المؤلفون: Stefano Woltersdorf, Dominik Vogt, Holger Stark, Simon B.M. Kretschmer, Ann-Kathrin Häfner, Bettina Hofmann, Dieter Steinhilber, Carmen B. Rödl

المصدر: Future Medicinal Chemistry. 8:149-164

مصطلحات موضوعية: 0301 basic medicine, Cell Survival, Stereochemistry, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Aminothiazole, Drug Discovery, Humans, Structure–activity relationship, Lipoxygenase Inhibitors, Cytotoxicity, IC50, Cells, Cultured, Pharmacology, chemistry.chemical_classification, Arachidonate 5-Lipoxygenase, U937 cell, biology, 010405 organic chemistry, Lipid signaling, 0104 chemical sciences, Thiazoles, 030104 developmental biology, Enzyme, chemistry, Biochemistry, Drug Design, Arachidonate 5-lipoxygenase, Leukocytes, Mononuclear, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bebf95f0118207cbb0a999890613f4e2
https://doi.org/10.4155/fmc.15.174

المؤلفون: Ewgenij Proschak, Bettina Hofmann, Sebastian Barzen, Simon B.M. Kretschmer, Astrid Brüggerhoff, Janosch Achenbach, Dieter Steinhilber, Holger Stark, Dominik Vogt, Carmen B. Rödl, Katja Ihlefeld

المصدر: European Journal of Medicinal Chemistry. 84:302-311

مصطلحات موضوعية: 5-Lipoxygenase-Activating Proteins, Inflammation, Pharmacology, Aminophenols, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Tumor Cells, Cultured, medicine, Humans, Enzyme Inhibitors, Thiazole, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, biology, Eicosanoid metabolism, Organic Chemistry, U937 Cells, General Medicine, Lipid signaling, Thiazoles, Enzyme, chemistry, Biochemistry, Cyclooxygenase 2, Arachidonate 5-lipoxygenase, biology.protein, Eicosanoids, Arachidonic acid, Cyclooxygenase, medicine.symptom, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c055d16a024bee48ba1412b3ac0fe79
https://doi.org/10.1016/j.ejmech.2014.07.025

المؤلفون: Manfred Schubert-Zsilavecz, Carmen B. Rödl, Astrid Brüggerhoff, Joanna M. Wisniewska, Dieter Steinhilber, Edmund Kostewicz, Astrid Kaiser, Florian Rörsch, Estel.la Buscató, Bettina Hofmann, Mario Wurglics, Sabine Grösch, Ewgenij Proschak

المصدر: Future Medicinal Chemistry. 5:865-880

مصطلحات موضوعية: Neutrophils, Pyridines, DNA Mutational Analysis, Drug Evaluation, Preclinical, Inflammation, Pharmacology, Cell Line, Mice, Structure-Activity Relationship, Immune system, Salmonella, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Lipoxygenase Inhibitors, Cytotoxicity, Whole blood, Arachidonate 5-Lipoxygenase, biology, Imidazoles, Lipid signaling, In vitro, Solubility, Biochemistry, Arachidonate 5-lipoxygenase, biology.protein, Molecular Medicine, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2d9b1752ff0057970a1826847910b5
https://doi.org/10.4155/fmc.13.72

المؤلفون: Holger Stark, Mario Wurglics, Aleksandra Živković, Marika Hoffmann, Manfred Schubert-Zsilavecz, Gisbert Schneider, Khader Awwad, Bettina Hofmann, Thorsten J. Maier, Ingrid Fleming, Oliver Rau, Dieter Steinhilber, Carmen B. Rödl, Angela A.Y. Michel, Maren Pellowska, Matthias G. Wacker, Astrid S. Kahnt

المصدر: British Journal of Pharmacology. 165:2304-2313

مصطلحات موضوعية: musculoskeletal diseases, Pharmacology, chemistry.chemical_classification, endocrine system diseases, integumentary system, biology, Chemistry, Allosteric regulation, food and beverages, Peroxisome proliferator-activated receptor, Arachidonic acid binding, Enzyme activator, Phospholipase A2, Biochemistry, Arachidonate 5-lipoxygenase, biology.protein, lipids (amino acids, peptides, and proteins), Mode of action, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::91b592568621fbb679113f86fdda8253
https://doi.org/10.1111/j.1476-5381.2011.01707.x

