المؤلفون: Lauren B. Coco, Caren L. Freel Meyers

المصدر: Frontiers in Chemical Biology, Vol 3 (2024)

مصطلحات موضوعية: 1-deoxy-D-xylulose 5-phosphate synthase, activity-based probe, alkyl acetylphosphonate, thiamin-dependent enzyme, antimicrobial target, vitamin biosynthesis, Biology (General), QH301-705.5, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fchbi.2024.1389620/full; https://doaj.org/toc/2813-530X

URL الوصول: https://doaj.org/article/008bf970ae624fc39362d11a562a45e1

المؤلفون: Eric C. Chen, Rachel L. Shapiro, Arindom Pal, David Bartee, Kevin DeLong, Davell M. Carter, Erika Serrano-Diaz, Rana Rais, Laura M. Ensign, Caren L. Freel Meyers

المصدر: Microbiology Spectrum, Vol 12, Iss 4 (2024)

مصطلحات موضوعية: 1-deoxy-d-xylulose 5-phosphate synthase, DXPS, antibiotic, central metabolism, MEP, acetylphosphonate, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2165-0497

URL الوصول: https://doaj.org/article/4a175573fe324e7f9a9516671ff42bae

المؤلفون: Paul Curley, James J. Hobson, Neill J. Liptrott, Edward Makarov, Amer Al-khouja, Lee Tatham, Christopher A. W. David, Helen Box, Megan Neary, Joanne Sharp, Henry Pertinez, David Meyers, Charles Flexner, Caren L. Freel Meyers, Larisa Poluektova, Steve Rannard, Andrew Owen

المصدر: Pharmaceutics, Vol 15, Iss 7, p 1835 (2023)

مصطلحات موضوعية: HIV, long-acting, pre-exposure prophylaxis, nano, emtricitabine, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1999-4923/15/7/1835; https://doaj.org/toc/1999-4923

URL الوصول: https://doaj.org/article/30c9897dc2e441029b763227a146a61d

المؤلفون: Eric C. Chen, Caren L. Freel Meyers

المصدر: Antibiotics, Vol 12, Iss 4, p 692 (2023)

مصطلحات موضوعية: 1-deoxy-d-xylulose 5-phosphate synthase, DXPS, MEP, DsdA, d-serine, bacterial adaptation, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2079-6382/12/4/692; https://doaj.org/toc/2079-6382

URL الوصول: https://doaj.org/article/ed97cd01c7b842dea1d921cb2bf8ab5e

المؤلفون: Eucolona M. Toci, Steven L. Austin, Ananya Majumdar, H. Lee Woodcock, Caren L. Freel Meyers

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Physical Sciences not elsewhere classified, nearby residues believed, putative network residues, network charge distribution, network causing changes, disrupting substitutions near, 2 , promote lthdp activation, prevent lthdp activation, active site network, shift dxps toward, lived lthdp intermediate, active site, substitutions predicted, network fails, shift dxps, conformational shift, lthdp persists, lthdp complex, lthdp also, activate lthdp, thiamin diphosphate, standing question, specific metabolite

Relation: https://figshare.com/articles/journal_contribution/Disruption_of_an_Active_Site_Network_Leads_to_Activation_of_C2_-Lactylthiamin_Diphosphate_on_the_Antibacterial_Target_1_Deoxy_d_xylulose-5-phosphate_Synthase/25274182

الاتاحة: https://doi.org/10.1021/acs.biochem.3c00735.s001
https://figshare.com/articles/journal_contribution/Disruption_of_an_Active_Site_Network_Leads_to_Activation_of_C2_-Lactylthiamin_Diphosphate_on_the_Antibacterial_Target_1_Deoxy_d_xylulose-5-phosphate_Synthase/25274182

المؤلفون: Melanie L. Johnston, Eucolona M. Toci, Alicia A. DeColli, Caren L. Freel Meyers

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biotechnology, Infectious Diseases, Computational Biology, third mechanism involving, ketol transfer reaction, freel meyers laboratory, dynamic metabolic landscape, c2 – c3, dxps forms dihydroxyethyl, cleavage reaction catalyzed, pyridoxal phosphate biosynthesis, donor substrate usage, examined x5p binding, dhe )­ thdp, ketose phosphate binding, bacterial enzyme 1, donor substrate, x5p binding, isoprenoid biosynthesis, dhe donors, bacterial adaptation, stable enzyme, point enzyme, donor used, demonstrated substrate, phosphate synthase, phosphate act

Relation: https://figshare.com/articles/journal_contribution/Antibacterial_Target_DXP_Synthase_Catalyzes_the_Cleavage_of_d_Xylulose_5_Phosphate_a_Study_of_Ketose_Phosphate_Binding_and_Ketol_Transfer_Reaction/20564666

