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    المصدر: Cell Chem Biol
    Marchesini, M, Gherli, A, Montanaro, A, Patrizi, L, Sorrentino, C, Pagliaro, L, Rompietti, C, Kitara, S, Heit, S, Olesen, C E, Møller, J V, Savi, M, Bocchi, L, Vilella, R, Rizzi, F, Baglione, M, Rastelli, G, Loiacono, C, La Starza, R, Mecucci, C, Stegmaier, K, Aversa, F, Stilli, D, Lund Winther, A M, Sportoletti, P, Bublitz, M, Dalby-Brown, W & Roti, G 2020, ' Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia ', Cell Chemical Biology, vol. 27, no. 6, pp. 678-697.e13 . https://doi.org/10.1016/j.chembiol.2020.04.002

    مصطلحات موضوعية: Male, CAD204520, Chronic lymphocytic leukemia, Clinical Biochemistry, Mice, SCID, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, 01 natural sciences, Biochemistry, Enzyme Inhibitors/chemical synthesis, Cell Proliferation/drug effects, chemistry.chemical_compound, Mice, NOTCH1, Mice, Inbred NOD, Signal Transduction/drug effects, hemic and lymphatic diseases, Drug Discovery, NOTCH1 mutation, Enzyme Inhibitors, Receptor, Notch1, Receptor, Notch1/antagonists & inhibitors, Antineoplastic Agents/chemical synthesis, Mice, Inbred BALB C, Mice, Inbred ICR, Molecular Structure, P-type ATPases screening, PEST mutation, SERCA, T cell acute lymphoblastic leukemia (T-ALL), crystal structure, mantle cell lymphoma (MCL), thapsigargin, ER STRESS, RECURRENT MUTATIONS, medicine.anatomical_structure, Toxicity, cardiovascular system, Molecular Medicine, Female, CALCIUM PUMPS, GAMMA-SECRETASE INHIBITORS, Signal Transduction, Thapsigargin, T cell, THAPSIGARGIN ANALOGS, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy, Antineoplastic Agents, Biology, Article, Neoplasms, Experimental/drug therapy, RETICULUM CA2+ ATPASE, Cell Line, Tumor, medicine, Animals, Humans, PROTON PUMP, Molecular Biology, Cell Proliferation, Pharmacology, THERAPEUTIC TARGET, UNFOLDED-PROTEIN-RESPONSE, 010405 organic chemistry, Endoplasmic reticulum, AMINO-ACID 256, Cancer, Neoplasms, Experimental, medicine.disease, 0104 chemical sciences, Calcium ATPase, chemistry, Mutation, Cancer research, Drug Screening Assays, Antitumor