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1
المؤلفون: Gabriel J. Sandoval, Katharine Feldman, Sal Topal, Ammar Adam, Hsin-Jung Wu, Darshan Sappal, Luis M. Soares, David L. Lahr, Lan Xu, Rishi G. Vaswani, Jordana Muwanguzi, Liyue Huang, Jessica Piel, Mike Collins, Ho Man Chan, Michael J. Thomenius, Steven F. Bellon, Ryan G. Kruger, Carl P. Decicco, Richard C. Centore, Martin Hentemann
المصدر: Cancer Research. 82:LB190-LB190
مصطلحات موضوعية: Cancer Research, Oncology
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2
المؤلفون: Neville John Anthony, Shawn Schiller, David L. Lahr, Kevin Wilson, Johannes Voigt, Jeremy W. Setser, Kimberly D. Barnash, Gabriel J. Sandoval, Luis M. Soares, Richard C. Centore, Jordana Muwanguzi, Martin Hentemann, Kana Ichikawa, Lan Xu, Rishi G. Vaswani, Ho Man Chan, Hong Fan, Carl P. Decicco, Ammar Adam, Zhifang Li, Xueying Chen, David Huang, Steven Bellon, Laura Zawadzke, Millan David Simon, Katharine Feldman
المصدر: Cancer Research. 81:1224-1224
مصطلحات موضوعية: Cancer Research, Oncology, Cancer research, Biology, Transcription factor
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3
المؤلفون: Animesh Goswami, Feng Qiu, Carl P. Decicco, Andrew T. Pudzianowski, Quentin Michaudel, Adrienne A. Tymiak, Patrick Y.S. Lam, Samuel J. Bonacorsi, Yingru Zhang, Benjamin P. Vokits, Bei Wang, Brad D. Maxwell, Bang-Chi Chen, Ronald L. Hanson, Jun Dai, Arvind Mathur, Dauh-Rurng Wu, Scott A. Shaw, W. Griffith Humphreys, Shun Su, Phil S. Baran, Janet Caceres Cortes, Balu Balasubramanian, Ruth R. Wexler, Zhiwei Guo, Rulin Zhao, Dawn Sun, Wenying Li, Li Peng, Kevin Cao
المصدر: The Journal of Organic Chemistry. 80:7019-7032
مصطلحات موضوعية: Analyte, Ticlopidine, Chemistry, Metabolite, Organic Chemistry, Stereoisomerism, Biological activity, Prodrug, Pharmacology, Clopidogrel, chemistry.chemical_compound, P2Y12, Piperidines, Biochemistry, Microsomes, Liver, medicine, Humans, Prodrugs, Platelet activation, Platelet Aggregation Inhibitors, Active metabolite, Biological Phenomena, medicine.drug
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4
المؤلفون: Karen A. Rossi, Yiming Wu, Joseph M. Luettgen, Mimi L. Quan, Zhen Lou, James R. Corte, Carl P. Decicco, Joanna J. Zheng, Steven Sheriff, Tianan Fang, Joseph E. Myers, Donald J. P. Pinto, Dietmar A. Seiffert, Ruth R. Wexler, Honey Osuna, Timothy W. Harper, Jeffrey M. Bozarth
المصدر: Journal of medicinal chemistry. 60(3)
مصطلحات موضوعية: Macrocyclic Compounds, Serine Proteinase Inhibitors, Stereochemistry, 030204 cardiovascular system & hematology, Ligands, 01 natural sciences, Factor XIa, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Amide, Drug Discovery, Imidazole, chemistry.chemical_classification, biology, Molecular Structure, 010405 organic chemistry, Hydrogen bond, Active site, Hydrogen Bonding, Ligand (biochemistry), Combinatorial chemistry, Amides, 0104 chemical sciences, Enzyme, chemistry, biology.protein, Molecular Medicine, Selectivity, Linker
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5
المؤلفون: Robert J. Cherney, Peggy A. Scherle, Matthew E. Voss, Persymphonie B. Miller, Qihong Zhao, Gengjie Yang, Sarah R. King, Gregory D. Brown, Sandhya Mandlekar, Carl P. Decicco, Percy H. Carter, Andrew J. Tebben, Yvonne C. Lo
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3311-3316
