciences, beta-Lactamases, Article, Enamine, 03 medical and health sciences, chemistry.chemical_compound, Catalytic Domain, Drug Discovery, polycyclic compounds, antimicrobial resistance, Tetrahydrofuran, serine-β-lactamases, 030304 developmental biology, Pharmacology, chemistry.chemical_classification, 0303 health sciences, penems, 010405 organic chemistry, Alkene, Hydrolysis, Organic Chemistry, β-lactams, Faropenem, Substrate (chemistry), General Medicine, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, 0104 chemical sciences, Anti-Bacterial Agents, Klebsiella pneumoniae, chemistry, Pseudomonas aeruginosa, metallo-β-lactamases, carbapenems, beta-Lactamase Inhibitors, Protein Binding
وصف الملف: application/pdf
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12
المؤلفون: James Spencer, Catherine L. Tooke, Philip Hinchliffe, Yuiko Takebayashi, Viivi H. A. Hirvonen, Charlotte K. Colenso, Eilis C. Bragginton
المصدر: Journal of Molecular Biology
Tooke, C, Hinchliffe, P, Bragginton, E, Colenso, C K, Hirvonen, V, Takebayashi, Y & Spencer, J 2019, ' β-Lactamases and β-Lactamase Inhibitors in the 21st Century ', Journal of Molecular Biology . https://doi.org/10.1016/j.jmb.2019.04.002مصطلحات موضوعية: β-lactam, QM/MM, quantum mechanics/molecular mechanics, TEM, Temoneira (β-lactamase), medicine.disease_cause, OXA, oxacillinase, Serine, carbapenemase, 0302 clinical medicine, Structural Biology, Catalytic Domain, polycyclic compounds, chemistry.chemical_classification, 0303 health sciences, SBL, serine β-lactamase, Enterobacteriaceae, 3. Good health, Anti-Bacterial Agents, NDM, New Delhi metallo-β-lactamase, Drug Combinations, DBO, diazabicyclooctane, beta-Lactamase Inhibitors, CTX-M, cefotaximase, metallo-β-lactamase, PBP, penicillin-binding protein, Computational biology, Biology, beta-Lactams, Article, beta-Lactamases, 03 medical and health sciences, Antibiotic resistance, Drug Resistance, Bacterial, Gram-Negative Bacteria, medicine, Humans, enzyme mechanism, antimicrobial resistance, Molecular Biology, Escherichia coli, MBL, metallo-β-lactamase, 030304 developmental biology, Pseudomonas aeruginosa, SFX, serial femtosecond crystallography, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Interspersed Repetitive Sequences, Enzyme, VIM, Verona imipenemase, Carbapenem-Resistant Enterobacteriaceae, chemistry, SHV, sulfydryl variant, Carbapenems, ESBL, extended spectrum β-lactamase, KPC, Klebsiella pneumoniae carbapenemase, Mobile genetic elements, 030217 neurology & neurosurgery, Bacteria
وصف الملف: application/pdf
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المؤلفون: Philip Hinchliffe, Adrian J. Mulholland, Catherine L. Tooke, Alen Krajnc, James Spencer, Jürgen Brem, Christopher J. Schofield
المصدر: RSC Med Chem
Tooke, C L, Hinchliffe, P, Kranjnc, A, Mulholland, A J, Brem, J, Schofield, C J & Spencer, J 2020, ' Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition ', RSC medicinal chemistry, vol. 11, no. 4, pp. 491-496 . https://doi.org/10.1039/c9md00557aمصطلحات موضوعية: medicine.drug_class, Stereochemistry, Klebsiella pneumoniae, Antibiotics, Complex formation, Pharmaceutical Science, High resolution, Biochemistry, 03 medical and health sciences, Drug Discovery, medicine, polycyclic compounds, Potency, Specific enzyme, 030304 developmental biology, Pharmacology, 0303 health sciences, Vaborbactam, Bicyclic molecule, biology, 030306 microbiology, Chemistry, Organic Chemistry, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, bacterial infections and mycoses, 3. Good health, Molecular Medicine
وصف الملف: application/pdf
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14
المؤلفون: Pauline A. Lang, James Spencer, Philip Hinchliffe, Catherine L. Tooke, Jürgen Brem, Adrian J. Mulholland, Christopher J. Schofield
