نتائج البحث - "Carol A. Capriotti"

1

Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2

المصدر: Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Communications Biology

مصطلحات موضوعية: Male, THP-1 Cells, Anti-Inflammatory Agents, Medicine (miscellaneous), Medicinal chemistry, Pharmacology, 01 natural sciences, Serine, Rats, Sprague-Dawley, Tissue Culture Techniques, Ubiquitin, Crohn Disease, Enzyme Stability, lcsh:QH301-705.5, 0303 health sciences, biology, medicine.diagnostic_test, Drug discovery, Chemistry, Ubiquitin ligase, Injections, Intravenous, Cytokines, Female, medicine.symptom, Inflammation Mediators, General Agricultural and Biological Sciences, Proteasome Endopeptidase Complex, Proteolysis, Ubiquitin-Protein Ligases, General Biochemistry, Genetics and Molecular Biology, Article, RIPK2, 03 medical and health sciences, Receptor-Interacting Protein Serine-Threonine Kinase 2, medicine, Animals, Humans, Pharmacokinetics, Rats, Wistar, Protein kinase A, 030304 developmental biology, Inflammation, Dose-Response Relationship, Drug, 010405 organic chemistry, Ubiquitination, 0104 chemical sciences, Mechanism of action, Pharmacodynamics, lcsh:Biology (General), Drug Design, biology.protein, Leukocytes, Mononuclear, Colitis, Ulcerative

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0dc940ac613e6d44979be8bc358056
http://link.springer.com/article/10.1038/s42003-020-0868-6

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2

Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases

المصدر: Journal of Medicinal Chemistry. 62:6482-6494

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::eaccf9e5808f38c133e85649c11ad3f1
https://doi.org/10.1021/acs.jmedchem.9b00575

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3

Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase

المؤلفون: Stéphane Sautet, Emilie Jigorel, Nicolas Faucher, Jamel Meslamani, Lara Kathryn Leister, Pascal Grondin, Julie A. Cox, Bryan W. King, Pamela Nassau, Gemma Victoria White, Brad J. Geddes, Alain Claude-Marie Daugan, Helen H. Sun, Michael T. Ouellette, Pauline Lamoureux, Elizabeth J. Rivera, Scott B. Berger, James H. Thorpe, Philip A. Harris, J. Mosley, Susan E. Hutchinson, Frédéric Donche, John Bertin, Sandra J. Hoffman, Natalie Wellaway, Patrick M. Eidam, Paris Ward, Florent Potvain, Clark A. Sehon, Sebastien Andre Campos, Robert W. Marquis, Peter J. Gough, Mukesh K. Mahajan, Veronique Beneton, Jae U. Jeong, Michelle C. Schaeffer, John D. Lich, Allison M. Beal, Rakesh Nagilla, James Michael Woolven, Bonnie L. Hoffman, Anderson Niall Andrew, Marie-Hélène Fouchet, Deepak Bandyopadhyay, Carol A. Capriotti, Rachel D. Totoritis, Joshua N. Finger, Kishore K. Pasikanti, David D. Wisnoski, Sze-Ling Ng, Nino Campobasso, Nicolas George, Michael Reilly

المصدر: Journal of Medicinal Chemistry. 62:5096-5110

مصطلحات موضوعية: Models, Molecular, Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, Necroptosis, Biological Availability, Inflammation, Pharmacology, 01 natural sciences, Cell Line, Mice, Structure-Activity Relationship, 03 medical and health sciences, In vivo, Psoriasis, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Enzyme Inhibitors, 030304 developmental biology, 0303 health sciences, Kinase, Chemistry, RNA-Binding Proteins, Haplorhini, medicine.disease, Ulcerative colitis, High-Throughput Screening Assays, Rats, 0104 chemical sciences, Mice, Inbred C57BL, Nuclear Pore Complex Proteins, 010404 medicinal & biomolecular chemistry, Drug Design, Rheumatoid arthritis, Chronic Disease, Pyrazoles, Molecular Medicine, medicine.symptom, Retinitis Pigmentosa

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ff65b82b2e1feff6acc28b9dcac4dc
https://doi.org/10.1021/acs.jmedchem.9b00318

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4

Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[

المصدر: Journal of medicinal chemistry. 62(14)

مصطلحات موضوعية: Male, Swine, Colitis, Phosphates, Molecular Docking Simulation, Rats, Sprague-Dawley, Mice, Dogs, Receptor-Interacting Protein Serine-Threonine Kinase 2, Drug Discovery, Quinazolines, Animals, Humans, Swine, Miniature, Benzothiazoles, Protein Kinase Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::ceb97ed99e9c95859d4d1b3bee6fd6c8
https://pubmed.ncbi.nlm.nih.gov/31265286

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5

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

المصدر: Journal of Medicinal Chemistry. 60:1247-1261

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc6dda831a1761e39a5fe91326c033a4
https://doi.org/10.1021/acs.jmedchem.6b01751