مصطلحات موضوعية: CCR2, Chemokine, Receptors, CCR2, Isostere, Stereochemistry, animal diseases, Clinical Biochemistry, Substituent, Biological Availability, Pharmaceutical Science, Biochemistry, Mice, chemistry.chemical_compound, parasitic diseases, Drug Discovery, Animals, Molecular Biology, G protein-coupled receptor, Dipeptide, biology, Organic Chemistry, Antagonist, hemic and immune systems, Amino Alcohols, chemistry, biology.protein, Molecular Medicine, CC chemokine receptors
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6
المؤلفون: Joel C. Barrish, Robert J. Cherney, Mary Ellen Cvijic, Michael G. Yang, Israel F. Charo, Carl P. Decicco, Percy H. Carter, Qihong Zhao, Zili Xiao, Ruowei Mo, Sandhya Mandlekar
المصدر: Bioorganic & medicinal chemistry letters, vol 24, iss 7
مصطلحات موضوعية: CCR2, Receptors, CCR2, animal diseases, Medicinal & Biomolecular Chemistry, Clinical Biochemistry, hERG, Molecular Conformation, Pharmaceutical Science, Pharmacology, Biochemistry, Article, Dose-Response Relationship, Mice, Structure-Activity Relationship, Medicinal and Biomolecular Chemistry, Chemokine receptor, GPCR, Pharmacokinetics, Cyclohexanes, parasitic diseases, Receptors, Drug Discovery, Animals, Humans, Structure–activity relationship, Sulfones, Molecular Biology, G protein-coupled receptor, Dose-Response Relationship, Drug, biology, Chemistry, Organic Chemistry, hemic and immune systems, CCR2 antagonist, Pharmacology and Pharmaceutical Sciences, In vitro, Bioavailability, 5.1 Pharmaceuticals, biology.protein, Molecular Medicine, Chemokine antagonist, Drug, Development of treatments and therapeutic interventions
وصف الملف: application/pdf
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7
المؤلفون: Sandhya Mandlekar, John V. Duncia, Joel C. Barrish, Robert J. Cherney, Joseph B. Santella, Yang Michael G, Carl P. Decicco, Matthew E. Voss, Mary Ellen Cvijic, Dayton T. Meyer, Yvonne C. Lo, Percy H. Carter, Ruowei Mo, Qihong Zhao, Persymphonie B. Miller, Peggy A. Scherle, Gengjie Yang
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:2425-2430
مصطلحات موضوعية: CCR2, Lactams, Cyclohexane, Receptors, CCR2, Stereochemistry, Chemotaxis, Organic Chemistry, Clinical Biochemistry, Glycine, Pharmaceutical Science, Metabolic stability, Biochemistry, Mice, chemistry.chemical_compound, chemistry, Cyclohexanes, Drug Discovery, Lactam, Animals, Molecular Medicine, CC chemokine receptors, Molecular Biology, G protein-coupled receptor
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8
المؤلفون: Peggy A. Scherle, Matthew E. Voss, Dayton T. Meyer, Persymphonie B. Miller, Gengjie Yang, Andrew J. Tebben, Yvonne C. Lo, Robert J. Cherney, Ruowei Mo, Carl P. Decicco, Percy H. Carter
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:3418-3422
مصطلحات موضوعية: CCR2, Tertiary amine, Receptors, CCR2, medicine.drug_class, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Sulfone, chemistry.chemical_compound, Cyclohexanes, Drug Discovery, Calcium flux, medicine, Molecular Medicine, Sulfones, CC chemokine receptors, Molecular Biology
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9
المؤلفون: Yvonne C. Lo, Carl P. Decicco, Dayton T. Meyer, Ruowei Mo, Sandhya Mandlekar, Percy H. Carter, Andrew J. Tebben, Kimberly A. Solomon, Gengjie Yang, David J. Nelson, Robert J. Cherney, Heather Jezak, Peggy A. Scherle, Zelda R. Wasserman
المصدر: Journal of Medicinal Chemistry. 51:721-724