المصدر: Tooke, C, Hinchliffe, P, Pauline, L, Mulholland, A, Brem, J, Schofield, C J & Spencer, J 2019, ' Molecular Basis of Class A β-lactamase Inhibition by Relebactam ', Antimicrobial Agents and Chemotherapy . https://doi.org/10.1128/AAC.00564-19, https://doi.org/10.1128/AAC.00564-19
Antimicrobial Agents and Chemotherapyمصطلحات موضوعية: Models, Molecular, Imipenem, antibiotic resistance, Klebsiella pneumoniae, Stenotrophomonas maltophilia, Gene Expression, Ceftazidime, Aztreonam, diazabicyclooctane, Pharmacology, chemistry.chemical_compound, polycyclic compounds, Pharmacology (medical), Cloning, Molecular, avibactam, 0303 health sciences, biology, Chromosomes, Bacterial, Enterobacteriaceae, Recombinant Proteins, 3. Good health, Isoenzymes, Drug Combinations, Infectious Diseases, beta-Lactamase Inhibitors, Plasmids, Protein Binding, medicine.drug, Avibactam, Genetic Vectors, Microbial Sensitivity Tests, beta-Lactam Resistance, beta-Lactamases, 03 medical and health sciences, Mechanisms of Resistance, relebactam, Escherichia coli, medicine, Humans, Protein Interaction Domains and Motifs, IC50, 030304 developmental biology, Binding Sites, 030306 microbiology, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, biology.organism_classification, Clinical Trials, Phase III as Topic, chemistry, serine β-lactamase inhibitors, Azabicyclo Compounds
وصف الملف: application/pdf
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المؤلفون: Christopher T, Lohans, Emily I, Freeman, Emma van, Groesen, Catherine L, Tooke, Philip, Hinchliffe, James, Spencer, Jürgen, Brem, Christopher J, Schofield
المصدر: Scientific Reports
مصطلحات موضوعية: Hydrolases, Antibiotics, Enzyme mechanisms, polycyclic compounds, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, Antimicrobial resistance, Article
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16
المؤلفون: Gareth W, Langley, Ricky, Cain, Jonathan M, Tyrrell, Philip, Hinchliffe, Karina, Calvopiña, Catherine L, Tooke, Emma, Widlake, Christopher G, Dowson, James, Spencer, Timothy R, Walsh, Christopher J, Schofield, Jürgen, Brem
المصدر: Bioorganic & Medicinal Chemistry Letters
مصطلحات موضوعية: Transition state analogue, Antibiotic resistance, β-Lactamase induction, Vaborbactam, Humans, Serine- and metallo-β-lactamase, Boronic Acids, beta-Lactamases, Article, ComputingMethodologies_COMPUTERGRAPHICS, Anti-Bacterial Agents, Boronate inhibitor
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17
المؤلفون: Christopher T. Lohans, H. T. Henry Chan, Tika R. Malla, Kiran Kumar, Jos J. A. G. Kamps, Darius J. B. McArdle, Emma van Groesen, Mariska de Munnik, Catherine L. Tooke, James Spencer, Robert S. Paton, Jürgen Brem, Christopher J. Schofield
المصدر: Angewandte Chemie International Edition, 131(7), 2012-2016
Angewandte Chemie (International Ed. in English)
Lohans, C T, Chan, H T H, Malla, T R, Kumar, K, Kamps, J J A G, McArdle, D J B, van Groesen, E, de Munnik, M, Tooke, C L, Spencer, J, Paton, R S, Brem, J & Schofield, C J 2019, ' Non-Hydrolytic β-Lactam Antibiotic Fragmentation by l,d-Transpeptidases and Serine β-Lactamase Cysteine Variants ', Angewandte Chemie-International Edition, vol. 58, no. 7, pp. 1990-1994 . https://doi.org/10.1002/anie.201809424مصطلحات موضوعية: 0303 health sciences, antibiotic resistance, 010405 organic chemistry, Communication, Molecular Conformation, β-lactamases, General Medicine, hydrolases, beta-Lactams, 01 natural sciences, Communications, beta-Lactamases, 0104 chemical sciences, Anti-Bacterial Agents, 03 medical and health sciences, Antibiotics, fragmentation, Peptidyl Transferases, transpeptidases, Cysteine, 030304 developmental biology
وصف الملف: application/pdf
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المؤلفون: Christopher T. Lohans, Emma van Groesen, Kiran Kumar, Catherine L. Tooke, James Spencer, Robert S. Paton, Jürgen Brem, Christopher J. Schofield
