المؤلفون: Andreas Varkaris, Ermira Pazolli, Hakan Gunaydin, Qi Wang, Levi Pierce, Alessandro A. Boezio, Artemisa Bulku, Lucian DiPietro, Cary Fridrich, Adam Frost, Fabrizio Giordanetto, Erika P. Hamilton, Katherine Harris, Michael Holliday, Tamieka L. Hunter, Amanda Iskandar, Yongli Ji, Alexandre Larivée, Jonathan R. LaRochelle, André Lescarbeau, Fabien Llambi, Brenda Lormil, Mary M. Mader, Brenton G. Mar, Iain Martin, Thomas H. McLean, Klaus Michelsen, Yakov Pechersky, Erika Puente-Poushnejad, Kevin Raynor, Dipali Rogala, Ramin Samadani, Alison M. Schram, Kelley Shortsleeves, Sweta Swaminathan, Shahein Tajmir, Gege Tan, Yong Tang, Roberto Valverde, Bryan Wehrenberg, Jeremy Wilbur, Bret R. Williams, Hongtao Zeng, Hanmo Zhang, W. Patrick Walters, Beni B. Wolf, David E. Shaw, Donald A. Bergstrom, James Watters, James S. Fraser, Pascal D. Fortin, D. Randal Kipp

مصطلحات موضوعية: Cancer, Methods and Technology, Computational Methods, Molecular modeling

Relation: https://figshare.com/articles/journal_contribution/Table_S1_from_Discovery_and_Clinical_Proof-of-Concept_of_RLY-2608_a_First-in-Class_Mutant-Selective_Allosteric_PI3K_Inhibitor_That_Decouples_Antitumor_Activity_from_Hyperinsulinemia/25183931

الاتاحة: https://doi.org/10.1158/2159-8290.25183931.v1
https://figshare.com/articles/journal_contribution/Table_S1_from_Discovery_and_Clinical_Proof-of-Concept_of_RLY-2608_a_First-in-Class_Mutant-Selective_Allosteric_PI3K_Inhibitor_That_Decouples_Antitumor_Activity_from_Hyperinsulinemia/25183931

المؤلفون: Andreas Varkaris, Ermira Pazolli, Hakan Gunaydin, Qi Wang, Levi Pierce, Alessandro A. Boezio, Artemisa Bulku, Lucian DiPietro, Cary Fridrich, Adam Frost, Fabrizio Giordanetto, Erika P. Hamilton, Katherine Harris, Michael Holliday, Tamieka L. Hunter, Amanda Iskandar, Yongli Ji, Alexandre Larivée, Jonathan R. LaRochelle, André Lescarbeau, Fabien Llambi, Brenda Lormil, Mary M. Mader, Brenton G. Mar, Iain Martin, Thomas H. McLean, Klaus Michelsen, Yakov Pechersky, Erika Puente-Poushnejad, Kevin Raynor, Dipali Rogala, Ramin Samadani, Alison M. Schram, Kelley Shortsleeves, Sweta Swaminathan, Shahein Tajmir, Gege Tan, Yong Tang, Roberto Valverde, Bryan Wehrenberg, Jeremy Wilbur, Bret R. Williams, Hongtao Zeng, Hanmo Zhang, W. Patrick Walters, Beni B. Wolf, David E. Shaw, Donald A. Bergstrom, James Watters, James S. Fraser, Pascal D. Fortin, D. Randal Kipp

مصطلحات موضوعية: Cancer, Methods and Technology, Computational Methods, Molecular modeling

Relation: https://figshare.com/articles/journal_contribution/Supplemental_Text_from_Discovery_and_Clinical_Proof-of-Concept_of_RLY-2608_a_First-in-Class_Mutant-Selective_Allosteric_PI3K_Inhibitor_That_Decouples_Antitumor_Activity_from_Hyperinsulinemia/25183934