الاتاحة: https://doi.org/10.1021/acs.biochem.2c00274.s001
https://figshare.com/articles/journal_contribution/Antibacterial_Target_DXP_Synthase_Catalyzes_the_Cleavage_of_d_Xylulose_5_Phosphate_a_Study_of_Ketose_Phosphate_Binding_and_Ketol_Transfer_Reaction/20564666

المؤلفون: Melanie L. Johnston, Eucolona M. Bonett, Alicia A. DeColli, Caren L. Freel Meyers

المصدر: Biochemistry. 61:1810-1823

مصطلحات موضوعية: Xylulose, Bacteria, Transferases, Ketoses, Thiamine Pyrophosphate, Glyceraldehyde 3-Phosphate, Biochemistry, Anti-Bacterial Agents, Phosphates

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dbbcf7472159ba9d60221db1f55145f
https://doi.org/10.1021/acs.biochem.2c00274

المؤلفون: Caren L. Freel Meyers, Christine L. Hann, Michelle A. Rudek, Ashani T. Weeraratna, Ming Zhao, Nick Connis, Chandrashekhar Kamat, Marie R. Webster

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966f3076782d9bb7bc676458096d5b4c
https://doi.org/10.1158/1535-7163.22499718.v1

المؤلفون: Caren L. Freel Meyers, Christine L. Hann, Michelle A. Rudek, Ashani T. Weeraratna, Ming Zhao, Nick Connis, Chandrashekhar Kamat, Marie R. Webster

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d880e71e939d9b16377a5c9da7b9b43f
https://doi.org/10.1158/1535-7163.c.6536238

المؤلفون: Sara Sanders, David Bartee, Mackenzie J Harrison, Paul D Phillips, Andrew T Koppisch, Caren L Freel Meyers

المصدر: PLoS ONE, Vol 13, Iss 5, p e0197638 (2018)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC5957436?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/19b7e8033cf742b58dbb7d982a978abf

المؤلفون: Caren L. Freel Meyers, Melanie L. Johnston

المصدر: Biochemistry. 60(12)

مصطلحات موضوعية: chemistry.chemical_classification, Models, Molecular, Glycolaldehyde, biology, ATP synthase, Bacteria, Chemistry, Active site, Substrate (chemistry), Metabolism, Transketolase, Biochemistry, Acceptor, Substrate Specificity, chemistry.chemical_compound, Enzyme, Transferases, Catalytic Domain, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e8df951f147f72c4d7cc7c1bbc6343
https://pubmed.ncbi.nlm.nih.gov/33660509

المؤلفون: Marco Siccardi, Paul Curley, Steve P. Rannard, Andrew Owen, Alison C. Savage, James J. Hobson, Charles Flexner, Amer Al-khouja, Caren L. Freel Meyers

المصدر: Nanoscale Advances. 1:4301-4307

مصطلحات موضوعية: Chromatography, Tenofovir, Aqueous medium, Depot, Chemistry, General Engineering, Bioengineering, General Chemistry, Atomic and Molecular Physics, and Optics, Long acting, medicine, Drug release, Anhydrous, General Materials Science, Drug nanoparticles, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad4baa319f4588d7efe05db0c90d011
https://doi.org/10.1039/c9na00529c

المؤلفون: David Bartee, Andrew T. Koppisch, Caren L. Freel Meyers, Paul D. Phillips, Mackenzie J. Harrison, Sara Sanders

المصدر: ACS infectious diseases. 5(3)

مصطلحات موضوعية: 0301 basic medicine, 030106 microbiology, Microbial Sensitivity Tests, Article, 03 medical and health sciences, chemistry.chemical_compound, Transferases, Escherichia coli, Prodrugs, Pyridoxal phosphate, Enzyme Inhibitors, chemistry.chemical_classification, Pentosephosphates, Natural product, biology, ATP synthase, Escherichia coli Proteins, Metabolism, Prodrug, Anti-Bacterial Agents, 030104 developmental biology, Infectious Diseases, Enzyme, chemistry, Biochemistry, biology.protein, DXP synthase, Antibacterial activity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c62224c3b248990c51b3855ce33a3a9
https://pubmed.ncbi.nlm.nih.gov/30614674

المؤلفون: David Bartee, Caren L. Freel Meyers

المصدر: Accounts of Chemical Research. 51:2546-2555

مصطلحات موضوعية: 0301 basic medicine, medicine.drug_class, Metabolite, Antibiotics, Article, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, Transferases, Catalytic Domain, Escherichia coli, medicine, Enzyme Inhibitors, Pyridoxal phosphate, chemistry.chemical_classification, Bacteria, 030102 biochemistry & molecular biology, ATP synthase, biology, General Medicine, General Chemistry, Metabolism, Antimicrobial, Anti-Bacterial Agents, 030104 developmental biology, Enzyme, chemistry, Biochemistry, Biocatalysis, biology.protein, DXP synthase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71dfdbcad70ba2f4c8156d6c8622e071
https://doi.org/10.1021/acs.accounts.8b00321