المصدر: Angewandte Chemie International Edition, 130(5), 1296-1299
Lohans, C T, van Groesen, E, Kumar, K, Tooke, C L, Spencer, J, Paton, R S, Brem, J & Schofield, C J 2018, ' A New Mechanism for β-Lactamases : Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation ', Angewandte Chemie-International Edition, vol. 57, no. 5, pp. 1282-1285 . https://doi.org/10.1002/anie.201711308
Angewandte Chemie (International Ed. in English)مصطلحات موضوعية: 0301 basic medicine, Communication, 030106 microbiology, β-lactamases, hydrolases, General Medicine, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, Communications, antibiotics, lactones, 3. Good health, 03 medical and health sciences, 030104 developmental biology, Antibiotic Resistance, polycyclic compounds, bacteria, carbapenems
وصف الملف: application/pdf
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19
المؤلفون: Neil G. Paterson, Tom A. Young, Philip Hinchliffe, Edward Portal, Jürgen Brem, Yang Wang, Adrian J. Mulholland, Lei Lei, Catherine L. Tooke, Maria J. Carvalho, Uttapoln Tansawai, Hui Li, Christopher J. Schofield, James Spencer, Natalie Fey, Zhangqi Shen, Qiu E. Yang, Mei Li, Jianzhong Shen, Pannika R. Niumsup, Timothy R. Walsh
المصدر: Scientific Reports
Hinchliffe, P, Yang, Q, Portal, E, Young, T, Li, H, Tooke, C, Mendes de Carvalho, M, Paterson, N, Brem, J, Ritivirool, P, Tansawai, U, Lei, L, Li, M, Shen, Z, Wang, Y, Schofield, C, Mulholland, A, Shen, J, Walsh, T, Fey, N & Spencer, J 2017, ' Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from the Crystal Structure of the Catalytic Domain of MCR-1 ', Scientific Reports, vol. 7, 39392 . https://doi.org/10.1038/srep39392مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Protein Conformation, 030106 microbiology, DNA Mutational Analysis, Protein Disulfide-Isomerases, Isomerase, Microbial Sensitivity Tests, medicine.disease_cause, Crystallography, X-Ray, Article, Toxicology, 03 medical and health sciences, Plasmid, Catalytic Domain, Drug Resistance, Bacterial, Metalloproteins, medicine, Metalloprotein, Escherichia coli, Disulfides, chemistry.chemical_classification, Multidisciplinary, biology, Colistin, Escherichia coli Proteins, Periplasmic space, Anti-Bacterial Agents, Zinc, DsbA, Biochemistry, chemistry, biology.protein, MCR-1, medicine.drug
وصف الملف: application/pdf
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المؤلفون: Valerie Castillo, Alejandro J. Vila, Graciela Mahler, Javier M. González, Maria F. Mojica, Cecilia Saiz, Magda Kosmopoulou, Mariano M. González, James Spencer, Catherine L. Tooke, Philip Hinchliffe, Robert A. Bonomo, Leticia I. Llarrull
المصدر: Hinchliffe, P, Gonzalez, M M, Mojica, M F, Gonzalez, J M, Castillo, V, Saiz, C, Kosmopoulou, M, Tooke, C, Llarrull, L, Mahler, G, Bonomo, R A, Villa, A J & Spencer, J 2016, ' Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes ', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 26, pp. E3745-E3754 . https://doi.org/10.1073/pnas.1601368113
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICETمصطلحات موضوعية: 0301 basic medicine, Models, Molecular, antibiotic resistance, Stereochemistry, metallo-β-lactamase, Otras Ciencias Biológicas, 030106 microbiology, Biology, beta-Lactamases, bisthiazolidines, purl.org/becyt/ford/1 [https], Ciencias Biológicas, 03 medical and health sciences, chemistry.chemical_compound, carbapenemase, Bacterial Proteins, Escherichia, Catalytic Domain, Hydrolase, inhibitors, Carboxylate, purl.org/becyt/ford/1.6 [https], chemistry.chemical_classification, Multidisciplinary, Bicyclic molecule, Hydrolysis, biology.organism_classification, In vitro, Anti-Bacterial Agents, Kinetics, Enzyme, Biochemistry, chemistry, PNAS Plus, Drug Design, Thiol, Thiazolidines, Enantiomer, beta-Lactamase Inhibitors, CIENCIAS NATURALES Y EXACTAS
وصف الملف: application/pdf
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