المؤلفون: Bettina Hofmann, Manfred Schubert-Zsilavecz, Carmen B. Rödl, Dieter Steinhilber, Holger Stark, Ewgenij Proschak, Joanna M. Wisniewska, Martina Hieke, Estel.la Buscató

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:1969-1975

مصطلحات موضوعية: Pyridines, Stereochemistry, Clinical Biochemistry, Anti-Inflammatory Agents, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Lipoxygenase Inhibitors, Drug Discovery, Pyridine, Leukocytes, Humans, Structure–activity relationship, Moiety, Molecular Biology, Virtual screening, Arachidonate 5-Lipoxygenase, Inhibitory potential, biology, Organic Chemistry, chemistry, Arachidonate 5-lipoxygenase, biology.protein, Molecular Medicine, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533429b14f1568076d2680c126e49082
https://doi.org/10.1016/j.bmcl.2012.01.038

المؤلفون: Florian Rörsch, Astrid S. Kahnt, Bettina Hofmann, Dieter Steinhilber, Carmen B. Rödl, Janosch Achenbach, Sabine Grösch, Ewgenij Proschak, Yusuf Tanrikulu, Gisbert Schneider, Jindrich Cinatl, Joanna M. Wisniewska, Estel.la Buscató, Sandra Ulrich

المصدر: Biochemical Pharmacology. 83:228-240

مصطلحات موضوعية: MAPK/ERK pathway, Cell Survival, Pyridines, Poly ADP ribose polymerase, Cell, Biochemistry, Mice, chemistry.chemical_compound, Allosteric Regulation, medicine, Animals, Humans, Lipoxygenase Inhibitors, Viability assay, Phosphorylation, Cells, Cultured, Pharmacology, chemistry.chemical_classification, Sheep, biology, Imidazoles, In vitro toxicology, U937 Cells, medicine.anatomical_structure, Enzyme, chemistry, Arachidonate 5-lipoxygenase, biology.protein, PMSF, Oxidation-Reduction, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::577232708abd8a092790de5ed03c77d0
https://doi.org/10.1016/j.bcp.2011.10.012

المؤلفون: Bettina Hofmann, Holger Stark, Dieter Steinhilber, Andreas Lill, Carmen B. Rödl

المصدر: European journal of medicinal chemistry. 89

مصطلحات موضوعية: Leukotrienes, chemistry.chemical_compound, Structure-Activity Relationship, Blood serum, Drug Discovery, Structure–activity relationship, Humans, Lipoxygenase Inhibitors, Solubility, Pharmacology, chemistry.chemical_classification, Leukotriene, Arachidonate 5-Lipoxygenase, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, General Medicine, Blood proteins, Thiazoles, Enzyme, Biochemistry, Arachidonate 5-lipoxygenase, biology.protein, Leukotriene Antagonists, Arachidonic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916193c8df30356facb4a869aad5d31a
https://pubmed.ncbi.nlm.nih.gov/25462262

المؤلفون: Ewgenij Proschak, René Blöcher, Bettina Hofmann, Daniel Moser, Björn Krüger, Frank Löhr, Janosch Achenbach, Franca-Maria Klingler, Ann-Kathrin Häfner, Holger Stark, Dieter Steinhilber, Carmen B. Rödl, Simon B.M. Kretschmer

المساهمون: Publica

مصطلحات موضوعية: Epoxide hydrolase 2, Ligand efficiency, In vivo, Chemistry, In silico, Organic Chemistry, Drug Discovery, Dual inhibitor, Biochemistry, Linker, Combinatorial chemistry, Chemical space

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2287dcddb1b53da8fdac2a2a2762d2
https://europepmc.org/articles/PMC4027374/

المؤلفون: Franca-Maria Klingler, Sandra K. Wittmann, Bettina Hofmann, Carmen B. Rödl, Joanna M. Wisniewska, Karin Meirer, Estel.la Buscató, Ann-Kathrin Häfner, Dirk Berressem, Ewgenij Proschak, Steffen Hahn, Sven George, Dieter Steinhilber

