المؤلفون: Zhuming Zhang (1846087), Avijit Ghosh (1428496), Peter J. Connolly (2456890), Peter King (234747), Thomas Wilde (6057116), Jianyao Wang (640348), Yawei Dong (2365990), Xueliang Li (585599), Daohong Liao (1393399), Hao Chen (5190), Gaochao Tian (2465608), Javier Suarez (2289811), William G. Bonnette (11173075), Vineet Pande (2538973), Karen A. Diloreto (11154645), Yifan Shi (4269262), Shefali Patel (11154648), Beth Pietrak (1940869), Lawrence Szewczuk (11154651), Carlo Sensenhauser (2181964), Shannon Dallas (7945637), James P. Edwards (2428411), Kurtis E. Bachman (5679542), David C. Evans (203487)

مصطلحات موضوعية: Biochemistry, Medicine, Physiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, adenoma progression, Colorectal Cancer, vivo 18 F-FDG uptake attenuation, efficacy proxy, survival extension, COX -2 inhibitors, COX -2-mediated CRC disease chemopr., colorectal adenomas, APC, exposure, chemoprotective effects, COX -2 inhibition, vivo dose-dependent inhibition

Relation: https://figshare.com/articles/journal_contribution/Gut-Restricted_Selective_Cyclooxygenase_2_COX-2_Inhibitors_for_Chemoprevention_of_Colorectal_Cancer/15019026

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00890.s003

المؤلفون: Shannon Dallas, Thomas Wilde, Avijit Ghosh, Jianyao Wang, Yawei Dong, Gaochao Tian, Daohong Liao, Xueliang Li, Lawrence Szewczuk, Peter King, David C. Evans, Yifan Shi, Kurtis E. Bachman, Javier Suarez, Beth Pietrak, James P. Edwards, Carlo Sensenhauser, Hao Chen, Vineet Pande, Peter J. Connolly, Karen DiLoreto, William G Bonnette, Shefali Patel, Zhuming Zhang

المصدر: Journal of Medicinal Chemistry. 64:11570-11596

مصطلحات موضوعية: Male, Adenoma, Cell Survival, Colorectal cancer, Antineoplastic Agents, Disease, Etoricoxib, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Animals, Humans, Cell Proliferation, Cyclooxygenase 2 Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, medicine.disease, Mice, Inbred C57BL, Celecoxib, Cyclooxygenase 2, biology.protein, Cancer research, Chemoprotective, Molecular Medicine, Cyclooxygenase, Drug Screening Assays, Antitumor, Colorectal Neoplasms, Ex vivo, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b02dbb581a1a9ad484e13ee726c09b
https://doi.org/10.1021/acs.jmedchem.1c00890

المؤلفون: Faraz Kazmi, Carlo Sensenhauser, Tony Greway

المصدر: Drug Metabolism and Disposition. 47:9-14

مصطلحات موضوعية: CYP2B6, Oligonucleotides, Pharmaceutical Science, Pharmacology, 030226 pharmacology & pharmacy, Cell Line, Inhibitory Concentration 50, 03 medical and health sciences, Imetelstat, 0302 clinical medicine, Cytochrome P-450 Enzyme System, In vivo, Cytochrome P-450 Enzyme Inhibitors, Humans, Drug Interactions, IC50, biology, CYP3A4, Chemistry, CYP1A2, Cytochrome P450, In vitro, 030220 oncology & carcinogenesis, Hepatocytes, Microsomes, Liver, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ba5eda7fc409e953545741188f51e8
https://doi.org/10.1124/dmd.118.084103

المؤلفون: Jan Snoeys, Carlo Sensenhauser, Paulien Ravenstijn, Ian Templeton

المصدر: Biopharmaceutics & Drug Disposition. 37:15-27

مصطلحات موضوعية: Pharmacology, Drug, CYP3A4, Chemistry, Itraconazole, CYP3A, media_common.quotation_subject, Pharmaceutical Science, General Medicine, 030226 pharmacology & pharmacy, Domperidone, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, In vivo, 030220 oncology & carcinogenesis, medicine, Pharmacology (medical), Ketoconazole, media_common, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a31c979f8be496f7113cd12bb5ea48dd
https://doi.org/10.1002/bdd.1992