مصطلحات موضوعية: Models, Molecular, CCR2, Receptors, CCR2, medicine.drug_class, Stereochemistry, Carboxamide, In Vitro Techniques, Binding, Competitive, Chemical synthesis, Radioligand Assay, Structure-Activity Relationship, Cyclohexanes, parasitic diseases, Drug Discovery, Calcium flux, medicine, Humans, Structure–activity relationship, Chemokine CCL2, G protein-coupled receptor, Chemistry, Stereoisomerism, Chemotaxis, Leukocyte, Leukocytes, Mononuclear, Mutagenesis, Site-Directed, Molecular Medicine, Calcium
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10
المؤلفون: Andrew J. Tebben, Wenqing Yao, Prabhakar Reddy, Carl P. Decicco, John V. Duncia, Eric A. Wadman, Kimberly A. Solomon, Percy H. Carter, Patricia K. Welch, Paul Davies, Sandhya Mandlekar, George V. Delucca, Soo S. Ko, Paul S. Watson, Ilona Kariv, Chongsheng Shi, Gardner Daniel S, Dean A. Wacker, Swamy Yeleswaram, Dani M. Graden, Joseph B. Santella
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:576-585
مصطلحات موضوعية: Cyclohexane, Stereochemistry, Receptors, CCR3, Clinical Biochemistry, Molecular Conformation, Ab initio, Administration, Oral, Pharmaceutical Science, Plasma protein binding, Biochemistry, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Piperidines, Drug Discovery, Animals, Cytochrome P-450 Enzyme Inhibitors, Urea, Molecular Biology, Chemistry, Organic Chemistry, Antagonist, Hydrogen Bonding, Chemotaxis, Rats, Eosinophils, Chemotaxis, Leukocyte, Eosinophil chemotaxis, Molecular Medicine, Linker
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11
المؤلفون: Robert J. Cherney, Kimberly A. Solomon, Carl P. Decicco, Percy H. Carter, Yvonne C. Lo, Peggy A. Scherle, Sarah R. Friedrich, Andrew J. Tebben, Heather Jezak, Gregory D. Brown, Gengjie Yang
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:5455-5461
مصطلحات موضوعية: CCR2, Monocyte chemotaxis, Receptors, CCR2, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Carboxamide, Peptide, Biochemistry, Chemical synthesis, Monocytes, Structure-Activity Relationship, chemistry.chemical_compound, Benzylamine, parasitic diseases, Drug Discovery, Peptide synthesis, medicine, Benzamide, Molecular Biology, Chemokine CCL2, chemistry.chemical_classification, Organic Chemistry, Hydrogen Bonding, hemic and immune systems, Dipeptides, Chemotaxis, Leukocyte, chemistry, Molecular Medicine, Calcium, Indicators and Reagents
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12
المؤلفون: Yevgeniya I. Orlovsky, Nicole Stowell, Anuk M. Das, David D. Christ, Kimberly A. Solomon, Dean A. Wacker, Douglas G. Batt, Lori L. Bostrom, Danielle M. Graden, Soo S. Ko, Erin McLaughlin, Carl P. Decicco, Gregory C. Houghton, Eric A. Wadman, Swamy Yeleswaram, Ilona Kariv, Percy H. Carter, Patricia K. Welch, Jeffrey G. Varnes, Robert C. Newton, Maryanne B. Covington, Paul Davies, James R. Pruitt, Shon K. Booker, Krishna Vaddi
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:2992-2997
مصطلحات موضوعية: Pan troglodytes, Stereochemistry, Receptors, CCR3, Clinical Biochemistry, Pharmaceutical Science, digestive system, Biochemistry, Cytochrome P-450 CYP2D6 Inhibitors, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Piperidines, immune system diseases, Benzyl Compounds, Drug Discovery, Animals, Humans, Structure–activity relationship, skin and connective tissue diseases, Molecular Biology, Cells, Cultured, Phenylurea Compounds, Aryl, Organic Chemistry, Antagonist, hemic and immune systems, chemistry, Lipophilicity, Molecular Medicine, Biological Assay, Receptors, Chemokine, Cytochrome P-450 CYP2D6, Selectivity, CC chemokine receptors
