يعرض 1 - 20 نتائج من 81 نتيجة بحث عن '"Carmine, Brian"', وقت الاستعلام: 0.51s تنقيح النتائج
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    المصدر: Huber, Florian A; Singhal, Vibha; Tuli, Shubhangi; Stanford, Fatima C; Carmine, Brian; Bouxsein, Mary L; Misra, Madhusmita; Bredella, Miriam A (2023). Biomechanical CT to Assess Bone After Sleeve Gastrectomy in Adolescents With Obesity: A Prospective Longitudinal Study. Journal of Bone and Mineral Research, 38(7):933-942.

    وصف الملف: application/pdf

    Relation: https://www.zora.uzh.ch/id/eprint/237310/1/ZORA237310.pdf; info:pmid/37073493; urn:issn:0884-0431

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    المساهمون: Department of Surgery, Department of Pediatrics

    المصدر: Bone ; 134 ; 115290

    Relation: Link to Article in PubMed; https://doi.org/10.1016/j.bone.2020.115290; Misra M, Singhal V, Carmine B, Bose A, Kelsey MM, Stanford FC, Bram J, Aidlen J, Inge T, Bouxsein ML, Bredella MA. Bone outcomes following sleeve gastrectomy in adolescents and young adults with obesity versus non-surgical controls. Bone. 2020 May;134:115290. doi:10.1016/j.bone.2020.115290. Epub 2020 Feb 19. PMID: 32084562; PMCID: PMC7138705. Link to article on publisher's site; 1873-2763 (Linking); http://hdl.handle.net/20.500.14038/43716; https://escholarship.umassmed.edu/peds_pp/301; peds_pp/301

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    Skeletal Effects of Sleeve Gastrectomy in AContext: Vertical sleeve gastrectomy (VSG) is an increasingly common tool to achieve weight loss and improve metabolic health in adolescents and young adults with obesity, although it may adversely affect bone health. Objective: This work aimed to evaluate the effect of VSG on bone health in youth. Methods: An observational 2-year study was conducted at a tertiary care center of 66 patients aged 13 to 24 years with moderate-to-severe obesity meeting criteria for VSG. The patients underwent VSG (n= 30) or nonsurgical (n=36) management per the decision of patient and clinical team. Main outcome measures included dual-energy x-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HRpQCT) measures of bone mineral density (BMD), geometry, and microarchitecture. Results: VSG patients achieved 25.3±2.0% weight loss at 2 years (P<.001) while control subjects gained 4.0±2.0% (P= .026). Total hip BMD declined 8.5±1.0% following VSG compared with 0.1±1.0% gain in controls (P< .001), with similar results at the femoral neck (P<.001). Total volumetric BMD (vBMD) decreased both at the distal radius and tibia following VSG (P<.001) driven primarily by trabecular vBMD loss (P< .001). Two-year changes in cortical vBMD did not differ between groups, though cortical porosity decreased following VSG both at the radius and tibia (P=.048 and P< .001). Cortical thickness increased in controls but not in VSG (P=.022 and P= .002 for between-group comparisons at the radius and tibia, respectively). Following VSG, estimated failure load decreased at the radius and did not demonstrate the physiologic increases at the tibia observed in controls. Conclusion: VSG leads to progressive changes in bone health over 2 years, and may lead to increased skeletal fragility in adolescents and young adults.dolescents and Young Adults: A 2-Year Longitudinal Study.

    المصدر: Journal of Clinical Endocrinology & Metabolism; Apr2023, Vol. 108 Issue 4, p847-857, 11p

    مصطلحات موضوعية: SLEEVE gastrectomy, BONE metabolism, ADOLESCENT obesity

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