المؤلفون: Shannon Dallas, Jose Silva, Xin Hong, Yinghua Qu, Rashidah Binte Sakban, N. Singh, Carlo Sensenhauser, Sylvia Zhao, Heng-Keang Lim, Hanry Yu, Michael McMillian, Lei Xia

المصدر: Journal of Applied Toxicology. 36:320-329

مصطلحات موضوعية: 0301 basic medicine, CYP2B6, CYP3A4, CYP1A2, Cytochrome P450, Biology, Toxicology, In vitro, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Biochemistry, In vivo, Hepatocyte, Transcriptional regulation, biology.protein, medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::260f81b504e4d08f88ecf9935798f29b
https://doi.org/10.1002/jat.3189

المؤلفون: Jan Snoeys, Ellen Scheers, David C. Evans, Carlo Sensenhauser, Heng-Keang Lim, Laurent Leclercq, Peter Verboven, Shannon Dallas, Michael F. Kelley, Mark D. Johnson, Filip Cuyckens, Rao N.V.S. Mamidi

مصطلحات موضوعية: Physiologically based pharmacokinetic modelling, Organic anion transporter 1, CYP2B6, In Vitro Techniques, Pharmacology, Models, Biological, 030226 pharmacology & pharmacy, Xenopus laevis, 03 medical and health sciences, 0302 clinical medicine, Cytochrome P-450 Enzyme System, Pharmacokinetics, medicine, Animals, Humans, Hypoglycemic Agents, Pharmacology (medical), Drug Interactions, Canagliflozin, CYP2C8, Letter to the Editor, biology, CYP3A4, Chemistry, Membrane Transport Proteins, Repaglinide, Area Under Curve, 030220 oncology & carcinogenesis, biology.protein, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2c9abf5fb872c233c8c45485ac3e9b
https://europepmc.org/articles/PMC5401984/

المؤلفون: Johan Monbaliu, James Jiao, Caly Chien, Hans Stieltjes, Johan W. Smit, Inneke Wynant, Martha Gonzalez, Carlo Sensenhauser, Jan Snoeys, Apexa Bernard

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 44(10)

مصطلحات موضوعية: medicine.medical_specialty, Cmax, Abiraterone Acetate, Pharmaceutical Science, Pharmacology, In Vitro Techniques, 030226 pharmacology & pharmacy, Cytochrome P-450 CYP2C8, 03 medical and health sciences, chemistry.chemical_compound, Prostate cancer, 0302 clinical medicine, In vivo, Internal medicine, medicine, Cytochrome P-450 Enzyme Inhibitors, Humans, CYP2C8, Abiraterone acetate, Prodrug, medicine.disease, Endocrinology, chemistry, 030220 oncology & carcinogenesis, Microsome, Microsomes, Liver, Pioglitazone, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9608d3f6a24c1ac96f597ba63d156f9
https://pubmed.ncbi.nlm.nih.gov/27504016

المؤلفون: Cindy Zakszewski, Rao N.V.S. Mamidi, Michael McMillia, Chao Han, Monica Singer, Carlo Sensenhauser, Shannon Dallas, Ameesha Batheja, Honghui Zhou, Jose Silva, Maria Markowska

المصدر: Current Drug Metabolism. 13:923-929

مصطلحات موضوعية: Male, Drug, Gene isoform, medicine.medical_specialty, media_common.quotation_subject, medicine.medical_treatment, Clinical Biochemistry, Biology, Pharmacology, Cytochrome P-450 Enzyme System, Risk Factors, Internal medicine, Psoriasis, Gene expression, medicine, Humans, Drug Interactions, media_common, Cryopreservation, chemistry.chemical_classification, Biological Products, Messenger RNA, CYP1A2, Middle Aged, medicine.disease, Endocrinology, Enzyme, Cytokine, chemistry, Child, Preschool, Hepatocytes, Cytokines, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cc911dc1aaf65cfb32dbfe0a40af92
https://doi.org/10.2174/138920012802138589

المؤلفون: Jose Silva, Heng-Keang Lim, Vedwatee Gopaul, Tynisha Thomas, Rhys Salter, Paul F. Jackson, Kevin Cook, Kenneth J. Rhodes, Carlo Sensenhauser, Stefanie Rassnick, David C. Evans, Chen Jie, Robert Preston, Brian C. Shook