الاتاحة: https://doi.org/10.1158/2159-8290.25183934.v1
https://figshare.com/articles/journal_contribution/Supplemental_Text_from_Discovery_and_Clinical_Proof-of-Concept_of_RLY-2608_a_First-in-Class_Mutant-Selective_Allosteric_PI3K_Inhibitor_That_Decouples_Antitumor_Activity_from_Hyperinsulinemia/25183934

المؤلفون: Andreas Varkaris, Ermira Pazolli, Hakan Gunaydin, Qi Wang, Levi Pierce, Alessandro A. Boezio, Artemisa Bulku, Lucian DiPietro, Cary Fridrich, Adam Frost, Fabrizio Giordanetto, Erika P. Hamilton, Katherine Harris, Michael Holliday, Tamieka L. Hunter, Amanda Iskandar, Yongli Ji, Alexandre Larivée, Jonathan R. LaRochelle, André Lescarbeau, Fabien Llambi, Brenda Lormil, Mary M. Mader, Brenton G. Mar, Iain Martin, Thomas H. McLean, Klaus Michelsen, Yakov Pechersky, Erika Puente-Poushnejad, Kevin Raynor, Dipali Rogala, Ramin Samadani, Alison M. Schram, Kelley Shortsleeves, Sweta Swaminathan, Shahein Tajmir, Gege Tan, Yong Tang, Roberto Valverde, Bryan Wehrenberg, Jeremy Wilbur, Bret R. Williams, Hongtao Zeng, Hanmo Zhang, W. Patrick Walters, Beni B. Wolf, David E. Shaw, Donald A. Bergstrom, James Watters, James S. Fraser, Pascal D. Fortin, D. Randal Kipp

مصطلحات موضوعية: Cancer, Methods and Technology, Computational Methods, Molecular modeling

Relation: https://figshare.com/articles/journal_contribution/Figure_S4_from_Discovery_and_Clinical_Proof-of-Concept_of_RLY-2608_a_First-in-Class_Mutant-Selective_Allosteric_PI3K_Inhibitor_That_Decouples_Antitumor_Activity_from_Hyperinsulinemia/25183949

الاتاحة: https://doi.org/10.1158/2159-8290.25183949.v1
https://figshare.com/articles/journal_contribution/Figure_S4_from_Discovery_and_Clinical_Proof-of-Concept_of_RLY-2608_a_First-in-Class_Mutant-Selective_Allosteric_PI3K_Inhibitor_That_Decouples_Antitumor_Activity_from_Hyperinsulinemia/25183949

المؤلفون: Christopher G. Thomson, Kelly Boss, Amy Calhoun, Cary Fridrich, Kevin M. Gardinier, Edward C. Hall, Keith Jendza, Louise Kirman, Nancy Labbé-Giguere, Kurt Laumen, Ming Qian, Sanjit Sanyal, Michael D. Shultz, Radka Snajdrova, Kian Tan, Kate Yaping Wang, Fan Yang, Feng Gao, Tao Hong, Elena Dale, Brent Kuzmiski, Danny Ortuno, Daniel S. Palacios

مصطلحات موضوعية: Biochemistry, Medicine, Molecular Biology, Pharmacology, Biotechnology, Evolutionary Biology, Ecology, Sociology, Infectious Diseases, Chemical Sciences not elsewhere classified, synthetic sequence toward, early medicinal chemistry, chiral route toward, muscarinic m4 agonists, 10 , m4 agonists, starting points, selective m1, bifunctional compounds, advanced intermediates

Relation: https://figshare.com/articles/journal_contribution/Transaminases_Provide_Key_Chiral_Building_Blocks_for_the_Synthesis_of_Selective_M1_M4_Agonists/24512113

الاتاحة: https://doi.org/10.1021/acsmedchemlett.3c00331.s001
https://figshare.com/articles/journal_contribution/Transaminases_Provide_Key_Chiral_Building_Blocks_for_the_Synthesis_of_Selective_M1_M4_Agonists/24512113

المؤلفون: Peukert, Stefan, Gulgeze Efthymiou, Hatice, Mo, Ruowei, Peng, Yunshan, Buono, Chiara, Daniels, Thomas, Zhang, Xia, Adachi, Yuichiro, Taggart, Andrew, Ma, Fupeng, Guillaume, Barbe, Gregory, Bebernitz, Cary, Fridrich, Eric, Williams, Lisha, Li, Mie, Abe