المصدر: Journal of medicinal chemistry. 56(4)

مصطلحات موضوعية: Epoxide hydrolase 2, Epoxide Hydrolases, Arachidonate 5-Lipoxygenase, biology, Chemistry, Stereochemistry, Pyridines, Imidazoles, In vitro, Recombinant Proteins, chemistry.chemical_compound, Structure-Activity Relationship, Biochemistry, Drug Discovery, Pyridine, Arachidonate 5-lipoxygenase, Urea, biology.protein, Molecular Medicine, Structure–activity relationship, Moiety, Humans, Arachidonic acid, Lipoxygenase Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e373da9b711edd3c7478aea398f692
https://pubmed.ncbi.nlm.nih.gov/23356879

المؤلفون: Ann-Kathrin Häfner, Joanna M. Wisniewska, Carmen B. Rödl, Bettina Hofmann, Dieter Steinhilber, Thorsten J. Maier, Stavroula Markoutsa, Michael Hörnig, Sven George, Oliver Werz, Michael Karas

المصدر: Biochimica et biophysica acta. 1821(2)

مصطلحات موضوعية: Adult, Models, Molecular, Stereochemistry, Protein Structure, Secondary, Serine, chemistry.chemical_compound, Mice, Animals, Humans, Cysteine, Lipoxygenase Inhibitors, Sulfhydryl Compounds, Estrenes, Molecular Biology, Cysteine metabolism, chemistry.chemical_classification, Leukotriene, Arachidonate 5-Lipoxygenase, Arachidonic Acid, biology, Phospholipase C, Sequence Homology, Amino Acid, Active site, Cell Biology, Pyrrolidinones, Amino acid, chemistry, Biochemistry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Arachidonate 5-lipoxygenase, biology.protein, Mutant Proteins, HeLa Cells, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983c7c789547f1cfbf1623c9daf30dbc
https://pubmed.ncbi.nlm.nih.gov/22137889

المؤلفون: Carmen B. Rödl, Gisbert Schneider, Andreas Kiehl, Sebastian Barzen, Holger Stark, Julia Borig, Dieter Steinhilber, Aleksandra Zivkovic, Bettina Hofmann

المصدر: Journal of medicinal chemistry. 54(6)

مصطلحات موضوعية: Virtual screening, Arachidonate 5-Lipoxygenase, biology, Stereochemistry, Cancer, Stereoisomerism, medicine.disease, Benzylidene Compounds, chemistry.chemical_compound, Structure-Activity Relationship, Thiazoles, chemistry, Benzylidene compounds, Drug Discovery, Arachidonate 5-lipoxygenase, biology.protein, medicine, Molecular Medicine, Potency, Moiety, Structure–activity relationship, Lipoxygenase Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb22293bc78f009e767d2c7504a74bc
https://pubmed.ncbi.nlm.nih.gov/21341744

المؤلفون: Carmen B. Rödl, Bettina Hofmann, Gisbert Schneider, Joanna M. Wisniewska, Ewgenij Proschak, Yusuf Tanrikulu, Dieter Steinhilber

المصدر: ChemMedChem. 6(6)

مصطلحات موضوعية: Pharmacology, Models, Molecular, Virtual screening, Arachidonate 5-Lipoxygenase, biology, L-Lactate Dehydrogenase, Chemistry, Drug discovery, Neutrophils, Organic Chemistry, Computational biology, Biochemistry, Cheminformatics, Cell Line, Tumor, Drug Design, Drug Discovery, Arachidonate 5-lipoxygenase, biology.protein, Molecular Medicine, Humans, Lipoxygenase Inhibitors, General Pharmacology, Toxicology and Pharmaceutics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af065d2b7189db808965594e104f534c
https://pubmed.ncbi.nlm.nih.gov/21506275

المؤلفون: Bettina Hofmann, Sebastian Barzen, Carmen B. Rödl, Andreas Kiehl, Julia Borig, Aleksandra Živković, Holger Stark, Gisbert Schneider, Dieter Steinhilber

المصدر: Journal of Medicinal Chemistry; Mar2011, Vol. 54 Issue 6, p1943-1947, 5p