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13
المؤلفون: Carl P. Decicco, Rui-Qin Liu, Andrew J. Tebben, Jingwu Duan, Chu-Biao Xue, James E. Sheppeck, John L. Gilmore
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:2769-2774
مصطلحات موضوعية: Models, Molecular, Molecular model, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Hydantoin, Carboxamide, ADAM17 Protein, Hydroxamic Acids, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Drug Discovery, medicine, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Bicyclic molecule, Chemistry, Hydantoins, Organic Chemistry, Imidazoles, Triazoles, ADAM Proteins, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, Pharmacophore
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14
المؤلفون: Kim L. R. Brouwer, Lauren E. Richards, Carl P. Decicco, Frank W. Lee, C. Edwin Garner, Hao Xiong, Gang Luo, Jingwu Duan, Thomas P. Maduskuie, Hanbo Hu, Liang Shang Gan, Helen Shen
المصدر: Drug Metabolism and Disposition. 35:835-840
مصطلحات موضوعية: musculoskeletal diseases, medicine.medical_specialty, Necrosis, Anti-Inflammatory Agents, Pharmaceutical Science, ADAM17 Protein, In Vitro Techniques, Kidney, Animals, Genetically Modified, chemistry.chemical_compound, Dogs, Pharmacokinetics, Internal medicine, medicine, Animals, Bile, Humans, Drug Interactions, Rats, Wistar, Pharmacology, biology, Chemistry, Multidrug resistance-associated protein 2, Kidney metabolism, Drug interaction, Rats, ADAM Proteins, Methotrexate, Endocrinology, Liver, Enzyme inhibitor, Antirheumatic Agents, Antifolate, Quinolines, biology.protein, ATP-Binding Cassette Transporters, medicine.symptom, medicine.drug
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15
المؤلفون: Andrew J. Tebben, Jingwu Duan, Anle Yang, Carl P. Decicco, Zelda R. Wasserman, James E. Sheppeck, John L. Gilmore
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:1408-1412
مصطلحات موضوعية: Models, Molecular, Steric effects, Lactams, Molecular model, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Hydantoin, Pyrimidinones, ADAM17 Protein, Hydroxamic Acids, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Molecular Biology, Coordination geometry, Binding Sites, biology, Chemistry, Hydantoins, Organic Chemistry, Active site, Biological activity, ADAM Proteins, Zinc, Enzyme inhibitor, biology.protein, Molecular Medicine, Pharmacophore
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16
المؤلفون: Carl P. Decicco, Nicole Stowell, George L. Trainor, Robert C. Newton, Nao Asakawa, Steven M. Friedman, Kimberly A. Solomon, Kim Harrison, Patricia K. Welch, Bin Jiang, Paul S. Watson, Maryanne B. Covington, Soo S. Ko, Eric A. Wadman, Paul Davies
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:5695-5699
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Receptors, CCR3, Organic Chemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Ring (chemistry), Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Piperidines, chemistry, Drug Discovery, Urea, Molecular Medicine, Structure–activity relationship, Receptors, Chemokine, Piperidine, Selectivity, Molecular Biology, Alkyl
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17