Relation: Peukert, Stefan, Gulgeze Efthymiou, Hatice, Mo, Ruowei, Peng, Yunshan, Buono, Chiara, Daniels, Thomas, Zhang, Xia, Adachi, Yuichiro, Taggart, Andrew, Ma, Fupeng, Guillaume, Barbe, Gregory, Bebernitz, Cary, Fridrich, Eric, Williams, Lisha, Li and Mie, Abe (2023) Discovery of a brain sparing GIRK1/4 inhibitor for pharmacological cardioversion of atrial fibrillation. Bioorganic and medicinal chemistry letters, 85 (129237). pp. 1-6. ISSN 0960-894X

الاتاحة: https://oak.novartis.com/49338/
https://www.sciencedirect.com/science/article/pii/S0960894X23001154?via%3Dihub
https://doi.org/10.1016/j.bmcl.2023.129237

المؤلفون: Jianwei Bian, James Roache, Sisi Zhang, Hui Wang, Jianhua Wang, Hongwei Yang, Tao Hong, Ruowei Mo, Feng Gao, Yizong Zhou, Cary Fridrich, Min Shi, Xiangguang Tian, Bin Wu, Pete Delgado, Jing Guo

المصدر: Organic Process Research & Development. 24:2780-2788

مصطلحات موضوعية: chemistry.chemical_classification, Ketone, 010405 organic chemistry, Chemistry, Organic Chemistry, Continuous manufacturing, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Factor XI inhibitor, 0104 chemical sciences, Pulmonary surfactant, Biocatalysis, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8f55cb33f8aba32b377cafb96ac88f81
https://doi.org/10.1021/acs.oprd.0c00412

المؤلفون: Sanchez Carina Cristina, Jay Larrow, Cary Fridrich, Malte S. Mikus

المصدر: Advanced Synthesis & Catalysis. 362:430-436

مصطلحات موضوعية: General interest, 010405 organic chemistry, Drug discovery, Aryl, chemistry.chemical_element, General Chemistry, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Catalysis, chemistry.chemical_compound, chemistry, Amine gas treating, Pharmacophore, Palladium

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::30fcf4363b75868f6328c6be4c77a78b
https://doi.org/10.1002/adsc.201901302

المؤلفون: Kelly Slocum, Jianmei Fan, Michael Dore, Palermo Mark G, Zhan Deng, Bakary-Barry Toure, Jorge Garcia-Fortanet, Dyuti Majumdar, Martin F. Hentemann, Nick Keen, Suzanne Zhu, Christopher Towler, Michael Shultz, William R. Sellers, Simon Mathieu, Denise Grunenfelder, Robert Koenig, Douglas C. Bauer, Shumei Liu, Jay Larrow, Victoriano Tamez, David Dunstan, Andreea Argintaru, Timothy Michael Ramsey, Zhouliang Chen, Gang Liu, Ying-Nan Chen, Rukundo Ntaganda, Bing Yu, Joanna Slisz, Hongyun Wang, Pascal D. Fortin, Christopher Sean Straub, Ji-Hu Zhang, Ping Wang, Laura R. LaBonte, Mitsunori Kato, Matthew J. Meyer, Fan Yang, Patrick James Sarver, Samuel B. Ho, Brant Firestone, Rajesh Karki, John F. Reilly, Troy Smith, Ho Man Chan, Cary Fridrich, John William Giraldes, Julie Boisclair, Chen Christine Hiu-Tung, Meir Glick, Zhao B. Kang, Morvarid Mohseni, Lawrence Blas Perez, Michael G. Acker, Sarah Williams, Matthew J. LaMarche, Martin Sendzik, Michelle Fodor, Huia-Xiang Hao, Peter Fekkes, Minying Pu, Travis Stams, Stanley Spence, Andriana Jouk

المصدر: Journal of medicinal chemistry. 63(22)