المصدر: Chemical Research in Toxicology. 24:1012-1030

مصطلحات موضوعية: Salmonella typhimurium, Pyrrolidines, Receptor, Adenosine A2A, Stereochemistry, Metabolite, Reactive intermediate, Mutagen, Adenosine A1 Receptor Antagonists, Toxicology, medicine.disease_cause, Adenosine receptor antagonist, Mass Spectrometry, Pyrrolidine, DNA Adducts, Mice, chemistry.chemical_compound, medicine, Animals, Humans, Biotransformation, Chromatography, High Pressure Liquid, Ions, Mutagenicity Tests, Receptor, Adenosine A1, Chemistry, Iminium, DNA, General Medicine, Adenosine A2 Receptor Antagonists, Rats, Pyrimidines, Indenes, Imines, Genotoxicity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e7471f9a767bbd6ed26775c7fa579a
https://doi.org/10.1021/tx1004437

المؤلفون: Faraz Kazmi, Shannon Dallas, Carlo Sensenhauser

المصدر: Drug Metabolism and Pharmacokinetics. 34:S52

مصطلحات موضوعية: Pharmacology, Human hepatocyte, Chemistry, In vivo, Extrapolation, Pharmaceutical Science, Pharmacology (medical), In vitro, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::185534c0b698705b6c095337028d96c9
https://doi.org/10.1016/j.dmpk.2018.09.183

المؤلفون: Jose Silva, David C. Evans, Kevin Cook, Jie Chen, Heng-Keang Lim, Carlo Sensenhauser

المصدر: Rapid Communications in Mass Spectrometry. 22:1295-1311

مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Reactive intermediate, Orbitrap, Tandem mass spectrometry, Mass spectrometry, Analytical Chemistry, law.invention, chemistry.chemical_compound, Isotopes, Tandem Mass Spectrometry, law, Humans, Molecule, Chromatography, High Pressure Liquid, Spectroscopy, Chromatography, Isotope, Organic Chemistry, Reproducibility of Results, Iminium, Glutathione, Pharmaceutical Preparations, chemistry, Isotope Labeling, Microsomes, Liver

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0877e57b5ee58c69fa59ce2479dd44
https://doi.org/10.1002/rcm.3504

المؤلفون: Lei, Xia, Xin, Hong, Rashidah Binte, Sakban, Yinghua, Qu, Nisha Hari, Singh, Michael, McMillian, Shannon, Dallas, Jose, Silva, Carlo, Sensenhauser, Sylvia, Zhao, Heng Keang, Lim, Hanry, Yu

المصدر: Journal of applied toxicology : JAT. 36(2)

مصطلحات موضوعية: Cytochrome P-450 Enzyme System, Hepatocytes, Drug Evaluation, Humans, Drug Interactions, Chemical and Drug Induced Liver Injury, Cells, Cultured

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::fa3047380280d2698e2d69548094e702
https://pubmed.ncbi.nlm.nih.gov/26201057

المؤلفون: Ian, Templeton, Paulien, Ravenstijn, Carlo, Sensenhauser, Jan, Snoeys

المصدر: Biopharmaceuticsdrug disposition. 37(1)

مصطلحات موضوعية: Adult, Male, Adolescent, Middle Aged, Models, Biological, Domperidone, Erythromycin, Young Adult, Ketoconazole, Microsomes, Liver, Cytochrome P-450 CYP3A Inhibitors, Dopamine Antagonists, Humans, Computer Simulation, Drug Interactions, Female, Caco-2 Cells, Itraconazole

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::e3bc08ef3f04bd016a31e4321f9765c6
https://pubmed.ncbi.nlm.nih.gov/26356245

المؤلفون: Shannon Dallas, Monica Singer, Carlo Sensenhauser

المصدر: Methods in Pharmacology and Toxicology ISBN: 9781627037419

مصطلحات موضوعية: Chemistry, Molecular biology, In vitro

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3e7c5f2470758cbd9c344e7c2ee66697
https://doi.org/10.1007/978-1-62703-742-6_14

المؤلفون: Carlo Sensenhauser

المصدر: Methods in Pharmacology and Toxicology ISBN: 9781627037419

مصطلحات موضوعية: Biochemistry, Chemistry, In vitro

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::412fd1eef63bce117e0afed0c668ec16
https://doi.org/10.1007/978-1-62703-742-6_9