المؤلفون: Michelle Pacholec, Caren L. Freel Meyers, Daniel Kahne, Christopher T. Walsh

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: https://walsh.med.harvard.edu/pubs/PDFs_2/SimL.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.513.1965

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.513.1965

المؤلفون: Luying Yang, Frank Jordan, Natalia S. Nemeria, Jieyu Zhou, Alicia A. DeColli, Caren L. Freel Meyers

المصدر: Proceedings of the National Academy of Sciences. 114:9355-9360

مصطلحات موضوعية: Models, Molecular, Phosphonoacetic Acid, 0301 basic medicine, Protein Conformation, Stereochemistry, Decarboxylation, Glyceraldehyde 3-Phosphate, Mass Spectrometry, 03 medical and health sciences, chemistry.chemical_compound, Protein structure, Biosynthesis, Transferases, Pyridoxal, chemistry.chemical_classification, Pentosephosphates, Multidisciplinary, 030102 biochemistry & molecular biology, biology, ATP synthase, Biological Sciences, 030104 developmental biology, Enzyme, chemistry, biology.protein, DXP synthase, Glyceraldehyde 3-phosphate, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4fc2da2ac06bc8ead20687f77b0eda
https://doi.org/10.1073/pnas.1619981114

المؤلفون: David Back, Andrew Owen, Caren L. Freel Meyers, Marco Siccardi, Charles Flexner, Steve P. Rannard, Rajith K. R. Rajoli

المصدر: Clinical pharmacokinetics

مصطلحات موضوعية: 0301 basic medicine, Drug, Pediatrics, medicine.medical_specialty, Adolescent, Anti-HIV Agents, Pyridones, media_common.quotation_subject, 030106 microbiology, Pharmacology, Models, Biological, Loading dose, Article, 03 medical and health sciences, chemistry.chemical_compound, Cabotegravir, Pharmacokinetics, medicine, Humans, Computer Simulation, Pharmacology (medical), Dosing, Child, media_common, Dose-Response Relationship, Drug, Maintenance dose, business.industry, Body Weight, Rilpivirine, Age Factors, Clinical trial, Drug Liberation, chemistry, Child, Preschool, Delayed-Action Preparations, business

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6224456f1ad4ae64924b664280c4e1d1
https://doi.org/10.1007/s40262-017-0557-x

المؤلفون: Alicia A. DeColli, Caren L. Freel Meyers, Melanie L. Johnston

المصدر: Comprehensive Natural Products III

مصطلحات موضوعية: chemistry.chemical_classification, Enzyme, chemistry, Mechanism (biology), Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4786edc4e7ab66af8c8f8c9ae6823fdd
https://doi.org/10.1016/b978-0-12-409547-2.14710-9

المؤلفون: Alicia A. DeColli, Frank Jordan, Caren L. Freel Meyers, Xu Zhang, Kathryn L. Heflin

المصدر: Biochemistry. 58(49)

مصطلحات موضوعية: Stereochemistry, Decarboxylation, Protein Conformation, Amino Acid Motifs, Crystallography, X-Ray, Biochemistry, Article, Catalysis, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, Protein structure, Biosynthesis, Transferases, Catalytic Domain, Escherichia coli, Histidine, Pyridoxal phosphate, Aldose-Ketose Isomerases, 0303 health sciences, Pentosephosphates, biology, ATP synthase, 030302 biochemistry & molecular biology, Active site, chemistry, biology.protein, DXP synthase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11cb0818074c16ad149b21993ea98121
https://pubmed.ncbi.nlm.nih.gov/31724401

المؤلفون: David Bartee, Caren L. Freel Meyers

المصدر: Biochemistry. 57(29)

مصطلحات موضوعية: 0301 basic medicine, Metabolite, Triazole, Acetaldehyde, 01 natural sciences, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, Biosynthesis, Transferases, Escherichia coli, Humans, Pyridoxal phosphate, Enzyme Inhibitors, Ternary complex, Escherichia coli Infections, chemistry.chemical_classification, Pentosephosphates, biology, 010405 organic chemistry, Metabolism, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, Enzyme, chemistry, Drug Design, biology.protein, DXP synthase, Deinococcus

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff18f85fd4ef261ec942d0cedf8f9f43
https://pubmed.ncbi.nlm.nih.gov/29944345