مصطلحات موضوعية: Drug, Programmed cell death, media_common.quotation_subject, Allosteric regulation, Antineoplastic Agents, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Protein tyrosine phosphatase, Pharmacology, 01 natural sciences, 03 medical and health sciences, Mice, Dogs, Allosteric Regulation, In vivo, Neoplasms, Drug Discovery, medicine, Tumor Cells, Cultured, Animals, Humans, Enzyme Inhibitors, Gene, 030304 developmental biology, media_common, 0303 health sciences, Chemistry, Cancer, medicine.disease, Xenograft Model Antitumor Assays, 0104 chemical sciences, Rats, PTPN11, 010404 medicinal & biomolecular chemistry, Macaca fascicularis, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345804676325a445ebbb9ef600ced79a
https://pubmed.ncbi.nlm.nih.gov/32910655

المؤلفون: Allan D'Arcy, Nikolaus Schiering, Cary Fridrich, Yu-Hsin Chiu, Donglei Liu, Micah Hollis-Symynkywicz, Edwige Lorthiois, Hyungchul Kim, Darija Dedic, Richard Sedrani, Rose Mo, Solene Dussauge, Calhoun Amy, Stefanie Harlfinger, Treeve Currie, Simon Ruedisser, Lionel Muller, Rohit Duvadie, Ulrich Hassiepen, Adelaide Druet, Louise Kirman, Jason Elliott, Kenji Namoto, Gabriela Monnet, Francesca Perruccio, Paul Ramage, Eva Altmann, David Louis Feldman, Fabien Tritsch, Xueming Huang, Joerg Berghausen, Tanzina Fazal, Richard Zessis, James Roache, Eric T Williams, Christopher M. Adams, Wilhelm A. Weihofen, Viktor Hornak, Peter Delgado, Peter Hoffmann, David Barnes-Seeman, Douglas Bevan, ShuangXi Wang, Hong Liu, Martin Renatus, Celine Dentel, Corinne Durand, Juergen Klaus Maibaum, Guiqing Liang, Kamal Fettis, Gordon Turner, Rajeshri Ganesh Karki, Loren Lindsley, Julie Lachal, Andreas Hein

المصدر: Journal of medicinal chemistry. 63(15)

مصطلحات موضوعية: Drug, Male, Proteases, Peptidomimetic, medicine.medical_treatment, media_common.quotation_subject, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Pharmacology, 01 natural sciences, Factor XIa, Rats, Sprague-Dawley, 03 medical and health sciences, Mice, Structure-Activity Relationship, Dogs, Complement Factor D, Drug Discovery, medicine, Animals, Humans, Amino Acid Sequence, 030304 developmental biology, ADME, media_common, Serine protease, 0303 health sciences, Protease, biology, Chemistry, 0104 chemical sciences, Rats, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Coagulation, biology.protein, Molecular Medicine, Factor Xa Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2ad110af1ecb6144e75a9298044b57
https://pubmed.ncbi.nlm.nih.gov/32551603

المؤلفون: Natalie Dales, Monish Jain, Sanchez Carina Cristina, Ryan Kerrigan, Atwood K. Cheung, Cary Fridrich, Donovan N. Chin, Brian Hurley, Keith Hoffmaster, Lin Deng, Ronald Tomlinson, Marc Hild, Rajeev Sivasankaran, Jake Axford, Aleem Fazal, Gary O’Brien, Christopher Towler, Mailin Van Hoosear, Youngah Shin, Dione Kobayashi, Shen Yiping, Lei Shu, William F. Dietrich, Karen S. Chen, Lawrence G. Hamann, Karin Briner, Rebecca Servais, Cheng Song, Emma Cody, Robert Sun, Daniel Curtis, Moo Je Sung, Ying Hou