المؤلفون: Carlo Sensenhauser, Jose Silva, Souvik Chattopadhyay, Shannon Dallas

المصدر: Pharmaceutical Sciences Encyclopedia

مصطلحات موضوعية: Drug, Drug metabolizing enzymes, Chemistry, media_common.quotation_subject, Pharmacokinetic modeling, Drug design, Context (language use), Computational biology, Drug interaction, Pharmacology, Small molecule, Expansive, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d841db35958450112dfac30c31e65502
https://doi.org/10.1002/9780470571224.pse474

المؤلفون: Ameesha Batheja, Carlo Sensenhauser, Jose Silva, Monica Singer, Souvik Chattopadhyay, Shannon Dallas

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 41(4)

مصطلحات موضوعية: CYP2B6, Pharmaceutical Science, Gene Expression, Pharmacology, Interleukin-23, Cytochrome P-450 Enzyme System, beta-Naphthoflavone, Cell surface receptor, Gene expression, medicine, Humans, Receptor, Cells, Cultured, biology, Interleukin-6, Tumor Necrosis Factor-alpha, Receptors, Interleukin-12, Cytochrome P450, Receptors, Interleukin, Interleukin-12, In vitro, medicine.anatomical_structure, C-Reactive Protein, Liver, Hepatocyte, Phenobarbital, biology.protein, Hepatocytes, Tumor necrosis factor alpha, Rifampin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ef0ebf03e8021d9dc417a838c32806
https://pubmed.ncbi.nlm.nih.gov/23349185

المؤلفون: Heng-Keang Lim, Jie Chen, Vangala V. Subrahmanyam, Carlo Sensenhauser, Kevin Cook

المصدر: Rapid communications in mass spectrometry : RCM. 21(12)

مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Metabolite, Adrenergic beta-Antagonists, Analytical chemistry, Carbazoles, Tandem mass spectrometry, Mass spectrometry, Orbitrap, Sensitivity and Specificity, Analytical Chemistry, law.invention, Propanolamines, chemistry.chemical_compound, law, Tandem Mass Spectrometry, Calibration, Molecule, Humans, Spectroscopy, Chromatography, High Pressure Liquid, Degree of unsaturation, Chromatography, Organic Chemistry, Reproducibility of Results, Mass spectrometric, chemistry, Microsomes, Liver, Carvedilol

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::defdb3ca27b25af07e6d3be1f4d31c5c
https://pubmed.ncbi.nlm.nih.gov/17497624

المؤلفون: Geert Mannens, Cis Van Looveren, Willem Meuldermans, Carlo Sensenhauser, Jan Noukens, Jos Van Houdt, Dirk Roymans, Pieter Annaert, Adri Weygers, Jose Silva, J. Hendrickx

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 33(7)

مصطلحات موضوعية: Cell, Blotting, Western, Pharmaceutical Science, Enzyme-Linked Immunosorbent Assay, Cryopreservation, Andrology, Cytochrome P-450 Enzyme System, medicine, Humans, Cells, Cultured, DNA Primers, Pharmacology, biology, Base Sequence, Gene Expression Profiling, CYP1A2, Cytochrome P450, In vitro, medicine.anatomical_structure, Biochemistry, Hepatocyte, biology.protein, Protein Expression Analysis, Hepatocytes, Electrophoresis, Polyacrylamide Gel, Drug metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2427e88966e7a4997d3c1d9d99161bb3
https://pubmed.ncbi.nlm.nih.gov/15802389

المؤلفون: Joseph E. Rice, Carlo Sensenhauser, Marianne C. Defloria, Edmond J. LaVoie

المصدر: Chemico-Biological Interactions. 68:127-136

مصطلحات موضوعية: Stereochemistry, Toxicology, DNA Adducts, Mice, chemistry.chemical_compound, In vivo, Cocarcinogen, Benzo(a)pyrene, polycyclic compounds, Animals, Carcinogen, Skin, Fluoranthene, Fluorenes, Binding Sites, Cocarcinogenesis, Dose-Response Relationship, Drug, DNA, General Medicine, Metabolism, Carcinogens, Environmental, Dose–response relationship, chemistry, Pyrene, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35858a30b5e7ef4f19650fafa11b011
https://doi.org/10.1016/0009-2797(88)90011-7