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6

Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel

المصدر: ACS Medicinal Chemistry Letters. 11:1353-1353

مصطلحات موضوعية: biology, Kinase, Organic Chemistry, Quinoline, hERG, Pharmacology, Biochemistry, chemistry.chemical_compound, Therapeutic index, chemistry, Drug Discovery, biology.protein, Identification (biology), Ion channel

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::86fc583fc629ca7da33971d5c6863f9b
https://doi.org/10.1021/acsmedchemlett.0c00260

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7

Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel

المصدر: ACS Med Chem Lett

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8905a378b661333d1e52909683d43cfc
https://pubmed.ncbi.nlm.nih.gov/32551024

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8

Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock

مصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Male, Immunology, Apoptosis, Caspase-11, Caspase 8, Article, Proinflammatory cytokine, 03 medical and health sciences, RIPK1, 0302 clinical medicine, Intestine, Small, Immunology and Allergy, Animals, Kinase activity, Caspase, Cells, Cultured, Escherichia coli Infections, Inflammation, Mice, Knockout, biology, Tumor Necrosis Factor-alpha, Intracellular Signaling Peptides and Proteins, Interferon-beta, Phosphate-Binding Proteins, Shock, Septic, Caspases, Initiator, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, Infectious Diseases, 030220 oncology & carcinogenesis, Caspases, Receptor-Interacting Protein Serine-Threonine Kinases, biology.protein, Tumor necrosis factor alpha, Female, Interferon Regulatory Factor-3, Apoptosis Regulatory Proteins, Spleen, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fbdf244c275c03e848f8c2615710ce
https://europepmc.org/articles/PMC6064639/

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9

Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

المؤلفون: Barb Swift, Peter J. Gough, Michelle C. Schaeffer, Lauren Dare, Angela Hughes-Earle, Philip A. Harris, Carol A. Capriotti, William J. Kaiser, Edward S. Mocarski, Michael Cook, Sandy Hoffman, Viera Kasparcova, Scott B. Berger, Joshua N. Finger, John Bertin

المصدر: The Journal of Immunology. 192:5476-5480

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af49c855898586982f3964acea52fde7
https://doi.org/10.4049/jimmunol.1400499

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10

DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

المصدر: Journal of medicinal chemistry. 59(5)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9168ddd779d483ed3d92b7e660ed9cf
https://pubmed.ncbi.nlm.nih.gov/26854747

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11

Characterization of GSK'963: a structurally distinct, potent and selective inhibitor of RIP1 kinase

المؤلفون: Scott B. Berger, Robert W. Marquis, Rakesh Nagilla, John Bertin, Sandy Hoffman, Carol A. Capriotti, Michael T. Ouellette, Michelle C. Schaeffer, Julie A. Cox, Bryan W. King, Michael Reilly, Philip A. Harris, Lauren Dare, P J Gough, Viera Kasparcova, David D. Wisnoski, Barbara A. Swift

المصدر: Cell Death Discovery

مصطلحات موضوعية: Cancer Research, Programmed cell death, Kinase, Necroptosis, Immunology, Inflammation, Cell Biology, Pharmacology, Biology, In vitro, digestive system diseases, Article, Cellular and Molecular Neuroscience, In vivo, medicine, medicine.symptom, Kinase activity, IC50

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee5ae2c85e25d04eeb72141c4d89d3b
https://pubmed.ncbi.nlm.nih.gov/27551444

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12

Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis

المصدر: ACS medicinal chemistry letters. 4(12)

مصطلحات موضوعية: Pyrimidine, Kinase, business.industry, Necroptosis, Organic Chemistry, Pharmacology, Hypothermia, Biochemistry, Small molecule, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, Transferase, Tumor necrosis factor alpha, medicine.symptom, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d25c3c72ab28ed2f60bf2c19827b607
https://pubmed.ncbi.nlm.nih.gov/24900635

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13

Tu1921 Selective Inhibitors of RIP2 Kinase Activity Reduce PRO-Inflammatory Cytokine Production in IBD Mucosal Biopsy Cultures and Inflammation in Murine TNBS-Induced Colitis

المؤلفون: Linda N. Casillas, Carol A. Capriotti, Bart Votta, Kevin Foley, Peter J. Gough, Michael Reilly, Barbara A. Swift, Robert W. Marquis, Pamela A. Haile, David B. Lipshutz, Biva M. Desai, John Bertin, Thomas T. MacDonald, Paolo Biancheri, Anna Vossenkämper

المصدر: Gastroenterology. 142:S-878

مصطلحات موضوعية: Cytokine, Hepatology, business.industry, medicine.medical_treatment, Immunology, Gastroenterology, medicine, Inflammation, Mucosal Biopsy, Kinase activity, medicine.symptom, business, Tnbs colitis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9c053b275e2f6cddac112f62c1f79fc3
https://doi.org/10.1016/s0016-5085(12)63408-8

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