المصدر: Journal of Medicinal Chemistry. 61:11021-11036

مصطلحات موضوعية: 0301 basic medicine, ERG1 Potassium Channel, Spliceosome, RNA Splicing, Phenotypic screening, Drug Evaluation, Preclinical, Administration, Oral, Quantitative Structure-Activity Relationship, SMN1, Crystallography, X-Ray, Cell Line, Muscular Atrophy, Spinal, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, medicine, Animals, Humans, Gene, Motor Neurons, Dose-Response Relationship, Drug, Chemistry, Brain, Spinal muscular atrophy, Motor neuron, medicine.disease, SMA, Survival of Motor Neuron 1 Protein, nervous system diseases, Mice, Inbred C57BL, Pyridazines, Survival of Motor Neuron 2 Protein, 030104 developmental biology, medicine.anatomical_structure, RNA splicing, Molecular Medicine, Neuroscience, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a86b835f8a7bec6e7356af0b03dae4
https://doi.org/10.1021/acs.jmedchem.8b01291

المؤلفون: Matthew J. LaMarche, Peter Fekkes, Jorge Garcia Fortanet, Michael Shultz, Denise Grunenfelder, Zhouliang Chen, Gang Liu, Chen Christine Hiu-Tung, Minying Pu, Travis Stams, Pascal D. Fortin, Palermo Mark G, Ping Wang, Samuel B. Ho, Brant Firestone, Matthew J. Meyer, Dyuti Majumdar, Laura R. LaBonte, Francois Lenoir, Rajesh Karki, Nick Keen, Cary Fridrich, Michelle Fodor, Jay Larrow, Sarah Williams, Christopher Towler, Timothy Michael Ramsey, Ji-Hu Zhang, Franco Lombardo, Ying-Nan P. Chen, Zhan Deng, Mitsunori Kato, Zhao B. Kang, Lawrence Blas Perez, Shumei Liu, William R. Sellers

المصدر: Journal of Medicinal Chemistry. 59:7773-7782

مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Programmed cell death, Allosteric modulator, Protein Conformation, Allosteric regulation, Administration, Oral, Mice, Nude, Antineoplastic Agents, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Protein tyrosine phosphatase, Crystallography, X-Ray, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Protein structure, Allosteric Regulation, Piperidines, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Chemistry, Small molecule, High-Throughput Screening Assays, Mice, Inbred C57BL, PTPN11, Pyrimidines, 030104 developmental biology, Biochemistry, Drug Design, Pyrazines, 030220 oncology & carcinogenesis, Heterografts, Molecular Medicine, Female, Allosteric Site, Neoplasm Transplantation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab8364be893583bdc1d3f32d1e22004
https://doi.org/10.1021/acs.jmedchem.6b00680

المؤلفون: Palermo Mark G, Timothy Michael Ramsey, Ping Zhu, Shumei Liu, Jay Larrow, Laura R. La Bonte, Rajesh Karki, Chen Christine Hiu-Tung, Kavitha Venkatesan, Jaison Jacob, Pascal D. Fortin, Francois Lenoir, Hui Gao, Guizhi Yang, Matthew J. Meyer, Ji-Hu Zhang, William R. Sellers, Michael Shultz, Denise Grunenfelder, Edmund Price, Jorge Garcia-Fortanet, Feng Fei, Zhouliang Chen, Gang Liu, Vesselina G. Cooke, Jing Yuan, Michelle Fodor, Ping Wang, Minying Pu, Nicholas Keen, Samuel B. Ho, Kathy Hsiao, Markus Warmuth, Travis Stams, Christopher Quinn, Mitsunori Kato, Subarna Shakya, Sarah Williams, Dyuti Majumdar, Peter Fekkes, Michael G. Acker, Cary Fridrich, Joanna Slisz, Huaixiang Hao, Matthew J. LaMarche, Ying-Nan P. Chen, Brandon Antonakos, Jason R. Dobson, Brant Firestone, Lawrence Blas Perez, Zhao B. Kang, Ho Man Chan, Zhan Deng

المصدر: Nature. 535:148-152

مصطلحات موضوعية: 0301 basic medicine, Multidisciplinary, biology, Cell growth, Protein tyrosine phosphatase, Receptor tyrosine kinase, Immune checkpoint, Cell biology, PTPN11, 03 medical and health sciences, 030104 developmental biology, Growth factor receptor, biology.protein, Signal transduction, Tyrosine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f58ee0fa5f3f5109027ba2125d369122
https://doi.org/10.1038/nature18621