المؤلفون: John L. Gilmore, Carl P. Decicco, Rui-Qin Liu, Jingwu Duan, Bryan W. King, Maryanne B. Covington, Robert J. Cherney
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:1028-1031
مصطلحات موضوعية: MMP Inhibitors, Clinical Biochemistry, Pharmaceutical Science, ADAM17 Protein, Matrix metalloproteinase, Pharmacology, Hydroxamic Acids, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, IC50, chemistry.chemical_classification, Sulfonamides, Hydroxamic acid, Molecular Structure, biology, Organic Chemistry, Biological activity, General Medicine, Tace inhibitor, In vitro, ADAM Proteins, Enzyme, chemistry, Enzyme inhibitor, Drug Design, Metalloproteases, biology.protein, Molecular Medicine
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18
المؤلفون: Kimberly A. Solomon, Joseph B. Santella, George L. Trainor, Robert C. Newton, Zhang Wang, Dean A. Wacker, George V. De Lucca, Anuk M. Das, Paul Davies, Ui Tae Kim, Maryanne B. Covington, Danielle M. Graden, Gardner Daniel S, Nicole Stowell, Changsheng Zheng, John V. Duncia, Brian J. Vargo, George C. Emmett, Eric A. Wadman, Carl P. Decicco, Patricia K. Welch, Swamy Yeleswaram, Ann Y. Liauw, Soo S. Ko
المصدر: Journal of Medicinal Chemistry. 48:2194-2211
مصطلحات موضوعية: Male, Stereochemistry, Receptors, CCR3, CCR3, Biological Availability, CHO Cells, In Vitro Techniques, Chemical synthesis, Permeability, Mice, Structure-Activity Relationship, Piperidines, Cyclohexanes, In vivo, Cricetinae, Drug Discovery, Hypersensitivity, Animals, Humans, Urea, Potency, Inflammation, Mice, Inbred BALB C, Chemistry, Phenylurea Compounds, Antagonist, Stereoisomerism, In vitro, Eosinophils, Mice, Inbred C57BL, Chemotaxis, Leukocyte, Molecular Medicine, Calcium, Female, Receptors, Chemokine, Caco-2 Cells, CC chemokine receptors, Linker
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19
المؤلفون: Carl P. Decicco, Lin Xu, Jingwu Duan, Rui-Qin Liu, William A. Schumacher, Xinkang Wang, Martin L. Ogletree, Hugh Wang, Giora Z. Feuerstein, Rebecca Taub
المصدر: Molecular Pharmacology. 65:890-896
مصطلحات موضوعية: Male, Ischemia, Gene Expression, Apoptosis, DNA Fragmentation, ADAM17 Protein, Pharmacology, Brain Ischemia, Proinflammatory cytokine, Rats, Sprague-Dawley, Piperidines, medicine.artery, medicine, Animals, Neuroinflammation, biology, Caspase 3, Chemistry, Metalloendopeptidases, Sheddase, medicine.disease, Enzyme assay, Rats, ADAM Proteins, Neuroprotective Agents, Caspases, Reperfusion Injury, Middle cerebral artery, Immunology, Quinolines, Systemic administration, biology.protein, Molecular Medicine, Tumor necrosis factor alpha
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المؤلفون: Chu-Biao Xue, Xiaohua He, John Roderick, Ronald L Corbett, James J.-W Duan, Rui-Qin Liu, Maryanne B Covington, Mingxin Qian, Maria D Ribadeneira, Krishna Vaddi, David D Christ, Robert C Newton, James M Trzaskos, Ronald L Magolda, Ruth R Wexler, Carl P Decicco
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:4299-4304
مصطلحات موضوعية: Models, Molecular, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Carboxamide, ADAM17 Protein, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Moiety, Enzyme Inhibitors, Molecular Biology, Hydroxamic acid, biology, Organic Chemistry, Quinoline, Rational design, Metalloendopeptidases, Succinates, ADAM Proteins, Kinetics, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Piperidine