المؤلفون: Steven F. Bellon, Monica Reese, Jay Larrow, Isabelle Dussault, Stephanie Springer, Paula Kaplan-Lefko, Jodi Moriguchi, David Bauer, Yajing Yang, Kavita Shah, Loren Berry, Jean-Christophe Harmange, Christiane Bode, Karen Rex, Brian K. Albrecht, Yihong Zhang, Doug Hoffman, Jasmine Lin, Deborah Choquette, Alessandro Boezio, Alexander M. Long, Roman Shimanovich, Anne B. O’Connor, Aaron C. Siegmund, April Chen, Cary Fridrich, Julia Lohman, Yohannes Teffera, Michele Potashman, Satoko Hirai

المصدر: Journal of Medicinal Chemistry. 51:2879-2882

مصطلحات موضوعية: Models, Molecular, C-Met, In Vitro Techniques, Crystallography, X-Ray, medicine.disease_cause, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Growth factor receptor, Drug Discovery, medicine, Animals, Phosphorylation, Molecular Structure, Oncogene, Hepatocyte Growth Factor, Chemistry, Kinase, Proto-Oncogene Proteins c-met, Triazoles, Rats, Pyridazines, Biochemistry, Microsomes, Liver, Cancer research, Molecular Medicine, Hepatocyte growth factor, Signal transduction, Carcinogenesis, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a031daf87fd230380ea41665042176aa
https://doi.org/10.1021/jm800043g

المؤلفون: Kavitha Venkatesan, Jaison Jacob, Shumei Liu, Fei Feng, Brandon Antonakos, Zhao B. Kang, Jonathan R. LaRochelle, Jason R. Dobson, Hui Gao, Laura R. La Bonte, Huaixiang Hao, Rajesh Karki, Samuel B. Ho, Guizhi Yang, Markus Warmuth, Ping Zhu, Matthew J. LaMarche, Brant Firestone, Matthew J. Meyer, Stephen C. Blacklow, Edmund Price, Kathy Hsiao, Jorge Garcia-Fortanet, Zhuoliang Chen, Chen Christine Hiu-Tung, Palermo Mark G, Vesselina G. Cooke, Cary Fridrich, Jay Larrow, Ping Wang, Sarah Williams, Ying-Nan P. Chen, Subarna Shakya, William R. Sellers, Nicholas Keen, Jing Yuan, Michael Shultz, Gang Liu, Michelle Fodor, Michael G. Acker, Pascal D. Fortin, Ho Man Chan, Timothy Michael Ramsey, Zhan Deng, Ji-Hu Zhang, Mitsunori Kato, Dyuti Majumdar, Peter Fekkes, Minying Pu, Travis Stams

المصدر: Cancer Research. 77:2084-2084

مصطلحات موضوعية: Cancer Research, biology, Philosophy, Allosteric regulation, Cancer therapy, Protein tyrosine phosphatase, medicine.disease, Mapk signaling, Oncology, Allosteric enzyme, Neuroblastoma, Cancer research, medicine, biology.protein, Tumor growth, Majumdar

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::80f0adb45534299e221531ab3cb2b319
https://doi.org/10.1158/1538-7445.am2017-2084

المؤلفون: Brian K. Albrecht, Jean-Christophe Harmange, David Bauer, Loren Berry, Christiane Bode, Alessandro A. Boezio, April Chen, Deborah Choquette, Isabelle Dussault, Cary Fridrich, Satoko Hirai, Doug Hoffman, Jay F. Larrow, Paula Kaplan-Lefko, Jasmine Lin, Julia Lohman, Alexander M. Long, Jodi Moriguchi, Anne O’Connor, Michele H. Potashman

المصدر: Journal of Medicinal Chemistry; Apr2008, Vol. 51 Issue 10, p2879-2882, 4p